Abstract: A filtration unit comprising a filtration media subunit secured in an outer frame. The subunit comprises a fibrous filtration media enclosed in an inner frame having an upstream frame element and a downstream frame element. Each frame element has longitudinal and transverse struts and the intersection of these struts is in a single plane on the side of the frame elements which contact the filtration media. In one embodiment the filtration unit is enclosed in a sock of knit fabric; in another embodiment, there is a piece of knit fabric between the outer frame and the downstream frame element of the inner frame. The longitudinal struts may have portions which are perpendicular to and project beyond the principal plane of the periphery of the downstream frame element. If such perpendicularly projecting portions are provided, they are preferably arcuate in configuration.

Abstract: Apparatus for heating or cooling fluids, particularly physiological fluids such as blood or plasma or fluids, such as dialysis fluid, which are used in the treatment of physiological fluids. Also disclosed are containers in which or through which fluids may be contained or circulated in order to effect heating or cooling.

Abstract: N-Aminoalkyl 1,5-benzothiazepines of the following formula (I): ##STR1## for the treatment of angina or hypertension or the prevention of heart attacks in mammals, in particular their use as coronary vasodilators.

Abstract: Heterocyclic acetylenes of the formula (I): ##STR1## wherein Y and R.sup.1 are substituents such as hydrogen, alkyl, alkoxy, chloro or fluoro, m is 0-2, R.sup.2 is branched alkyl and Het is an aromatic heterocycle. The acetylenes are useful in treating hypertension and/or angina.

Abstract: Propylamines of the formula (I): ##STR1## and isomers thereof, particularly those enantiomers and racemates relative to the chiral carbon indicated by an asterisk (*). The propylamines can be used for the treatment of hypertension or angina in humans. A is pyrrolidine, piperidine or morpholine and B is an aromatic heterocycle, aromatic carbocycle or saturated carbocycle.

Abstract: Various indole and benzothiophene compounds having a pendant pyrrolidinylidene amino or piperidinylideneamino group are useful in the prevention of ventricular fibrillation, e.g., in humans. The invention comprises methods for the treatment of ventricular dysrhythmia or the prevention of ventricular fibrillation.

Abstract: Acetylenes of the following formula (I): ##STR1## wherein Y, m, R.sup.1, R.sup.2, R.sup.3, n and R.sup.4 are defined herein and R.sup.5 is hydrogen, alkyl, cycloalkyl or substituted alkyl are useful vasodilators and antihypertensives.

Abstract: Novel compounds are disclosed, which are derivatives of 1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]-isoquinolines, represented by general formula (I): ##STR1## as well as pharmaceutical compositions and methods for the treatment of depression in warm-blooded animals, e.g., man. Novel intermediates are also part of the invention.

Abstract: Pyrrolidinylidene compounds substituted at the 5-position of the following formula (I): ##STR1## wherein R=H, alkyl or alkanoyl, and their use as hypoglycemic agents, e.g. in the treatment of diabetes, in a manner similar to linogliride.

Abstract: Octahydroquinolizine and corresponding octahydroquinolizinium compounds of formulae (I) and (Va): ##STR1## where A is a 3 to 7 membered carbocyclic ring, R.sup.1 is a substituent, n is 0-2, x is 0-3, and Y is an anion. Also, pharmaceutical compositions for treating pain containing (I) and methods for synthesis and use as well as novel intermediates in the synthesis.

Abstract: Tetrahydroazeto[2,1-a]isoquinoline of the formula (I): ##STR1## wherein R, R.sup.1, R.sup.2 and R.sup.3 are substituents and x and y are 0-2. Also pharmaceutical compositions for relieving depression in mammals, e.g. in humans, and methods for synthesis and use of formula (I) compounds as well as novel intermediates in the synthesis.

Abstract: A removable U.V. light array assembly for use in a photoactivatable agent, patient treatment system wherein photoactivatable agents, in contact with patient blood cells, are irradiated extracorporeally and then returned to the patient.

Abstract: There is provided an inexpensive disposable temperature monitoring probe for use in a patient treatment system wherein photoactivatable agents, in contact with patient cells, are irradiated extracorporeally to photoactivate said agents and then returned to the patient.

Abstract: Novel synthetic steps and intermediates leading to guanidines such as the anti-diabetic compound linogliride.

Abstract: Cyclopenta[b]thiophenes of the following formulae (I) and (II): ##STR1## wherein R.sup.1 and R.sup.4 are H or alkyl and R.sup.2, R.sup.3, R.sup.5 andR.sup.6 are alkyl, as well their salts, are anti-inflammatory agents having pharmacological profiles similar to that of steroids. Also part of the invention are pharmaceutical compositions and methods for the pharmaceutical treatment of mammals such as man.

Abstract: Pump block for interfacing an irradiation chamber with a roller pump in an apparatus for use in a photoactivatable agent, patient treatment system wherein photoactivatable agents, in contact with patient blood cells, are irradiated extracorporeally and then returned to the patient.

Abstract: Octahydroindolizidines and corresponding ketones of the formulae (I) and (II): ##STR1## where A is a 3-7 carbon or hetero-containing ring, R.sup.1 is a substituent, n is 0-6 and x is 0-3. Also, pharmaceutical compositions for treating pain containing (I) or (II) and methods for synthesis and use as well as novel intermediates in the synthesis.

Abstract: Automatic operating zero insertion force socket for use in a photoactivatable reagent treatment system wherein photoactivatable agents, in contact with patient blood cells, are irradiated extracorporeally and then returned to the patient.

Abstract: Octahydroindolizine compounds of formula (I): ##STR1## wherein Q is --NR--, --(CH.sub.2).sub.z --, --CH.dbd.CH--, --C.tbd.C--, --OCH.sub.2 --, --SCH.sub.2 --, --SO.sub.2 --, --SO--, --CO--, or an oxygen or a sulfur atom and where R, R.sup.1 and R.sup.2 are substituents such as alkyl and x, y and z are independently the integers 0-3. Also, pharmaceutical compositions containing (I), intermediates and methods for treating pain.

Abstract: Manually overridable servo controlled valve mechanisms for controlling the flow of fluids through a flexible tube for use in a photoactivatable agent treatment system wherein photoactivatable agents, in contact with patient blood cells, are irradiated extracorporeally and then returned to the patient.