Abstract: A polymer matrix is provided comprising an amine-containing polyampholyte covalently crosslinked with an electrophilic polymer to yield an immunocompatible polymer matrix. A hydrogel system incorporating the polymer matrix is also provided.
Abstract: Techniques in a mobile communication device for communicating with a wireless access point (AP) are described. The mobile device receives from the AP data which indicate a plurality of activated service intervals in the superframe that are made available to mobile devices for communication access. The mobile device attempts to access, during the indicated activated service intervals, a radio medium via the AP. The mobile device refrains from attempting to access the radio medium via the AP during each power conservation interval provided in between the indicated activated service intervals.
Type:
Grant
Filed:
May 2, 2012
Date of Patent:
September 16, 2014
Assignee:
McMaster University
Inventors:
Ahmad Mohammad Kholaif, Mohammed N. Smadi, Polychronis Koutsakis, Terence Douglas Todd
Abstract: Therapeutic compositions and methods for treatment of late-onset Gaucher disease are described herein. The compositions comprise compounds having activity as pharmacological chaperones for mutant forms of the beta-glucocerebrosidase. Methods of treatment involve providing therapeutically effective amounts of such compositions to subjects in need thereof.
Type:
Application
Filed:
April 17, 2014
Publication date:
September 4, 2014
Applicants:
The Hospital for Sick Children, McMaster University
Inventors:
Don J. Mahuran, Michael B. Tropak, Justin D. Buttner, Jan E. Blanchard, Eric D. Brown
Abstract: A method for painting a complex or compound curved three-dimensional surface of a portion of an article. The method comprises providing a paint film (24); providing sheet metal (26) having opposite major surfaces; laminating the paint film onto a major surface of the sheet metal to form a painted sheet metal laminate (22) comprising a first portion and a second portion; permanently deforming the first portion of the painted sheet metal laminate into a formed portion of the article having a complex or compound curved three-dimensional shape; applying an initial force for securing the second portion of the painted sheet metal laminate during an initial stage of said permanently deforming step; and applying a later force for securing the second portion of the painted sheet metal laminate during a later stage of said permanently deforming step. The later applied force is greater than the initially applied force.
Type:
Application
Filed:
August 15, 2012
Publication date:
August 28, 2014
Applicants:
McMaster University, 3M INNOVATIVE PROPERTIES COMPANY
Inventors:
Kent E. Nielsen, Mukesh K. Jain, Mohamed Elnagmi, Moisei Bruhis
Abstract: An immuno-compatible hydrogel system is provided that is resistant to protein binding. The hydrogel system is prepared by contacting a hydrogel solution with a cross-linking agent to form a gel, exposing the gel to an aqueous solution comprising a first polyelectrolyte to form a polyelectrolyte-coated hydrogel, exposing the polyelectrolyte-coated hydrogel to a second polyelectrolyte to form a crosslinked matrix and exposing the matrix to conditions which eliminates, or at least reduces, protein binding sites on the matrix.
Type:
Grant
Filed:
June 2, 2010
Date of Patent:
August 26, 2014
Assignee:
McMaster University
Inventors:
Harald Stover, Nicholas Burke, Casey Mills
Abstract: Therapeutic compositions and methods for treatment of late-onset Gaucher disease are described herein. The compositions comprise compounds having activity as pharmacological chaperones for mutant forms of the beta-glucocerebrosidase. Methods of treatment involve providing therapeutically effective amounts of such compositions to subjects in need thereof.
Type:
Application
Filed:
April 17, 2014
Publication date:
August 21, 2014
Applicants:
The Hospital for Sick Children, McMaster University
Inventors:
Don J. Mahuran, Michael B. Tropak, Justin D. Buttner, Jan E. Blanchard, Eric D. Brown
Abstract: Described are methods and compositions for treating cancer that include a dopamine receptor (DR) antagonist such as thioridazine and a chemotherapeutic agent. Optionally, the chemotherapeutic agent is a DNA synthesis inhibitor such as cytarabine or a microtubule inhibitor such as paclitaxel or docetaxel. The methods and compositions are useful for the treatment of cancers such as acute myeloid leukemia.
Abstract: Various embodiments are described herein for a switched reluctance machine having a rotor excitation. In one example embodiment, the switched reluctance machine comprises a stator and a rotor. The rotor may be disposed inside or outside the stator. The rotor is spaced from the stator, and the rotor and the stator are concentrically disposed. The rotor has a plurality of rotor poles having an excitation source, where the excitation source comprises at least one adjustable parameter. The excitation source is provided by a permanent magnet. The dimensions and various other parameters associated with the permanent magnets are adjustable.
Abstract: A tandem solar cell includes a bottom solar cell having an energy bandgap with Eg1 and at least a top solar cell having an energy bandgap Eg2, the energy bandgaps satisfying a relationship Eg1<Eg2. The bottom and top solar cells are vertically stacked and electrically interconnected in series in which an area of the bottom solar cell is larger than an area of the top solar cell in an appropriate ratio to provide for a substantially current matched photovoltaic device for operation in a 2-terminal configuration. This tandem structure may contain more than two (2) cells and each cell may be composed of more than one solar cell. In this case the top solar cell has the largest bandgap, the bottom solar cell has the smallest bandgap, and intervening solar cells have intermediate bandgaps that descend in magnitude from the top to the bottom solar cell.
