Patents Assigned to McNeilabs, Inc.
  • Process for the preparation of 1,6-dichloro-1,6-dideoxy-.beta.-D-fructofuranosyl-4-chloro-4-deoxy-.alpha. -
    Patent number: 4801700
    Abstract: A process for the preparation of 1,6-dichloro-1,6-dideoxy-.beta.-D-fructofuranosyl-4-chloro-4-deoxy-.alpha. -galactopyranoside comprising the steps of (a) reacting sucrose with a tritylating agent; (b) acetylating the tritylated reaction product; (c) detritylating the acetylated reaction product; (d) isomerizing the resulting penta-acetate; (e) chlorinating the isomerized product; and (f) deacetylating the chlorinated reaction product.
    Type: Grant
    Filed: October 20, 1986
    Date of Patent: January 31, 1989
    Assignee: McNeilab, Inc.
    Inventors: William Tully, Nicholas M. Vernon, Peter A. Walsh
  • Hexahydropyrrolizine compounds useful as analgesics
    Patent number: 4800207
    Abstract: Hexahydropyrrolizines of the formula (I): ##STR1## wherein A is a 3-7 carbon or hetero-containing ring,R.sup.1 is a substituent, andx is 0-3.Also, pharmaceutical compositions for treating pain and methods for synthesis and use as well as novel intermediates in the synthesis.
    Type: Grant
    Filed: November 2, 1987
    Date of Patent: January 24, 1989
    Assignee: McNeilab, Inc.
    Inventors: Richard J. Carmosin, John R. Carson
  • Process for producing 1-(5-substituted-2-ethynylphenyl)-2-propanones
    Patent number: 4798893
    Abstract: A method for the synthesis of the 2-propanone (I) is described starting from alkoxide (II) through the lactone (IV). ##STR1## Excellent control of the location of the substitution on the phenyl ring is achieved and the reaction proceeds in high yield.
    Type: Grant
    Filed: September 21, 1987
    Date of Patent: January 17, 1989
    Assignee: McNeilab, Inc.
    Inventors: David A. Cherry, Cynthia A. Maryanoff, John E. Mills, Roy A. Olofson, James D. Rodgers
  • Anticonvulsant phenethyl sulfamates
    Patent number: 4792569
    Abstract: Sulfamates of the following formula (I) are anticonvulsants and are useful in the treatment of epilepsy: ##STR1## wherein R is one or more substituents such as alkyl, halo, alkoxy, CH.sub.3 or nitro; andx is 0-3.
    Type: Grant
    Filed: August 27, 1987
    Date of Patent: December 20, 1988
    Assignee: McNeilab, Inc.
    Inventors: Bruce E. Maryanoff, Samuel O. Nortey
  • Chlorination of carbohydrates and other alcohols
    Patent number: 4783526
    Abstract: Chlorination of carbohydrates and alcohols utilizing a chlorinating reagent selected from triphenylphosphine oxide/thionyl chloride, thiphenylphosphine oxide/phosgene, triphenylphosphine sulfide/thionyl chloride and triphenylphosphine sulfide/phosgene.
    Type: Grant
    Filed: October 20, 1986
    Date of Patent: November 8, 1988
    Assignee: McNeilab, Inc.
    Inventors: Eleanor A. O'Brien, Thomas O'Connor, Mathew R. J. Tuite, Leroy B. High
  • Process for producing amidine sulfonic acid intermediates for guanidines
    Patent number: 4781866
    Abstract: An efficient synthesis of quanidines, e.g. of the formula (III), by oxidizing a thiourea, e.g. of the following formula (II): ##STR1## with H.sub.2 O.sub.2 and a molybdenum catalyst to yield an aminoiminomethane sulfonic acid which can then be reacted with an amine followed by optional transamination steps.
    Type: Grant
    Filed: November 24, 1986
    Date of Patent: November 1, 1988
    Assignee: McNeilab, Inc.
