Patents Assigned to Mayo Foundation for Medical Education and Research
  • Publication number: 20240165178
    Abstract: This document relates to materials and methods involved in treating cancer. For example, materials and methods for using one or more oncolytic viruses (e.g., one or more oncolytic viruses) to treat cancer in a mammal (e.g., a human) identified as having a cancer likely to respond to oncolytic virotherapy are provided.
    Type: Application
    Filed: November 28, 2023
    Publication date: May 23, 2024
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Evanthia Galanis, S. Keith Anderson, Cheyne B. Kurokawa, Ianko D. Iankov
  • Patent number: 11987847
    Abstract: Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as colorectal cancer.
    Type: Grant
    Filed: December 14, 2020
    Date of Patent: May 21, 2024
    Assignees: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH, EXACT SCIENCES CORPORATION
    Inventors: David A. Ahlquist, William R. Taylor, Douglas W. Mahoney, Graham P. Lidgard, Hatim T. Allawi
  • Publication number: 20240158467
    Abstract: This document provides methods and materials involved in treating cancer. For example, chimeric antigen receptor T cells having reduced levels of GM-CSF are provided. Also provided as methods for making and using chimeric antigen receptor T cells having reduced levels of GM-CSF.
    Type: Application
    Filed: March 15, 2022
    Publication date: May 16, 2024
    Applicants: HUMANIGEN, INC., MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: Cameron DURRANT, Dale CHAPPELL, Saad J. KENDERIAN, Michelle J. COX, Reona SAKEMURA
  • Publication number: 20240157130
    Abstract: Embodiments herein relate to implantable systems for cancer treatment and related methods. In an embodiment, an implantable system for cancer treatment can be included having a therapy output circuit configured to generate an electrical output for one or more electrodes to create one or more electric fields. The implantable system can include control circuitry that causes the therapy output circuit to generate the one or more electric fields at frequencies between 10 kHz and 1 MHz within a bodily tissue. The one or more electric fields can be effective to prevent and./or disrupt cellular mitosis in a cell. The implantable system can further include a therapy zone temperature sensor. The implantable system can be configured to measure the temperature and/or record the temperature data of a patient over time. The temperature data can include tissue temperature and time stamps of the same. Other embodiments are also included herein.
    Type: Application
    Filed: November 3, 2023
    Publication date: May 16, 2024
    Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: Devon N. Arnholt, Michael J. Kane, Brian L. Schmidt
  • Publication number: 20240156599
    Abstract: Devices, systems, and methods for delivery and deployment of an implantable device. The implantable device may be an anchor. The device includes an anchor garage configured to deliver the anchor, therein, to a target site, and an atraumatic shield movable with respect to the anchor garage. A biasing element biases the atraumatic shield into position with respect to the anchor garage. In some embodiments, the distal end of the anchor garage is a sharp tissue-penetrating end, and the atraumatic shield is biased distally over such sharp end. A limit stop may be provided to limit the extent to which the anchor garage extends distally, thereby limiting tissue penetration by the anchor garage and the depth of deployment of the anchor. An indicator may be positioned and/or configured to provide an indication of the relative positions of the anchor garage and the atraumatic shield.
    Type: Application
    Filed: November 9, 2023
    Publication date: May 16, 2024
    Applicants: BOSTON SCIENTIFIC SCIMED, INC., MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: Joel T. Eggert, Daniel Shuey, Troy Anthony Giese
  • Publication number: 20240157145
    Abstract: Electrical stimulation devices can be used to treat tinnitus. For example, tinnitus can be treated using implantable electrodes and stimulation devices for delivering electrical stimulation to a patient's cochlear region. Cochlear surface electrode(s), endosteal electrode(s), subendosteal electrode(s), intraosseous electrode(s), or short intracochlear electrode(s) (or a combination thereof), connected to existing or modified cochlear implant receiver/stimulator technology, can provide a successful model for long-term treatment of tinnitus in a large number of patients. In some cases, patients can simply turn on the tinnitus implant when experiencing troublesome tinnitus and gain instant relief.
    Type: Application
    Filed: December 22, 2023
    Publication date: May 16, 2024
    Applicant: Mayo Foundation for Medical Education and Research
    Inventor: Matthew L. Carlson
  • Patent number: 11980473
    Abstract: This specification discloses systems, methods, devices, and other techniques for determining the location of a seizure-generating region of the brain of a mammal.
