Abstract: A system and method for isolating target substrates includes a microfluidic chip, comprising a plurality of processing units, each processing unit comprising: an inlet port, a plurality of first chambers connected to the inlet port by a fluid channel, the fluid channel comprising a plurality of valves, a plurality of second chambers, each of the second chambers connected to a respective first chamber by a fluid channel, each fluid channel including a controllable blocking valve, and a plurality of respective outlet ports, each outlet port in fluid communication with a respective one of said second chambers and each outlet port including a blocking valve. A magnet is adjacent the microfluidic chip and is movable relative to the microfluidic chip. A valve control is capable of actuating certain ones of the controllable blocking valves in response to a control signal.

Abstract: Reversible phase-change materials (PCMs) can be added to or incorporated into meta-lenses, wave plates, waveguides, gratings, and other optical components to form active optical devices with controllable and adjustable optical characteristics. Local heating can be used to induce solid-state phase changes and large refractive index changes in the PCMs. The phase and index changes can provide large changes in the device's optical characteristics. Optical devices with PCM can be used for imaging applications, orbital angular momentum control, photonic integrated circuits and optical communication systems, beam steering, and other application.

Abstract: Various embodiments address removal of one or more species from a gas stream by exposing the gas stream to divided portions of a fluid, such as droplets of water or mist, where the fluid, and/or content of the fluid, can absorb or modify the species and thereby remove it at least partially from the gas stream. Removal of CO2 from a combustion exhaust stream is one embodiment.

Abstract: Senescent cells can be detected using magnetic resonance relaxometry.

Abstract: Femto-satellites are very small satellites that can be deployed in constellations from a larger mothership satellite for distributed measurement. They are too small to accommodate the GNSS receivers that many satellites use for navigation, but they can be located with an electromagnetic beam from the mothership satellite. The mothership satellite scans this beam across a constellation of femto-satellites. When the beam scans across a particular femto-satellite, the femto-satellite transmits an acknowledgement to the mothership satellite, e.g., by retroreflecting the beam or via a separate radio link. The beam can be modulated with commands for the femto-satellite, such as to make a measurement or transmit previously acquired data, as well with commands for determining the femto-satellite's location, such as a time stamp or beam pointing information.

Abstract: Use a computerized trained graph neural network model to classify an input instance with a predicted label. With a computerized graph neural network interpretation module, compute a gradient-based saliency matrix based on the input instance and the predicted label, by taking a partial derivative of class prediction with respect to an adjacency matrix of the model. With a computerized user interface, obtain user input responsive to the gradient-based saliency matrix. Optionally, modify the trained graph neural network model based on the user input; and re-classify the input instance with a new predicted label based on the modified trained graph neural network model.

Abstract: A system and method for oxidizing organic molecules as an oxygen-atom source using an electrochemical process is described.

Abstract: Binary-phase-shift-key, phase-modulated waveforms with gigahertz bandwidths, suitable for kilowatt-class fiber amplifiers, can be narrowed back to the source laser's linewidth via second-harmonic, sum-frequency, or difference-frequency generation in a second-order nonlinear crystal. The spectrum of an optical signal phase-modulated with a pseudo-random bit sequence (PRBS) waveform recovers its original optical spectrum when frequency-doubled using second-harmonic generation (SHG). Conceptually, the PRBS waveform is cancelled by the SHG process, and the underlying laser spectrum is converted to the second-harmonic wavelength as though the PRBS modulation were not present. The same cancellation is possible with sum-frequency generation (SFG) and difference frequency generation (DFG), making it possible to construct high-power, narrow-linewidth lasers at wavelengths from the visible to the long-wave infrared.

Abstract: An ultrasound patch may conform to a curved surface of a large, curvilinear part of a human body, and may capture ultrasound images of underlying tissue for detection of disease. The patch may comprise a flexible, elastomeric substrate, in which phased arrays of piezoelectric ultrasound transducers are embedded. The phased arrays may steer ultrasound beams through a wide angle to image a large volume of tissue. Mechanical deformation of the flexible substrate as it conforms to a curvilinear body part may change the relative 3D positions of the phase arrays. However, localization may be performed to detect these 3D positions. Data captured by the phased arrays may be processed, to create an ultrasound image of the underlying tissue. A semi-flexible, intermediate layer may partially encapsulate each phased array, to distribute stress at an interface between the rigid phased array and more flexible substrate.

Abstract: The present disclosure provides, e.g., compounds, compositions, kits, methods of synthesis, and methods of use, involving epipolythiodiketopiperazines and polythiodiketopiperazines.

Abstract: The present invention provides tools and methods for the systematic analysis of genetic interactions between cells. The present invention provides tools and methods for modulating cell phenotypes and compositions, combinatorial probing of cellular circuits, for dissecting cellular circuitry, for delineating molecular pathways, and/or for identifying relevant targets for therapeutics development.

