Abstract: Siloxene and siloxene derivatives are compatible with silicon and may be generated as epitaxial layer on a silicon monocrystal. This permits the production of novel and advantageous electroluminescent devices, such as displays, image converters, optoelectric integrated circuits. Siloxene and siloxene derivatives may also be advantageously employed in lasers as laser-active material and in fluorescent lamps or tubes as luminescent material.

Abstract: In order to isolate an inhibitor of the proliferation of endothelial cells from the tissue of vertebrates the tissue selected as the starting material e.g. embryonic tissue or adult brain tissue from birds or mammals, is centrifuged, homogenized and subsequently the tissue extract is applied to a cation exchanger and the substances which bind to the cation exchanger are subjected to a fractionation, the active fractions are separated by gel filtration chromatography and they are purified by reverse phase HPLC. The new inhibitor obtained in this way is suitable for treating disease states in which an inhibition of capillary growth is necessary such as for the treatment of tumors, rheumatoid arthritis, diabetic retinopathy and retrolental fibroplasia and for treating wounds in order to regulate the regeneration of blood vessels.

Abstract: To produce a layer by liquid-phase heteroepitaxy a molten metal serving as the solvent is saturated at a first temperature with substrate material and compounded with layer material. The solution and the substrate are then separatly "overheated" to a second, higher temperature and then brought into contact with each other. Due to the overheating a negative thermodynamic driving force results for the epitaxy which compensates the positive driving force for the epitaxy at least in part due to the different interfacial energies between layer material and solution and substrate material and solution. The degree of overheating determines the resulting total driving force for the epitaxy which may be reduced to zero. Very thin layers, down to a monolayer thickness may be grown in this way from the solution with a layer thickness exact to a monolayer with no dislocation.

Abstract: A method for the formation of a layer on at least one substrate. A liquid, which contains the material for forming the layer, flows over the surface of the substrate of the substrate to be coated. A concentration gradient of the layer-forming material is produced in a direction, perpendicular to the direction of the flow of the liquid. As a result, the concentration of the layer-forming material becomes a maximum at one side of the liquid.

Abstract: STM probe, in particular for use in an SEM for examining a surface of a sle by STM and/or SEM operation, comprising an outer and an inner piezotube; an object carrier plate mounted on the annular top face of the inner piezotube; a triangular head plate mounted on the annular top face of the outer piezotube and having a recess substantially concentric with the tubes in the triangle side crossing the tubes, the object carrier plate being arranged in this recess with play on all sides; a triangular test-prod attachment plate arranged at a space above the head plate and having a test-prod attachment made of an insulating material in the triangle side passing above the object carrier plate, for receiving a test prod; the corner areas of the plates being provided with fine-thread spindles for setting the space between the plates; and the two plates being held together by means of three springs engaging the corners.

Abstract: The present invention provides a process for the production of a K- or Rb-.beta."- or -.beta.-aluminum oxide powder preparation, wherein a cubic densely packed aluminum oxide (.gamma.-aluminum oxide) or a precursor thereof is subjected to attrition together with a doping material or a precursor thereof, the so obtained mixture is calcined in an oxygen-containing atmosphere, potassium oxide or rubidium oxide or a precursor of these compounds is added to the calcination product obtained, the mixture is subjected to attrition and then calcined in an oxygen-containing atmosphere at a temperature greater than 900.degree. C. The present invention also provides a process for the production of a ceramic formed body in which a powder obtained by the above process is converted by attrition, isostatic pressing and sintering into a ceramic formed body. Such a ceramic formed body can be used as an ion conductor.

