Patents Assigned to Mayo Foundation for Medical Education and Research
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Publication number: 20240148443Abstract: A trans-illuminating needle guide device for guiding a needle into and illuminating an arteriovenous (AV) fistula in a subject includes: a housing comprising a base, a needle guide insert having a pair of opposing side walls defining a first angled slot, a second angled slot, and a plurality of grooves, a needle guide having a guide channel configured to receive the needle, a first deflectable plate configured to be received by the first angled slot and the plurality of grooves, and a second deflectable plate configured to be received by the second angled slot, a first plurality of light emitting diodes (LEDs) disposed within the housing and configured to emit light of a first wavelength, and a second plurality of LEDs disposed within the housing and configured to emit light of a second wavelength, the second wavelength differing from the first wavelength.Type: ApplicationFiled: November 3, 2023Publication date: May 9, 2024Applicant: Mayo Foundation for Medical Education and ResearchInventor: Nabeel Aslam
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Publication number: 20240148959Abstract: Disclosed herein are systems, devices, and methods for accessing a subdural space. In some embodiments, an apparatus may comprise a shaft configured to be slidably disposed within a lumen of a catheter. The shaft may be configured to be advanced distally from a distal end of the catheter and into a blood vessel of a subject. The shaft may include a perforating tip including an energy element configured to generate radiofrequency energy to form an opening through a wall of the blood vessel and dura of the subject and into an extravascular space of the subject. A curved section may be configured to be radially constrained within the lumen of the catheter and to curve toward the wall of the blood vessel and the dura upon exiting the lumen of the catheter such that the energy element is positioned to form the opening.Type: ApplicationFiled: September 18, 2023Publication date: May 9, 2024Applicant: Mayo Foundation for Medical Education and ResearchInventors: Luis E. SAVASTANO, Yang LIU
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Patent number: 11976040Abstract: Provided herein are novel lipase inhibitors and methods for using the same to treat inflammation, multisystem organ failure, necrotic pancreatic acinar cell death, acute pancreatitis, sepsis (e.g., culture negative sepsis), burns, and acne. For example, provided herein are two novel lipase inhibitors useful in the methods described herein: or a pharmaceutically acceptable salt thereof.Type: GrantFiled: March 3, 2023Date of Patent: May 7, 2024Assignee: Mayo Foundation for Medical Education and ResearchInventors: Vijay P. Singh, Sampath-Kumar Anandan, Kevin Greenman, Zeeshan Kamal
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Patent number: 11975065Abstract: This document relates to methods and materials for making and using viruses (e.g., measles viruses or adenoviruses) having a reduced susceptibility to antibody neutralization (e.g., antibody neutralization by serum from measles virus vaccines). For example, recombinant morbilliviruses (e.g., recombinant measles viruses) having a modified H gene and a modified F gene, as well as methods of using a recombinant virus are provided.Type: GrantFiled: November 3, 2021Date of Patent: May 7, 2024Assignee: Mayo Foundation for Medical Education and ResearchInventors: Miguel A. Munoz Alia, Stephen James Russell
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Publication number: 20240139010Abstract: A gastric bypass device includes an occlusion device that is adapted to be deployed relative to a patient's pyloric sphincter and a liner that extends distally from the occlusion device. A tether extends from the occlusion device. A dynamic leash may be secured relative to the occlusion device and may work in conjunction with the tether to help hold the occlusion device in place.Type: ApplicationFiled: July 18, 2023Publication date: May 2, 2024Applicants: BOSTON SCIENTIFIC SCIMED, INC., MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCHInventors: Roger W. McGowan, Barham K. Abu Dayyeh, Alexander James Wiedmann, Daniel Lee Krautkremer, Jessica Brand
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Publication number: 20240139011Abstract: A gastric bypass device includes an occlusion device that is adapted to be deployed relative to a patient's pyloric sphincter, an anastomosis anchor that is adapted to be deployed relative to an anastomosis between the patient's stomach and their small intestine, and a tether that extends through the patient's small intestine between the occlusion device and the anastomosis anchor. A dynamic leash may be secured relative to the occlusion device and may work in conjunction with the tether to help hold the occlusion device in place. The gastric bypass device may be deployed using a variety of methods including a push-pull wire method, a rail method, a garage method, a two-piece method and a comprehensive method.Type: ApplicationFiled: July 18, 2023Publication date: May 2, 2024Applicants: Boston Scientific Scimed, Inc., Mayo Foundation for Medical Education and ResearchInventors: Roger W. McGowan, Barham K. Abu Dayyeh, Daniel Lee Krautkremer, Jessica Brand, Alexander James Wiedmann, Andrew O'Brien
