Patents Assigned to Mayo Foundation for Medical Education and Research
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Publication number: 20240083966Abstract: This document provides methods and materials related to vesicular stomatitis viruses. For example, vesicular stomatitis viruses, nucleic acid molecules encoding VSV polypeptides, methods for making vesicular stomatitis viruses, and methods for using vesicular stomatitis viruses to treat cancer are provided.Type: ApplicationFiled: March 13, 2023Publication date: March 14, 2024Applicant: Mayo Foundation for Medical Education and ResearchInventors: Stephen James Russell, Shruthi Naik
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Publication number: 20240081653Abstract: Systems, methods, devices, and techniques for estimating a heart disease prediction of a mammal. An electrocardiogram (ECG) procedure is performed on a mammal, and a computer system obtains ECG data that describes results of the ECG over a period of time. The system provides a predictive input that is based on the ECG data to a predictive model, such as a neural network or other machine-learning model. In response, the predictive model processes the input to generate an estimated heart disease predictive characteristic of the mammal. The system outputs the estimated heart disease prediction of the mammal for presentation to a user.Type: ApplicationFiled: October 31, 2023Publication date: March 14, 2024Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCHInventors: Itzhak Zachi Attia, Paul A. Friedman, Francisco Lopez-Jimenez, Suraj Kapa
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Publication number: 20240082330Abstract: This document relates to methods and materials involved in treating cancer. For example, methods and materials for using one or more oncolytic viruses (e.g., one or more replicating oncolytic viruses) to treat cancer in a mammal (e.g., a human) identified as having a cancer likely to respond to oncolytic virotherapy are provided.Type: ApplicationFiled: November 14, 2023Publication date: March 14, 2024Applicant: Mayo Foundation for Medical Education and ResearchInventors: Kah-Whye Peng, Stephen James Russell, Mitesh J. Borad, Yumei Zhou, Amber C. Miller
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Patent number: 11925640Abstract: Provided herein are methods and materials for improving arteriovenous fistula (AVF) maturation and/or maintaining AVF functionality. For example, methods and materials for using one or more senolytic agents to improve AVF maturation, to maintain AVF functionality, and/or to maintain the patency of an AVF are provided. Methods and materials for using one or more senolytic agents to maintain functionality and/or patency of a venous graft (e.g., a venous graft that bypasses an occluded artery) also are provided.Type: GrantFiled: June 21, 2019Date of Patent: March 12, 2024Assignee: Mayo Foundation for Medical Education and ResearchInventors: Karl A. Nath, James L. Kirkland, Tamar Tchkonia
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Publication number: 20240075073Abstract: This document provides materials and methods for treating a damaged optic nerve in a mammal to restore visual function comprising administering a population of induced pluripotent stem cell-derived oligodendrocyte precursor cells. This document also provides materials and methods for determining a remyelination potential quotient of a population of induced pluripotent stem cell-derived oligodendrocyte precursor cells. This document also provides materials and methods for screening factors that enhance maturation or myelination efficiency of an induced pluripotent stem cell-derived oligodendrocyte precursor cell or cells.Type: ApplicationFiled: June 30, 2023Publication date: March 7, 2024Applicant: Mayo Foundation for Medical Education and ResearchInventors: Charles L. Howe, Miranda M. Standiford, Kanish Mirchia
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Patent number: 11923876Abstract: In accordance with some embodiments of the disclosed subject matter, mechanisms (which can, for example, include systems, methods, and media) for low-power encoding of continuous physiological signals are provided. In some embodiments, a system comprises: a physiological sensor; and a remote monitor comprising: a battery; memory storing a k-ary tree including a root with k branches corresponding to k delta values, k nodes at a first depth below the Leads root node each having k branches corresponding to the k delta values the nodes indexed to indicate the lateral position of the node within the depth; a processor programmed to: receive a first sample value from the sensor; receive a second sample value; calculate a difference between the second first sample values; determine that the delta corresponds to a first delta of the k delta values; encode a sequence of deltas based on a depth and node index.Type: GrantFiled: July 15, 2019Date of Patent: March 5, 2024Assignee: Mayo Foundation for Medical Education and ResearchInventors: Christopher L. Felton, Barry K. Gilbert, Clifton R. Haider