Abstract: Apparatus for the production of short-wave electromagnetic radiaion, especially in the x-ray and gamma-ray region, by means of the interaction between accelerated charged particles, especially electrons or positrons, and a crystal lattice, with a charged-particle source for the production of a beam of energetic charged particles and with a crystal arrangement which is so arranged in the path of the charged particle radiation beam that the charged particles traverse the crystal lattice of the crystal arrangement parallel to a predetermined lattice direction ("channeling-condition"). In order to produce an electromagnetic radiation beam with predetermined convergence or divergence, there are used a correspondingly convergent or divergent charged particle radiation beam (212) as well as a crystal arrangement (214) which is so bent that the channeling condition is at least approximately fulfilled for all charged particle paths in the crystal. (FIG.

Abstract: The present invention relates, in general, to an extracellular signal regulated kinase, ERK-5. In particular, the present invention relates to nucleic acid molecules coding for ERK-5; ERK-5 polypeptides; recombinant nucleic acid molecules; cells containing the recombinant nucleic acid molecules; antisense ERK-5 nucleic acid constructs; antibodies having binding affinity to an ERK-5 polypeptide; hybridomas containing the antibodies; nucleic acid probes for the detection of ERK-5 nucleic acid; a method of detecting ERK-5 nucleic acid or polypeptide in a sample; kits containing nucleic acid probes or antibodies; a method of detecting a compound capable of binding to ERK-5 or a fragment thereof; a method of detecting an agonist or antagonist of ERK-5 activity; a method of agonizing or antagonizing ERK-5 associated activity in a mammal; and a pharmaceutical composition comprising an ERK-5 agonist or antagonist.

Abstract: A process serves for producing a plate comprising at least one well having ts opening facing upwards, for receiving chemical and/or biochemical and/or microbiological substances. The process, wherein the wells are made in the plate with the aid of a molding die, comprises the steps of:a) Applying a plastic film, which is deformable by the action of heat, on a molding block which serves as a molding die and which has the negative shape of the wells to be formed; andb) subjecting the plastic film, for a predetermined period of time, to the action of a hot gas flow of a predetermined first temperature, the gas flow impinging upon at least an area of the plastic film covering one of the recessed portions, heating up this area and pressing it into the recessed portion so that it comes to lie flat against the latter's inner wall which is smooth throughout.

Abstract: Device for setting the temperature of a sample selectively to different ves comprising a sample holder block having good thermal conductivity properties and at least one recess (14) for receiving a sample whose temperature is to be adjusted, and a device for adjusting the temperature of a sample holder block, wherein the device for adjusting the temperature of the sample holder block (12) comprises at least two bodies (18, 20) whose temperatures can be controlled via separate thermostats and whose temperatures can be adjusted to different values and wherein a transporter (30, 32, 34) is provided by a way in which the sample holder block (12) can be brought into thermal contact with one of the bodies (18, 20).

Abstract: The present invention relates to nucleic acid sequences encoding brain derived neurotrophic factor (BDNF), as well as BDNF protein produced in quantity using these nucleic acid sequences, as well as fragments and derivatives thereof. In addition, the invention relates to pharmacologic compositions and therapeutic uses of BDNF, having provided, for the first time, the means to generate sufficient quantities of substantially pure BDNF for clinical use. In a specific embodiment, BDNF may be used to promote the survival of substantia nigra dopaminergic neurons and basal forebrain cholinergic neurons, thereby providing a method for treating, respectively, Parkinson's disease and Alzheimer's disease. The invention also relates to antibodies directed toward BDNF or fragments thereof, having provided a method for generating sufficient immunogen.

Abstract: The present invention provides compounds of the formula: ##STR1## wherein R is a erucyl, brassidyl or nervonyl radical, R.sup.1, R.sup.2 and R.sup.3 are defined in the specification, A is a valency bond or a radical as defined in the specification, and X is an oxygen atom when A is a valency bond or is an oxygen or sulphur atom when A is another radical.The present invention also provides a process for the preparation of the compounds of general formula (I) and pharmaceutical compositions containing them which can be used for the treatment of protozoal and fungal diseases, auto-immune diseases and bone marrow damage.

