Patents Assigned to McNeilabs, Inc.
  • Pyrimido[6,1-a]isoguinoline-4-one derivatives
    Patent number: 4454319
    Abstract: Pyrimido[6,1-a]isoquinoline-4-one derivatives of the formula: ##STR1## wherein R is C.sub.1 -C.sub.6 lower alkyl or 2-haloethyl (halo=Cl, Br or I) having antihypertensive activity.
    Type: Grant
    Filed: June 1, 1982
    Date of Patent: June 12, 1984
    Assignee: McNeilab, Inc.
    Inventors: Bruce E. Maryanoff, Albert J. Molinari
  • Derivatives of 2-ureido-7-phenylhexahydrobenzo[a]quinolizines
    Patent number: 4421917
    Abstract: 2-Ureido-7-phenylhexahydrobenzo[a]quinolizines of the structural formula, ##STR1## wherein R.sub.1 =H or lower alkyl (one to three carbons) and R.sub.2 =H, lower alkyl (one to six carbons), or phenyl, and which exhibit antihypertensive activity.
    Type: Grant
    Filed: July 16, 1982
    Date of Patent: December 20, 1983
    Assignee: McNeilab, Inc.
    Inventors: Bruce E. Maryanoff, David F. McComsey
  • Heterocyclic derivatives of guanidine
    Patent number: 4414211
    Abstract: 5-Membered, 6-membered and 7-membered heterocyclic derivatives of guanidine having hypoglycemic activity.
    Type: Grant
    Filed: March 14, 1980
    Date of Patent: November 8, 1983
    Assignee: McNeilab, Inc.
    Inventor: Chris R. Rasmussen
  • N-Aryl-N'-(3-methyl or ethyl-4-oxothiazolidinylidene)ureas useful for the treatment of epilepsy
    Patent number: 4402964
    Abstract: N-aryl-N'-(3-methyl or ethyl-4-oxothiazolidinylidene)urea compounds of Formula I ##STR1## wherein: R is CH.sub.3, C.sub.2 H.sub.5 ;R.sub.1 is chosen from F, Cl, Br, CH.sub.3, C.sub.2 H.sub.5, OCH.sub.3 and CF.sub.3 ;R.sub.2 is H or CH.sub.3 ;R.sub.3 is H or F;R.sub.4 is chosen from F, Cl, Br, CH.sub.3, C.sub.2 H.sub.5, OCH.sub.3 and CF.sub.3 ;have anticonvulsant activity and are useful in the treatment of epilepsy.
    Type: Grant
    Filed: November 16, 1981
    Date of Patent: September 6, 1983
    Assignee: McNeilab, Inc.
    Inventor: Chris R. Rasmussen
  • N-Aryl-N-(4,5,6,7-tetrahydro-1H-1,3, diazepin-2-yl)ureas as antihypertensives
    Patent number: 4379786
    Abstract: N-(Substituted phenyl)-N'-(4,5,6,7-tetrahydro-1H-1,3-diazepin-2-yl)ureas, and pharmaceutically-acceptable salts thereof, are disclosed, as are compositions containing said ureas in a pharmaceutically-acceptable carrier, to have antihypertensive activity and to be useful in a method of reducing arterial pressure in hypertensive subjects.
    Type: Grant
    Filed: September 28, 1981
    Date of Patent: April 12, 1983
    Assignee: McNeilab, Inc.
    Inventor: Chris R. Rasmussen
  • Method for controlling hypertension
    Patent number: 4370343
    Abstract: Hypertension is controlled by administration of glycidic or thioglycidic acid derivatives substituted in the .alpha.-position with a long chain alkyl or alkenyl or dibromoalkyl radical.
    Type: Grant
    Filed: September 21, 1981
    Date of Patent: January 25, 1983
    Assignee: McNeilab, Inc.
    Inventors: Richard Mohrbacher, Winston Ho, Gene Tutwiler
  • Antisecretory 4-diphenylmethyl-1-[(oxoalkyl)imino]methyl-piperidines and their derivatives
    Patent number: 4370335
    Abstract: 4-Diphenyl-1-[(oxo and oxo-related alkyl)imino]methyl-piperidine derivatives are disclosed which are useful for the inhibition of gastric acid secretion.
    Type: Grant
    Filed: February 2, 1982
    Date of Patent: January 25, 1983
    Assignee: McNeilab, Inc.
    Inventor: Malcolm K. Scott
  • (1-Methyl-2-quinolinylidene) derivatives of guanidine
    Patent number: 4345083
    Abstract: (1-Methyl-2-pyridinylidene) and (1-methyl-2-quinolinylidene) derivatives of guanidine having hypoglycemic activity.
    Type: Grant
    Filed: December 10, 1979
    Date of Patent: August 17, 1982
    Assignee: McNeilab, Inc.
    Inventor: Chris R. Rasmussen
  • Analgesic potentiation
    Patent number: 4338324
    Abstract: The analgesic effect of zomepirac is potentiated by simultaneously or sequentially administering to a subject suffering from pain, butorphanol, in a nonanalgesic amount thereby significantly reducing the dosage of zomepirac.
    Type: Grant
    Filed: March 17, 1981
    Date of Patent: July 6, 1982
    Assignee: McNeilab, Inc.
    Inventor: Joseph F. Gardocki
  • Electrochemical sensor with temperature compensation means
    Patent number: 4338174
    Abstract: A disposable gas sensor, such as for monitoring pO.sub.2 in blood or administered gases, includes a housing, a passageway therein for blood or gas, a membrane-anode-cathode polarographic assembly, and a temperature sensing element. The temperature sensing element penetrates the housing and includes a removable thermistor, which is matable with the housing for thermal contact with a metallic element, and which in turn is in direct contact with the fluid being monitored.