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Publication number: 20240060975Abstract: The invention provides prognostic methods for evaluating the severity of NMO and NMO-associated diseases as well as methods of treating NMO and NMO-associated diseases.Type: ApplicationFiled: May 5, 2023Publication date: February 22, 2024Applicant: Mayo Foundation for Medical Education and ResearchInventors: Vanda A. Lennon, Sean J. Pittock, Shannon Hinson
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Publication number: 20240058296Abstract: Described herein are compositions of modified binding agents and modified carrier proteins, as well as nanoparticle complexes comprising modified binding agents and modified carrier proteins with optionally at least one therapeutic agent, and methods of making and using the same, in particular, as a cancer therapeutic.Type: ApplicationFiled: January 11, 2023Publication date: February 22, 2024Applicant: Mayo Foundation for Medical Education and ResearchInventors: Svetomir N. Markovic, Wendy K. Nevala, John Thomas Butterfield, Daniel Joseph Knauer
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Patent number: 11904165Abstract: A method for providing galvanic vestibular stimulation corresponding to accelerations in scenes of a video. Embodiments include (1) receiving a three dimensional video signal including three dimensional video angular velocity information, (2) receiving a three dimensional head orientation signal including three dimensional head angular velocity information, (3) calculating resultant three dimensional angular velocity information based on the video angular velocity information and the head angular velocity information, (4) calculating three dimensional acceleration information based on the resultant three dimensional angular velocity information, and (5) generating three dimensional galvanic vestibular stimulation signals corresponding to the resultant three dimensional angular acceleration information, wherein the three dimensional stimulation signals will stimulate three dimensional acceleration sensations corresponding to accelerations on the user viewing the displayed scenes.Type: GrantFiled: March 21, 2022Date of Patent: February 20, 2024Assignee: Mayo Foundation for Medical Education and ResearchInventors: Gaurav N. Pradhan, Michael J. Cevette, Jan Stepanek
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Patent number: 11903670Abstract: Devices and methods for the treatment of heart conditions, and other medical purposes, include cardiac pacing systems. For example, this document describes temporary transvenous endocardial pacemaker systems and devices for deploying such systems without the need for conventional imaging procedures.Type: GrantFiled: February 27, 2019Date of Patent: February 20, 2024Assignee: Mayo Foundation for Medical Education and ResearchInventors: Peter M. Pollak, Samuel J. Asirvatham, Charles J. Bruce, Paul A. Friedman
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Publication number: 20240050008Abstract: This document describes systems, methods, and devices for sensing electrical activity in a brain of a mammal. Some aspects include a cortical electrode assembly configured, in use, to sense electrical activity at a surface of a brain, the assembly comprising: a ring-shaped substrate; and a plurality of electrical sensors affixed to the ring-shaped substrate, wherein the plurality of electrical sensors are spaced along the ring-shaped substrate so as to form a ring of electrical sensors that substantially encircle an aperture formed by the ring-shaped substrate.Type: ApplicationFiled: August 25, 2023Publication date: February 15, 2024Applicant: Mayo Foundation for Medical Education and ResearchInventors: Karim ReFaey, William Tatum, Alfredo Quinones-Hinojosa
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Patent number: 11897931Abstract: Analogues of an alternatively spliced form of atrial natriuretic peptide (MANP) that exhibit pGC-A gain of function and can be used to treat cardiorenal and metabolic disease are described herein.Type: GrantFiled: June 25, 2021Date of Patent: February 13, 2024Assignee: Mayo Foundation for Medical Education and ResearchInventor: John C. Burnett, Jr.
