Patents Assigned to Mayo Foundation for Medical Education and Research
  • Publication number: 20240083966
    Abstract: This document provides methods and materials related to vesicular stomatitis viruses. For example, vesicular stomatitis viruses, nucleic acid molecules encoding VSV polypeptides, methods for making vesicular stomatitis viruses, and methods for using vesicular stomatitis viruses to treat cancer are provided.
    Type: Application
    Filed: March 13, 2023
    Publication date: March 14, 2024
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Stephen James Russell, Shruthi Naik
  • Publication number: 20240081653
    Abstract: Systems, methods, devices, and techniques for estimating a heart disease prediction of a mammal. An electrocardiogram (ECG) procedure is performed on a mammal, and a computer system obtains ECG data that describes results of the ECG over a period of time. The system provides a predictive input that is based on the ECG data to a predictive model, such as a neural network or other machine-learning model. In response, the predictive model processes the input to generate an estimated heart disease predictive characteristic of the mammal. The system outputs the estimated heart disease prediction of the mammal for presentation to a user.
    Type: Application
    Filed: October 31, 2023
    Publication date: March 14, 2024
    Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: Itzhak Zachi Attia, Paul A. Friedman, Francisco Lopez-Jimenez, Suraj Kapa
  • Publication number: 20240082330
    Abstract: This document relates to methods and materials involved in treating cancer. For example, methods and materials for using one or more oncolytic viruses (e.g., one or more replicating oncolytic viruses) to treat cancer in a mammal (e.g., a human) identified as having a cancer likely to respond to oncolytic virotherapy are provided.
    Type: Application
    Filed: November 14, 2023
    Publication date: March 14, 2024
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Kah-Whye Peng, Stephen James Russell, Mitesh J. Borad, Yumei Zhou, Amber C. Miller
  • Patent number: 11925640
    Abstract: Provided herein are methods and materials for improving arteriovenous fistula (AVF) maturation and/or maintaining AVF functionality. For example, methods and materials for using one or more senolytic agents to improve AVF maturation, to maintain AVF functionality, and/or to maintain the patency of an AVF are provided. Methods and materials for using one or more senolytic agents to maintain functionality and/or patency of a venous graft (e.g., a venous graft that bypasses an occluded artery) also are provided.
    Type: Grant
    Filed: June 21, 2019
    Date of Patent: March 12, 2024
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Karl A. Nath, James L. Kirkland, Tamar Tchkonia
  • Publication number: 20240075073
    Abstract: This document provides materials and methods for treating a damaged optic nerve in a mammal to restore visual function comprising administering a population of induced pluripotent stem cell-derived oligodendrocyte precursor cells. This document also provides materials and methods for determining a remyelination potential quotient of a population of induced pluripotent stem cell-derived oligodendrocyte precursor cells. This document also provides materials and methods for screening factors that enhance maturation or myelination efficiency of an induced pluripotent stem cell-derived oligodendrocyte precursor cell or cells.
    Type: Application
    Filed: June 30, 2023
    Publication date: March 7, 2024
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Charles L. Howe, Miranda M. Standiford, Kanish Mirchia
  • Patent number: 11923876
    Abstract: In accordance with some embodiments of the disclosed subject matter, mechanisms (which can, for example, include systems, methods, and media) for low-power encoding of continuous physiological signals are provided. In some embodiments, a system comprises: a physiological sensor; and a remote monitor comprising: a battery; memory storing a k-ary tree including a root with k branches corresponding to k delta values, k nodes at a first depth below the Leads root node each having k branches corresponding to the k delta values the nodes indexed to indicate the lateral position of the node within the depth; a processor programmed to: receive a first sample value from the sensor; receive a second sample value; calculate a difference between the second first sample values; determine that the delta corresponds to a first delta of the k delta values; encode a sequence of deltas based on a depth and node index.
    Type: Grant
    Filed: July 15, 2019
    Date of Patent: March 5, 2024
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Christopher L. Felton, Barry K. Gilbert, Clifton R. Haider
  • Publication number: 20240060975
    Abstract: The invention provides prognostic methods for evaluating the severity of NMO and NMO-associated diseases as well as methods of treating NMO and NMO-associated diseases.
