Patents Assigned to McGill University
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Publication number: 20130029989Abstract: The present invention relates to novel compositions and therapeutic methods for the treatment of pain, in particular neuropathic, ischemic, muscle, arthritic or multiple sclerosis pain. The compositions include a combination of an alpha2-adrenergic agonist or a nitric oxide donor combined with a phosphodiesterase (PDE) or a phosphatidic acid (PA) inhibitor, which have been found to act together synergistically to provide effective treatment for pain, especially when administered topically.Type: ApplicationFiled: April 13, 2011Publication date: January 31, 2013Applicant: The Royal Institution for the Advancement of Learning/McGill UniversityInventors: Terence Coderre, Andre Laferriere, Vaigunda Ragavendran Jegadeesan
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Publication number: 20130023489Abstract: Nutraceutical or pharmaceutical compositions, functional foods, extracts, dietary supplements and food/feed additives enriched in phytochemicals having antioxidant and/or anti-inflammatory activity may be derived from the skin, pith, or cortex from stem tubers of select potato cultivars, including an Onaway potato cultivar optionally complemented by a Russet Burbank, Purple Valley or Bora Valley cultivar. These cultivars and combinations thereof provide a useful antioxidant source enriched in ferulic acid, caffeic acid, chlorogenic acids, ascorbic acid, anthocyanins, and rutin, isomers or derivatives thereof having antioxidant and/or anti-inflammatory activity.Type: ApplicationFiled: December 24, 2010Publication date: January 24, 2013Applicant: The Royal Institution For The Advancement Of Learning/McGill UniversityInventors: Stanley Kubow, Danielle Donnelly, Andre Piccolomini, Luis Agellon
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Patent number: 8345253Abstract: A system and method for molecule detection uses a surface plasmon resonance (SPR) system with detection spots having fixed nanostructures. An SPR assembly may be combined with a digital microfluidic control system such as an electrowetting-on-dielectric (EWOD) chip. The microfluidic system individually directs sample droplets to different detection spots of the SPR assembly, thus allowing the SPR examination of different samples or sample reactions on the same surface. The nanostructures at the detection spots enhance the sensitivity of the SPR signals.Type: GrantFiled: February 21, 2008Date of Patent: January 1, 2013Assignee: The Royal Institution for the Advancement of Learning/McGill University and Her Majesty the Queen in Right of CanadaInventors: Lidija Malic, Maryam Tabrizian, Teodor Veres, Bo Cui, Francois Normandin
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Patent number: 8324358Abstract: Block copolymers labelled with molecular recognition units and comprising a hydrophobic block and a luminescent block are presented. A method of detecting biomolecules using such block copolymers is also presented. More specifically, the block copolymers of the present invention have the following Formula (I): wherein “A” is a hydrophobic block; “B” is a luminescent block; “C” is a hydrophilic block; “D” is a molecular recognition unit; “n” and “m” are integers ranging from 1 to 75; “x” is either 0 or an integer ranging from 1 to 75; and “Y” is either 0 or 1.Type: GrantFiled: May 26, 2006Date of Patent: December 4, 2012Assignee: McGill UniversityInventors: Hanadi Sleiman, Bingzhi Chen, Kim Metera
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Patent number: 8321000Abstract: The invention relates to a method for determining a pathology in a subject, said method comprising: a) correlating N-N intervals with rate dependent fluctuations of electrocardiographic parameters derived from an electrocardiogram (ECG) of said subject or other recordings reflecting cardiac activity of said subject to derive electrocardiographic parameters correlation values, wherein said pathology is determined based on said correlation values.Type: GrantFiled: July 9, 2007Date of Patent: November 27, 2012Assignees: The Royal Institution for the Advancement of Learning/McGill University, Beth Israel Deaconess Medical CenterInventors: Leon Glass, Claudia Lerma, Ary Goldberger
