Abstract: The disclosure provides biodegradable implantable devices such as a stent comprising a biodegradable polymeric material wherein the polymeric material is treated to control crystallinity and/or Tg. The stent is capable of expanding at body temperature in a body lumen from a crimped configuration to a deployed diameter and will have sufficient strength to support a body lumen when expanded.

Abstract: A medical device system for use in patient resuscitation and medical device management includes a fleet of medical devices associated with a common administrator and distributed over multiple locations. Each medical device includes a memory, a processor configured to store medical device information including device status information and clinical event information, and a communication component configured to transmit the stored medical device information via a network. The system includes one or more servers communicatively coupled to the fleet of medical devices and one or more user devices located remotely from the servers. The servers include a communication component configured to receive the medical device information from the fleet of medical devices, a memory configured to store the received medical device information, and a processor configured to provide a report comprising the device status information for the fleet of medical devices at a medical device dashboard accessible by the user devices.

Abstract: A method and a platform for detecting an immunogenicity of a tumor neoantigen are provided. Specifically, the detection method includes the following steps: culturing human peripheral blood monocytes ex vivo for 13 days, adding an antigenic peptide fragment of human influenza virus and stimulating and activating cytokines, antigenic peptides, and immunoadjuvants during the 13 days, and finally conducting enzyme-linked immunospot (ELISPOT) chromogenic reaction and instrument-based scanning, counting, and analysis to detect the immunogenicity of tumor neoantigen. An application of the detection method and platform in biomedicine is provided. Compared with the prior art, the detection method and platform have advantages and characteristics of a short detection period, high convenience, low consumption of experimental cells, and low detection cost. Therefore, the detection method and platform can be used for ex vivo high-throughput assay for the immunogenicity of the tumor neoantigen.

Abstract: A yoke for use with infrasonic sensing elements, where the yoke is Y shaped, flexible, and assists in positioning, on a human subject, the sensing elements appropriately on the carotid arteries and on the heart.

Abstract: Methods and devices are disclosed for the treatment of a subject suffering from drug intoxication by cleansing a contaminated sample from the subject with adsorption media. The adsorption media composition is selected for its antithrombogenic properties and for its ability to adhere to one or more drug targets to be reduced or eliminated. The media can further be held in a cartridge for use in extracorporeal treatments such as those of hemoperfusion. Contacting the contaminated sample from the subject with the absorption medium allows for the separation of a portion of the drug target from the sample, producing a cleansed sample that can be infused into the subject.

Abstract: A system for assisting with a cardiopulmonary resuscitation (CPR) treatment being administered to a patient. In one aspect, the system includes electrodes to provide an ECG signal of the patient, one or more sensors configured to measure an intrinsic myocardial wall movement of the patient, and one or more processors. The one or more processors are configured to perform operations including: during the CPR treatment being administered to the patient, receiving an input from the sensor(s), processing the input from the sensor(s) and the ECG signal, determining, based on processing, whether the intrinsic myocardial wall movement is indicative of a perfusion movement of the patient's heart, and providing an indication to a user of the system based on the determination.

Abstract: A medical system for assisting with an intubation procedure for a patient. The system comprising airflow sensors configured to obtain data indicative of airflow in the patient's airway and physiological sensors configured to obtain information regarding airflow in the patient's lungs. The system further including a monitoring device communicatively coupled to the airflow sensors and the physiological sensors. The patient monitoring device comprising at least one processor coupled to memory and configured to: provide a user interface on a display and assist the rescuer in determining proper placement of an endotracheal tube, receive the data indicative of the airflow in the patient's airway, receive the physiological information regarding the airflow in the patient's lungs, and determine whether the tube is properly placed based on the received physiological information, and present an output of the determination of whether the ET tube was properly placed.

Abstract: An electrosurgical apparatus with a retractable blade for use in cold plasma applications, electrosurgical cutting and mechanical cutting is provided. The electrosurgical apparatus employs a tip of the retractable blade as a sharp conductive point to generate a plasma beam or discharge. When the blade is retracted within the electrosurgical apparatus, it is electrically energized while an inert gas flows over it, producing a cold plasma discharge. In the de-energized state, the blade is advanced and used as a traditional, mechanical surgical blade.

Abstract: A system for supporting and aligning a patient during a color alteration procedure includes a laser system that delivers a laser in a first direction. A control computer may be adjacent the laser system for controlling the laser system. The control computer system may include a user interface in a first plane substantially perpendicular to the first direction. The system may include a patient support structure having a patient support surface extending in a second direction substantially perpendicular to the first direction and configured to be adjustable to set a patient position or alignment relative to the laser system. Coarse adjustment hardware may be configured to cause automated and/or manual adjustments to the patient support surface in the first direction. Fine adjustment hardware may be configured to cause automated fine adjustments to the patient support surface in the first direction based on instructions received from the control computer.

Abstract: A chest drainage system including a collection device configured to receive fluid from the pleural cavity of a patient. A sensor is included to detect a pressure differential in the fluid. A display is configured to display a trend in occurrences of changes in pressure of the fluid over time in predetermined time increments based on a number of detections of pressure differentials that exceed a predetermined pressure differential during each of the predetermined time increments. The trend is correlative to the percentage of time that the patient is deemed to have an air leak in the pleural cavity in the predetermined time increments. The trend is derived from a ratio of the quantity of respiratory cycles of the patient for which the predetermined pressure differential is detected (QRCleak) in the predetermined time increments to the total quantity of respiratory cycles of the patient in respective predetermined time increments (QRCtotal).

