Abstract: For measuring an oxidative stress component in a patient, an optical analyzer having a light source and a light detector is used for measuring an optical property of a medium and generating optical measurement data. A processor analyzes the optical measurement data and generates a value for one or more oxidative stress component in the form of a redox signature for the patient. Probability data of the presence of an oxidative stress dependent disease can be calculated. By observing at least one additional clinical condition of the disease, a diagnosis using said at least one additional condition and said redox signature can be obtained.
Type:
Application
Filed:
December 29, 2011
Publication date:
July 5, 2012
Applicant:
McGill University
Inventors:
Scott Rosendahl, Dirk Bandilla, Hyman Schipper, David H. Burns
Abstract: The present invention relates to an immunogenic agent comprising a low dose of an antigenic component from one or more pathogens and an agent capable of increasing an amount of IL-12 in animal, and use thereof for reducing infection or improving recovery from an infection from the pathogen. The immunogenic agent preferably comprises CpG nucleic acid, IL-12 protein and/or IL-12 nucleic acid. The pathogen is preferably an intracellular pathogen comprising one or more species and strains, such as Plasmodium spp. The invention also relates to a pharmaceutical composition comprising the immunogenic agent. The pharmaceutical composition is preferably an immunotherapeutic composition. The immunotherapeutic composition, is preferably a vaccine capable of providing protection against or treating Plasmodium spp infection, the causative agent of malaria in humans.
Type:
Grant
Filed:
June 30, 2004
Date of Patent:
June 26, 2012
Assignees:
The Council of the Queensland Institute of Medical Research, McGill University
Abstract: According to an aspect of the invention a method is provided comprising: providing a model for a predetermined location within an electrical power system having therein distributed resources (DR), the model based on known system conditions, the model indicative of first sensed characteristics of the electrical power system at the predetermined location; sensing at the predetermined location characteristics of the electrical power system corresponding to at least some of the first sensed characteristics; determining a status of the electrical power system network indicative of an islanding event in dependence upon sensing and other than in dependence upon other sensed data sensed remotely from the predetermined location; and, controlling a distributed resource in dependence upon the status.
Type:
Grant
Filed:
March 31, 2009
Date of Patent:
June 12, 2012
Assignee:
The Royal Institution for the Advancement of Learning/McGill University
Inventors:
Geza Joos, Khalil El-Arroudi, Donald McGillis, Reginald Brearley
Abstract: The present invention relates to novel oligonucleotide chimera used as therapeutic agents to selectively prevent gene transcription and expression in a sequence-specific manner. In particular, this invention is directed to the selective inhibition of protein biosynthesis via antisense strategy using oligonucleotides constructed from arabinonucleotide or modified arabinonucleotide residues, flanking a series of deoxyribose nucleotide residues of variable length. Particularly this invention relates to the use of antisense oligonucleotides constructed from arabinonucleotide or modified arabinonucleotide residues, flanking a series of deoxyribose nucleotide residues of variable length, to hybridize to complementary RNA such as cellular messenger RNA, viral RNA, etc.
Type:
Grant
Filed:
September 4, 2001
Date of Patent:
May 15, 2012
Assignee:
McGill University
Inventors:
Masad Jose Damha, Michael A. Parniak, Chun-Nam Lok, Ekaterina Vlazovkina
Abstract: The present disclosure relates to structurally defined imidazolium-type ionic oligomers of the formula: wherein n is an integer ranging from 1 to 20; A is N or m is an integer ranging from 1 to 5; X is selected from the group consisting of Br, OTf, CF3CO2, CH3CO2, BF4, PF6, NTf2, F, Cl and I; and R is selected from the group consisting of hydrogen and C1-10 alkyl. The imidazolium-type ionic oligomers lend themselves as soluble/solid supports for biopolymer synthesis.
Type:
Grant
Filed:
March 12, 2008
Date of Patent:
May 1, 2012
Assignees:
The Royal Institution for the Advancement of Learning/McGill University, The Hong Kong Polytechnic University
Abstract: Methods and spectra for monitoring fetal growth and predicting birth weight of an infant prior to birth are provided wherein one or more selected biological markers are measured in a sample of amniotic fluid obtained from a pregnant woman. Levels of the selected biochemical markers and/or spectra correlate with one or more medical conditions, such as fetal growth and birth weight of the infant, and gestational diabetes. A measurement probe for in situ measurement can be used safely and repeatedly. Monitoring and/or treatment of maternal and fetal health is also provided.