    Type: Grant
    Filed: May 25, 2018
    Date of Patent: May 14, 2024
    Assignees: Mayo Foundation for Medical Education and Research, The Board of Trustees of the University of Illinois and St. Anne's University Hospital Brno
    Inventors: Brent M. Berry, Gary C. Sieck, Gregory A. Worrell, Benjamin H. Brinkmann, Yogatheesan Varatharajah, Vaclav Kremen, Ravishankar Krishnan Iyer, Zbigniew Kalbarczyk, Jan Cimbalnik
  • Patent number: 11980616
    Abstract: Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.
    Type: Grant
    Filed: December 7, 2020
    Date of Patent: May 14, 2024
    Assignees: Mayo Foundation for Medical Education and Research, Buck Institute for Research on Aging, Unity Biotechnology, Inc.
    Inventors: Remi-Martin Laberge, Judith Campisi, Marco Demaria, Nathaniel David, James L. Kirkland, Tamar Tchkonia, Yi Zhu
  • Patent number: 11981962
    Abstract: This document provides methods and materials for using low coverage whole genome sequencing techniques to assess genomes. For example, methods and materials for using targeted nucleic acid amplification and/or capture techniques in combination with low coverage whole genome sequencing techniques to obtain high coverage sequencing data for one or more pre-selected regions of a genome are provided.
    Type: Grant
    Filed: June 16, 2017
    Date of Patent: May 14, 2024
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Jean-Pierre A. Kocher, Chen Wang
  • Publication number: 20240148959
    Abstract: Disclosed herein are systems, devices, and methods for accessing a subdural space. In some embodiments, an apparatus may comprise a shaft configured to be slidably disposed within a lumen of a catheter. The shaft may be configured to be advanced distally from a distal end of the catheter and into a blood vessel of a subject. The shaft may include a perforating tip including an energy element configured to generate radiofrequency energy to form an opening through a wall of the blood vessel and dura of the subject and into an extravascular space of the subject. A curved section may be configured to be radially constrained within the lumen of the catheter and to curve toward the wall of the blood vessel and the dura upon exiting the lumen of the catheter such that the energy element is positioned to form the opening.
    Type: Application
    Filed: September 18, 2023
    Publication date: May 9, 2024
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Luis E. SAVASTANO, Yang LIU
  • Publication number: 20240148443
    Abstract: A trans-illuminating needle guide device for guiding a needle into and illuminating an arteriovenous (AV) fistula in a subject includes: a housing comprising a base, a needle guide insert having a pair of opposing side walls defining a first angled slot, a second angled slot, and a plurality of grooves, a needle guide having a guide channel configured to receive the needle, a first deflectable plate configured to be received by the first angled slot and the plurality of grooves, and a second deflectable plate configured to be received by the second angled slot, a first plurality of light emitting diodes (LEDs) disposed within the housing and configured to emit light of a first wavelength, and a second plurality of LEDs disposed within the housing and configured to emit light of a second wavelength, the second wavelength differing from the first wavelength.
    Type: Application
    Filed: November 3, 2023
    Publication date: May 9, 2024
    Applicant: Mayo Foundation for Medical Education and Research
    Inventor: Nabeel Aslam
  • Patent number: 11975065
    Abstract: This document relates to methods and materials for making and using viruses (e.g., measles viruses or adenoviruses) having a reduced susceptibility to antibody neutralization (e.g., antibody neutralization by serum from measles virus vaccines). For example, recombinant morbilliviruses (e.g., recombinant measles viruses) having a modified H gene and a modified F gene, as well as methods of using a recombinant virus are provided.
    Type: Grant
    Filed: November 3, 2021
    Date of Patent: May 7, 2024
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Miguel A. Munoz Alia, Stephen James Russell
  • Patent number: 11976040
    Abstract: Provided herein are novel lipase inhibitors and methods for using the same to treat inflammation, multisystem organ failure, necrotic pancreatic acinar cell death, acute pancreatitis, sepsis (e.g., culture negative sepsis), burns, and acne. For example, provided herein are two novel lipase inhibitors useful in the methods described herein: or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: March 3, 2023
    Date of Patent: May 7, 2024
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Vijay P. Singh, Sampath-Kumar Anandan, Kevin Greenman, Zeeshan Kamal
  • Publication number: 20240139011
    Abstract: A gastric bypass device includes an occlusion device that is adapted to be deployed relative to a patient's pyloric sphincter, an anastomosis anchor that is adapted to be deployed relative to an anastomosis between the patient's stomach and their small intestine, and a tether that extends through the patient's small intestine between the occlusion device and the anastomosis anchor. A dynamic leash may be secured relative to the occlusion device and may work in conjunction with the tether to help hold the occlusion device in place. The gastric bypass device may be deployed using a variety of methods including a push-pull wire method, a rail method, a garage method, a two-piece method and a comprehensive method.