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Patent number: 8313966Abstract: Semiconductor micro- and nanotubes allow the incorporation of ordered structures such as quantum wells and quantum dots into them providing the potential for ultralow threshold micro- and nanoscale lasers for use in applications such as future ultrahigh-speed photonic systems as well as quantum information processing. According to the invention a means of manufacturing these with high reproducibility, low processing complexity, and at high densities is provided. Also provided is a means of releasing these micro- and nanotubes with low stress and a method of “pick-and-place” allowing micro- and nanotubes to be exploited in devices integrated on substrates that are either incompatible with the manufacturing technique or where the area of substrate required to manufacture them is detrimental to the cost or performance of the circuit.Type: GrantFiled: January 4, 2011Date of Patent: November 20, 2012Assignee: The Royal Institution for the Advancement of Learning/McGill UniversityInventor: Zetian Mi
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Publication number: 20120288044Abstract: A method and a circuit are provided for providing phase or frequency synthesis using sigma-delta modulation bit-stream techniques in which data is encoded utilizing sigma-delta modulation and then digital-to-time conversion (DTC) or digital-to-frequency conversion (DFC). In some embodiments this encoded data stream is further subjected to phase or frequency domain filtering, which in some embodiments is carried out by a higher-order phase-locked loop (PLL).Type: ApplicationFiled: May 9, 2011Publication date: November 15, 2012Applicant: The Royal Institution for the Advancement of Learning/McGill UniversityInventors: Gordon Roberts, Sadok Aouini
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Patent number: 8309517Abstract: The present invention relates to a novel method to promote regeneration or repair of the central or peripheral nervous system following injury The present invention concerns the use of a leucine-rich, glioma-inactivated protein (LGIn), or an analog or derivative thereof, to promote the regeneration or remyelination of neurons after injury to the central nervous system LGIns are endogenous proteins secreted by central neurons that promote regeneration of neurons after injury to the central nervous system The present invention includes an assay to measure the interaction of LGIn with LINGOn and p75NTRn as well as to identify factors that enhance or disrupt these interactions The invention further includes cell lines capable of expressing LGIn, LINGOn and p75NTRn molecules, as well as the proteins purified from these cells.Type: GrantFiled: May 16, 2006Date of Patent: November 13, 2012Assignee: McGill UniversityInventors: Philip A. Barker, Alyson Fournier, Jose Manuel Morante Redolat, Jordi Perez-Tur
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Publication number: 20120280770Abstract: A method and an apparatus are provided for providing a tunable substrate integrated waveguide (SIW) for which a parameter of at least some element or portion thereof may be altered or varied to alter the propagation of a signal propagating through the SIW thereby achieving a tunable SIW. In some embodiments a plurality of capacitively variably loaded transverse slots achieve the tunability for the SIW.Type: ApplicationFiled: May 6, 2011Publication date: November 8, 2012Applicant: The Royal Institution for the Advancement of Learning/McGill UniversityInventors: Ramesh Abhari, Kasra Payandehjoo, Asanee Suntives
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Publication number: 20120271362Abstract: A bone screw is described which includes a one-piece threaded screw body composed at least partially of a rigid foam. The screw body is headless and includes a bore extending therethrough to define a cannula and thereby providing the screw body with an annular shape defining a radial wall thickness. At least a central portion of the screw body is formed of the rigid foam which defines a matrix having a plurality of inter-connected pores therein. The inter-connected pores are disposed throughout the complete radial wall thickness of the screw body from an outer surface of the screw body to an inner surface thereof within the cannula, such as to permit bone in-growth through the complete radial wall thickness of the annular screw body. The inter-connected pores and the cannula thereby respectively allow bone in-growth through the complete radial wall thickness and the full axial length of the screw body.Type: ApplicationFiled: October 13, 2010Publication date: October 25, 2012Applicant: The Royal Institution for the Advancement of Learn McGill UniversityInventors: Paul A. Martineau, Louis-Philippe Lefebvre, Edward J. Harvey
