Patents Assigned to Mayo Foundation for Medical Education and Research
  • Patent number: 10934592
    Abstract: Provided herein is technology for prostate cancer screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of prostate cancer.
    Type: Grant
    Filed: February 27, 2018
    Date of Patent: March 2, 2021
    Assignees: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH, EXACT SCIENCES DEVELOPMENT COMPANY, LLC
    Inventors: David A. Ahlquist, William R. Taylor, John B. Kisiel, Tracy C. Yab, Douglas W. Mahoney, Brian A. Dukek, Matthew T. Gettman, Hatim T. Allawi
  • Patent number: 10934594
    Abstract: Provided herein is technology for breast cancer screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of breast cancer.
    Type: Grant
    Filed: November 28, 2018
    Date of Patent: March 2, 2021
    Assignees: Mayo Foundation for Medical Education and Research, Exact Sciences Development Company, LLC
    Inventors: David A. Ahlquist, William R. Taylor, Douglas W. Mahoney, Tracy C. Yab, John B. Kisiel, Hatim T. Allawi, Graham P. Lidgard, Michael W. Kaiser
  • Publication number: 20210052889
    Abstract: This specification describes systems, methods, devices, and other techniques for activating muscle groups in a mammal using an implantable epidural electrical stimulation (EES) system, and for using spinal landmarks to determine implant locations for an EES probe. In some aspects, a first set of electrodes of an EES system is provided at a first set of locations on the dura mater of a spine of a mammal, the first set of locations on the dura mater corresponding to a first muscle group of the mammal, a second set of electrodes is provided at a second set of locations on the dura mater of the spine of the mammal, the second set of locations on the dura mater corresponding to a second muscle group of the mammal, and the first and second sets of locations on the dura mater are stimulated by electrically energizing the first and second sets of electrodes.
    Type: Application
    Filed: January 23, 2019
    Publication date: February 25, 2021
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Peter J. Grahn, Igor A. Lavrov, Kristin D. Zhao, Kendall H. Lee, Megan L. Gill
  • Patent number: 10925901
    Abstract: This document provides methods and materials relating to platelet lysates. For example, methods and materials for using platelet lysate compositions to grow adult stem cells, to differentiate adult stem cells, to grow primary cell cultures, to grow tumor stem cells, and to identify effective growth factors are provided.
    Type: Grant
    Filed: December 28, 2018
    Date of Patent: February 23, 2021
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Allan B. Dietz, Michael P. Gustafson, Greg W. Butler
  • Patent number: 10918292
    Abstract: Non-invasive systems can be used to estimate cardiac output and stroke volume. For example, this document provides cuff occlusion systems and methods for their use so that cardiac output and stroke volume can be estimated in a non-invasive fashion. In some implementations, a patient's brachial artery is occluded by an inflatable cuff device for a period of time. A heart rate and a plurality of blood pressure pulse wave measurement curves can be measured using the cuff device. The data collected can be used to calculate an estimate of the patient's cardiac output and stroke volume.
    Type: Grant
    Filed: July 18, 2017
    Date of Patent: February 16, 2021
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Pavol Sajgalik, Vaclav Kremen, Bruce D. Johnson
  • Publication number: 20210038338
    Abstract: A surgical system includes a skull attachment device that includes a support base configured to seat against a skull of a patient and one or more pins extending from a bottom surface of the support base and configured to pierce the scalp to seat the skull attachment device against the skull. The surgical system also includes an interface disposed along a top surface of the support base and having a shape that compliments a profile of a mating feature of a stereotactic device for defining a position and an orientation of the stereotactic device with respect to the support base while the interface is engaged with the mating feature.
    Type: Application
    Filed: February 6, 2019
    Publication date: February 11, 2021
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Kendall H. Lee, Stephan J. Goerss
  • Publication number: 20210040148
    Abstract: The present invention provides benzothiadiazine and chroman derivatives and particularly diazoxide and cromakalim derivatives for use in treating glaucoma, retinopathy, treating age related macular degeneration, treating, stabilizing and/or inhibiting blood and lymph vascularization, and reducing intraocular pressure by administering a pharmaceutically effective amount of a prodrug disposed in an ophthalmically acceptable carrier to the eye, wherein the prodrug specifically modulates a KATP channel to reduce an intraocular pressure.
