Abstract: Therapeutic compositions and methods for treatment of late-onset Gaucher disease are described herein. The compositions comprise compounds having activity as pharmacological chaperones for mutant forms of the beta-glucocerebrosidase. Methods of treatment involve providing therapeutically effective amounts of such compositions to subjects in need thereof.

Abstract: Hydrophobic CNCs were successfully prepared by grafting amine- and thiol terminated hydrocarbons to CNCs that have been previously coated with plant polyphenols. Hydrocarbons of various chain lengths can be used to tune the hydrophobicity of the modified CNCs. After the surface modification process, CNCs can be easily redispersed in nonpolar solvents highlighting the potential of the hydrophobic CNCs in, for example, CNC reinforced nanocomposites and non-aqueous formulations.

Abstract: A hybrid powertrain for an aircraft may include a drive shaft, the drive shaft, an internal combustion engine to selectably drive the drive shaft, a propeller coupled to the drive shaft and an electric motor having a stator and a rotor and operable to selectably drive the drive shaft. The drive shaft may extend through the electric motor. The rotor may be coupled to the drive shaft to rotate with the drive shaft and the rotor is a flywheel for the internal combustion engine.

Abstract: Novel solid-phase biosensors that utilize ink jet printing of biocompatible sol-gel based inks to create sensor strips are reported herein. Biomolecules and other reagents useful in bioassays to detect, for example, pathogenic microorganisms or toxic substances, are immobilized on a substrate, which can be paper based, by layering these substances between two layers of biomolecule compatible sol gel. The sol gel precursor solutions and solutions of the assay reagents are printed from separate nozzles in a layered approach which avoids clogging of the nozzles by the pre-mature gelling of the sol gel precursor solution. In certain embodiments of the application, a capture agent is used to concentrate a compound to be detected in specific areas on the substrate to facilitate detection.

Abstract: A powertrain system for a vehicle is provided, including an internal combustion engine, a drivetrain gear for connection to a drivetrain of the vehicle, a gearset connecting the internal combustion engine to the drivetrain gear, a first electric machine connected to the gearset, a second electric machine, and at least one dynamic clutch selectively coupling the second electric machine to the drivetrain gear and the gearset. In a compound mode of operation, the at least one dynamic clutch couples the second electric machine and the gearset. In a split mode of operation, the at least one dynamic clutch couples the second electric machine and the drivetrain gear.

Abstract: A vehicle powertrain system including a differential gear set, a planetary gear set coupled to the differential gear set, an engine coupled to the planetary gear set to transfer power between the engine and the planetary gear set, a first electric machine coupled to the planetary gear set via a first clutch and selectively engagable, via actuation of the first clutch, to transfer power between the first electric machine and the planetary gear set, and a second electric machine coupled to the planetary gear set via a second clutch and selectively engagable, via actuation of the second clutch, to transfer power between the second electric machine and the planetary gear set.

Abstract: A hybrid vehicle transmission including a double-rotor electric machine, two planetary gear sets, an input shaft, and an output shaft, where the input shaft, the output shaft, and a first rotor of the double-rotor electric machine are each coupled to a member of the first planetary gear set, the output shaft and a second rotor of the double-rotor electric machine are each coupled to a member of the second planetary gear set, and a member of the second planetary gear set not coupled to the output shaft or the second rotor is selectively coupled to the first rotor via a first torque transfer device, and selectively coupled to a transmission housing via a second torque transfer device.

Abstract: The invention provides novel reagents and methodologies for detecting free versus bound enzyme. It is particularly useful to detect thrombin when it is not bound to A2M in the presence of thrombin bound to A2M by using a modified substrate that is sterically hindered from reacting with the bound thrombin.

Abstract: The present application is directed to methods and systems for identifying small molecule compounds in mixtures using a library comprising calculated structures and corresponding calculated mass spectral fragmentation patterns of known and/or hypothetical small molecule compounds that may be in the mixture and screening of a mass spectrum of the mixture using the library to identify matching fragmentation patterns. If a mass spectral fragmentation pattern present in the mass spectrum of the mixture matches a calculated fragmentation pattern of one of the known or hypothetical compounds this confirms the identity of a compound in the mixture as the known or hypothetical compound. The method represents a platform method that can be used for a multitude of purposes related to the screening and identification of compounds in mixtures.

