Abstract: The present disclosure provides compositions that enable sustained release of a small molecule tyrosine kinase inhibitor, such as axitinib from a bioerodible polyester polymer implant for the treatment of disease. The composition is especially suitable for treating ophthalmic indications, such as neovascular age related macular degeneration and diabetic macular edema, by intravitreal injection of the implant. The implant is designed to be pre-loaded into a small diameter needle and injected via self-sealing scleral needle penetration at the pars plana. Small molecule tyrosine kinase inhibitors may be released from the implants over a period of one week to three years.

Abstract: A system for monitoring performance of a resuscitation activity on a patient by an acute care provider is provided. The system includes: a first wearable sensor configured to sense movement of a first portion of an acute care provider's hand; a second wearable sensor configured to sense movement of a second portion of the acute care provider's hand; and a controller. The controller is configured to: receive and process signals representative of performance of a resuscitation activity from the first sensor and the second sensor; identify from the processed signals information indicative of at least one of a relative distance, a relative orientation, a change in relative distance and a change in relative orientation between the first sensor and the second sensor during performance of the resuscitation activity; and determine at least one resuscitation activity parameter based, at least in part, on the identified information.

Abstract: A wearable medical device includes a waterproof harness, a plurality of ECG sensing electrodes configured to detect a patient's ECG, and a plurality of therapy electrodes configured to provide at least one biphasic shock to the patient. The device includes a control unit in electronic communication with the ECG sensing electrodes and therapy electrodes and configured to monitor the sensed ECG and, in response to detecting a cardiac arrhythmia, provide the biphasic shock(s). The control unit is comprised within a waterproof case. The device includes a water-resistant or waterproof connection pod that is configured to electrically couple the ECG sensing electrodes, therapy electrodes, and control unit. The connection pod provides the sensed ECG signal to the control unit and the biphasic shock current to the therapy electrodes. The device includes a user interface device in electronic communication with the control unit that includes at least one patient responsiveness button.

Abstract: An electrosurgical apparatus including a robotic tip is provided. The electrosurgical apparatus includes a plurality of actuators and hinging members. The robotic tip includes a retractable electrode. The actuators are coupled to the hinging members via a plurality of pulling mechanisms, such that, one or more of the actuators is rotated to selectively pull one or more of the plurality of pulling mechanisms to pivot and rotate the robotic tip and/or extend and retract the electrode. The electrode is coupled to a gas source and an energy source, such that, the electrode can produce plasma for use in surgical applications.

Abstract: A magnetic powder dispensing structure for tablet printing comprises a powder collecting device, a printing device, a guide rod device and a printing platform, the powder collecting device comprises a powder collecting box, a powder feeding device, a plurality of stirring rods, a plurality of rocker arms, a pressing rod, a driving motor and a first electromagnetic attraction device; the printing device comprises a second electromagnetic attraction device. The printing device and the powder collecting device are capable of moving laterally through the guide rod device, and capable of being magnetically attracted with each other or detached from each other by energizing or de-energizing the first electromagnetic attraction device and the second electromagnetic attraction device, thereby the powder collecting device can be driven when dispensing powder, and the printing device is capable of operating independently during printing.

Abstract: A medical device is disclosed. The device may include a service component for use in detecting patient data, at least one processor coupled with the service component, a care protocol module executable by the at least one processor to provide healthcare to a patient at least in part by generating a request for processing by the service component, and a resource module executable by the at least one processor to manage access to the service component by identifying a level of service associated with the care protocol module and responding to the request by managing the service component to meet the level of service. The care protocol module implements a patient care protocol that includes a sequence of actions directed to the patient. The level of service indicates a level of performance that the patient care protocol requires of the resource module. Selective offloading of modular functions is also enabled.

Abstract: The present invention relates to a combination of a histone deacetylase (HDAC) inhibitor, chidamide in an acidic salt form, and a nonsteroidal anti-inflammatory drugs (NSAIDs), celecoxib in a basic salt form. The present invention also relates to methods which significantly regulate tumor microenvironment and therefore dramatically improve anti-cancer activity.