    Type: Application
    Filed: October 22, 2020
    Publication date: February 11, 2021
    Applicants: Mayo Foundation for Medical Education and Research, Regents of the University of Minnesota
    Inventors: Michael P. Fautsch, Peter Dosa, Michael A. Walters, Gunda I. Georg
  • Publication number: 20210044533
    Abstract: Systems, methods, and computer program product embodiments are disclosed for performing electrophysiology (EP) signal processing. An embodiment includes an electrocardiogram (ECG) circuit board configured to process an ECG signal. The embodiment further includes a plurality of intracardiac (IC) circuit boards, each configured to process a corresponding IC signal. The ECG circuit board and the plurality of IC circuit boards share substantially a same circuit configuration and components. The ECG circuit board further processes the ECG signal using substantially a same path as each IC circuit board uses to process its corresponding IC signal.
    Type: Application
    Filed: October 28, 2020
    Publication date: February 11, 2021
    Applicants: BioSig Technologies, Inc., Mayo Foundation for Medical Education and Research
    Inventors: Budimir S. DRAKULIC, Sina FAKHAR, Thomas G. FOXALL, Branislav VLAJINIC, Samuel J. ASIRVATHAM
  • Publication number: 20210038561
    Abstract: The present application provides methods for treating or preventing diseases and conditions associated with tissue fibrosis.
    Type: Application
    Filed: January 31, 2019
    Publication date: February 11, 2021
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Daniel J. Tschumperlin, Andrew J. Haak
  • Patent number: 10913775
    Abstract: This document provides methods and materials related to the use of nucleic acid coding for viruses to reduce the number of viable cancer cells within a mammal. For example, methods for using infectious nucleic acid to treat cancer, engineered viral nucleic acid, methods for making engineered viral nucleic acid, methods for identifying infectious nucleic acid for treating cancer, methods and materials for controlling virus-mediated cell lysis, and methods and materials for assessing the control of virus-mediated cell lysis are provided.
    Type: Grant
    Filed: March 27, 2018
    Date of Patent: February 9, 2021
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Stephen James Russell, Elizabeth J. Kelly, Elizabeth M. Hadac
  • Patent number: 10909675
    Abstract: A system and method for characterizing tissues of a subject using multi-parametric imaging are provided. In some aspects, the method includes receiving a set of multi-parametric magnetic resonance (“MR”) images acquired from a subject using an MR imaging system, and selecting at least one region of interest (“ROI”) in the subject using one or more images in the set of multi-parametric MR images. The method also includes performing a texture analysis on corresponding ROIs in the set of multi-parametric MR images to generate a set of texture features, and applying a classification scheme, using the set of texture features, to characterize tissues in the ROI. The method further includes generating a report indicative of characterized tissues in the ROI.
    Type: Grant
    Filed: October 11, 2016
    Date of Patent: February 2, 2021
    Assignees: Mayo Foundation for Medical Education and Research, Arizona Board of Regents on Behalf of Arizona State University
    Inventors: Leland S. Hu, J. Ross Mitchell, Jing Li, Teresa Wu
  • Publication number: 20210023233
    Abstract: Materials and methods for diagnosing and treating clinical conditions such as cancer using polypeptide complexes that include (a) a polypeptide component, (b) a therapeutic agent or a label, and (c) an antibody, are provided herein. Specifically, the polypeptide complex comprising: (a) a specified polypeptide component, (b) one or more cisplatin molecules or the polypeptide is labeled with 99Tcm, and (c) a monoclonal antibody that specifically binds to a tumor antigen, for treating or diagnosing cancer, respectively.
    Type: Application
    Filed: February 6, 2019
    Publication date: January 28, 2021
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Wendy K. Nevala, Svetomir N. Markovic, John T. Butterfield, Daniel J. Knauer
  • Patent number: 10900090
    Abstract: Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting neoplasms such as cholangiocarcinoma.
