Patents Assigned to Mayo Foundation for Medical Education and Research
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Patent number: 12290521Abstract: Methods and materials involved in identifying and treating mammals having a cancer resistant to BET inhibitors are provided. For example, methods and materials for administering (a) one or more AKT inhibitors and/or one or more CDK inhibitors and/or one or more CBP/p300 inhibitors in combination with (b) one or more BET inhibitors to mammals identified as having a cancer resistant to treatment with one or more BET inhibitors in the absence of AKT, CDK, and CBP/p300 inhibitors are provided.Type: GrantFiled: July 25, 2019Date of Patent: May 6, 2025Assignee: Mayo Foundation for Medical Education and ResearchInventor: Haojie Huang
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Patent number: 12286413Abstract: This document provides compounds, compositions, and methods for treating cancers including renal cancer (e.g., renal cell carcinoma) as well as ovarian, breast, prostate, colon, pancreatic, bladder, liver, lung, and thyroid cancers and melanoma. For example, compounds, compositions, and methods for using one or more inhibitors of SCD1 to treat renal cell carcinoma (e.g., clear cell renal cell carcinoma (ccRCC)), thyroid cancer, or liver cancer; or to increase the efficacy of treatment for the same.Type: GrantFiled: April 5, 2022Date of Patent: April 29, 2025Assignee: Mayo Foundation for Medical Education and ResearchInventors: John A. Copland, III, Han W. Tun, Thomas R. Caulfield, Christina Von Roemeling, Laura Ann Marlow
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Patent number: 12285427Abstract: This invention establishes a new paradigm for treatment of Parkinson's disease (PD) by eliminating senescent cells that reside in or around the site of the disease pathophysiology. Exposure of test subjects to the herbicide paraquat (PQ) increases the risk for developing Parkinson's disease. The data in this disclosure show that PQ induces a senescence arrest and SASP in astrocytes, in culture and in vivo in mice, and senescent cell markers were present in astrocytes in midbrain tissue from PD patients. In a transgenic mouse model, senescent cell ablation protected against PQ-induced PD-like neuropathology. Removal of senescent cells from affected sites using small molecule agents that specifically target senescent cells can help prevent or ameliorate signs and symptoms of the disease.Type: GrantFiled: August 7, 2023Date of Patent: April 29, 2025Assignees: Unity Biotechnology, Inc., Mayo Foundation for Medical Education and Research, Buck Institute for Research on AgingInventors: Remi-Martin Laberge, Judith Campisi, Marco Demaria, Bennett G. Childs, Jan M. A. Van Deursen, Nathaniel David, Alain Philippe Vasserot
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Patent number: 12280036Abstract: This document relates to materials and methods for treating fibrosis (e.g., pulmonary fibrosis). For example, this document provides methods for using one or more fatty acid synthase (FASN) inhibitors to treat a mammal having fibrosis (e.g., pulmonary fibrosis), and/or a complication associated with fibrosis (e.g., hypoxia caused by pulmonary fibrosis).Type: GrantFiled: February 16, 2022Date of Patent: April 22, 2025Assignee: Mayo Foundation for Medical Education and ResearchInventors: Edward B. Leof, Ruth Lupu, Jeong-Han Kang, Mi-Yeon Jung
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Patent number: 12274543Abstract: Described here are systems and methods for separating magnetic resonance signals that are changing over a scan duration (i.e., dynamic signals) from magnetic resonance signals that are static over the same duration. As such, the systems and methods described in the present disclosure can be used to remove artifacts associated with dynamic signals from images of static structures, or to better image the dynamic signal (e.g., pulsatile blood flow or respiratory motion).Type: GrantFiled: January 29, 2021Date of Patent: April 15, 2025Assignee: Mayo Foundation for Medical Education and ResearchInventor: James G. Pipe
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Patent number: 12274883Abstract: This document describes methods and materials for improving the delivery of electroporation. For example, this document describes methods and devices for delivering electroporation while mitigating risks of ventricular fibrillation.Type: GrantFiled: December 30, 2022Date of Patent: April 15, 2025Assignee: Mayo Foundation for Medical Education and ResearchInventor: Samuel J. Asirvatham
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Publication number: 20250114380Abstract: The invention provides methods and compositions for inhibiting CD38 activity, and methods of treating or preventing various disorders associated with CD38 activity.Type: ApplicationFiled: June 10, 2024Publication date: April 10, 2025Applicants: President and Fellows of Harvard College, Mayo Foundation for Medical Education and ResearchInventors: David A. Sinclair, Nathan L. Price, Eduardo N. Chini, Jon C. Clardy, Shugeng Cao