    Type: Grant
    Filed: January 8, 1979
    Date of Patent: July 6, 1982
    Assignee: McNeilab, Inc.
    Inventor: Paul S. Tamura
  • N-(Substituted phenyl)-N'-(2-imidazolidinylidene)ureas
    Patent number: 4298746
    Abstract: N-(Mono- and (di-substituted phenyl)-N'-(2-imidazolidinylidene)urea compounds and acid addition salts thereof are taught, which are useful as antihypertensive agents.
    Type: Grant
    Filed: June 6, 1980
    Date of Patent: November 3, 1981
    Assignee: McNeilab, Inc.
    Inventor: Chris R. Rasmussen
  • Preparation of 5-(arylcyanohydroxymethyl)-1-loweralkylpyrrole-2-acetic acid derivatives
    Patent number: 4294760
    Abstract: 5-(Arylcyanohydroxymethyl)-1-loweralkylpyrrole-2-acetic acid derivatives are prepared by the protic acid catalyzed reaction of aroylcyanides with 1-loweralkylpyrrole-2-acetic acid derivatives, which is then converted by treatment with alkali metal hydroxides or heat to form 5-aroyl-1-loweralkylpyrrole-2-acetic acid or derivatives thereof.
    Type: Grant
    Filed: April 17, 1980
    Date of Patent: October 13, 1981
    Assignee: McNeilab, Inc.
    Inventor: John R. Carson
  • N-Aryl-N'-(1,4,5,6-tetrahydropyrimidine-2-yl)ureas as antihypertensives
    Patent number: 4285948
    Abstract: A process for controlling hypertension employing N-(substituted-phenyl)-N'-(1,4,5,6-tetrahydroprimidin-2-yl)ureas, and pharmaceutical compositions containing said ureas is described.
    Type: Grant
    Filed: June 16, 1980
    Date of Patent: August 25, 1981
    Assignee: McNeilab, Inc.
    Inventor: Chris R. Rasmussen
  • Process for preparing pyrrole-2-acetic acids
    Patent number: 4284562
    Abstract: N-H and N-loweralkyl pyrrole-2-acetic acids are prepared by the reduction of 1-H and 1-loweralkyl-.alpha.-trichloromethylpyrrole-2-methanol with sodium dithionite (sodium hydrosulfite) in the presence of a base, MOH, wherein M is an alkali metal, an alkaline earth metal or tetraalkyl ammonium.
    Type: Grant
    Filed: June 20, 1980
    Date of Patent: August 18, 1981
    Assignee: McNeilab, Inc.
    Inventors: Neal G. Anderson, John R. Carson
  • Disposable polarographic gas sensor system
    Patent number: 4269685
    Abstract: A partially disposable, partially reusable polarographic sensor includes a fixed membrane and gel electrolyte in the disposable portion, and includes all electrical/metallic parts in the reusable portion. The disposable portion comprises a housing having a flow chamber for fluids to be monitored, adjacent to which is the membrane. Behind the membrane is the gel electrolyte, and a screw structure for engaging the reusable part. In turn, the reusable part employs a matable screw portion, and a fixed, coaxial anode-cathode assembly, which when mounted to the disposable portion, engages the membrane.
    Type: Grant
    Filed: October 16, 1979
    Date of Patent: May 26, 1981
    Assignee: McNeilabs, Inc.
    Inventor: Dawood Parker
  • N-Aryl-N'-imidazol-2-ylureas
    Patent number: 4265900
    Abstract: N-aryl-N'-imidazol-2-ylureas useful for their antihypertensive, antidiarrheal, anti-irritable bowel syndrome, and anti-secretory activities.
    Type: Grant
    Filed: October 29, 1979
    Date of Patent: May 5, 1981
    Assignee: McNeilab, Inc.
    Inventors: C. Royce Rasmussen, Henry I. Jacoby
  • (1-Methyl-2-pyridinylidene) derivatives of guanidine
    Patent number: 4266062
    Abstract: (1-Methyl-2-pyridinylidene) and (1-methyl-2-quinolinylidene) derivatives of guanidine having hypoglycemic activity.
    Type: Grant
    Filed: September 18, 1978
    Date of Patent: May 5, 1981
    Assignee: McNeilab, Inc.
    Inventor: Chris R. Rasmussen
  • Preparation of 5-aroyl-1-loweralkylpyrrole-2-acetic acid derivatives
    Patent number: 4255335
    Abstract: Known types of 5-aroyl-1-loweralkylpyrrole-2-acetic acid derivatives are prepared by the thermal reaction of an aroylcyanide with a 1-alkylpyrrole-2-acetic acid derivative.
    Type: Grant
    Filed: April 3, 1980
    Date of Patent: March 10, 1981
    Assignee: McNeilab, Inc.
    Inventor: John R. Carson
  • Substituted N-iminomethylpiperidines
    Patent number: 4251655
    Abstract: Substituted N-iminomethylpiperidines are disclosed which are useful for the inhibition of gastric acid secretion.
    Type: Grant
    Filed: September 20, 1979
    Date of Patent: February 17, 1981
    Assignee: McNeilab, Inc.
    Inventors: Malcolm K. Scott, Chris R. Rasmussen
  • Analgesic potentiation
    Patent number: 4242353
    Abstract: A method for producing analgesia by administering a 4-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-.alpha.-methylbenzeneacetic acid compound with acetaminophen, and compositions therefor.
    Type: Grant
    Filed: December 18, 1978
    Date of Patent: December 30, 1980
    Assignee: McNeilab, Inc.
    Inventor: Joseph F. Gardocki