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Patent number: 11896379Abstract: Systems, methods, and computer program product embodiments are disclosed for displaying cardiac signals based on a signal pattern. An embodiment operates by accessing an input cardiac signal. The embodiment matches a portion of the input cardiac signal to a known signal pattern. The embodiment then displays an indication of a degree of the match.Type: GrantFiled: August 16, 2019Date of Patent: February 13, 2024Assignees: BioSig Technologies, Inc., Mayo Foundation for Medical Education and ResearchInventors: Budimir S. Drakulic, Sina Fakhar, Thomas G. Foxall, Branislav Vlajinic, Samuel J. Asirvatham
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Patent number: 11891620Abstract: Platelet lysate compositions and cell culture media compositions for maintaining and/or growing mammalian cells, such as mammalian endothelial cells (ECs) and mammalian endothelial progenitor cells (EPCs), in particular human ECs (huECs) and human EPCs (huEPCs), such as primary huECs and primary huEPCs, are provided. The cell culture media compositions contain a basal medium, a platelet lysate and, optionally, one or more exogenously added growth factors. Also provided are methods for making and using such cell culture media compositions to grow and/or maintain ECs and EPCs, including huECs and huEPCs, as well as cell culture vessels, dishes, plates, and/or flasks pretreated with the cell culture media compositions.Type: GrantFiled: May 14, 2015Date of Patent: February 6, 2024Assignee: Mayo Foundation for Medical Education and ResearchInventors: Allan B. Dietz, Gaylord Knutson
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Patent number: 11890119Abstract: Methods of using a soft tissue cutting device are disclosed. The methods include providing the soft tissue cutting device, positioning the soft tissue cutting device in a priming slot of a tray configured for receiving and holding the soft tissue cutting device, attaching a priming syringe to the soft tissue cutting device, priming a balloon disposed on a distal end of the soft tissue cutting device by equalizing a first pressure inside the balloon to a second pressure inside the priming syringe, removing the soft tissue cutting device from the priming slot, and positioning the distal end of the soft tissue cutting device on a safety slot included in the tray to determine whether the tissue cutting device has been properly primed.Type: GrantFiled: December 7, 2020Date of Patent: February 6, 2024Assignee: Sonex Health, Inc. and Mayo Foundation for Medical Education and ResearchInventors: Darryl E. Barnes, Aaron Keenan, Jay Smith, Kevin Arnal, Sara Schlick
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Publication number: 20240033352Abstract: Described herein are methods, formulations and kits for treating a patient with cancer with anti-VEGF antibodies and albumin-bound chemotherapeutic/anti-VEGF antibody nanoparticle complexes.Type: ApplicationFiled: March 17, 2023Publication date: February 1, 2024Applicant: Mayo Foundation for Medical Education and ResearchInventors: Gerald F. SWISS, Svetomir N. MARKOVIC, Wendy K. NEVALA
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Patent number: 11884845Abstract: A tissue adhesive material that provides fast and robust adhesion even on tissue surfaces covered in bodily fluids. The tissue adhesive material is formed of a hydrophobic matrix and a plurality of bioadhesive microparticles dispersed within the hydrophobic matrix configured such that disposing the adhesive material directly on a fluid covered surface and applying pressure causes the (a) hydrophobic matrix to repel the fluid, (b) the bioadhesive particles to compress forming an adhesive layer, and (c) the bioadhesive particles to form temporary crosslinks followed by covalent crosslinks with the surface.Type: GrantFiled: December 3, 2020Date of Patent: January 30, 2024Assignees: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCHInventors: Xuanhe Zhao, Hyunwoo Yuk, Xinyu Mao, Christoph Nabzdyk
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Patent number: 11884958Abstract: This document provides methods and materials involved in assessing and/or treating a mammal having a functional gastrointestinal disorder (FGID) such as irritable bowel syndrome (IBS). For example, methods and materials provided herein can be used for determining if a mammal having a FGID is likely to respond to a particular FGID treatment. This document also provides methods and materials for treating a mammal having a FGID.Type: GrantFiled: April 24, 2020Date of Patent: January 30, 2024Assignee: Mayo Foundation for Medical Education and ResearchInventor: Purna C. Kashyap
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Patent number: 11883078Abstract: An implant for fusing a joint between first and second bone portions. The implant includes a screw member, and a washer polyaxially rotatable relative to the screw member. The screw member includes a head, a lag zone, and a threaded engagement zone. The implant includes a fusion zone for joint compression, extending from the washer to the proximal end of the engagement zone. Fenestrations may be present in the fusion zone. The length of the fusion zone ranges from about 10 mm to about 37 mm. Different surface finishes including roughened and non-roughened may be applied selectively to selected portions of the implant. In an embodiment, the joint is a sacro-iliac joint, and upon implantation the implant extends from the exterior of the ilium, across the joint and into the sacral vertebral body. Instrumentation and methods for preparing the joint and implanting the implant are disclosed.Type: GrantFiled: September 13, 2021Date of Patent: January 30, 2024Assignees: IMDS LLC, Mayo Foundation for Medical Education and ResearchInventors: Brian Scott Schumacher, Nicholas Slater, William W. Cross, III
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Patent number: 11878002Abstract: This document provides materials and methods related to bacterial compositions containing at least one bacterial organism having tryptophan decarboxylase activity. For example, bacterial compositions containing at least one bacterial organism having tryptophan decarboxylase activity and methods for using such bacterial compositions to improve gastrointestinal epithelial function and/or to treat gastrointestinal disorders are provided.Type: GrantFiled: April 8, 2021Date of Patent: January 23, 2024Assignees: Mayo Foundation for Medical Education and Research, Regents of the University of CaliforniaInventors: Purna C. Kashyap, Michael Fischbach, Brianna B. Williams