Abstract: Provided is a laryngoscope that includes a display screen, a handle connected to the display screen, a lens connected to the handle, and a housing portion that is sleeved on the lens and the handle and fitted with the handle. The housing portion includes a housing and a transparent cover fastened with the housing. The lens is inserted into the housing and a shooting portion of the lens is exposed out of the housing. The transparent cover covers the shooting portion of the lens and is sealingly fastened with the housing.

Abstract: Sublingual Semaglutide compositions may comprise both Semaglutide or a salt thereof and a gastric peptide or salt thereof, in combination. The use of a gastric peptide mitigates gastrointestinal side effects of Semaglutide. A weight loss regimen comprises administration of sublingual Semaglutide compositions in the physical form of sublingual tablets. In preferred embodiments, each sublingual Semaglutide tablet provides about 500 mcg Semaglutide or 750 mcg Semaglutide in combination with 300 mcg of gastric peptide, with the gastric peptide preferably comprising Body Protection Compound-157 (BPC-157). Sublingual administration of Semaglutide finds use in suppressing appetite, losing weight, and maintaining a desired personal appearance.

Abstract: Abdominal approximation devices and methods are described where one variation of the tissue securement assembly may generally include a fixation member having a length, a thickness control securement member which is adjustably securable along the length, and a frame which is adjustably securable to the thickness control securement member. The frame may have a relaxed configuration and a biasing configuration which imparts a biasing force against the thickness control securement member when in the biasing configuration such that the biasing force is applied at a distance from tissue to be approximated via the fixation member.

Abstract: A pneumatic tourniquet has a constricting device that comprises a rocker, such that when the rocker is angularly displaced by contact with a wounded limb, a clamping force is applied by a rocker surface and a clamping edge onto a sealing element to prevent flow of the pressurized gas from an interposed inflated strap to a free end, causing the strap free end to be considerably thinner than the main strap section. In one embodiment, a gas flow control assembly comprises a casing containing a force transmitting element and a gas cartridge; and a pivotable activation handle, wherein, upon pivoted displacement of the activation handle, pressurized gas is caused to be discharged from the gas cartridge and flow to an interior of the strap. In other embodiments, the pneumatic tourniquet comprises one or more of a flow control unit, a manual pressure release initiator, and a puncture mitigating connection section.

Abstract: Provided is an isolated nucleic acid molecule encoding a chimeric antigen receptor (CAR), in which the CAR includes a single chain antibody or single chain antibody fragment, a costimulatory domain, a primary intracellular signaling domain. The single chain antibody or single chain antibody fragment includes a murine anti-CD19 binding domain, wherein the murine anti-CD19 binding domain includes a heavy chain variable (VH) region comprising a heavy chain complementarity determining region (CDR H1), a CDR H2, and a CDR H3; and a light chain variable (VL) region comprising a light chain complementarity determining region 1 (CDR L1), a CDR L2, and a CDR L3. The costimulatory domain includes 4-1BB, and the primary intracellular signaling domain includes a native intracellular signaling domain of CD3 zeta.

Abstract: The invention relates to an installation (1) for the three-dimensional printing of a medical device directly at a location where the medical device is to be used. According to the invention, the installation comprises a container (2) comprising inside it: a production module (3) comprising a 3D printer (6); a clean room (4) comprising means (12) for washing and disinfection of the printed medical device, and a machine (13) for packaging the washed and disinfected medical device.

Abstract: Provided is reward system activation for therapeutic purposes. Accordingly there is provided a method of treating a disease in a subject in need thereof, the method comprising subjecting the subject to a treatment module which activates the reward system of the subject.

Abstract: A method for performing an inhalation using a nebulizer includes filling a reservoir with a medication fluid or connecting a medication container to a designated connecting piece; connecting a nebulizer unit to a control unit and a mouthpiece, at least temporarily activating the nebulizer unit; atomizing the medication fluid into a fine particulate aerosol which is emitted into an aerosol chamber formed by the nebulizer unit and the mouthpiece during activation of the nebulizer unit; performing the inhalation, with a user enclosing the mouthpiece with the lips and during inhalation, drawing air from outside into the aerosol chamber, where the air mixes with the aerosol, and then passes further through the mouthpiece as an air stream and into the respiratory tract and, possibly into the user's lung; measuring a pressure within the aerosol chamber and/or a flow rate through the aerosol chamber or the mouthpiece using the control unit; activating the nebulizer unit with each breath on occurrence of at least one

Abstract: A storage apparatus is provided for storage of elongate articles in a vertical orientation, such as for storage of flexible esophageal dilators. The storage apparatus includes a gripping element of flexible material supported at a support frame. The gripping element includes receiving slots or apertures aligned with the spaced holes in the rigid panel. The support frame may include a rigid support panel with a pattern of spaced holes corresponding to respective ones of the receiving apertures of the gripping element. The gripping element grips and holds elongate articles at respective receiving apertures to suspend the articles in a vertical orientation. The elongate articles are retained in the gripping element until a user exerts a removal force on the article to retrieve it from the storage apparatus. The support frame may be disposed inside of a container, such as a cabinet or drawer.