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Patent number: 8278103Abstract: The invention relates to oligonucleosides having alternating segments of sugar-modified nucleosides and 2?-deoxynucleosides, and uses thereof. The invention further relates to oligonucleotides having alternating segments of sugar-modified nucleotides and 2?-deoxynucleotides, and uses thereof. Such uses include the preparation of antisense oligonucleotides and their use for the prevention or depletion of function of a target nucleic acid of interest, such as an RNA, in a system. Accordingly, an oligonucleotide of the invention is useful for therapeutic, analytical and diagnostic methods and uses, as well as a component of compositions and commercial packages corresponding to such methods and uses.Type: GrantFiled: January 31, 2003Date of Patent: October 2, 2012Assignee: McGill UniversityInventors: Masad J. Damha, Michael A. Parniak
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Publication number: 20120231411Abstract: There is described a hand-held dental instrument for detection of carious lesions which includes a handle portion defining a longitudinal axis therethrough and at least a first working end, mounted on the handle portion, which includes a probe body extending from the handle portion and a probe tip disposed at a remote end. The probe tip is configured for exploring teeth and/or periodontal pockets. The probe body is curved and has a curette portion disposed on the probe body between the handle portion and the probe tip, the curette portion having at least two scraping fins each defining a curved blade for removing at least one of biofilm, plaque and tartar from a curved tooth surface.Type: ApplicationFiled: October 19, 2010Publication date: September 13, 2012Applicant: The Royal Institution For The Advancement of Learning / McGill UniversityInventor: Jacques Verronneau
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Publication number: 20120232135Abstract: A method of reducing tumor cell growth, the method including administering an effective amount of a compound having the formula:Type: ApplicationFiled: March 9, 2012Publication date: September 13, 2012Applicants: The Hong Kong Polytechnic University, McGill University, University of South Florida, Wayne State UniversityInventors: Tak-Hang CHAN, Wai-Har Lam, Larry Ming-Cheung Chow, Qing Ping Dou, Deborah Joyce Kuhn, Aslamuzzaman Kazi, Sheng Biao Wan, Kristin R. Landis-Piwowar
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Patent number: 8263986Abstract: Quantitative understanding of neural and biological activity at a sub-millimeter scale requires an integrated probe platform that combines biomarker sensors together with electrical stimulus/recording sites. Optically addressed biomarker sensors within such an integrated probe platform allows remote interrogation from the activity being measured. Monolithic or hybrid integrated silicon probe platforms would beneficially allow for accurate control of neural prosthetics, brain machine interfaces, etc as well as helping with complex brain diseases and disorders. According to the invention a silicon probe platform is provided employing ultra-thin silicon in conjunction with optical waveguides, optoelectronic interfaces, porous filter elements, and integrated CMOS circuitry. Such probes allowing simultaneously analysis of both neural electrical activities along with chemical activity derived from multiple biomolecular sensors with porous membrane filters.Type: GrantFiled: June 30, 2010Date of Patent: September 11, 2012Assignee: The Royal Institution for the Advancement of Learning/McGill UniversityInventors: Mohamad Hajj-Hassan, Vamsy Chodavarapu, Sam Musallam
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Patent number: 8258892Abstract: The present invention relates to a method and system for high-speed bandpass serial data communication. A driver receives at least one data signal and generates a bandpass data signal for transmission through a bandpass waveguide interconnect. The bandpass data signal is launched into the bandpass waveguide interconnect using a first adaptor and extracted therefrom after transmission using a second adaptor. A receiver connected to the second adaptor recovers the at least one data signal from the extracted bandpass data signal. A dispersion compensation circuit receives one of the at least one data signal and the bandpass data signal and information indicative of a phase response of the bandpass waveguide interconnect and dispersion compensates the one of the at least one data signal and the bandpass data signal by compensating the phase response of the bandpass waveguide interconnect.Type: GrantFiled: February 19, 2009Date of Patent: September 4, 2012Assignee: The Royal Institution for the Advancement of Learning/McGill UniversityInventors: Ramesh Abhari, Asanee Suntives, Gordon W. Roberts, Nathan Smith