Abstract: The systems and methods described herein determine metrics of cardiac performance via a mechanical circulatory support device and use the cardiac performance to calibrate, control and deliver mechanical circulatory support for the heart. The systems include a controller configured to operate the device, receive inputs indicative of device operating conditions and hemodynamic parameters, and determine vascular performance, including vascular resistance and compliance, and native cardiac output. The systems and methods operate by using the mechanical circulatory support device (e.g., a heart pump) to introduce controlled perturbations of the vascular system and, in response, determine heart parameters such as stroke volume, vascular resistance and compliance, left ventricular end diastolic pressure, and ultimately determine native cardiac output.

Abstract: What is disclosed relates to a novel reactor system design for chemical looping solar fuel production processes incorporating temperature swing between two or more zones, wherein two or more individual reactors are employed, and heat is recuperated between the reactors by means including radiative heat exchange. Each individual reactor comprising the overall system is isolated from other reactors and the external environment for gas exchange purposes, so that the inflow and outflow of chemical species from individual reactors can be controlled. Individual reactors are arranged in the form of a moving train, and heat exchange between a pair of reactors is facilitated by radiative exchange. External heat addition and removal between the system and its environment may be achieved by means including radiative heat exchange with the hot source and convective exchange with the cold source. This may include, in a particular embodiment, the use of solar irradiation.

Abstract: A method for hiding data within cover audio uses a set of sample codebook waveforms that are each assigned a unique representative digit value. A hidden data sequence representing the data is formed from the waveforms by concatenation of the waveforms assigned to the digit values of the data. The sequence is superimposed upon segments of the cover audio at a fractional amplitude. After transmission, the received signal is decompressed if necessary, the hidden data sequence is recovered from the cover audio, and the data is recovered from the hidden data sequence. This may be done by recovering the locations of the codebook waveforms and interpolating the time markers of the locations. The recovered data may be cleaned up by using estimated distances between successive cross-correlations to discard extraneous correlation peaks and sequence recurrence to probabilistically delete overlapping correlation peaks.

Abstract: The present disclosure describes functional oligomers or functional polymers. The functional oligomers or functional polymers may contain functional groups, e.g., —OH and/or —CHO. The functional oligomers or functional polymers may be obtained from hydrolyzing certain copolymers and may be soluble in commercially available solvents. The copolymers may be thermosetting polymers. The functional oligomers and functional polymers may be useful for recycling thermosetting polymers and may be useful as starting materials for preparing additional oligomers or polymers.

Abstract: System and methods related to lyophilization of pharmaceutical products are disclosed. In some embodiments, vials of product are moved through a system using one or more movers which are electromagnetically levitated and moved through the system without making mechanical contact with each other or the system. Load lock chambers may allow a mover to enter from one process region's environment and then be brought to an environment condition of the next process region to allow materials to be passed through conditioning, nucleation, and/or vacuum drying regions prior to finally exit the system to an unloading zone. The movers may then be cleaned or reloaded with vials to begin the process again with a new load of vials.

Abstract: The typical approach to transfer quantum information between two superconducting quantum computers is to transduce the quantum information into the optical regime at the first superconducting quantum computer, transmit the quantum information in the optical regime to the second superconducting quantum computer, and then transduce the quantum information back into the microwave regime at the second superconducting quantum computer. However, direct microwave-to-optical and optical-to-microwave transduction have low fidelity due to the low microwave-optical coupling rates and added noise. These problems compound in consecutive microwave-to-optical and optical-to-microwave transduction steps. We break this rate-fidelity trade-off by heralding end-to-end entanglement with one detected photon and teleportation. In contrast to cascaded direct transduction, our technology absorbs the low optical-microwave coupling efficiency into the entanglement heralding step.

Abstract: An integrated structure for an optoelectronic device and a method of fabricating an integrated structure for an optoelectronic device.

Abstract: A method includes receiving data representing graphomotor motion during a succession of executions of graphomotor diagnostic tasks performed in a medical context by a subject, processing the received data using a computer, including determining a first set of quantitative features from a first execution of a task by the subject, and determining a second set of quantitative features from a second execution of a task by the subject, determining one or more metrics based on a comparison to the successive executions, including using at least the first set of quantitative features and the second set of quantitative features to determine said metrics, and providing a diagnostic report associated with neurocognitive mechanisms underlying the subject's execution of the tasks based on the determined metrics.

Abstract: Aspects of the present disclosure relate to methods and compositions useful for in vivo and/or in vitro profiling of proteases present in the lung. In some embodiments, the disclosure provides methods of in vivo enzymatic processing of exogenous molecules followed by detection of detectable markers as representative of the presence of active proteases associated with a lung disease, for example, lung cancer and lung infections. In some embodiments, the disclosure provides compositions and methods for production of a lung disease signature and diagnosis of lung disease.