Abstract: The invention relates generally to the field of compositions including one or more conjugates of di-sugar and a nonsteroidal anti-inflammatory drug (NSAID), and use of same in methods for treating a disease or a disorder in a subject in need thereof.

Abstract: An applicator for a syringe is provided that includes a hub configured to be disposed at least partially within a nozzle of the syringe and defining a fluid passage therethrough, with one or barbs on the hub that frictionally and sealingly engage an interior of the nozzle in a manner minimizing void space associated with waste of deliverable material, and an applicator tip extending distally from the hub. The barb(s) may have varying diameters in order to enable the applicator to be engaged and utilized with syringes having different diameter nozzles. Further the fluid passage through the hub and applicator tip is dimensioned to minimize the volume of material that is retained within the applicator after use, thereby increasing the volume of material that can dispensed from the syringe for use in a procedure or procedures and minimize waste.

Abstract: The present invention disclosed a 1,4-diheterocyclic substituted aromatic ring or aromatic heterocyclic compound represented by formula (I). The compound can effectively inhibit the generation of 20-HETE, and has high activity, high selectivity and good pharmacokinetic characteristics. By means of the inhibition on the generation of 20-HETE, the compound can be used for treating various diseases related to 20-HETE, and thus has a great application value.

Abstract: A method of determining a type of a brain dysfunction is discloses. The method may include: receiving an electroencephalogram (EEG) signal from an electrode placed on the head; calculating a regularity index for an electric activity of the brain based on EEG signal; detecting a temporal change in the regularity index; receiving a medical related input; and determining the type of brain dysfunction based on the temporal change in the regularity index and the medical related input.

Abstract: A method includes detecting in a sample a mammalian antibody binding specifically to ZSCAN5. A mammalian antibody binds specifically to ZSCAN5, and a carrier with a solid phase with at least one immobilized polypeptide includes at least one epitope of ZSCAN5 or a variant thereof. The mammalian antibody is used for diagnosing a neurological autoimmune disease or a cancer.

Abstract: A head fixation device includes a rocker arm assembly containing one or more stabilizing features. The rocker arm is rotatably adjustable about a longitudinal axis of the rocker arm assembly to any rotational position in a non-stepped fashion. The rocker arm assembly is removable from the head fixation device for easy of cleaning. A lever of the rocker arm assembly translates a shaft and includes eccentric features to provide a camming action for moving locking features of the rocker arm assembly to an unlocked state such that the rocker arm can be rotationally adjusted.

Abstract: A blood pump system, comprising: a heart circulation pump (1) for being arranged in a heart so as to pump blood in the heart into an aorta; an aorta circulation pump (2) for being arranged in the aorta so as to supply blood in the aorta to a set organ; and a power transmission section (3) connected between the heart circulation pump (1) and the aorta circulation pump (2) so as to realize power transmission. The blood pump system is capable of accelerating the circulation of the blood in the heart and the blood in the aorta by means of the heart circulation pump (1) and the aorta circulation pump (2), respectively, thus assisting in improving the blood supply function of the heart. Moreover, rotating blades (112) of the blood pump system are adjustable.

Abstract: Arrangements are described for monitoring cochlear implantation surgery. During surgical insertion of a cochlear implant electrode array into a patient cochlea, at least one measurement difference value is determined for at least one electrode contact currently located at a given insertion depth into the patient cochlea based on comparing current stimulus response data for the at least one electrode contact to prior stimulus response data for at least one prior electrode contact previously located at the given insertion depth. A potential trauma response is identified when the at least one measurement difference value exceeds a defined difference value.

Abstract: The present disclosure is directed to methods and compositions comprising photopolymerizable compositions for use in additive manufacturing, particularly for digital light processing, stereolithography or continuous liquid interface processing.

Abstract: Effective delivery of an insecticide to a growing plant can sometimes be problematic. Topical delivery of an insecticide at the post-emergence stage of growth can sometimes be ineffective. It can also be difficult to deliver an insecticide to the roots of a growing plant, such as to combat a subsurface insect infestation. Accordingly, soil blends having insecticidal activity can comprise a soil medium, a porous soil additive, and an insecticide dispersed within the soil medium. Such soil blends may be used in conjunction with cultivating a variety of plants. Methods for producing the soil blends can comprise providing a soil medium and a porous soil additive, and dispersing the porous soil additive and an insecticide within the soil medium.