Abstract: Disclosed is a method for identifying an individual who has an altered risk for developing colorectal cancer comprising detecting a single nucleotide polymorphism (SNP).
Type:
Grant
Filed:
June 5, 2007
Date of Patent:
April 10, 2012
Assignees:
Cancer Care Ontario, McGill University
Inventors:
Michelle Cotterchio, Steven Gallinger, Celia Greenwood, Thomas J. Hudson, Brent W. Zanke, Michael Phillips, Saravanan Sundararajan, Alexandre Montpetit, Phillippe Laflamme, Vincent Ferretti
Abstract: The present invention relates to a process enhancing the extraction of phytochemicals from plant materials using pulsed electric field. The process is also used with a step of pressing, wherein the pressing and the pulse electric field treatment can be accomplished in a unique treatment chamber.
Type:
Grant
Filed:
September 18, 2007
Date of Patent:
April 3, 2012
Assignee:
The Royal Institution for the Advancement of Learning/McGill University
Inventors:
Michael Ngadi, Vijaya Raghavan, Tanya Gachovska
Abstract: The invention concerns compounds, compositions and methods for the treatment of skin cells. Described herein are CD109 polypeptides and uses thereof for the in vivo treatment of various skin disorders, including skin fibrosis, skin scarring, wound healing and psoriasis.
Type:
Application
Filed:
February 19, 2010
Publication date:
March 29, 2012
Applicant:
The Royal Institution for the Advancement of Learning/McGill University
Inventors:
Anie Philip, Joshua Vorstenbosch, Carter Li, Kenneth Finnson, Hahn Soe-Lin, Xiao-Yong Man, Albane Bizet, Hasan Al-Ajmi
Abstract: The present invention relates to methods for modulating the inflammatory response of respiratory tract cells using an agent that increases ceramide levels in the cells of the respiratory tract.
Type:
Grant
Filed:
July 2, 2010
Date of Patent:
March 27, 2012
Assignee:
McGill University
Inventors:
Stan Kubow, Regina Maria Vilela, Larry Lands
Abstract: The present invention relates to epilepsy. More particularly, the present invention relates to idiopathic generalized epilepsy (IGE) and to the identification of three genes mapping to chromosome 2, which show mutations in patients with epilepsy. The invention further relates to nucleic acid sequences, and protein sequences of these loci (SCNA) and to the use thereof to assess, diagnose, prognose or treat epilepsy, to predict an epileptic individual's response to medication and to identify agents which modulate the function of the SCNA. The invention also provides screening assays using SCN1A, SCN2A and/or SCN3A which can identify compounds which have therapeutic benefit for epilepsy and related neurological disorders.
Type:
Grant
Filed:
December 14, 2009
Date of Patent:
March 27, 2012
Assignee:
McGill University
Inventors:
Guy A. Rouleau, Ronald G. Lafrenière, Daniel Rochefort
Abstract: The present invention relates to a method for diagnosis of cancer and for monitoring the progression of cancer and/or the therapeutic efficacy of an anti-cancer treatment in a sample of a subject by detecting oncogenic proteins in microvesicles, and to the use of an agent blocking exchange of microvesicles for treating cancer.
Type:
Application
Filed:
August 8, 2008
Publication date:
March 22, 2012
Applicants:
The Royal Institution for the Advancement of Learning/McGill University, University of Toronto
Inventors:
Janusz Rak, Khalid Al-Nedawi, Brian Meehan, Abhijit Guha
Abstract: Low-Density Parity-Check (LDPC) codes offer error correction at rates approaching the link channel capacity and reliable and efficient information transfer over bandwidth or return-channel constrained links with data-corrupting noise present. They also offer performance approaching channel capacity exponentially fast in terms of the code length, linear processing complexity, and parallelism that scales with code length. They also offer challenges relating to decoding complexity and error floors limiting achievable bit-error rates.
Type:
Application
Filed:
August 24, 2011
Publication date:
March 1, 2012
Applicant:
The Royal Institution for the Advancement of Learning / McGill University
Abstract: A decoding method and system for stochastic decoding of linear codes with the parity check matrix comprising elements of a Galois field is provided. Each encoded sample of a set of encoded samples is first scaled by a scaling factor proportional to a noise level of the set of encoded samples. Each of the scaled encoded samples is then converted into a corresponding probability. For each probability a corresponding probability message is the generated by encoding each probability as a sequence of symbols or bits. Each probability message is then provided to a respective variable node of a logic circuitry for stochastic decoding. The logic circuitry represents a factor graph of the parity check matrix of the linear code.