Abstract: A self-supporting electric conductor arrangement, in particular a coil, suitable for arrangement in a vacuum container, contains, as a supporting structure, a tube (18a) of insulating material, e.g. quartz glass, in which is arranged an electric conductor (18b) in the form of a flexible chord or an electrically conducting layer precipitated on the inner wall of the tube. A preferred field of application is a coil-shaped insulated antenna situated in the plasma for a high frequency plasma generator.

Abstract: The present invention provides a vaccine against Lyme disease, wherein it contains one or more monoclonal antibodies which are specific for the 31 kD antigen (OspA) or the 34 kD antigen (OspB) of Borrelia burgdorferi.The present invention also provides a process for obtaining this vaccine, as well as new monoclonal antibodies and antigens.

Abstract: A device (10) for tempering substances has a metal block arrangement (12) th at least one zone (32) the temperature of which can be set at a determined mean value, as well as at least another zone (32'). The device (10) has a metallic base plate (31) with a receptacle for the substances, and at least one of its outer surfaces can be brought into thermal contact with the metal block arrangement (12). In addition, a pressure generator (49) generates a pressure that deviates from the ambient pressure between at least one outer surface and the metal block arrangement. The device (10) further has a conveyor (33) that selectively conveys the base plate (31) into one of the zones (32, 32') of the metal block arrangement (12) along a conveying path (44). The pressure generator (49) is capable of generating an overpressure or a depression.

Abstract: The invention relates to wound-stimulated DNA from Solanum tuberosum as well as parts thereof, their use for the development of gene products in higher plants using wounding or pathogen attack, DNA-transfer vectors containing these, and plants or plant portions containing these. The promoter of this DNA-sequence can be used for the expression of gene products in higher plants using wound and/or pathogen attack.

Abstract: For the enzymatic cleavage of fusion proteins and for the isolation of deed components of these fusion proteins(1) a junction region, in which two components of the fusion protein are joined together, is modified by means of genetic engineering so that at least one IgA protease recognition site with the amino acid sequence Y-Pro.!.X-Pro is formed in this junction region, in which X can be any amino acid and Y can be one or several arbitrary amino acids,(2) the fusion protein which results from step (1) is cleaved by IgA protease at the position in the recognition site marked with .!. and(3) after the cleavage one or several desired components of the fusion protein are isolated.

Abstract: Illuminating apparatus for a microscope including a semitransparent, in picular dichroic, microscope mirror for reflecting illuminating light from an external illuminating unit into a microscope beam path. The illuminating unit comprises a coupling-in unit having a first beam path which leads from a light exit end of a first optical waveguide through a semitransparent coupling-in mirror and an adapter optical system to the microscope mirror, furthermore, a second beam path which leads from a light exit end of a second optical waveguide via the semitransparent coupling-in mirror operating in reflection and the adapter optical system to the microscopic mirror, a first light source unit which is optically coupled to a light entrance end of the first optical waveguide and a second light source unit for flashlight which is optically coupled to a light entrance end of the second optical waveguide.

Abstract: Illuminating apparatus for a microscope comprising a light source and fil changer which is arranged in a beam path between the light source and a specimen location of the microscope. The light source and the filter changer are arranged in a unit spatially and mechanically separate from the microscope and the beam path between the filter changer and the microscope includes a flexible fiber light guide.

Abstract: By a liquid epitaxial process monocrystalline semiconductor layers are produced having a high degree of crystal perfection in a multi-layer arrangement on intermediate layers of an insulating material and/or carbone and/or metal, in order to produce three-dimensional semiconductor structures which offer low mechanical stresses and load-bearing densities of between 10.sup.14 and 10.sup.21 per cm.sup.3. Very low manufacturing temperatures can be used, for example between 300.degree. and 900.degree. C. The seeding for each epitaxial layer is performed in the openings of the intermediate layer where a monocrystalline material is located in a free state. From these openings, the lateral and monocrystalline growth of the intermediate layers takes place. The repeated application of the liquid epitaxial process described allows three-dimensional integration in monocrystalline multilayer structures which are extremely devoid of defects.