Abstract: Therapeutic compositions and methods for treatment of late-onset Gaucher disease are described herein. The compositions comprise compounds having activity as pharmacological chaperones for mutant forms of the beta-glucocerebrosidase. Methods of treatment involve providing therapeutically effective amounts of such compositions to subjects in need thereof.

Abstract: Technologies and implementations for de-interlacing an interlaced digital video and up-converting a frame rate of a digital video are generally disclosed.

Abstract: Therapeutic compositions and methods for treatment of late-onset Gaucher disease are described herein. The compositions comprise compounds having activity as pharmacological chaperones for mutant forms of the beta-glucocerebrosidase. Methods of treatment involve providing therapeutically effective amounts of such compositions to subjects in need thereof.

Abstract: Methods and systems of analyzing an operating environment of wireless communication equipment in a wireless communication system are provided. A stimulus in the operating environment at a location of the wireless communication equipment is sensed and linearly expanded in Slepian sequences using a multitaper spectral estimation procedure. A singular value decomposition is performed on the linearly expanded stimulus, and a singular value of the linearly expanded stimulus provides an estimate of interference at the location of the wireless communication equipment.

Abstract: Therapeutic compositions and methods for treatment of late-onset Gaucher disease are described herein. The compositions comprise compounds having activity as pharmacological chaperones for mutant forms of the beta-glucocerebrosidase. Methods of treatment involve providing therapeutically effective amounts of such compositions to subjects in need thereof.

Abstract: A mobile station is assisted to perform a handoff from a current access point in a current extended service set (ESS) to a new access point in a target ESS. A HandOver Mediator, possibly in conjunction with a handover server, performs an authentication process and an association process with an access point in the target ESS while masquerading as the mobile station. Parameters resulting from the authentication process and the association process are then passed to the mobile station and the mobile station can perform a handoff to the new access point.

Abstract: A polymer matrix is provided comprising an amine-containing polyampholyte covalently crosslinked with an electrophilic polymer to yield an immunocompatible polymer matrix. A hydrogel system incorporating the polymer matrix is also provided.

Abstract: Techniques in a mobile communication device for communicating with a wireless access point (AP) are described. The mobile device receives from the AP data which indicate a plurality of activated service intervals in the superframe that are made available to mobile devices for communication access. The mobile device attempts to access, during the indicated activated service intervals, a radio medium via the AP. The mobile device refrains from attempting to access the radio medium via the AP during each power conservation interval provided in between the indicated activated service intervals.

Abstract: Therapeutic compositions and methods for treatment of late-onset Gaucher disease are described herein. The compositions comprise compounds having activity as pharmacological chaperones for mutant forms of the beta-glucocerebrosidase. Methods of treatment involve providing therapeutically effective amounts of such compositions to subjects in need thereof.

Abstract: A method for painting a complex or compound curved three-dimensional surface of a portion of an article. The method comprises providing a paint film (24); providing sheet metal (26) having opposite major surfaces; laminating the paint film onto a major surface of the sheet metal to form a painted sheet metal laminate (22) comprising a first portion and a second portion; permanently deforming the first portion of the painted sheet metal laminate into a formed portion of the article having a complex or compound curved three-dimensional shape; applying an initial force for securing the second portion of the painted sheet metal laminate during an initial stage of said permanently deforming step; and applying a later force for securing the second portion of the painted sheet metal laminate during a later stage of said permanently deforming step. The later applied force is greater than the initially applied force.

Abstract: An immuno-compatible hydrogel system is provided that is resistant to protein binding. The hydrogel system is prepared by contacting a hydrogel solution with a cross-linking agent to form a gel, exposing the gel to an aqueous solution comprising a first polyelectrolyte to form a polyelectrolyte-coated hydrogel, exposing the polyelectrolyte-coated hydrogel to a second polyelectrolyte to form a crosslinked matrix and exposing the matrix to conditions which eliminates, or at least reduces, protein binding sites on the matrix.