    Type: Application
    Filed: July 18, 2023
    Publication date: May 2, 2024
    Applicants: Boston Scientific Scimed, Inc., Mayo Foundation for Medical Education and Research
    Inventors: Roger W. McGowan, Barham K. Abu Dayyeh, Daniel Lee Krautkremer, Jessica Brand, Alexander James Wiedmann, Andrew O'Brien
  • Publication number: 20240139010
    Abstract: A gastric bypass device includes an occlusion device that is adapted to be deployed relative to a patient's pyloric sphincter and a liner that extends distally from the occlusion device. A tether extends from the occlusion device. A dynamic leash may be secured relative to the occlusion device and may work in conjunction with the tether to help hold the occlusion device in place.
    Type: Application
    Filed: July 18, 2023
    Publication date: May 2, 2024
    Applicants: BOSTON SCIENTIFIC SCIMED, INC., MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: Roger W. McGowan, Barham K. Abu Dayyeh, Alexander James Wiedmann, Daniel Lee Krautkremer, Jessica Brand
  • Patent number: 11971412
    Abstract: Complexes containing a labeled polypeptide and an antibody, and the use of such complexes as research, diagnostic, and clinical tools, are described herein.
    Type: Grant
    Filed: November 8, 2022
    Date of Patent: April 30, 2024
    Assignee: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: Wendy K. Nevala, Svetomir N. Markovic, John T. Butterfield, Daniel J. Knauer
  • Patent number: 11969250
    Abstract: This specification discloses a brain electrode device. The brain electrode device includes a set of contact points and a set of sub-circuits. The sub-circuits include sensor ports configured to connect to the contact to the respective ones of the contact points. The device can further include an intelligent multiplexer that aggregates signals from the set of sub-circuits and generates an aggregate signal. The aggregate signal is transmitted to a signal acquisition device.
    Type: Grant
    Filed: November 13, 2020
    Date of Patent: April 30, 2024
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Patrick J. Zabinski, Gregory A. Worrell, Clifton R. Haider
  • Patent number: 11969197
    Abstract: This document describes methods and devices for treating ventricular fibrillation. For example, this document describes methods of performing electroporation of a ventricle and electroporation catheters. The methods can include inserting a distal end portion of a catheter into a ventricle of a heart of a patient, inflating a balloon coupled to the distal end portion of the catheter, occluding a valve of the heart associated with the ventricle with the balloon, injecting a fluid into the ventricle via an aperture defined by the distal end portion of the catheter, and generating an electrical current via an electrode on the distal end portion of the catheter.
    Type: Grant
    Filed: October 15, 2018
    Date of Patent: April 30, 2024
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Christopher V. DeSimone, Samuel J. Asirvatham, Christopher J. McLeod
  • Patent number: 11963957
    Abstract: Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.
    Type: Grant
    Filed: December 7, 2020
    Date of Patent: April 23, 2024
    Assignees: Mayo Foundation for Medical Education and Research, Unity Biotechnology, Inc., Buck Institute for Research on Aging
    Inventors: Remi-Martin Laberge, Judith Campisi, Albert Davalos, Marco Demaria, Nathaniel David, Jan M. A. van Deursen, Darren J. Baker, Bennett G. Childs
  • Publication number: 20240116990
    Abstract: This document provides methods and materials related to selected engineered analogs of atrial natriuretic peptides. For example, this document provides compositions that contain one or more selected engineered analogs of atrial natriuretic peptides provided herein and that have the ability to treat, prevent, or alleviate the symptoms of cardiovascular, cardiorenal, and metabolic disease.
    Type: Application
    Filed: September 15, 2023
    Publication date: April 11, 2024
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: John C. BURNETT, Jr., Shuchong PAN, Sasantha Jeson SANGARALINGHAM, Ye ZHENG