Abstract: Thermally stable absorbable fiber populations, i.e. fiber populations that do not undergo thermally induced crystallization, can be intermixed with thermally unstable fibers to yield a stabilizing effect without altering morphological properties of a fiber system. Via this, one may minimize thermally induced shrinkage and maintain physical properties of electrospun materials in the as-formed state.

Abstract: Thermally stable absorbable fiber populations, i.e. fiber populations that do not undergo thermally induced crystallization, can be intermixed with thermally unstable fibers to yield a stabilizing effect without altering morphological properties of a fiber system. Via this, one may minimize thermally induced shrinkage and maintain physical properties of electrospun materials in the as-formed state.

Abstract: An apparatus is for the automated production of a daughter radionuclide from a parent radionuclide using a generator comprising a solid medium onto which the parent nuclide is fixed and whereby the daughter nuclide is formed by radioactive decay of the parent nuclide. The apparatus includes a fluid circuit including a chromatography column having a head port and a tail port, at least one connection port for connecting the generator to the fluid circuit, at least one inlet port for connecting fluid sources to the fluid circuit and at least one valve controlled by an electronic control unit for selectively connecting the chromatography column, the connection port and the at least one inlet port in various configurations.

Abstract: The invention is to articles of extracellular matrix. The articles comprise one or more sheets of mammalian extracellular matrix laminated together. A single sheet can be folded over and laminated on 3 sides. Two or more sheets can be laminated to each other at their edges. The sheets can further encase a composition comprising a cell or cells, such as for example, a stem cell. A single sheet can be folded over to encase a composition, or rolled to encase a composition with lamination at either end of the roll, for example. The invention also includes methods of using these articles to regenerate tissue at tissue defects, or heal wounds in damaged tissue.

Abstract: A pedicle insulator implant is designed to protect the nerves and surrounding tissue from injury by pedicle screws or other surgical devices and instruments. The implant is configured to shield a fixture, reduce nerve root irritation, and diminish loosening of the fixture, when the fixture is implanted into the void of a target site. The implant includes features for stabilizing and securing the implant within the void at the target site. For example, in one embodiment, the implant includes one or more ridges and one or more teeth sections that stabilize the implant against rotational and extractive forces that could disturb the implant.

Abstract: Absorbable composite medical devices such as surgical meshes and braided sutures, which display two or more absorption/biodegradation and breaking strength retention profiles and exhibit unique properties in different clinical settings, are made using combinations of at least two types of yarns having distinctly different physicochemical and biological properties and incorporate in the subject construct special designs to provide a range of unique properties as clinically useful implants.

Abstract: Porous and microporous parts prepared by additive manufacturing as disclosed herein are useful in medical and non-medical applications. The parts are prepared from a composition containing both a solvent soluble component and a solvent insoluble component. After a part is printed by an additive manufacturing process it is exposed to solvent to extract solvent soluble component away front the printed part, resulting in a part having surface cavities.

Abstract: The present disclosure relates generally to a device and method for aiding in the repair of a dural tear. According to example embodiments, the device is placed substantially within a dural sac interior to a dural tear. The device provides a shield that prevents the underlying nerve roots (including rootlets) of the spinal cord from intruding into the torn area and prevents them from being injured during the repair procedure. The device also redirects cerebrospinal fluid from the area, which aids the surgeon in viewing the procedure site during suturing and/or repair.

Abstract: In an embodiment, an electronic device includes a display screen, a memory circuit, and computing circuitry, which is coupled to the display screen and to the memory circuit, and which is configured to cause the display screen to display icons that are each related to respective data regarding a patient at a medical facility, to retrieve, from the memory, the respective data in response to a user of the electronic device selecting, via the display screen, a corresponding one of the displayed icons, and to cause the display screen to display the retrieved respective data.

Abstract: Exemplary head stabilization devices or head fixation devices (HFDs) include a central head support for providing subjacent support to a head of a patient, and multiple lateral head supports for providing lateral support to the head of the patient. The central head support includes a cushion with one or more chambers that are fillable with a material. Similarly, the lateral head supports include respective pads with chambers that are fillable with a material. In some instances, the cushion and the pads used with the HFDs can include ports that permit pressure control by way of controlling a fluid volume within specific chambers of the cushion and/or pads.