Abstract: A cardiac monitoring and treatment system includes a controller, a first wearable portion, and a second wearable portion separate from the first wearable portion. The first wearable portion includes an elongated strap configured to encircle a thoracic region of a patient, a plurality of ECG sensing electrodes disposed about the elongated strap, one or more receiving ports configured to receive one or more additional components including a treatment electrode and/or an additional sensor, and a plurality of conductive wires configured to couple the plurality of ECG sensing electrodes and the one or more receiving ports with the controller. The second wearable portion is configured to be worn over at least one shoulder of the patient and includes a wearable substrate, one or more treatment electrodes disposed on the wearable substrate, and at least one conductive wire configured to releasably connect the one or more treatment electrodes to the controller.

Abstract: Apparatuses and methods are provided for automatically determining which type of resuscitation treatment is most appropriate for a patient. Methods are provided that include the following. One or more time domain signal measurements are transformed into frequency domain data representative of a frequency content of the one or more time domain signal measurements. The frequency domain data is processed to identify peaks. For each of the peaks, for each of multiple points in time, multiple parameters of the peak are determined. Based on the multiple parameters of the peaks for each of the multiple points in time, a trajectory is determined. The determined trajectory is analyzed in determining a recommended type of resuscitation treatment. An output indication is provided of the recommended type of resuscitation treatment.

Abstract: A medical device that includes a power source, a therapy delivery interface, therapy electrodes, electrocardiogram (ECG) sensing electrodes to sense ECG signal of a heart of a patient, a sensor interface to receive and digitize the ECG signal, and a processor. The processor is configured to analyze the ECG signal to determine a cardiac rhythm and a transform value representing a magnitude of a frequency component of the cardiac rhythm, analyze the cardiac rhythm and the transform value to detect a shockable cardiac arrhythmia by classifying the cardiac rhythm as a noise rhythm or a shockable cardiac arrhythmia rhythm based on the transform value, and causing the processor to detect the cardiac arrhythmia if classifying the cardiac rhythm as a shockable cardiac arrhythmia rhythm, initiate a treatment alarm sequence, adjust the shock delivery parameter for a defibrillation shock, and provide the defibrillation shock via the therapy electrodes.

Abstract: A system including an ambulatory medical treatment device is provided. The ambulatory medical treatment device includes a memory, a treatment component configured to treat a patient, at least one processor coupled to the memory and the treatment component, a user interface component, and a system interface component. The user interface component is configured to receive an update session request and to generate the update session identifier responsive to receiving the request. The system interface component is configured to receive an encoded request including an identifier of an update session and device update information, to decode the encoded request to generate a decoded request including the device update information and the identifier of the update session, to validate the decoded request by determining that the update session identifier matches the identifier of the update session, and to apply the device update information to the ambulatory medical treatment device.

Abstract: A wearable medical device comprises a harness, a therapy electrode and an electrocardiogram (ECG) sensing electrode included within the harness, an audio transducer coupled to the therapy electrode or to the ECG electrode and configured to monitor heart sounds of a user of the wearable therapeutic device, and a controller configured to receive signals from the audio transducer regarding the heart sounds of the user and to transmit data regarding the heart sounds to an external system for processing and analysis.

Abstract: An optical detection system capable of providing auxiliary light source projection including an optical detection apparatus and an optical module is disclosed. The optical module and the optical detection apparatus are combined with each other in a specific combination type. The specific combination type can be a direct integration type, a bending type, a foldable type, a low height type or an attachable type. The optical module is used to provide additional auxiliary light source projection to improve a condition for testee to gaze and observe a pattern. The optical module includes a light source, a lens set and a reflecting mirror. The light source can be designed as different types of multiple light sources, such as an opposite-direction type multiple light sources or a ring type multiple light sources, to provide a uniform light source.

Abstract: The present disclosure is directed toward an electrosurgical apparatus including an electrosurgical generator that may be coupled to an electrosurgical applicator. In one aspect of the present disclosure, a controller of the electrosurgical generator is configured to execute a dynamic leakage current compensation algorithm or function to compensate for the leakage current of an electrosurgical applicator and accompanying cable coupling the electrosurgical applicator to electrosurgical generator. In another aspect of the present disclosure, the controller of the electrosurgical generator is configured to execute a dynamic radio frequency modulation algorithm or function to dynamically control the crest factor of the output waveform of the electrosurgical generator based on the measured impedance across an active and return terminal of the electrosurgical generator.

Abstract: The present invention provides methods for removing a significant amount of bacteria (e.g., gram-negative bacteria and gram-positive bacteria, including bacteria with no or low affinity for heparan sulfate) from whole blood, serum or plasma using an adsorption media. The method can be used in extracorporeal treatments involving high volumetric flow rates and high linear flow rates.

Abstract: A system for configuring an ambulatory medical device includes an ambulatory medical device configured to monitor at least one electrocardiogram signal received from a patient for an occurrence of one or more cardiac events. The system also includes a remote computing device configured to receive a set of threshold values related to operation of the ambulatory medical device. The threshold values identify one or more conditions indicative of an occurrence of one or more cardiac events. The remote computing device is configured to query a master lookup table to determine a lookup code associated with the received set of threshold values, establish a communication link with the ambulatory medical device, receive an activation notification indicating that the ambulatory medical device has been activated, and encode a key. The encoded key includes the lookup code. The remote computing device is configured to transmit the encoded key to the ambulatory medical device.

Abstract: The invention relates to a method of removing immune suppression in a tumor microenvironment or stimulating an immune system against cancer cells, comprising administering to a subject a combination of a HDAC inhibitor and an NSAID in combination with an immune checkpoint inhibitor.