Type:
Grant
Filed:
July 15, 2009
Date of Patent:
January 31, 2012
Assignee:
The Royal Institute for the Advancement of Learning/McGill University
Inventors:
Warren J. Gross, Shie Mannor, Gabi Sarkis
Abstract: The present invention relates to a decoding method and system for stochastic decoding of LDPC codes. Each encoded sample of a set of encoded samples is first scaled by a scaling factor proportional to a noise level of the set of encoded samples. Each of the scaled encoded samples is then converted into a corresponding probability. For each probability a corresponding probability message is the generated by encoding each probability as a sequence of digital bits. Each probability message is then provided to a respective node of a logic circuitry for stochastic decoding. The logic circuitry represents a factor graph of the parity check matrix of the LDPC code. Using the logic circuitry each probability message is processed for determining an estimated sequence of information bits. If an equality node is in a hold state a chosen bit is provided from a corresponding edge memory which is updated by storing output bits from the equality node when the same is in a state other than a hold state.
Abstract: The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying dengue status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as infected with dengue or not infected with dengue. The biomarkers can be detected by SELDI mass spectrometry.
Type:
Application
Filed:
October 14, 2009
Publication date:
January 26, 2012
Applicants:
Mahidol University, The Royal Institution for the Advancement of Learning/McGill University
Inventors:
Brian Ward, Momar Ndao, Takol Chareonsirisuthikul, Sukathida Ubol
Abstract: The present invention relates to a decoding method and system for stochastic decoding of linear block codes with parity check matrix. Each encoded sample of a set of encoded samples is converted into a corresponding probability. For each probability a corresponding probability message is the generated by encoding each probability as a sequence of digital symbols. Each probability message is then provided to a respective node of a logic circuitry for stochastic decoding. The logic circuitry represents a factor graph of the parity check matrix of the linear block code. Using the logic circuitry each probability message is processed for determining an estimated sequence of information symbols. If an equality node is in a hold state a chosen symbol is provided from a corresponding memory which is updated by storing output symbols from the equality node when the same is in a state other than a hold state.
Type:
Grant
Filed:
May 23, 2008
Date of Patent:
January 10, 2012
Assignee:
The Royal Institution for the Advancement of Learning/McGill University
Inventors:
Warren J. Gross, Shie Mannor, Saeed Sharifi Tehrani
Abstract: A micro strip antenna comprising a planar substrate fabricated from a dielectric material and a pair of like elements arranged in mirror image on the planar substrate, each of the elements comprising a radiating portion comprising an elongate conductive strip of a constant thickness, the elongate conductive strip comprising first arcuate side edges mutually diverging between a narrow end and a wide end. There is also disclosed a system for detecting the presence of a region having a first dielectric constant within a medium having a second dielectric constant different from the first dielectric constant, such as a tumour embedded in a fatty tissue.
Type:
Grant
Filed:
May 30, 2008
Date of Patent:
January 3, 2012
Assignee:
The Royal Institution for the Advancement of Learning/McGill University
Abstract: A method and calculator for obtaining spin polarized quantum transport in 3-dimensional atom-scale spintronic (spin electronics) devices under finite bias voltage, based on implementing Density Function Theory (DFT) in combination with the Keldysh non-equilibrium Greens function (NEGF) formalism to calculate spin polarized quantum transport in 3-dimensional nanostructures under finite bias and external voltage.
Type:
Grant
Filed:
January 16, 2008
Date of Patent:
December 20, 2011
Assignee:
The Royal Institution for the Advancement of Learning/McGill University
Abstract: A method of providing microelectromechanical structures (MEMS) that are compatible with silicon CMOS electronics is provided. The method provides for processing and manufacturing is steps limiting a maximum exposure of an integrated circuit upon which the MEMS is manufactured during MEMS manufacturing to below a temperature wherein CMOS circuitry is adversely affected, for example below 400° C., and sometimes to below 300° C. or 250° C., thereby allowing direct manufacturing of the MEMS devices onto electronic integrated circuits, such as Si CMOS circuits.
Type:
Grant
Filed:
December 22, 2008
Date of Patent:
December 6, 2011
Assignee:
The Royal Institution for the Advancement of Learning/McGill University
Inventors:
Frederic Nabki, Mourad El-Gamal, Tomas A. Dusatko, Srikar Vengallatore