    Type: Application
    Filed: May 5, 2023
    Publication date: February 22, 2024
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Vanda A. Lennon, Sean J. Pittock, Shannon Hinson
  • Publication number: 20240058296
    Abstract: Described herein are compositions of modified binding agents and modified carrier proteins, as well as nanoparticle complexes comprising modified binding agents and modified carrier proteins with optionally at least one therapeutic agent, and methods of making and using the same, in particular, as a cancer therapeutic.
    Type: Application
    Filed: January 11, 2023
    Publication date: February 22, 2024
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Svetomir N. Markovic, Wendy K. Nevala, John Thomas Butterfield, Daniel Joseph Knauer
  • Patent number: 11904165
    Abstract: A method for providing galvanic vestibular stimulation corresponding to accelerations in scenes of a video. Embodiments include (1) receiving a three dimensional video signal including three dimensional video angular velocity information, (2) receiving a three dimensional head orientation signal including three dimensional head angular velocity information, (3) calculating resultant three dimensional angular velocity information based on the video angular velocity information and the head angular velocity information, (4) calculating three dimensional acceleration information based on the resultant three dimensional angular velocity information, and (5) generating three dimensional galvanic vestibular stimulation signals corresponding to the resultant three dimensional angular acceleration information, wherein the three dimensional stimulation signals will stimulate three dimensional acceleration sensations corresponding to accelerations on the user viewing the displayed scenes.
    Type: Grant
    Filed: March 21, 2022
    Date of Patent: February 20, 2024
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Gaurav N. Pradhan, Michael J. Cevette, Jan Stepanek
  • Patent number: 11903670
    Abstract: Devices and methods for the treatment of heart conditions, and other medical purposes, include cardiac pacing systems. For example, this document describes temporary transvenous endocardial pacemaker systems and devices for deploying such systems without the need for conventional imaging procedures.
    Type: Grant
    Filed: February 27, 2019
    Date of Patent: February 20, 2024
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Peter M. Pollak, Samuel J. Asirvatham, Charles J. Bruce, Paul A. Friedman
  • Publication number: 20240050008
    Abstract: This document describes systems, methods, and devices for sensing electrical activity in a brain of a mammal. Some aspects include a cortical electrode assembly configured, in use, to sense electrical activity at a surface of a brain, the assembly comprising: a ring-shaped substrate; and a plurality of electrical sensors affixed to the ring-shaped substrate, wherein the plurality of electrical sensors are spaced along the ring-shaped substrate so as to form a ring of electrical sensors that substantially encircle an aperture formed by the ring-shaped substrate.
    Type: Application
    Filed: August 25, 2023
    Publication date: February 15, 2024
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Karim ReFaey, William Tatum, Alfredo Quinones-Hinojosa
  • Patent number: 11897931
    Abstract: Analogues of an alternatively spliced form of atrial natriuretic peptide (MANP) that exhibit pGC-A gain of function and can be used to treat cardiorenal and metabolic disease are described herein.
    Type: Grant
    Filed: June 25, 2021
    Date of Patent: February 13, 2024
    Assignee: Mayo Foundation for Medical Education and Research
    Inventor: John C. Burnett, Jr.
  • Patent number: 11896379
    Abstract: Systems, methods, and computer program product embodiments are disclosed for displaying cardiac signals based on a signal pattern. An embodiment operates by accessing an input cardiac signal. The embodiment matches a portion of the input cardiac signal to a known signal pattern. The embodiment then displays an indication of a degree of the match.
    Type: Grant
    Filed: August 16, 2019
    Date of Patent: February 13, 2024
    Assignees: BioSig Technologies, Inc., Mayo Foundation for Medical Education and Research
    Inventors: Budimir S. Drakulic, Sina Fakhar, Thomas G. Foxall, Branislav Vlajinic, Samuel J. Asirvatham
  • Patent number: 11891620
    Abstract: Platelet lysate compositions and cell culture media compositions for maintaining and/or growing mammalian cells, such as mammalian endothelial cells (ECs) and mammalian endothelial progenitor cells (EPCs), in particular human ECs (huECs) and human EPCs (huEPCs), such as primary huECs and primary huEPCs, are provided. The cell culture media compositions contain a basal medium, a platelet lysate and, optionally, one or more exogenously added growth factors. Also provided are methods for making and using such cell culture media compositions to grow and/or maintain ECs and EPCs, including huECs and huEPCs, as well as cell culture vessels, dishes, plates, and/or flasks pretreated with the cell culture media compositions.