    Inventors: Cynthia A. Maryanoff, James N. Plampin, Robin C. Stanzione
  • 1,2-1,4 addition reaction sequence leading to disubstituted acelylenes
    Patent number: 4772755
    Abstract: A method for synthesizing a tri-substituted phenyl compound (I) by using a 1,2-addition followed by a 1,4-addition to 1,4-benzoquinone (II): ##STR1## wherein X is hydroxy, alkoxy or alkanoyloxy, Ar.sup.1 is an organic group and R is an unsubstituted or substituted alkyl group.
    Type: Grant
    Filed: March 19, 1987
    Date of Patent: September 20, 1988
    Assignee: McNeilab, Inc.
    Inventors: Dennis C. Liotta, Cynthia A. Maryanoff, Vasken Paragamian
  • 3-alkoxy-2-aminopropyamines, cardiovascular compositions and use
    Patent number: 4758563
    Abstract: Propylamines of the formula (I): ##STR1## and isomers thereof, particularly those enantiomers and racemates relative to the chiral carbon indicated by an asterisk (*). The propylamines can be used for the treatment of hypertension or angina in humans. A is pyrrolidine, piperidine or morpholine and B is an aromatic heterocycle, aromatic carbocycle or saturated carbocycle.
    Type: Grant
    Filed: November 9, 1987
    Date of Patent: July 19, 1988
    Assignee: McNeilab, Inc.
    Inventors: Philip P. Grous, Richard J. Mohrbacher
  • Multi-walled tamper-proof container and method for enhancing tamper evidence
    Patent number: 4755405
    Abstract: A tamper-resistant vessel which contains a liquid is provided with a non-adherent multi-walled construction having, in one embodiment, at least two adjacent non-adherent layers for providing a void in between to enable tamper indication by discoloration indicative of gross spoliage. In one embodiment, the container or vessel has an opaque inner wall and a closely spaced transparent outer wall, with a void in between. Puncture from the outside through the two walls provides seepage of the interiorly-carried liquid between the multiple walls to provide the look of spoilage.
    Type: Grant
    Filed: May 20, 1987
    Date of Patent: July 5, 1988
    Assignee: McNeilab Inc.
    Inventors: Arthur A. Massucco, E. Joseph Stilwell, George E. Pickering, Richard E. Merrill
  • D-arabinose-1,5-diphosphate salts and methods for the treatment of diabetes
    Patent number: 4745185
    Abstract: Novel D-arabinose-1,5-diphosphate salts of the formula (I): ##STR1## wherein n is from about 3 to 4 and M.sup.+ is a cation as well as racemic and isomeric mixtures of the so-defined and forms of formula (I) are useful as hypoglycemic agents for the treatment of diabetes, e.g., in man.
    Type: Grant
    Filed: December 12, 1985
    Date of Patent: May 17, 1988
    Assignee: McNeilab, Inc.
    Inventors: Bruce E. Maryanoff, Allen B. Reitz
  • Process for preparing retinoyl chlorides
    Patent number: 4743400
    Abstract: A process to prepare retinoyl chlorides, e.g., of the following formula (I): ##STR1## under very mild chlorinating conditions by the action of a reagent amount of dimethylchloroformamidinium chloride on a corresponding retinoic acid.
    Type: Grant
    Filed: September 22, 1986
    Date of Patent: May 10, 1988
    Assignee: McNeilab, Inc.
    Inventor: Cynthia A. Maryanoff
  • Dihydropyridine compounds having 1,4,4-trisubstitution useful as antihypertensive agents
    Patent number: 4742068
    Abstract: Dihydropyridine compounds having 1,4,4-trisubstitution of the following formula (I): ##STR1## wherein R is one of --COR.sup.3, R.sup.3 being a group such as phenyl or benzyl; R.sup.4 where R.sup.4 is a heterocycle; --(CH.sub.2).sub.n NR.sup.5 R.sup.6, with R.sup.5 and R.sup.6 being alkyl or joined to define a ring; or --(CH.sub.2).sub.n COOR.sup.7, with R.sup.7 being alkyl or benzyl.R.sup.1 and R.sup.2 are alkyl, phenyl or substituted phenyl.The compounds are useful for the treatment of hypertension in mammals, e.g., in humans.
