Abstract: This document relates to methods and materials involved in detecting gene amplification in a mammal. For example, methods and materials for detecting amplification at CPM and MDM2 loci to determine the presence or absence of a malignant lipomatous neoplasm in a mammal are provided.

Abstract: Described are stable nanoparticle complexes of 100 nm to 900 nm comprising paclitaxel, albumin and an antibody. The nanoparticle complexes are suitable for the treatment of cancer.

Abstract: This document provides methods and materials related to assessing male mammals (e.g., humans) with prostate cancer. For example, methods and materials for predicting (1) which patients, at the time of PSA reoccurrence, will later develop systemic disease, (2) which patients, at the time of retropubic radial prostatectomy, will later develop systemic disease, and (3) which patients, at the time of systemic disease, will later die from prostate cancer are provided.

Abstract: This document relates to methods and materials for treating cancer. For example, methods and materials for using CRISPR/Cas9 systems to treat cancer are provided.

Abstract: This document provides methods and materials for modulating afferent nerve signals to treat medical conditions such as CHF, CHF respiration, dyspnea, peripheral vascular disease (e.g., peripheral arterial disease or venous insufficiency), hypertension (e.g., age-associated hypertension, resistant hypertension, or chronic refractory hypertension), COPD, sleep apnea, and chronic forms of lung disease where muscle dysfunction is a part of the disease pathophysiology. For example, methods and materials involved in using electrical and/or chemical techniques to block or reduce afferent nerve signals (e.g., nerve signals of group III and/or IV afferents coming from skeletal muscle and/or the kidneys) are provided.

Abstract: This document relates to methods and materials for treating chronic cough, nasal congestion, and/or one or more conditions causing chronic cough and/or nasal congestion (e.g., posterior rhinorrhea, also known as post-nasal drip (PND), and/or rhinitis). For example, this document relates to compositions containing a steroid (e.g., mometasone furoate), an anticholinergic (e.g., ipratropium bromide), and an antihistamine (e.g., diphenhydramine) as well as methods of using such compositions to reduce or eliminate one or more conditions causing chronic cough (e.g., PND and/or rhinitis).

Abstract: This document provides methods and materials involved in performing flow cytometry assay methods. For example, flow cytometry assay methods and kits are provided.

Abstract: This document relates to devices and methods for the treatment of heart conditions. For example, this document provides devices and methods for treating heart failure with preserved ejection fraction, including diastolic heart failure, by performing a pericardial modification procedure.

Abstract: Systems and methods for ultrafast synthetic transmit aperture (“USTA”) ultrasound imaging using coded virtual sources are described. The methods can implement spatially distinct or spatially overlapping sub-apertures with appropriate timing of transmission between the spatially overlapping sub -apertures. The systems and methods described here are capable of increasing signal-to-noise ratio (“SNR”) and spatial resolution to reduce frame rate.

Abstract: This document provides devices and methods for the treatment of heart conditions, hypertension, and other medical disorders. For example, this document provides devices and methods for treating atrial fibrillation by performing thoracic vein ablation procedures, including pulmonary vein myocardium ablation. In some embodiments, the ablation is performed in coordination with the delivery a pharmacological agent that can abate the formation of tissue stenosis or neointimal hyperplasia caused by the ablation.

Abstract: This document provides methods and materials for treating cancer. For example, methods and materials for identifying antigens and combinations of antigens that can be used to treat cancer as well as combinations of antigens having the ability to reduce established tumors (e.g., gliomas) within a mammal (e.g., a human) are provided.

Abstract: Described herein are compositions of antibodies and carrier proteins and methods of making and using the same, in particular, as a cancer therapeutic. Also described are lyophilized compositions of antibodies and carrier proteins and methods of making and using the same, in particular, as a cancer therapeutic.

Abstract: This document provides methods and materials for using butyrylcholinesterases (BChE) to treat cancer (e.g., triple negative breast cancer or prostate cancer). For example, methods and materials for using nucleic acid vectors (e.g., viral vectors) to express BChE polypeptides under conditions that reduce the number of cancer cells (e.g., triple negative breast cancer cells or prostate cancer cells) within a mammal (e.g., a human) and/or reduce the growth rate of cancer cells (e.g., triple negative breast cancer cells or prostate cancer cells) within a mammal (e.g., a human) are provided.

Abstract: A system and method for generating a spatial map of parameters that describe the mechanically-induced harmonic motion information present within a magnetic resonance elastography (MRE) data set is provided. A first temporal harmonic signal is estimated using a graph-cut based optimization strategy, and can subsequently be used to generate a spatial map of mechanical parameters. The MRE data set is used to estimate the harmonic. The spatial map is of a mechanical parameter derived from the estimated harmonic.

Abstract: Provided herein is technology for lung neoplasia screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of lung cancer.

Abstract: Systems, methods, and other techniques for estimating the level of an analyte present in a patient during a time interval using electrocardiogram (ECG) signals. The estimate can be improved using information about the patient's posture.

Abstract: This document provides methods and materials for activating muscle remodeling. For example, methods and materials for using GAR1 inhibitors to activate muscle remodeling are provided.

Abstract: The invention provides methods for establishing which genomic alterations are truly clonal in cancer, and for determining the confidence for calling true clonal mutations in individual tumors using multi-region sequencing data. The invention further provides methods for treating cancer that comprise confidently determining truly clonal genomic alternations in the target cancer that is to be treated.

Abstract: The peptides described herein can function as carrier peptides. These peptides can associate with (e.g., non-covalently bind) biologically active molecules or imaging agents to transport the biologically active molecules or imaging across the blood-brain barrier. In some cases, such transport may increase the effectiveness of the biological molecules or imaging agents.

Abstract: This document provides materials related to treating cancer (e.g., skin cancer). For example, materials relating to the use of a composition containing albumin-containing nanoparticle/antibody complexes (e.g., albumin-bound paclitaxel/anti-VEGF polypeptide antibody complexes) to treat cancer (e.g., skin cancer) are provided).