Abstract: A wearable medical device for detecting and treating life-threatening arrhythmias includes a wearable vest portion, sensing electrodes, therapy pads, at least one motion sensor, and a cardiac monitor. The cardiac monitor is configured to detect whether the patient is experiencing a treatable arrhythmia using an ECG signal and in response, determine a confidence level for the detected treatable arrhythmia using outputs from the at least one motion sensor. Determining the confidence level includes detecting patient motion prior to the detection of the treatable arrhythmia. Determining the confidence level further includes increasing the confidence level in response to determining that the patient is motionless coinciding with the detection of the treatable arrhythmia, or decreasing the confidence level in response to determining the patient motion after the detection of the treatable arrhythmia. The cardiac monitor is configured to determine whether to deliver a treatment shock based on the confidence level.

Abstract: An ambulatory medical device includes two or more response mechanisms; a memory storing an active operation mode parameter identifying an active operation mode from a plurality of operation modes; a controller connected with the two or more response mechanisms; and a therapy manager component executable by the controller and configured to identify the active operation mode, detect a physiological parameter indicative of a health disorder of the patient, request that the patient change the state of one of the two or more response mechanisms in response to detection of the physiological parameter, monitor the state of each of the two or more response mechanisms within a first predetermined period, and delay therapy to the patient in response to detection of a first change in the state of one of the two or more response mechanisms within the predetermined period and identification of a first mode as the active operation mode.

Abstract: The presently described catheter is an improved multi-function hypospadias catheter adapted to be urethrally inserted and secured within a patient's bladder using an attached internal crescent shaped retention balloon. The inverted crescent configuration of the balloon reduces the contact surface area between the balloon and a patient's bladder wall to reduce bladder spasms. The catheter is removed from the patient (when needed) via deflation of the crescent shaped balloon, which deflates completely so as to not contact a patient's urethra during insertion and removal of the catheter. The catheter includes a double lumen with a one-way flow valve. One lumen provides a passageway to drain urine from a patient's bladder. The second lumen provides a passageway to inflate and deflate the crescent shaped retention balloon.

Abstract: An implantable vein frame is contemplated in which two ring members are rigidly joined in spaced axial alignment via one or more interconnecting members. One of the one or more interconnecting members defines a protruding region that acts upon the implant placed within the frame and/or the vein that the vein frame is placed within to define a sinus region. The implant is placed within and scaffolded by the vein frame, and the vein frame is subsequently inserted within a vein via a venotomy, or interposed between two vein segments via vein interposition graft. The vein frame acts to support the structural integrity of the implant, and to scaffold and anchor the implant in place with the vein.

Abstract: A wearable monitoring and therapeutic device includes at least two sensing electrodes, including at least one of conductive thread sewn into a garment and/or a metallic surface sewn into the garment. The device includes at least two therapy electrodes and the garment, wherein the garment is configured to be worn about a torso of a subject. The garment includes a breathable and stretchable fabric, an elastic material, and a loose material. The device includes at least one defibrillator component including a power source, a conductive wiring configured to stretch to accommodate the subject's chest size and enhance comfort and couple any of the at least two therapy electrodes and the at least two sensing electrodes to the at least one defibrillator component, an alarm module operatively coupled to the at least one defibrillator component, and one or more response buttons operatively coupled to that at least one defibrillator component.

Abstract: A medical ventilation monitoring system is provided. The system includes: a patient ventilation unit defining an airflow path, and arranged so that when the unit is applied to a patient, the airflow path is in fluid communication with the patient's airway. The patient ventilation unit includes: an airflow sensor positioned to sense the presence of ventilation airflow to or from the patient and a communication link. The system also includes at least one processor arranged to communicate with the ventilation unit by the communication link. The at least one processor is configured to: provide an initial treatment protocol for providing care to the patient, receive data regarding a current condition of the patient from the ventilation unit, and determine an updated treatment protocol. The updated treatment protocol includes applying ventilation at an updated ventilation volume or at an updated ventilation rate based on information from the airflow sensor.