    Type: Grant
    Filed: June 9, 1986
    Date of Patent: May 3, 1988
    Assignee: McNeilab, Inc.
    Inventor: Michael J. Kukla
  • Peptide antagonists of neurokinin B and opthalmic solutions containing them
    Patent number: 4742156
    Abstract: Four decapeptides found to be analgesics and have antagonist activity to Neurokinin B which is also known as Neuromedin K. The decapeptide are of the following formula (I):A.sup.1 -D-Pro.sup.2 His.sup.3 -D.sup.4 Phe.sup.5 D-Trp.sup.6 Val.sup.7 -D-Trp.sup.8 -Leu.sup.9 -Nle.sup.10 -NH.sub.2 (I)wherein A.sup.1 and D.sup.4 are Asp or D-Asp amino acids. Also described is an opthalmic solution to treat pain or inflammation and an HPLC separation method using piperidine.
    Type: Grant
    Filed: August 29, 1986
    Date of Patent: May 3, 1988
    Assignee: McNeilab, Inc.
    Inventor: David E. Wright
  • Aralykyl (arylethynyl)aralkyl amines and their use as vasodilators and antihypertensives
    Patent number: 4742084
    Abstract: Acetylenes of the formula (I): ##STR1## wherein Y, m, R.sup.1, R.sup.2, q, Alk, R.sup.3 n and R.sup.4 are as defined herein and Ar.sup.1 and Ar.sup.2 are aromatic, including the salts and ammonium derivatives of formula (I), in treating angina, hypertension and cardiac arrhythmias. Pharmaceutical compositions, methods of use and synthesis and novel intermediates are also part of the invention.
    Type: Grant
    Filed: November 19, 1986
    Date of Patent: May 3, 1988
    Assignee: McNeilab, Inc.
    Inventor: John R. Carson
  • Irradiation chamber for photoactivation patient treatment system
    Patent number: 4737140
    Abstract: A removable U.V. light array assembly for use in a photoactivatable agent, patient treatment system wherein photoactivatable agents, in contact with patient blood cells, are irradiated extracorporeally and then returned to the patient.
    Type: Grant
    Filed: May 22, 1987
    Date of Patent: April 12, 1988
    Assignee: McNeilab, Inc.
    Inventors: Kyu H. Lee, Vernon H. Troutner, Jack Goss, Martin J. King
  • Tablet
    Patent number: D295683
    Type: Grant
    Filed: August 12, 1985
    Date of Patent: May 10, 1988
    Assignee: McNeilab, Inc.
    Inventor: John R. Kirk
  • Tablet
    Patent number: D295794
    Type: Grant
    Filed: August 12, 1985
    Date of Patent: May 17, 1988
    Assignee: McNeilab, Inc.
    Inventor: John R. Kirk
  • Disposable patient fluid irradiation chamber
    Patent number: D298279
    Type: Grant
    Filed: February 27, 1986
    Date of Patent: October 25, 1988
    Assignee: McNeilab, Inc.
    Inventors: Kyu H. Lee, Vernon H. Troutner, Jack Goss
  • Flexible patient fluid container
    Patent number: D298567
    Type: Grant
    Filed: February 27, 1986
    Date of Patent: November 15, 1988
    Assignee: McNeilab, Inc.
    Inventor: Livingston B. Morris
  • Patient photopheresis treatment unit
    Patent number: D299531
    Type: Grant
    Filed: February 27, 1986
    Date of Patent: January 24, 1989
    Assignee: McNeilab, Inc.
    Inventors: Vernon H. Troutner, Martin J. King