    Type: Grant
    Filed: May 14, 2015
    Date of Patent: February 6, 2024
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Allan B. Dietz, Gaylord Knutson
  • Patent number: 11890119
    Abstract: Methods of using a soft tissue cutting device are disclosed. The methods include providing the soft tissue cutting device, positioning the soft tissue cutting device in a priming slot of a tray configured for receiving and holding the soft tissue cutting device, attaching a priming syringe to the soft tissue cutting device, priming a balloon disposed on a distal end of the soft tissue cutting device by equalizing a first pressure inside the balloon to a second pressure inside the priming syringe, removing the soft tissue cutting device from the priming slot, and positioning the distal end of the soft tissue cutting device on a safety slot included in the tray to determine whether the tissue cutting device has been properly primed.
    Type: Grant
    Filed: December 7, 2020
    Date of Patent: February 6, 2024
    Assignee: Sonex Health, Inc. and Mayo Foundation for Medical Education and Research
    Inventors: Darryl E. Barnes, Aaron Keenan, Jay Smith, Kevin Arnal, Sara Schlick
  • Publication number: 20240033352
    Abstract: Described herein are methods, formulations and kits for treating a patient with cancer with anti-VEGF antibodies and albumin-bound chemotherapeutic/anti-VEGF antibody nanoparticle complexes.
    Type: Application
    Filed: March 17, 2023
    Publication date: February 1, 2024
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Gerald F. SWISS, Svetomir N. MARKOVIC, Wendy K. NEVALA
  • Patent number: 11884845
    Abstract: A tissue adhesive material that provides fast and robust adhesion even on tissue surfaces covered in bodily fluids. The tissue adhesive material is formed of a hydrophobic matrix and a plurality of bioadhesive microparticles dispersed within the hydrophobic matrix configured such that disposing the adhesive material directly on a fluid covered surface and applying pressure causes the (a) hydrophobic matrix to repel the fluid, (b) the bioadhesive particles to compress forming an adhesive layer, and (c) the bioadhesive particles to form temporary crosslinks followed by covalent crosslinks with the surface.
    Type: Grant
    Filed: December 3, 2020
    Date of Patent: January 30, 2024
    Assignees: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: Xuanhe Zhao, Hyunwoo Yuk, Xinyu Mao, Christoph Nabzdyk
  • Patent number: 11884958
    Abstract: This document provides methods and materials involved in assessing and/or treating a mammal having a functional gastrointestinal disorder (FGID) such as irritable bowel syndrome (IBS). For example, methods and materials provided herein can be used for determining if a mammal having a FGID is likely to respond to a particular FGID treatment. This document also provides methods and materials for treating a mammal having a FGID.
    Type: Grant
    Filed: April 24, 2020
    Date of Patent: January 30, 2024
    Assignee: Mayo Foundation for Medical Education and Research
    Inventor: Purna C. Kashyap
  • Patent number: 11883078
    Abstract: An implant for fusing a joint between first and second bone portions. The implant includes a screw member, and a washer polyaxially rotatable relative to the screw member. The screw member includes a head, a lag zone, and a threaded engagement zone. The implant includes a fusion zone for joint compression, extending from the washer to the proximal end of the engagement zone. Fenestrations may be present in the fusion zone. The length of the fusion zone ranges from about 10 mm to about 37 mm. Different surface finishes including roughened and non-roughened may be applied selectively to selected portions of the implant. In an embodiment, the joint is a sacro-iliac joint, and upon implantation the implant extends from the exterior of the ilium, across the joint and into the sacral vertebral body. Instrumentation and methods for preparing the joint and implanting the implant are disclosed.
    Type: Grant
    Filed: September 13, 2021
    Date of Patent: January 30, 2024
    Assignees: IMDS LLC, Mayo Foundation for Medical Education and Research
    Inventors: Brian Scott Schumacher, Nicholas Slater, William W. Cross, III
  • Patent number: 11878002
    Abstract: This document provides materials and methods related to bacterial compositions containing at least one bacterial organism having tryptophan decarboxylase activity. For example, bacterial compositions containing at least one bacterial organism having tryptophan decarboxylase activity and methods for using such bacterial compositions to improve gastrointestinal epithelial function and/or to treat gastrointestinal disorders are provided.
    Type: Grant
    Filed: April 8, 2021
    Date of Patent: January 23, 2024
    Assignees: Mayo Foundation for Medical Education and Research, Regents of the University of California
    Inventors: Purna C. Kashyap, Michael Fischbach, Brianna B. Williams