Abstract: A medical device including a probe configured to be orally inserted into a lumen extending into the thorax of the subject, a plurality of electrodes, and a control circuit. The probe includes a first electrode. The plurality of electrodes includes at least one second electrode and at least one third electrode configured to be disposed externally on the thorax of the subject on a first side of a sternum of the subject and a second side of the sternum of the subject, respectively, the second side opposite the first side. The control circuit is electrically coupled to the first electrode and the at least one second and third electrodes and configured to measure an impedance between the first electrode and each of the at least one second and third electrodes and determine a ratio of arterial blood volume relative to venous blood volume based upon the measured impedance.

Abstract: A system for providing a visual summary of a condition of a patient when traumatic brain injury (TBI) is suspected or diagnosed includes at least one patient condition sensor configured to sense data representative of a patient condition parameter of interest for a TBI patient; at least one airflow sensor configured to sense data representative of ventilations provided to the patient; at least one visual display for providing the visual summary to a user; and at least one controller. The at least one controller is configured to cause the visual display to provide the visual summary. The visual summary can include at least one visual representation of at least one patient condition parameter for each time interval of a plurality of time intervals, at least one visual representation of ventilation information, and a visual indication of when at least one patient condition parameter is outside of a target range.

Abstract: A cochlear implant and analysis system includes a stimulator, an input source, a signal processor, a wireless communication interface, and an external device. The system can receive an acoustic stimulus, generate an input signal representative thereof, and apply a transfer function to the input signal to generate and output a stimulation signal to the stimulator. The signal processor can receive an analysis input indicating a first signal for analysis and generate an analysis signal based on the received analysis input. The first signal can be an input signal from an input source or a result of one or more processing steps. The signal processor can output the analysis signal to the wireless communication interface with the wireless communication interface configured to output a signal representative of the analysis signal to an external device.

Abstract: Apparatus for automatic delivery of chest compressions and ventilation to a patient. The apparatus includes a chest compressing device configured to deliver compression phases during which pressure is applied to compress the chest and decompression phases during which approximately zero pressure is applied to the chest a ventilator configured to deliver positive, negative, or approximately zero pressure to the airway; control circuitry and processor, wherein the circuitry and processor are configured to cause the chest compressing device to repeatedly deliver a set containing a plurality of systolic flow cycles, each systolic flow cycle including a systolic decompression phase and a systolic compression phase, and at least one diastolic flow cycle interspersed between sets of systolic flow cycles, each diastolic flow cycle including a diastolic decompression phase and a diastolic compression phase, wherein the diastolic decompression phase is substantially longer than the systolic decompression phase.

Abstract: A computing device includes a memory configured to store instructions. The computing device also includes a processor to execute the instructions to perform operations that include providing an alternating electrical signal to a patient through at least a pair of electrodes, and determining transthoracic impedance of the patient from a measurement associated with the applied alternating electrical signal. Operations also include identifying, from the transthoracic impedance, a sequence of resistance values for controlling the discharge of a charge storage device located external to the patient, and controlling the discharge of the charge storage device using the identified sequence of resistance values.

Abstract: In one aspect, a system for automatically processing a medical claim includes a billing automation platform, a navigation device with a global positioning system for collecting patient transport information including a location of a medical encounter, and a computing device for receiving the patient transport information and patient charting information and transmitting the information for use by the billing automation platform. The billing automation platform may access fee schedule(s) based on a location of the medical encounter, automatically populate the medical claim based on the patient charting information, the patient transport information, and the fee schedule(s), and automatically route the medical claim through workflow paths of a claim processing workflow.

Abstract: A wearable medical device is provided for monitoring a cardiac condition of a patient, where the device is releasably mounted to the patient's chest and includes at least two skin-facing electrodes forming a first one or more ECG leads for ongoing monitoring of heart functioning and at least one touch electrode for intermittently obtaining additional circuit vectors for deriving additional metrics regarding the functioning of the patient's heart. Each touch electrode is configured to form an additional lead/vector that is a larger vector and/or separated by at least 15° from a corresponding first lead/vector formed from the first one or more ECG leads in a vector cardiogram representation of the first one or more ECG leads and the additional lead/vector.

Abstract: Data samples derived from raw physiological data captured by sensors of a wearable medical device monitoring a patient's heart, such as a first ECG channel data sample, a second ECG channel data sample, and/or a cardio-vibrational data sample, are applied to a multi-tier machine learning engine to determine a cardiac condition measure traditionally calculated based upon information typically derived in a laboratory or clinical setting. A first tier of the multi-tier machine learning engine may analyze the physiological data sample(s) using first machine learning classifier(s) to obtain a first result. The first result may then be applied to second machine learning classifier(s) of a second tier of the machine learning engine, along with physiological metrics and/or patient clinical information, to determine the cardiac condition measure.

Abstract: Guidewires having conductive elements are described where in one variation, the guidewire may be formed by disposing an insulative layer upon a surface of the guidewire core, and printing one or more conductive traces directly upon a surface of the insulative layer.

Abstract: A wearable defibrillator for use in monitoring patient movement and cardiac activity and treating a patient includes a garment configured to be worn by the patient, treatment electrodes configured to apply an electric current to the patient, and an alarm module configured to provide audio, visual, and haptic notifications. The notifications are configured to indicate that an electric current will be administered imminently and prompt the patient to provide a response input. The wearable defibrillator includes a motion sensor configured to detect motion and body position of a patient, and a controller in electrical communication with the alarm module and the motion sensor. The controller is configured to monitor for the response input after the prompt, determine, based on the detected motion and body position, whether the patient is sleeping, and cause a change in one or more characteristics of the prompt on determining that the patient is sleeping.