Patents Assigned to Mayo Foundation for Medical Education and Research
  • Publication number: 20190276896
    Abstract: This document relates to methods and materials involved in detecting gene amplification in a mammal. For example, methods and materials for detecting amplification at CPM and MDM2 loci to determine the presence or absence of a malignant lipomatous neoplasm in a mammal are provided.
    Type: Application
    Filed: February 11, 2019
    Publication date: September 12, 2019
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Andre M. Oliveira, Michele R. Erickson-Johnson
  • Patent number: 10406224
    Abstract: Described are stable nanoparticle complexes of 100 nm to 900 nm comprising paclitaxel, albumin and an antibody. The nanoparticle complexes are suitable for the treatment of cancer.
    Type: Grant
    Filed: February 24, 2016
    Date of Patent: September 10, 2019
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Svetomir N. Markovic, Wendy K. Nevala
  • Patent number: 10407731
    Abstract: This document provides methods and materials related to assessing male mammals (e.g., humans) with prostate cancer. For example, methods and materials for predicting (1) which patients, at the time of PSA reoccurrence, will later develop systemic disease, (2) which patients, at the time of retropubic radial prostatectomy, will later develop systemic disease, and (3) which patients, at the time of systemic disease, will later die from prostate cancer are provided.
    Type: Grant
    Filed: September 17, 2015
    Date of Patent: September 10, 2019
    Assignee: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: George G. Klee, Robert B. Jenkins, Thomas M. Kollmeyer, Karla V. Ballman, Eric J. Bergstralh, Bruce W. Morlan, S. Keith Anderson, Tohru Nakagawa
  • Publication number: 20190270980
    Abstract: This document relates to methods and materials for treating cancer. For example, methods and materials for using CRISPR/Cas9 systems to treat cancer are provided.
    Type: Application
    Filed: July 24, 2017
    Publication date: September 5, 2019
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Yasuhiro Ikeda, Yuichi Machida, Jason M. Tonne, Salma G. Morsy
  • Publication number: 20190269923
    Abstract: This document provides methods and materials for modulating afferent nerve signals to treat medical conditions such as CHF, CHF respiration, dyspnea, peripheral vascular disease (e.g., peripheral arterial disease or venous insufficiency), hypertension (e.g., age-associated hypertension, resistant hypertension, or chronic refractory hypertension), COPD, sleep apnea, and chronic forms of lung disease where muscle dysfunction is a part of the disease pathophysiology. For example, methods and materials involved in using electrical and/or chemical techniques to block or reduce afferent nerve signals (e.g., nerve signals of group III and/or IV afferents coming from skeletal muscle and/or the kidneys) are provided.
    Type: Application
    Filed: May 21, 2019
    Publication date: September 5, 2019
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Michael j. Joyner, Bruce D. Johnson, Thomas P. Olson
  • Publication number: 20190269703
    Abstract: This document relates to methods and materials for treating chronic cough, nasal congestion, and/or one or more conditions causing chronic cough and/or nasal congestion (e.g., posterior rhinorrhea, also known as post-nasal drip (PND), and/or rhinitis). For example, this document relates to compositions containing a steroid (e.g., mometasone furoate), an anticholinergic (e.g., ipratropium bromide), and an antihistamine (e.g., diphenhydramine) as well as methods of using such compositions to reduce or eliminate one or more conditions causing chronic cough (e.g., PND and/or rhinitis).
    Type: Application
    Filed: May 16, 2017
    Publication date: September 5, 2019
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Kaiser G. Lim, Roger A. Warndahl
  • Patent number: 10401360
    Abstract: This document provides methods and materials involved in performing flow cytometry assay methods. For example, flow cytometry assay methods and kits are provided.
    Type: Grant
    Filed: April 29, 2014
    Date of Patent: September 3, 2019
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Patricio Escalante, Tobias Peikert
  • Publication number: 20190262019
    Abstract: This document relates to devices and methods for the treatment of heart conditions. For example, this document provides devices and methods for treating heart failure with preserved ejection fraction, including diastolic heart failure, by performing a pericardial modification procedure.
    Type: Application
    Filed: May 8, 2019
    Publication date: August 29, 2019
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Samuel J. Asirvatham, Barry A. Borlaug, Vojtech Melenovsky
  • Publication number: 20190261948
    Abstract: Systems and methods for ultrafast synthetic transmit aperture (“USTA”) ultrasound imaging using coded virtual sources are described. The methods can implement spatially distinct or spatially overlapping sub-apertures with appropriate timing of transmission between the spatially overlapping sub -apertures. The systems and methods described here are capable of increasing signal-to-noise ratio (“SNR”) and spatial resolution to reduce frame rate.
    Type: Application
    Filed: September 14, 2017
    Publication date: August 29, 2019
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Ping Gong, Pengfei Song, Shigao Chen
  • Patent number: 10390879
    Abstract: This document provides devices and methods for the treatment of heart conditions, hypertension, and other medical disorders. For example, this document provides devices and methods for treating atrial fibrillation by performing thoracic vein ablation procedures, including pulmonary vein myocardium ablation. In some embodiments, the ablation is performed in coordination with the delivery a pharmacological agent that can abate the formation of tissue stenosis or neointimal hyperplasia caused by the ablation.
    Type: Grant
    Filed: May 20, 2014
    Date of Patent: August 27, 2019
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Samuel J. Asirvatham, David R. Holmes, Jr.
