Abstract: Described are methods of treating a cancer comprising administering to a subject in need thereof an effective amount of a dopamine receptor (DR) antagonist. The DR antagonist may be a phenothiazine derivative, such as thioridazine or chlorpromazine. Optionally, the cancer is acute myeloid leukemia. Also described are methods for identifying subjects with cancer, methods for providing a prognosis for a subjects with cancer and/or subjects likely to be responsive to therapy with DR receptor antagonists. Methods for identifying cancer stem cells and chemotherapeutic compounds that are DR receptor antagonists as also provided.

Abstract: A wireless access point supports data rates and advertises an indication of a minimum data rate for advertisement. Those of the supported data rates that are less than the minimum data rate for advertisement are reserved for limited use. A mobile station that requests to communicate with the wireless access point at one of the one or more supported data rates that are reserved for limited use is informed by the wireless access point how much time communications with the wireless access point at one or more of the one or more supported data rates reserved for limited use will be permitted.

Abstract: A medical insertion device which may be used with or installed within an imaging system, such as magnetic resonance imaging (MRI). The medical insertion device can generally be used to retain, position and effect insertion of a medical instrument, for example a biopsy device or an ablation treatment device. The device can generally provide linear and/or angular degrees of freedom for positioning of the medical instrument prior to an insertion of the medical instrument. The medical insertion device includes a mounting arm, an interface connected to the mounting arm for interfacing with a medical instrument, a mechanism for movement of the medical instrument or a part of the medical instrument in an insertion direction, a carriage connected to a distal end of the mounting arm, and a pivot connection between the carriage and the distal end of the mounting arm to permit pitch or yaw of the mounting arm.

Abstract: A method of treating mucosal inflammation associated with a pathological condition in a mammal is provided. The method comprises the step of inhibiting 5-HT signaling at a target site in order to block 5-HT7 receptor function.

Abstract: A powertrain system for a vehicle is provided. The powertrain system includes an internal combustion engine, a first gearset connected to the internal combustion engine, a first electric machine connected to the first gearset, a drivetrain gear for connection to a drivetrain of the vehicle, a second gearset connecting the first gearset to the drivetrain gear, a second electric machine, and at least one dynamic clutch selectively coupling the second electric machine to the first electric machine, the first gearset, and the second gearset. In a first mode of operation, the at least one dynamic clutch couples the second electric machine and the first electric machine. In a second mode of operation, the at least one dynamic clutch couples the second electric machine and the first gearset. In a third mode of operation, the at least one dynamic clutch couples the second electric machine and the second gearset.

Abstract: A method of modulating the level of lipoproteins in human cells comprising the step of inhibiting resistin in the cells or cellular environment. The method is useful to treat cardiovascular disease.

Abstract: A vehicle powertrain system including a differential gear set, a planetary gear set coupled to the differential gear set, an engine coupled to the planetary gear set to transfer power between the engine and the planetary gear set, a first electric machine coupled to the planetary gear set via a first clutch and selectively engagable, via actuation of the first clutch, to transfer power between the first electric machine and the planetary gear set, and a second electric machine coupled to the planetary gear set via a second clutch and selectively engagable, via actuation of the second clutch, to transfer power between the second electric machine and the planetary gear set.

Abstract: A powertrain system for a vehicle is provided, including an internal combustion engine, a drivetrain gear for connection to a drivetrain of the vehicle, a gearset connecting the internal combustion engine to the drivetrain gear, a first electric machine connected to the gearset, a second electric machine, and at least one dynamic clutch selectively coupling the second electric machine to the drivetrain gear and the gearset. In a compound mode of operation, the at least one dynamic clutch couples the second electric machine and the gearset. In a split mode of operation, the at least one dynamic clutch couples the second electric machine and the drivetrain gear.

Abstract: A self-reinforced masonry block comprises a main body having opposed substantially parallel stacking surfaces and at least one tubular cell defined therethrough from one stacking surface to the other. At least one confining reinforcement is embedded in the main body to surrounding a corresponding cell. Each confining reinforcement extends substantially entirely along the longitudinal length of its corresponding cell and terminates inwardly of the stacking surfaces. The self-reinforced masonry blocks may be used in construction of a grout-filled, vertically reinforced masonry block wall, with the self-reinforced masonry blocks being used for those portions of the wall where the grouted cells are prone to crushing due to high levels of compressive stress, and conventional unreinforced masonry blocks being used for other portions of the wall. A method for making the self-reinforced masonry blocks is also described.