Abstract: The invention relates to a method for the resolution of pro-tumour inflammation by means of a pharmaceutical preparation. Leukocytes are isolated from the buffy coat obtained from whole blood and a portion of the leukocytes is placed in a first pouch receiving a differentiation factor and stored in conditions that preserve cellular viability for several days, before a defined, fresh culture medium is supplied, after which said leukocyte portion is left to rest for a further several days, which results in the production of macrophages. A further portion of the leukocytes is placed in a second pouch and irradiated therein. The two pouches are then mixed and the supernatant is recovered to serve as pharmaceutical preparation. The invention also relates to the use in the treatment of cancers, either alone or in combination with other therapies, in human and veterinary medicine.

Abstract: A biopsy marker having a spring-loaded anchor. The biopsy marker includes an insertion orientation and an anchored orientation. In the insertion orientation, the biopsy marker is manipulated under force to reduce the lateral span/cross-sectional area of the marker. In the anchored orientation, the biopsy marker is released and free to actively spring into a configuration in which the lateral span/cross-sectional area is greater than the lateral span/cross-sectional area of the biopsy marker when in the insertion orientation. In an embodiment, the spring-loaded anchor is configured to spring about a predefined rotational axis. An embodiment of the biopsy marker may be comprised of a single wire construction.

Abstract: A fitting arrangement is described for fitting electrode contacts of cochlear implant electrode array implanted in a cochlea of an implanted patient. This involves iteratively fitting multiple fitting electrode contacts by for each of the fitting electrode contacts: i. delivering fitting stimulation signals to the fitting electrode contact and at least one neighboring electrode contact to stimulate adjacent auditory neural tissue, wherein the fitting stimulation signals are characterized by a charge level distribution function having a non-zero noise level charge at the at least one neighboring electrode contact and a response level charge much greater than the noise level charge at the fitting electrode contact, and ii. obtaining patient responses from the implanted patient to the fitting stimulation signals. A patient-specific fit map is then defined for the electrode contacts of cochlear implant electrode array based on the patient responses.

Abstract: A germicidal device includes a lighting member operably in an on-state in which the lighting member emits ultraviolet light for killing microorganisms, or in an off-state in which the lighting member emits no light; a sensing member operably detecting at least one event occurred in an area; and a microcontroller unit coupled with the lighting member and the sensing member for controlling operations of the lighting member in a respective state in accordance with the at least one event occurred in the area. The at least one event includes a movement in the area, an acoustic wave in the area, an intrusion into the area, an expiration of an on-state time period in which the lighting member is in the on-state, an expiration of an off-state time period in which the lighting member is in the off-state, and/or an instruction from a remote operation.

Abstract: A biopsy marker having a spring-loaded anchor. The biopsy marker includes an insertion orientation and an anchored orientation. The lateral span/cross-sectional area of the marker is configured to change when transitioning between the insertion orientation and the anchored orientation. In an embodiment, the spring-loaded anchor is configured to spring about a predefined rotational axis. An embodiment of the biopsy marker may be comprised of a single wire construction.

Abstract: An ultrasound image recognition system and a data output module are provided. The ultrasound image recognition system includes an image analyzing device, a data processing device, and a data output module. The image analyzing device is configured to receive an image having a predetermined format. The image analyzing device generates a plurality of physiological image parameters. The data processing device is connected to the data processing device. The image analyzing device provides the plurality of physiological image parameters and the image having a predetermined format to the data processing device. The data processing device provides a comparison result of physiological parameter based on the plurality of physiological image parameters and a plurality of predetermined physiological image parameters. The data processing device converts the image having a predetermined format into an image having a first format.

Abstract: The present disclosure is directed to an instrument kit tracking system that includes a housing that has tracking electronics that is contained in either a compartment or wall of the medical instrument kit or in a standalone unit that is affixed to a medical instrument kit to contain and protect an electronic device from external temperatures up to 132° C., and higher; where the medical instrument kit contains at least one medical instrument. The internal temperature of the instrument kit tracking system is maintained such that the electronic device contained therein is operable when the external temperature is up to 132° C., and higher. Hardware system architecture and integrated power management intelligently controls power consumption of electronic components for electronic component safety and integrity, efficiency and long term battery life of the device.

Abstract: A method for preparing one or more generators with a high radium-228 content from an aqueous solution comprising thorium-232 and radium-228. The generator(s) can be used, in particular, for producing thorium-228, from which radium-224, then lead-212 and bismuth-212 can be obtained. The method and the generator(s) that it can be used to prepare are therefore applicable, in particular, in the manufacture of radiopharmaceuticals made from lead-212 or bismuth-212, which can be used in nuclear medicine and, in particular, in targeted alpha radiotherapy for the treatment of cancers.

Abstract: A head stabilization device having the form of a skull clamp includes a first pin assembly and a second pin assembly. The pin assemblies are positioned opposite each other, and the first pin assembly has a first pin while the second pin assembly has a pair of pins. The pins used with the skull clamp are non-uniform. In this respect skull clamp can apply an equal force to a head of a patient from both sides. Additionally, the pressure at each pin location can be the same or substantially the same. This allows each of the pins to have the same or similar bone penetration when in use stabilizing the head of the patient.