Patents Assigned to Mayo Foundation for Medical Education and Research
  • Patent number: 11324431
    Abstract: Systems, methods, and computer program product embodiments are disclosed for performing electrophysiology (EP) signal processing. An embodiment includes an electrocardiogram (ECG) circuit board configured to process an ECG signal. The embodiment further includes a plurality of intracardiac (IC) circuit boards, each configured to process a corresponding IC signal. The ECG circuit board and the plurality of IC circuit boards share substantially a same circuit configuration and components. The ECG circuit board further processes the ECG signal using substantially a same path as each IC circuit board uses to process its corresponding IC signal.
    Type: Grant
    Filed: September 25, 2019
    Date of Patent: May 10, 2022
    Assignees: BioSig Technologies, Inc., Mayo Foundation for Medical Education and Research
    Inventors: Budimir S. Drakulic, Sina Fakhar, Thomas G. Foxall, Branislav Vlajinic, Samuel J. Asirvatham
  • Patent number: 11328391
    Abstract: System and methods are provided for producing computed tomography (CT) images. In some aspects, a method includes obtaining medical image data sets acquired using the multiple energies of irradiating radiation and analyzing the medical image data sets for spatial and spectral features. The method also includes comparing the spatial and spectral features of the medical image data sets to identify similarities and using the similarities, weighting the medical image data sets to generate images of the subject having reduced noise compared to images of the subject produced from the medical image data sets without weighting.
    Type: Grant
    Filed: May 8, 2017
    Date of Patent: May 10, 2022
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Zhoubo Li, Cynthia H. McCollough, Shuai Leng, Lifeng Yu, Armando Manduca
  • Patent number: 11325892
    Abstract: This document provides compounds, compositions, and methods for treating cancers including renal cancer (e.g., renal cell carcinoma) as well as ovarian, breast, prostate, colon, pancreatic, bladder, liver, lung, and thyroid cancers and melanoma. For example, compounds, compositions, and methods for using one or more inhibitors of SCD1 to treat renal cell carcinoma (e.g., clear cell renal cell carcinoma (ccRCC)), thyroid cancer, or liver cancer; or to increase the efficacy of treatment for the same.
    Type: Grant
    Filed: May 24, 2019
    Date of Patent: May 10, 2022
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: John A. Copland, III, Han W. Tun, Thomas R. Caulfield, Christina Von Roemeling, Laura Ann Marlow
  • Publication number: 20220133468
    Abstract: This document describes intraocular lenses and methods for their use. For example, this document describes intraocular lenses that are shaped with a concave posterior peripheral portion that mitigates occurrences of dysphotopsia. The intraocular lenses described herein are designed to reduce positive and negative dysphotopsias after cataract surgery.
    Type: Application
    Filed: January 13, 2022
    Publication date: May 5, 2022
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Jay C. Erie, Mark H. Bandhauer
  • Patent number: 11317872
    Abstract: Apparatuses and methods are provided to predict or diagnose an ischemic event, such as a stroke or a transient ischemic attack (TIA). A machine-learning model such as a neural network is generated that allows for recognition of an ECG consistent with an ischemic event. A system is trained and used to process a recording of ECG data from a patient to generate a prediction indicating a likelihood that the patient will experience a stroke. In other examples, a system is trained and used to process a recording of ECG data from a patient and detect an ischemic event for the patient who did not appear to have such an ischemic event.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: May 3, 2022
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Itzhak Zachi Attia, Paul A. Friedman, Samuel J. Asirvatham, Peter A. Noseworthy, Suraj Kapa, Francisco Lopez-Jimenez
  • Publication number: 20220127370
    Abstract: This document provides antibodies against tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) short, and more particularly to humanized TRAILshort antibodies that can neutralize TRAILshort. For example, materials and methods for using one or more humanized TRAILshort antibodies to induce apoptosis (e.g., via TRAIL mediated cell death, natural killer (NK) cytotoxicity, and/or CD8+ T cell killing) are provided.