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Publication number: 20120205613Abstract: Amongst the candidates for very high efficiency solid state light sources and full solar spectrum solar cells are devices based upon InGaN nanowires. Additionally these nanowires typically require heterostructures, quantum dots, etc which all place requirements for these structures to be grown with relatively few defects and in a controllable reproducible manner. Additionally flexibility according to the device design requires that the nanowire at the substrate may be either InN or GaN. According to the invention a method of growing relatively defect free nanowires and associated structures for group IIIA-nitrides is presented without the requirement for foreign metal catalysts and overcoming the non-uniform growth of prior art non-catalyst growth techniques. According to other embodiments of the invention self-organizing dot-within-a-dot nanowire and dot-within-a-dot-within-a-well nanowire structures are presented.Type: ApplicationFiled: February 10, 2012Publication date: August 16, 2012Applicant: The Royal Institution for the Advancement of Learning / McGill UniversityInventors: Zetian Mi, Kai Cui, Hieu Pham Trung Nguyen
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Patent number: 8230738Abstract: An instrumented ball for collecting data in an industrial mill comprising a durable sphere defining an enclosed cavity and having a substantial thickness, the sphere manufactured from a resilient material able to withstand pressures exerted by a working industrial mill, electronics disposed in the cavity comprising: a plurality of devices for sensing physical conditions inside the mill, wherein each of the sensing devices outputs a series of sensed values, the devices comprising at least an accelerometer, a gyroscope, a thermocouple, a microphone and a wear sensor, a memory for storing the sensed values, and a communication port for transmitting the sensed values to an external device located outside of the mill, and a power source disposed in the cavity for powering the electronics.Type: GrantFiled: July 20, 2007Date of Patent: July 31, 2012Assignee: McGill UniversityInventors: Peter Radziszewski, Wei Li, Coleman Benson, Sudarshan Martins, Tapiwanashe Chenje
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Patent number: 8227245Abstract: This invention relates to multipotent stem cells, purified from the peripheral tissue of mammals, and capable of differentiating into neural and non-neural cell types. These stem cells provide an accessible source for autologous transplantation into CNS, PNS, and other damaged tissues.Type: GrantFiled: April 18, 2008Date of Patent: July 24, 2012Assignee: McGill UniversityInventors: Jean Toma, Mahnaz Akhavan, Karl J. L. Fernandes, Mathieu Fortier, Freda Miller
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Publication number: 20120179636Abstract: Stabilizing the visual system for any sighted mobile system increases immunity of the mobile system's gaze and reduces information processing task complexity. Two human reflexes are the optokinetic reflex and vestibulo-ocular reflex (VOR). The VOR stabilizes retinal images during head movement by producing eye movements in the opposite direction. Improved analysis of the VOR in humans would improve the diagnosis/treatment of patients, provide improvements in visual prosthesis performance for patients, and also vision systems performance for mobile robotic systems. However, an important issue for prior art mathematical analysis techniques is the requirement to classify the nystagmus segments before applying any analysis techniques, wherein this classification should be preferably performed non-subjectively. Accordingly the inventors overcome these limitations by performing classification, i.e.Type: ApplicationFiled: January 11, 2012Publication date: July 12, 2012Applicant: The Royal Institution for the Advancement of Learning / McGill UniversityInventors: Henrietta Galiana, Atiyeh Ghoreyshi
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Publication number: 20120178690Abstract: Netrin proteins and their receptors regulate cell and axon migration, and are implicated in tissue morphogenesis, tumorigenesis and angiogenesis. Deregulation of mechanisms that control cell motility plays a key role in tumor progression by promoting tumor cell dissemination. Unwanted neovascularization also contributes to tumor progression and metastasis and to ocular diseases which are a leading cause of blindness. Here, we describe novel netrin-derived polypeptides and fragments or derivatives thereof that selectively inhibit cell growth, migration or branching. Methods and compositions for the treatment and prevention of conditions involving cell migration or neovascularization, such as cancer and ocular disease, are also provided.Type: ApplicationFiled: June 9, 2010Publication date: July 12, 2012Applicant: The Royal Institution for the Advancement of Learning/McGill UniversityInventor: Timothy E. Kennedy