Abstract: Intra-enterprise wireless handset (WH) calls between WHs operating in a wireless local area network (WLAN) are established directly between the WHs via a call connection that is maintained within the LAN without being routed through the cellular network (CN). This eliminates the cost of placing and maintaining calls through the CN for intra-enterprise calls, and also enables use of capabilities that are available in the enterprise telecomm equipment. Upon detection of a trigger condition, if and when it is more likely that a complete vertical handover (VHO) may be needed, the call connection between the WHs in the LAN is replaced by one that is routed through the CN. Thereafter, a VHO may occur (if at all) upon detection of a radio handover condition.
Type:
Grant
Filed:
April 27, 2007
Date of Patent:
June 10, 2014
Assignees:
BlackBerry Limited, McMaster University
Inventors:
Vytautas Robertas Kezys, Terence D. Todd
Abstract: The present invention provides a tiled optical fiber display device structure which includes a light emitting diode (LED) backlit liquid crystal display (LCD). Light from the LCD enters an array of optical fibers that directs the light to a viewing screen. The optical fibers eliminate the use of energy absorbing color filters in conventional LCD's, and also enable the seamless tiling of multiple display modules.
Abstract: Various embodiments are described herein for a double-rotor switched reluctance machine. In one example embodiment, the double-rotor switched reluctance machine comprises an interior rotor, an exterior rotor spaced from the interior rotor and coaxially and concentrically disposed outside the interior rotor, and at least one stator disposed concentrically with the interior rotor and the exterior rotor. The interior rotor, the exterior rotor and the at least one stator are disposed within one machine set to provide an interior switched reluctance machine and an exterior switched reluctance machine. The interior switched reluctance machine and the exterior switched reluctance machine can operate as two motors, two generators, or a motor and a generator simultaneously.
Abstract: A method of controlling nematode response in a microfluidic environment is provided comprising exposing the nematode to an electric field that induces a nematode response. In one embodiment, a method of sorting a group of nematodes based on a selected parameter is provided comprising the step of exposing the nematodes to an electric field that induces a differential response among the nematodes based on the selected parameter, wherein the differential response functions to separate the nematodes based on the selected parameter. Devices useful to achieve these methods are also provided.
Type:
Grant
Filed:
September 15, 2011
Date of Patent:
April 22, 2014
Assignee:
McMaster University
Inventors:
Ravi (Ponnambalam) Selvaganapathy, Bhagwati Gupta, Pouya Rezai
Abstract: The present application relates to methods of preparing radiohalogenated compounds, to compounds useful in such methods and to radiohalogenated compounds useful for imaging and/or therapy.
Type:
Application
Filed:
August 28, 2013
Publication date:
March 6, 2014
Applicant:
MCMASTER UNIVERSITY
Inventors:
John Valliant, Alla Darwish, Stephanie Rathmann, Afaf Genady
Abstract: Technologies are generally described for automatically optimizing an efficiency of camera placement, numbers, and resolution in multi-camera monitoring and surveillance applications. In some examples, a fraction of a total area may be monitored at a higher resolution than the rest. Employing techniques such as combinatorial state Viterbi technique or combinatorial state trellis technique, a minimum number of cameras that provide the coverage at the needed resolution may be selected. Similarly, a number of points may be covered with at least a predefined number of cameras. For example, a subject of interest may be tracked in a public area, where specific camera(s) may be used to image the subject's face at a higher resolution than the background.
Abstract: Methods and devices for automatically determining a suitable bit-width for data types to be used in computer resource intensive computations. Methods for range refinement for intermediate variables and for determining suitable bit-widths for data to be used in vector operations are also presented. The invention may be applied to various computing devices such as CPUs (Central Processing Units), GPUs (Graphic Processing Units), FPGAs (Field Programmable Gate Arrays), etc.
Abstract: A hybrid vehicle transmission including a double-rotor electric machine, two planetary gear sets, an input shaft, and an output shaft, where the input shaft, the output shaft, and a first rotor of the double-rotor electric machine are each coupled to a member of the first planetary gear set, the output shaft and a second rotor of the double-rotor electric machine are each coupled to a member of the second planetary gear set, and a member of the second planetary gear set not coupled to the output shaft or the second rotor is selectively coupled to the first rotor via a first torque transfer device, and selectively coupled to a transmission housing via a second torque transfer device.
Abstract: A hybrid powertrain for an aircraft may include a drive shaft, the drive shaft, an internal combustion engine to selectably drive the drive shaft, a propeller coupled to the drive shaft and an electric motor having a stator and a rotor and operable to selectably drive the drive shaft. The drive shaft may extend through the electric motor. The rotor may be coupled to the drive shaft to rotate with the drive shaft and the rotor is a flywheel for the internal combustion engine.
Abstract: The disclosure relates to a method of generating catalytic nucleic acid probes useful for detecting microorganisms such as bacterial pathogens. In one embodiment, the catalytic nucleic acid probes are fluorogenic DNAzymes. The disclosure also relates to catalytic nucleic acid probes and methods of using the probes for detecting microorganisms.
Type:
Application
Filed:
March 8, 2012
Publication date:
January 2, 2014
Applicant:
McMaster University
Inventors:
Yingfu Li, M. Monsur Ali, Sergio D. Aguirre
Abstract: The present application is directed to a novel approach for rapid, selective and sensitive detection of heavy metals using a solid-phase bioactive lab-on-paper sensor that is ink-jet printed with sol-gel entrapped reagents to allow colorimetric visualization of the enzymatic activity. The bioactive paper assay is able to detect a range of heavy metals, either alone or as mixtures, in as little as 10 min. The paper-based assay was immune to interferences from non-toxic metal ions such as Na+ or K+, could be used to detect heavy metals that were spiked into tap water or lake water, and provided quantitative data that was in agreement with values obtained by atomic absorption. The paper-based sensor is of value for rapid, on-site screening of trace levels of heavy metals in resource limited areas and developing countries.