  • Patent number: 10391159
    Abstract: This document provides methods and materials for treating cancer. For example, methods and materials for identifying antigens and combinations of antigens that can be used to treat cancer as well as combinations of antigens having the ability to reduce established tumors (e.g., gliomas) within a mammal (e.g., a human) are provided.
    Type: Grant
    Filed: December 5, 2018
    Date of Patent: August 27, 2019
    Assignees: Mayo Foundation for Medical Education and Research, University of Leeds
    Inventors: Richard G. Vile, Timothy J. Kottke, Jill M. Thompson, Jose S. Pulido, Alan A. Melcher, Peter Selby
  • Patent number: 10391055
    Abstract: Described herein are compositions of antibodies and carrier proteins and methods of making and using the same, in particular, as a cancer therapeutic. Also described are lyophilized compositions of antibodies and carrier proteins and methods of making and using the same, in particular, as a cancer therapeutic.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: August 27, 2019
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Svetomir N. Markovic, Wendy K. Nevala
  • Publication number: 20190255154
    Abstract: This document provides methods and materials for using butyrylcholinesterases (BChE) to treat cancer (e.g., triple negative breast cancer or prostate cancer). For example, methods and materials for using nucleic acid vectors (e.g., viral vectors) to express BChE polypeptides under conditions that reduce the number of cancer cells (e.g., triple negative breast cancer cells or prostate cancer cells) within a mammal (e.g., a human) and/or reduce the growth rate of cancer cells (e.g., triple negative breast cancer cells or prostate cancer cells) within a mammal (e.g., a human) are provided.
    Type: Application
    Filed: September 15, 2017
    Publication date: August 22, 2019
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: William S. Brimijoin, Liewei Wang, Yang Gao, Ping Chen, Liyi Geng, Jia Yu, Judy C. Boughey, Matthew P. Goetz
  • Patent number: 10386438
    Abstract: A system and method for generating a spatial map of parameters that describe the mechanically-induced harmonic motion information present within a magnetic resonance elastography (MRE) data set is provided. A first temporal harmonic signal is estimated using a graph-cut based optimization strategy, and can subsequently be used to generate a spatial map of mechanical parameters. The MRE data set is used to estimate the harmonic. The spatial map is of a mechanical parameter derived from the estimated harmonic.
    Type: Grant
    Filed: April 17, 2015
    Date of Patent: August 20, 2019
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Joshua D. Trzasko, Armando Manduca
  • Patent number: 10385406
    Abstract: Provided herein is technology for lung neoplasia screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of lung cancer.
    Type: Grant
    Filed: March 28, 2017
    Date of Patent: August 20, 2019
    Assignees: EXACT SCIENCES DEVELOPMENT COMPANY, LLC, Mayo Foundation for Medical Education and Research
    Inventors: Hatim Allawi, Graham P. Lidgard, Maria Giakoumopoulos, David A. Ahlquist, William R. Taylor, Douglas Mahoney
  • Publication number: 20190246966
    Abstract: Systems, methods, and other techniques for estimating the level of an analyte present in a patient during a time interval using electrocardiogram (ECG) signals. The estimate can be improved using information about the patient's posture.
    Type: Application
    Filed: September 12, 2017
    Publication date: August 15, 2019
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Paul A. Friedman, Michael J. Ackerman, Samuel J. Asirvatham, Itzhak Zachi Attia, Kevin E. Bennet, Charles J. Bruce, John J. Dillon, Jennifer L. Dugan, Dorothy J. Ladewig, Virend K. Somers
  • Publication number: 20190247415
    Abstract: This document provides methods and materials for activating muscle remodeling. For example, methods and materials for using GAR1 inhibitors to activate muscle remodeling are provided.
    Type: Application
    Filed: July 10, 2017
    Publication date: August 15, 2019
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Stephen C. EKKER, Noriko UMEMOTO
  • Publication number: 20190249261
    Abstract: The invention provides methods for establishing which genomic alterations are truly clonal in cancer, and for determining the confidence for calling true clonal mutations in individual tumors using multi-region sequencing data. The invention further provides methods for treating cancer that comprise confidently determining truly clonal genomic alternations in the target cancer that is to be treated.
    Type: Application
    Filed: May 12, 2017
    Publication date: August 15, 2019
    Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: David DINGLI, Benjamin WERNER, Ame TRAULSEN
  • Patent number: 10377813
    Abstract: The peptides described herein can function as carrier peptides. These peptides can associate with (e.g., non-covalently bind) biologically active molecules or imaging agents to transport the biologically active molecules or imaging across the blood-brain barrier. In some cases, such transport may increase the effectiveness of the biological molecules or imaging agents.
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: August 13, 2019
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Geoffry L. Curran, Gobinda Sarkar, Joseph F. Poduslo, Robert B. Jenkins, Val J. Lowe, Eric W. Mahlum
  • Patent number: 10376579
    Abstract: This document provides materials related to treating cancer (e.g., skin cancer). For example, materials relating to the use of a composition containing albumin-containing nanoparticle/antibody complexes (e.g., albumin-bound paclitaxel/anti-VEGF polypeptide antibody complexes) to treat cancer (e.g., skin cancer) are provided).
    Type: Grant
    Filed: February 24, 2016
    Date of Patent: August 13, 2019
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Svetomir N. Markovic, Wendy K. Nevala