    Type: Application
    Filed: August 24, 2021
    Publication date: April 28, 2022
    Applicant: Mayo Foundation for Medical Education and Research
    Inventor: Andrew D. Badley
  • Patent number: 11311631
    Abstract: Described herein are nanoparticle compositions comprising binding agents, carrier proteins and an amount of paclitaxel derivative, and optionally a therapeutic agent. Also described herein are nanoparticle compositions comprising carrier proteins and an amount of paclitaxel, and optionally binding agents and/or a therapeutic agent, wherein the paclitaxel is present in an amount that is less than an amount that provides a therapeutic effect. Also disclosed herein are nanoparticles which contain (a) carrier protein, (b) a paclitaxel derivative, the paclitaxel derivative having reduced toxicity compared to paclitaxel, and optionally (c) a binding agent and/or (d) a therapeutic agent. Also described are methods of making and using the same, in particular, as a cancer therapeutic.
    Type: Grant
    Filed: September 6, 2017
    Date of Patent: April 26, 2022
    Assignee: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: Svetomir N. Markovic, Wendy K. Nevala
  • Publication number: 20220118080
    Abstract: This document relates to methods and materials for making and using viruses (e.g., measles viruses or adenoviruses) having a reduced susceptibility to antibody neutralization (e.g., antibody neutralization by serum from measles virus vaccines). For example, recombinant morbilliviruses (e.g., recombinant measles viruses) having a modified H gene and a modified F gene, as well as methods of using a recombinant virus are provided.
    Type: Application
    Filed: November 3, 2021
    Publication date: April 21, 2022
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Miguel A. Munoz Alia, Stephen James Russell
  • Patent number: 11307280
    Abstract: Described here are systems and methods for correcting motion-encoding gradient nonlinearities in magnetic resonance elastography (“MRE”). In general, the systems and methods described in the present disclosure compute gradient nonlinearity corrected displacement data based on information about the motion-encoding gradients used when acquiring magnetic resonance data.
    Type: Grant
    Filed: June 3, 2019
    Date of Patent: April 19, 2022
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Joshua D. Trzasko, Philip A. Araoz, Matthew A. Bernstein, Richard L. Ehman, Arvin Forghanian-Arani, John Huston, III, Yunhong Shu
  • Patent number: 11305020
    Abstract: This disclosure relates to methods for improving the therapeutic index of a chemotherapeutic drug in the treatment of patients afflicted with cancer, by reducing chemotherapy-related toxicity to a level that allows the chemotherapeutic drug to be used in humans.
    Type: Grant
    Filed: March 21, 2017
    Date of Patent: April 19, 2022
    Assignee: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: Svetomir N. Markovic, Wendy K. Nevala
  • Publication number: 20220112566
    Abstract: This document provides methods and materials involved in using measles viruses. For example, methods and materials for identifying mammals (e.g., humans) likely to respond to standard measles virus vaccines or standard measles virus-based therapies as well as methods and materials for identifying mammals (e.g., humans) unlikely to respond to standard measles virus vaccines or standard measles virus-based therapies are provided.
    Type: Application
    Filed: December 21, 2021
    Publication date: April 14, 2022
    Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: RICHARD B. KENNEDY, GREGORY A. POLAND, INNA G. OVSYANNIKOVA, IANA H. HARALAMBIEVA
  • Patent number: 11300616
    Abstract: A technique for non-invasively assessing current drawn by a device under test (DUT) by monitoring a supply voltage to the DUT. Frequency data for the DUT may be generated and used to form a current estimation model. First and second voltages are simultaneously measured using first and second test probes electrically connected to the DUT, while the first test probe is connected at a current source, and while the second test probe is connected at a DUT load that is configured to draw current from the current source. The current drawn by the DUT is then assessed by applying the current estimation model to the measured first and second voltages. In one case, the current drawn by the DUT is estimated without insertion of a circuit component into the DUT or extraction of a circuit conductor from the DUT.
    Type: Grant
    Filed: July 11, 2018
    Date of Patent: April 12, 2022
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Jonathan L. Fasig, Christopher K. White, Chad M. Smutzer, Michael J. Degerstrom
  • Patent number: 11291838
    Abstract: This document describes methods and devices for using electrical stimulation to control physiological functions such as breathing of patients suffering from respiratory impairment. For example, this document describes methods and devices for generating effective breaths and airway protection by determining times and depths of breaths in accordance with physiological demand, and coordinating respiratory muscle stimulation with the breaths to control breathing.