Abstract: If a handoff by a mobile station currently associated with a particular access point is probable, then the particular access point sends an activation alert to one or more other access points. An access point receiving the activation alert that is in a low-power state enters a higher-power state. An access point receiving the activation alert that is in a higher-power state, remains in that higher-power state.

Abstract: A method of determining risk of heart failure in a mammal is provided comprising the steps of measuring in a biological sample obtained from a mammal the level of each of IL-6, MCP-1, IL-10, VEGF, and EGF biomarkers in the sample, wherein a positive result of at least three of said biomarkers is indicative of a risk of heart failure in the mammal.

Abstract: Therapeutic compositions and methods for treatment of late-onset Gaucher disease are described herein. The compositions comprise compounds having activity as pharmacological chaperones for mutant forms of the beta-glucocerebrosidase. Methods of treatment involve providing therapeutically effective amounts of such compositions to subjects in need thereof.

Abstract: A mesh node of an infrastructure wireless local area network ‘WLAN’ is coupled to a battery which is coupled to a device that is able to harness energy from a source of renewable energy. Energy management of the mesh node includes conducting simulations of a system comprising the mesh node, the device, and the battery in its current state of charge, determining an admissible load for the mesh node from the simulations, and withholding communication services by the mesh node for one or more periods of time a cumulative duration of which is related to power consumption of the mesh node when handling the admissible load. The simulations involve meteorological data related to the source of renewable energy in the vicinity of the mesh node.

Abstract: The present invention provides a cross linked polyolefin thermoset material, comprising maleic anhydride functionalized reactive polyolefin wax cross linked with a polyamine. The thermoset may be made by a method involving reaction of a maleic anhydride functionalized reactive polyolefin wax with a polyamine. The polyolefin may be polyethylene, polypropylene and their copolymers. The polyamine is a primary or secondary alkyl polyamines, alkyl ether polyamines, aryl polyamines. Polyols may be used instead of polyamines, for example alkyl polyols, alkyl ether polyols or aryl polyols.

Abstract: A medical insertion device which may be used with or installed within an imaging system, such as magnetic resonance imaging (MRI). The medical insertion device can generally be used to retain, position and effect insertion of a medical instrument, for example a biopsy device or an ablation treatment device. The device can generally provide linear and/or angular degrees of freedom for positioning of the medical instrument prior to an insertion of the medical instrument. The medical insertion device includes a mounting arm, an interface connected to the mounting arm for interfacing with a medical instrument, a mechanism for movement of the medical instrument or a part of the medical instrument in an insertion direction, a carriage connected to a distal end of the mounting arm, and a pivot connection between the carriage and the distal end of the mounting arm to permit pitch or yaw of the mounting arm.

Abstract: A mobile communication device is able to communicate with wireless local area network and with a cellular network. A communication system is able to route a communication session between the mobile communication device and another communication device either by way of the wireless local area network or the cellular network. The communication system is able to trigger the mobile communication device via the cellular network to search for and attempt to connect to the wireless local area network. The mobile communication device, in response to reception of signaling via the cellular network, is able to activate a wireless local area network interface of the mobile communication device and to establish a connection to the wireless local area network.

Abstract: For initially establishing a voice call, a first connection leg for the voice call is established between a mobile device operating in a wireless network and a conference room of a conferencing gateway. A second connection leg is established via the conferencing gateway between a processor and a communication device connected in a telephone network. Subsequently, the processor sends a message to the conferencing gateway for transferring the second connection leg from between the processor and the communication device to the conference room and the communication device, for initially establishing the voice call. The conference gateway is configured to combine media streams of connection legs of the voice call.

Abstract: This disclosure relates to methods of treating exacerbation of chronic obstructive pulmonary disease (COPD) with antibodies and antagonists to interleukin 1 receptor 1 (IL-1R1) or IL-1?.

Abstract: A process for preparing the cutting edge of a cutting tool having a rake face and a clearance face. The process comprises the elimination of material from the cutting edge by providing a series of rapidly recurring electrical spark discharges in a gap located between the tool edge and a counterface. The spark discharges vaporize and melt the tool edge to form a desired radius.

Abstract: A method is presented for adapting the packet size for VoIP communications, determined on-the-fly by the total network delay inherent at the time of packet transmission. If network delays are small relative to the maximum permissible latency for VoIP communications, the payload size per packet may be increased to maximize efficiency for the transmitted call. Alternatively, if network delays are large, the payload size per packet may be decreased in order to assure that the perceived quality of the transmitted call is acceptable.