    Type: Grant
    Filed: January 8, 2019
    Date of Patent: January 26, 2021
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: John B. Kisiel, David A. Ahlquist, William R. Taylor, Douglas W. Mahoney, Tracy C. Yab
  • Patent number: 10893865
    Abstract: Devices, systems, and methods can be used for the closure of surgical wounds. For example, surgical wounds can be closed using magnetic closure devices rather than the conventional methods of using sutures, clips, or staples. Additionally, in some implementations the magnetic closure devices provided herein are delivered laparoscopically or endoscopically via a vacuum catheter.
    Type: Grant
    Filed: April 8, 2016
    Date of Patent: January 19, 2021
    Assignee: Mayo Foundation for Medical Education and Research
    Inventor: Navtej S. Buttar
  • Patent number: 10894034
    Abstract: Compounds and methods involving inhibition of the enzymatic activity of QSOX1 (FIG. 13). The compounds and methods can be used in treatment of neoplastic cells, for example, to suppress tumor growth and invasion in a variety of cancers, including but not limited to myeloma and cancers of the breast, kidney, and pancreas.
    Type: Grant
    Filed: September 13, 2016
    Date of Patent: January 19, 2021
    Assignees: Arizona Board of Regents on behalf of Arizona State University, Mayo Foundation for Medical Education and Research
    Inventors: Douglas Lake, Erik Castle, Paul Hanavan, Douglas Faigel, Thai Ho
  • Publication number: 20210010079
    Abstract: Various methods and devices for spatial molecular analysis from tissue is provided. For example, a method of spatially mapping a tissue sample is provided with a microarray having a plurality of wells, wherein adjacent wells are separated by a shearing surface; overlaying said microarray with a tissue sample; applying a deformable substrate to an upper surface of said tissue sample; applying a force to the deformable substrate, thereby forcing underlying tissue sample into the plurality of wells; shearing the tissue sample along the shearing surface into a plurality of tissue sample islands, with each unique tissue sample island positioned in a unique well; and imaging or quantifying said plurality of tissue sample islands, thereby generating a spatial map of said tissue sample. The imaging and/or quantifying may use a nucleic acid amplification technique.
    Type: Application
    Filed: July 27, 2020
    Publication date: January 14, 2021
    Applicants: The Board of Trustees of the University of Illinois, Mayo Foundation for Medical Education and Research
    Inventors: Rashid BASHIR, Anurup GANGULI, Farhad KOSARI
  • Patent number: 10881545
    Abstract: Devices and methods for treating penile aberrations include the use of traction devices. For example, this document describes devices and methods for applying longitudinal and/or contralateral penile traction forces to treat anatomical aberrations related to Peyronie's disease and other conditions.
    Type: Grant
    Filed: June 7, 2017
    Date of Patent: January 5, 2021
    Assignees: Mayo Foundation for Medical Education and Research, PathRight Medical Inc.
    Inventors: Landon W. Trost, Jason Gerold, Zachary M. Hoffman, David Talen
  • Patent number: 10883144
    Abstract: Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as colorectal cancer.
    Type: Grant
    Filed: January 9, 2020
    Date of Patent: January 5, 2021
    Assignees: Mayo Foundation for Medical Education and Research, Exact Sciences Development Company, LLC
    Inventors: David A. Ahlquist, William R. Taylor, Douglas W. Mahoney, Graham P. Lidgard, Hatim T. Allawi
  • Publication number: 20200405671
    Abstract: This document relates to methods and materials for treating polycystic kidney disease (PKD) and/or a complication associated with a PKD (e.g., a cardiovascular complication). For example, one or more betaines (e.g., trimethylglycine) can be administered to a mammal having, or at risk of developing, a PKD to treat the mammal.
    Type: Application
    Filed: June 25, 2020
    Publication date: December 31, 2020
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Maria V. Irazabal Mira, Vicente E. Torres
  • Patent number: 10875923
    Abstract: This document provides methods and materials for detecting B7-H1 polypeptides (e.g., soluble B7-H1 polypeptides). For example, antibodies (e.g., monoclonal antibodies) that bind to a B7-H1 polypeptide (e.g., a soluble B7-H1 polypeptide) are provided.
    Type: Grant
    Filed: October 26, 2016
    Date of Patent: December 29, 2020
    Assignee: Mayo Foundation for Medical Education and Research
    Inventor: Haidong Dong