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Patent number: 12268383Abstract: A suture-carrying apparatus includes a suture engaging ridge for placement and retention of surgical sutures, and a base for conveniently mounting the apparatus to a predetermined location, such as a body structure, which is reachable by robotic arms during a robot-assisted surgical operation. The base may be configured to allow stability of the apparatus for one-handed placement and retrieval of sutures from the ridges.Type: GrantFiled: April 14, 2020Date of Patent: April 8, 2025Assignee: Mayo Foundation for Medical Education and ResearchInventor: Steven Bowers
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Patent number: 12264189Abstract: This document provides methods and materials for generating T cells expressing a selected antigen receptor (e.g., a chimeric antigen receptor) in vivo. For example, viral particles containing nucleic acid encoding a selected antigen receptor, cells capable of producing such viral particles, and methods for administering such viral particles and/or cells to a mammal to generate T cells expressing that selected antigen receptor within the mammal are provided.Type: GrantFiled: October 31, 2019Date of Patent: April 1, 2025Assignee: Mayo Foundation for Medical Education and ResearchInventors: Saad J. Kenderian, Stephen James Russell
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Patent number: 12264163Abstract: The present application provides methods for treating or preventing diseases and conditions associated with tissue fibrosis.Type: GrantFiled: July 29, 2020Date of Patent: April 1, 2025Assignee: Mayo Foundation for Medical Education and ResearchInventors: Daniel J. Tschumperlin, Andrew J. Haak
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Patent number: 12263118Abstract: This document describes methods and materials for the treatment of pathological conditions, including arrhythmias and trauma, using temperature modulation via implantable devices. For example, this document relates to methods and devices for treating atrial and/or ventricular fibrillation by cooling the epicardium.Type: GrantFiled: January 16, 2019Date of Patent: April 1, 2025Assignee: Mayo Foundation for Medical Education and ResearchInventors: Paul A. Friedman, Samuel J. Asirvatham
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Publication number: 20250099769Abstract: This document relates to methods and materials for providing stimulation or ablation to the stellate ganglion. For example, this document relates to methods and devices for providing stimulation or ablation to the stellate ganglion to modify blood pressure.Type: ApplicationFiled: May 16, 2024Publication date: March 27, 2025Applicant: Mayo Foundation for Medical Education and ResearchInventors: Yong-Mei CHA, Samuel J. ASIRVATHAM
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Patent number: 12258576Abstract: Platelet lysate compositions and cell culture media compositions for maintaining and/or growing mammalian cells, such as mammalian endothelial cells (ECs) and mammalian endothelial progenitor cells (EPCs), in particular human ECs (huECs) and human EPCs (huEPCs), such as primary huECs and primary huEPCs, are provided. The cell culture media compositions contain a basal medium, a platelet lysate and, optionally, one or more exogenously added growth factors. Also provided are methods for making and using such cell culture media compositions to grow and/or maintain ECs and EPCs, including huECs and huEPCs, as well as cell culture vessels, dishes, plates, and/or flasks pretreated with the cell culture media compositions.Type: GrantFiled: May 31, 2017Date of Patent: March 25, 2025Assignee: Mayo Foundation for Medical Education and ResearchInventors: Allan B. Dietz, Gaylord Knutson
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Patent number: 12258572Abstract: This document provides adenovirus vectors and methods and materials related to using adenovirus vectors. For example, adenoviruses for delivering nucleic acid encoding one or more immunogens (e.g., one or more immunogens associated with a pathogen causing an infection) to cells within a mammal such that the mammal produces an effective immune response against the immunogen(s) are provided.Type: GrantFiled: September 8, 2021Date of Patent: March 25, 2025Assignee: Mayo Foundation for Medical Education and ResearchInventor: Michael A. Barry