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Patent number: 11969250Abstract: This specification discloses a brain electrode device. The brain electrode device includes a set of contact points and a set of sub-circuits. The sub-circuits include sensor ports configured to connect to the contact to the respective ones of the contact points. The device can further include an intelligent multiplexer that aggregates signals from the set of sub-circuits and generates an aggregate signal. The aggregate signal is transmitted to a signal acquisition device.Type: GrantFiled: November 13, 2020Date of Patent: April 30, 2024Assignee: Mayo Foundation for Medical Education and ResearchInventors: Patrick J. Zabinski, Gregory A. Worrell, Clifton R. Haider
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Patent number: 11969197Abstract: This document describes methods and devices for treating ventricular fibrillation. For example, this document describes methods of performing electroporation of a ventricle and electroporation catheters. The methods can include inserting a distal end portion of a catheter into a ventricle of a heart of a patient, inflating a balloon coupled to the distal end portion of the catheter, occluding a valve of the heart associated with the ventricle with the balloon, injecting a fluid into the ventricle via an aperture defined by the distal end portion of the catheter, and generating an electrical current via an electrode on the distal end portion of the catheter.Type: GrantFiled: October 15, 2018Date of Patent: April 30, 2024Assignee: Mayo Foundation for Medical Education and ResearchInventors: Christopher V. DeSimone, Samuel J. Asirvatham, Christopher J. McLeod
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Patent number: 11971412Abstract: Complexes containing a labeled polypeptide and an antibody, and the use of such complexes as research, diagnostic, and clinical tools, are described herein.Type: GrantFiled: November 8, 2022Date of Patent: April 30, 2024Assignee: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCHInventors: Wendy K. Nevala, Svetomir N. Markovic, John T. Butterfield, Daniel J. Knauer
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Patent number: 11963957Abstract: Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.Type: GrantFiled: December 7, 2020Date of Patent: April 23, 2024Assignees: Mayo Foundation for Medical Education and Research, Unity Biotechnology, Inc., Buck Institute for Research on AgingInventors: Remi-Martin Laberge, Judith Campisi, Albert Davalos, Marco Demaria, Nathaniel David, Jan M. A. van Deursen, Darren J. Baker, Bennett G. Childs
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Publication number: 20240116990Abstract: This document provides methods and materials related to selected engineered analogs of atrial natriuretic peptides. For example, this document provides compositions that contain one or more selected engineered analogs of atrial natriuretic peptides provided herein and that have the ability to treat, prevent, or alleviate the symptoms of cardiovascular, cardiorenal, and metabolic disease.Type: ApplicationFiled: September 15, 2023Publication date: April 11, 2024Applicant: Mayo Foundation for Medical Education and ResearchInventors: John C. BURNETT, Jr., Shuchong PAN, Sasantha Jeson SANGARALINGHAM, Ye ZHENG
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Publication number: 20240110917Abstract: This document relates to methods and materials for identifying and/or treating mammals having cancer. For example, small extracellular vesicles (EVs), such as exosomes, obtained from a mammal suspected of having a cancer can be used to identify the mammal as having cancer and, optionally, the mammal can be treated.Type: ApplicationFiled: October 11, 2023Publication date: April 4, 2024Applicant: Mayo Foundation for Medical Education and ResearchInventors: Luz M. Cumba-Garcia, Ian F. Parney
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Publication number: 20240108374Abstract: Some embodiments provide a soft tissue device, such as a transverse carpal ligament cutting device having one or more balloons that are deflated when the device is in an inactive position and are inflated when the device is in an active position. Other embodiments provide a soft tissue cutting method, such as a method of cutting a transverse carpal ligament that uses a soft tissue cutting device.Type: ApplicationFiled: December 13, 2023Publication date: April 4, 2024Applicant: Mayo Foundation for Medical Education and ResearchInventors: DARRYL E. BARNES, JAY SMITH
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Patent number: 11946937Abstract: This document provides materials and methods for identifying and quantifying AIM polypeptides in a sample using mass spectrometry techniques. For example, methods of using mass spectrometry to identify and quantify AIM polypeptides in a serum sample are provided. In some cases, quantification of AIM polypeptides can be used to diagnose and/or treat patients having a disease or disorder characterized by altered (e.g., increased or decreased) AIM polypeptide levels.Type: GrantFiled: September 13, 2018Date of Patent: April 2, 2024Assignee: Mayo Foundation for Medical Education and ResearchInventors: David L. Murray, David R. Barnidge