    Type: Grant
    Filed: August 30, 2018
    Date of Patent: April 5, 2022
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Brent M. Berry, Carlos B. Mantilla, Obaid Khurram, Soudabeh Kargar, Joseph D. Mozingo, Michal T. Kucewicz, Erik S. Daniel, Gary C. Sieck
  • Patent number: 11291413
    Abstract: Described herein are methods and systems for clustering events in temporal signals, such as physiological signals. In some embodiments, a method for identifying events of interest from noisy physiological signal data is provided, the method comprising: receiving physiological signal data; generating filtered signal using a filter defined by a spectral band; generating signal peak data by identifying, for each of a plurality of time windows, a signal peak in the filtered data; grouping waveforms corresponding to the time windows based on the signal peak data to generate clustered event data; determining parameters for a noise beta distribution; identifying a cluster of waveforms that does not fall within the noise beta distribution; generating a graphical representation based on the waveforms in the cluster; and displaying the graphical representation.
    Type: Grant
    Filed: December 15, 2016
    Date of Patent: April 5, 2022
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Mark R. Bower, Regina S. Bower, Michael T. Kucewicz, Gregory A. Worrell
  • Patent number: 11288278
    Abstract: A computer-implemented method includes receiving, at a computer system, a question; identifying one or more first semantic elements in the question; selecting, from one or more electronic documents, a plurality of candidate responses to the question based on comparison of the one or more first semantic elements to second semantic elements; determining completeness scores for the plurality of candidate responses, wherein each of the completeness scores indicates how completely a corresponding candidate response from the plurality of candidate responses answers the question; determining relevance scores for the plurality of candidate responses, wherein each of the relevance scores indicates how relevant a corresponding candidate response from the plurality of candidate responses is to the question; and providing, by the computer system, at least a portion of the plurality of candidate responses based, at least in part, on the completeness scores and the relevance scores.
    Type: Grant
    Filed: July 15, 2019
    Date of Patent: March 29, 2022
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Felicity Enders, Farrell J. Lloyd, Dale R. Zwart
  • Patent number: 11285221
    Abstract: This document provides methods and materials related to treating myelomas. For example, methods and materials relating to the use of a composition containing albumin-containing nanoparticle/antibody complexes (e.g., ABRAXANE®/anti-CD38 polypeptide antibody complexes) to treat myelomas are provided.
    Type: Grant
    Filed: January 14, 2019
    Date of Patent: March 29, 2022
    Assignee: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: Svetomir N. Markovic, Wendy K. Nevala
  • Patent number: 11285085
    Abstract: Gastric and intestinal feeding tube devices and methods can be enhanced to provide better patient outcomes. For example, this document provides gastric and intestinal feeding tube devices that include an external bumper with pressure sensors and pressure indicators that facilitate usage of the feeding tube devices within an appropriate range of skin surface pressure. This document also provides external bumpers with deflectable elements that facilitate the application of a controlled amount of force between the external bumpers and the skin surface.
    Type: Grant
    Filed: February 3, 2020
    Date of Patent: March 29, 2022
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Paul A. Lorentz, Manpreet S. Mundi, Drew J. Smith, Stephen M. Corner
  • Patent number: 11279953
    Abstract: This document relates to adenovirus vectors and methods and materials related to using adenovirus vectors. For example, viruses, nucleic acid molecules encoding viruses, cell lines containing viral vectors, and methods for using viruses to deliver nucleic acid to cells in vitro or in vivo are provided. Methods and materials for using adenovirus vectors to induce immune responses and to treat cancer also are provided.
    Type: Grant
    Filed: April 30, 2020
    Date of Patent: March 22, 2022
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Michael A. Barry, Eric Weaver
  • Patent number: 11278643
    Abstract: The disclosure provides a method of using blood or fractions thereof, e.g., serum, obtained from a mammal subjected to liver surgery, for example, obtained following a partial hepatectomy, to increase the engraftment, proliferation and/or functionality of cells on a biocompatible scaffold.
    Type: Grant
    Filed: September 6, 2017
    Date of Patent: March 22, 2022
    Assignees: Mayo Foundation for Medical Education and Research, Miromatrix Medical Inc.
    Inventors: Jeffrey Ross, Anne Young, Allie Haarstad, Scott Nyberg
  • Patent number: 11274131
    Abstract: Materials and methods for using multivalent molecules (e.g., antibodies) to modulate cellular function. A molecule can be targeted to a particular type of cell, either through direct binding to an epitope on the surface of the cell, or through a linker that recognizes both the multivalent molecule and a marker on the cell surface.
    Type: Grant
    Filed: December 27, 2018
    Date of Patent: March 15, 2022
    Assignee: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: Larry R. Pease, Moses Rodriguez