Abstract: An example of a system for assisting a rescuer in providing CPR includes a motion sensor configured to generate signals indicative of chest motion during CPR chest compressions, and a defibrillator including a display screen configured to provide CPR feedback and defibrillation information and a processor configured to receive the signals, generate a compression waveform based on the signals, detect, in the compression waveform, features characteristic of chest compressions, compare the detected features to a predetermined criterion that distinguishes between manually delivered and compressions delivered by an automated compression device, and selectively provide the CPR feedback based on whether the compressions are the manually delivered or the automated compressions, where the selective provision of the CPR feedback includes displaying CPR parameters for the manually delivered compressions, and a removing from the display screen at least one CPR parameter of the CPR parameters for the automated compression

Abstract: A system including a medical device is provided. The medical device includes at least one sensor configured to acquire first data descriptive of a patient, first memory storing a plurality of templates, and at least one processor coupled to the at least one sensor and the first memory. The at least one processor is configured to identify a first template of the plurality of templates that is similar to the first data, to determine first difference data based on the first template and the first data, and to store the first difference data in association with the first template. The system may further include the programmable device.

Abstract: A system and method for aiding in the proper placement of ECG electrodes and other resuscitation parameters. The system includes motion sensors disposed on the ECG electrodes, and a defibrillator control system operable to interpret motion signals from the motions sensors to determine that an electrode is in motion, and thus being handled by rescuer setting up the system for use, and, based on this determination, prompt the rescuer to place the electrode in its intended location on the body of the patient. The control system may also be operable to determine relative motion and/orientation of the motion sensors and control resuscitation based on the relative motion and/orientation of the motion sensors.

Abstract: A patient-worn arrhythmia monitoring and treatment device weight between 250 grams and 2,500 grams includes at least one contoured pad configured to be adhesively coupled to a patient's torso, a plurality of therapy electrodes, at least one of which is integrated with the at least one contoured pad, and a plurality of ECG sensing electrodes, at least one of which is integrated with the at least one contoured pad. At least one housing configured to form a watertight seal with the at least one contoured pad extends no more than 5 cm from the contoured pad. A processor disposed within the housing is coupled to a therapy delivery circuit and configured to detect one or more treatable arrhythmias based on at least one ECG signal and cause a therapy delivery circuit to deliver at least one defibrillation pulse on detecting the one or more treatable arrhythmias.

Abstract: Diagnostic screening tests that can be used to identify if a patient is a good candidates for an implantable vagus nerve stimulation device. One or more analyte, such as a cytokine or inflammatory molecule, can be measured from a blood sample taken prior to implantation of a vagus nerve stimulator to determine the patient's responsiveness to VNS for treatment of an inflammatory disorder.

Abstract: A device for assisting a caregiver in delivering cardiac resuscitation to a patient, the device comprising a user interface configured to deliver prompts to a caregiver to assist the caregiver in delivering cardiac resuscitation to a patient; at least one sensor configured to detect the caregiver's progress in delivering the cardiac resuscitation, wherein the sensor is configured to provide a signal containing information indicative of ventilation; a memory in which a plurality of different prompts are stored, including at least one ventilation progress prompt to guide the rescuer's performance of ventilation; a processor configured to process the output of the sensor to determine a parameter descriptive of ventilation progress and to determine whether the ventilation progress prompt should be selected for delivery. Possible parameters descriptive of ventilation progress include ventilation rate, delivered tidal volume, and flow rate.

Abstract: An externally worn cardiac monitoring and/or treatment system with battery detachment detection is provided. The system includes detachment circuitry and audible and/or vibrational alarm circuitry operably coupled to the detachment circuitry. The detachment circuitry is configured to detect whether the rechargeable battery is detached from the battery-powered externally worn cardiac device by monitoring a connection established between the rechargeable battery and the at least one processor and output a battery status signal indicating whether the rechargeable battery is detached from the battery-powered externally worn cardiac device. The audible and/or vibrational alarm circuitry is configured to receive the battery status signal and output an audible alert in a predetermined frequency range and/or a tactile alert if the rechargeable battery is detached.

Abstract: An inventory management system includes a wearable cardiac device comprising an associated plurality of separate wearable cardiac device components stored as inventory at a first inventory location; a plurality of communication interface circuits associated with a corresponding one of the plurality of separate wearable cardiac device components and configured to facilitate transmission of inventory information through a network; at least one server device disposed at a central location and comprising a processor; and a memory comprising instructions that cause the processor to receive the inventory information from the plurality of communication interface circuits; receive a prescription for a patient; retrieve one or more prescription parameters based on the prescription; locate, in the inventory information, the wearable cardiac device based on the prescription parameters; determine a deployment status of the wearable cardiac device; and select the wearable cardiac device for the patient.

Abstract: The present invention relates to a method for predicting a prognosis of a lung adenocarcinoma patient. The present invention relates to a method for predicting a prognosis of a lung adenocarcinoma patient after cancer resection. The present invention also relates to a method for treating a lung adenocarcinoma patient.

Abstract: An aspiration catheter includes a catheter body having a proximal end, a distal end, and an aspiration lumen therebetween. A distal segment comprising an expandable distal tip of the aspiration catheter comprises a membrane and an expandable supporting structure, such as a scaffold, configured to radially expand the expandable distal tip. The expandable supporting structure may include supporting elements and other features which increase resistance to collapse of the expandable membrane under vacuum or negative pressure applied to aspirate clot through the aspiration lumen in the expanded configuration.