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Patent number: 12257235Abstract: This document provides materials and methods related to bacterial compositions containing at least one bacterial organism having tryptophan decarboxylase activity. For example, bacterial compositions containing at least one bacterial organism having tryptophan decarboxylase activity and methods for using such bacterial compositions to improve gastrointestinal epithelial function and/or to treat gastrointestinal disorders are provided.Type: GrantFiled: December 12, 2023Date of Patent: March 25, 2025Assignees: Mayo Foundation for Medical Education and Research, The Regents of the University of CaliforniaInventors: Purna C. Kashyap, Michael Fischbach, Brianna B. Williams
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Patent number: 12257286Abstract: This document relates to methods and materials involved in treating mammals having a cancer (e.g., a cancer having one or more CD19 positive extracellular vesicles (EVs) and/or one or more small EVs in the tumor microenvironment). For example, methods of treating a mammal having a blood cancer including one or more CD19 positive EVs and/or one or more small EVs in the blood by administering one or more cancer immunotherapies (e.g., one or more chimeric antigen receptor (CAR) T-cell therapies) to the mammal are provided.Type: GrantFiled: October 31, 2019Date of Patent: March 25, 2025Assignee: Mayo Foundation for Medical Education and ResearchInventors: Saad J. Kenderian, Neil E. Kay, Michelle J. Cox, Fabrice Lucien-Matteoni
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Publication number: 20250093356Abstract: Scoring functions for predicting response of a dMMR and/or MSI-H colorectal tumor to a PD-1 axis-directed therapy are disclosed, as well as methods and systems for evaluating tissue samples for the presence of feature metrics useful in computing such scoring functions. The scoring functions integrate one or more spatial relationships between cell types into a numerical indication of the likelihood that the tumor will respond to the PD-1 axis-directed therapy. Based on the output of the scoring function, a subject may then be selected to receive a PD-1 axis-directed therapy (if the scoring function indicates a sufficient likelihood of positive response) or an alternative therapy (if the scoring function indicates an insufficient likelihood of positive response).Type: ApplicationFiled: September 27, 2024Publication date: March 20, 2025Applicants: Ventana Medical Systems, Inc., Mayo Foundation for Medical Education and ResearchInventors: Eze O. AHANONU, Sara Marie MCMAHON, Kandavel SHANMUGAM, Frank A. SINICROPE, Crystal Sue WILLIAMS, Dongyao YAN, Wenjun ZHANG
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Patent number: 12251228Abstract: A system obtains a maternal electrocardiogram (ECG) signal that represents an ECG of a pregnant mother during a first time interval. The system further obtains a mixed maternal-fetal ECG signal that represents a combined ECG of the mother and her fetus during the first time interval; processes the maternal ECG signal and the mixed maternal-fetal ECG signal to generate a fetal ECG signal that represents the ECG of the fetus during the time interval, the fetal ECG signal substantially excluding the maternal ECG signal; and provides an output based on the fetal ECG signal.Type: GrantFiled: January 7, 2022Date of Patent: March 18, 2025Assignee: Mayo Foundation for Medical Education and ResearchInventors: Paul A. Friedman, Dorothy J. Ladewig, Itzhak Zachi Attia, Kyle D. Traynor
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Patent number: 12239365Abstract: Endolumenal devices and methods can be used for the treatment of health conditions including obesity and diabetes. In some embodiments, the methods and systems provided herein can cause weight loss or control diabetes by reducing the caloric absorption of an individual. For example, this document provides several devices and methods for treating obesity and diabetes by using electroporation to modulate the duodenal mucosa. In addition, this document provides devices and methods for bypassing portions of the gastrointestinal tract to reduce nutritional uptake.Type: GrantFiled: November 17, 2021Date of Patent: March 4, 2025Assignee: Mayo Foundation for Medical Education and ResearchInventors: Christopher V. Desimone, Barham K. Abu Dayyeh, Samuel J. Asirvatham
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Patent number: 12239536Abstract: This document describes methods and devices for securing epicardial devices. For example, this document describes methods and devices for securing epicardial devices by passing a sheath into a pericardial space of a patient through a first percutaneous access site, passing a guidewire through the sheath into the pericardial space of the patient, passing the guidewire through a transverse sinus of the patient, passing a snare device into the pericardial space through a second percutaneous access site, and capturing a free end portion of the guidewire using the snare device.Type: GrantFiled: September 13, 2023Date of Patent: March 4, 2025Assignee: Mayo Foundation for Medical Education and ResearchInventors: Samuel J. Asirvatham, Paul A. Friedman