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Patent number: 11937845Abstract: The invention provides a tissue cutting device comprising a handle, a first blade, and a second blade. The second blade is coupled to the handle. The second blade is rotatable relative to the first blade such that the second blade is configured to rotate between a first position and a second position. The second blade is in a same plane as the first blade when the second blade is in the first position. The second blade is rotated into a different plane from the first blade when the second blade is rotated from the first position toward the second position.Type: GrantFiled: January 8, 2020Date of Patent: March 26, 2024Assignee: Mayo Foundation for Medical Education and ResearchInventors: Darryl E. Barnes, Jay Smith
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Patent number: 11937973Abstract: In accordance with some embodiments, systems, methods, and media for automatically localizing and diagnosing thyroid nodules are provided. In some embodiments, a system for automatically diagnosing thyroid nodules comprises: an ultrasound machine; and a processor programmed to: receive a B-mode ultrasound of a thyroid from the ultrasound machine; provide the B-mode ultrasound to a classification model trained to automatically segment B-mode ultrasound; receive an output indicating which portions of the B-mode ultrasound correspond to a nodule; provide at least a portion of the B-mode ultrasound corresponding to the nodule to a second classification model trained to automatically classify thyroid nodules based B-mode, color Doppler, and shear wave elastography ultrasound; and receive, from the second trained classification model, an output indicative of the likelihood that the nodule is malignant.Type: GrantFiled: May 31, 2019Date of Patent: March 26, 2024Assignee: Mayo Foundation for Medical Education and ResearchInventors: Zeynettin Akkus, Bradley J. Erickson, Matthew R. Callstrom
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Patent number: 11939378Abstract: The invention features methods of diagnosis by assessing B7-H1 expression in a tissue from a subject that has, or is suspected of having, cancer, methods of treatment with agents that interfere with B7-H1-receptor interaction, methods of selecting candidate subjects likely to benefit from cancer immunotherapy, and methods of inhibiting expression of B7-H1.Type: GrantFiled: August 13, 2021Date of Patent: March 26, 2024Assignee: Mayo Foundation for Medical Education and ResearchInventors: Lieping Chen, Scott E. Strome, Eugene D. Kwon
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Patent number: 11938169Abstract: The present invention relates to methods of treating subjects suffering from a pulmonary NTM infection refractory to treatment, for example to antibiotic treatment.Type: GrantFiled: October 16, 2018Date of Patent: March 26, 2024Assignees: drugrecure APS, Mayo Foundation for Medical Education and ResearchInventors: Inge Tarnow, Cecilia Ganslandt, Mark E. Wylam
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Patent number: 11938098Abstract: This document provides methods and materials involved in killing HIV infected cells (e.g., CD4 T cells). For example, methods and materials for using one or more Bcl-2 inhibitors (e.g., ABT-199) alone or in combination with one or more agents capable of reactivating HIV (e.g., latency reversing agent) to kill HIV infected cells (e.g., CD4 T cells) are provided.Type: GrantFiled: March 16, 2021Date of Patent: March 26, 2024Assignee: Mayo Foundation for Medical Education and ResearchInventors: Andrew D. Badley, Amy M. Nguyen, Scott H. Kaufmann, Yuan-Ping Pang, Haiming Dai
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Patent number: 11938290Abstract: The present disclosure generally relates to systems and methods of use for draining cerebrospinal fluid (CSF) from a brain or a spinal canal in a subject, for example, to treat hydrocephalus or other conditions. In some embodiments, the disclosure relates to a device comprising a flow controller positioned within a conduit that allows CSF to flow through the conduit from a first end to a second end. This may allow the CSF to drain, for example, from an intradural space (such as a thecal sac) into, for example, a paraspinal space, paraspinal vein or other venous space, or peritoneal cavity. A variety of methods may be used to hold or anchor the device in place, for example, an expansion apparatus. In some embodiments, the device can be implanted percutaneously at a location along or within a subject's spinal column, thus reducing the need for surgery, general anesthesia, and hospitalizations.Type: GrantFiled: April 27, 2023Date of Patent: March 26, 2024Assignee: Mayo Foundation for Medical Education and ResearchInventors: Fredric B. Meyer, Mohamed Bydon