Abstract: A stent device includes generally cylindrical rings aligned along a longitudinal axis, and interconnected by interconnecting members. Each interconnecting member includes a first coupling end, a second coupling end, and an elongate portion therebetween. The first coupling end, the elongate portion, and the second coupling end combine in either a first orientation or a second orientation, which are substantially mirror images. For each interconnecting member, the first coupling end can intersect with a midpoint of a transition region of a substantially repeating curved segment on one of the rings, and the second coupling end can intersect with a midpoint of a curved segment of a different and immediately adjacent ring. The interconnecting members can be arranged in rows extending longitudinally along the device. Along each row, consecutive interconnected members alternate between the first orientation and the second orientation. A cover may be provided over the stent device.

Abstract: Cochlear implant systems can comprise a cochlear implant system comprising a cochlear electrode, a stimulator in electrical communication with the cochlear electrode, a return electrode, and one or more controllers. The cochlear electrode can include a first contact electrode and the stimulator can include a first source element in electrical communication with the first contact electrode. The one or more controllers can be configured to cause the stimulator to emit a predetermined current from the first source element to the return electrode via a first current path and determine a first voltage at the first contact electrode and a second voltage at the return electrode. The one or more controllers can determine an impedance associated with the first current path and determine one or more stimulation parameters, such as a compliance voltage for sourcing a prescribed current, for the source element based on the determined impedance.

Abstract: A ventilator is configured to supply a gas mixture to the lungs of a subject. The gas mixture comprises a first gas (e.g. oxygen) and a second gas (e.g. ambient air). The ventilator comprise a first gas inlet, a second gas inlet, flow modulator of the first gas, a flow modulator of the second gas, a junction configured to mix the first gas and the second gas, a patient interface configured to deliver the gas mixture to a subject, a pressure sensor, a plurality of flow sensors comprising at least a first flow sensor and a second flow sensor, and at least one controller configured for obtaining data from the pressure sensor and flow sensors and controlling the flow modulators to provide a gas mixture having a target pressure and a target oxygen content.

Abstract: Devices, systems, and methods for providing patient wear compliance information are provided. For example, a medical device includes a plurality of electrodes configured to be continuously coupled externally to a patient and to monitor electrical activity on the skin of the patient. The system also includes at least one motion sensor configured to generate a motion signal based upon movement of the patient. The system further includes a processor configured to receive an electrical signal based on the monitored electrical activity, record a wear onset event based on the electrical signal and the motion signal, record a wear offset event based on one or more of the electrical signal and the motion signal indicating that the patient is not wearing the medical device, and output a graphical representation including information regarding the patient's wear compliance based on the recorded wear onset event and the recorded wear offset event.

Abstract: A system includes a first computing device comprising a processor coupled to a memory. The processor and the memory are configured to receive at least one of (i) information indicative of treatment of a victim by a first caregiver using the first computing device and (ii) information indicative of a health status of the victim; determine that treatment of the victim by the first caregiver using the first computing device is completed; and transmit the received information to a second computing device.

Abstract: A remote monitoring device and related systems and methods for monitoring and managing by a monitoring service via a communications network a condition of an Automated External Defibrillator (AED) based on audio signals from the AED The remote monitoring device includes a housing configured to be positioned outside of the AED such that audio sounds from the AED can be detected. The housing contains at least one processor, a communications module, a first audio sensor, a first audio detection circuitry, a second audio sensor, and a second audio detection circuitry. The communications module is operably connected to the at least one processor and configured to transmit electronic communications to the monitoring service via the communications network. The at least one processor is configured to power on in response to the wakeup notification signal, process digital audio signals, and transmit a signal to the monitoring service to report a condition of the AED.

Abstract: A non-invasive bodily-attached ambulatory medical monitoring and treatment device with pacing is provided. The noninvasive ambulatory pacing device includes a battery, at least one therapy electrode coupled to the battery, a memory storing information indicative of a patient's cardiac activity, and at least one processor coupled to the memory and the at least one therapy electrode. The at least one processor is configured to identify a cardiac arrhythmia within the information and execute at least one pacing routine to treat the identified cardiac arrhythmia.