Abstract: The present disclosure provides a medical connector for enteral applications. The medical connector includes a body portion having a distal patient access fitting and a proximal fluid delivery device fitting as well as an administration port. The administration port for administrating or extracting fluids or medicine includes a cylindrical cavity, an administration port seal having a normally-closed slit, a plunger, a plunger sleeve, and a compression member. Engaging a non-luer female tip with the administration port actuates the compression member such that the plunger pierces the normally-closed slit, causing it to open allowing fluid communication with the body portion.

Abstract: This invention provides methods for the processing of platinum metallized high temperature co-fired ceramic (HTCC) components with minimum deleterious reactions between platinum and the glass constituents of the ceramic-glass body. The process comprises co-firing a multilayer laminate green ceramic-glass body with via structures filled with a platinum powder-based material in a reducing atmosphere with a specified level of oxygen partial pressure. The oxygen partial pressure should be maintained above a minimum threshold value for a given temperature level.

Abstract: A garment or accessory is provided having an elasticized portion, said elasticized portion being free of stitches or holes. The elasticized portion comprises a fabric portion of the accessory or garment to be elasticized; and a length of elastic element. The length of elastic element is applied to the fabric by a means selected from the group consisting of direct welding and indirect welding. A method is provided for elasticizing a fabric, said elasticized fabric being free of stitches or holes. The method involves providing a stack of fabric to be elasticized; stretching and positioning a length of elastic element against a first of the fabric in the stack; applying one or more ends of the elastic element to the fabric by a means selected from directly welding and indirectly welding; moving the first fabric to expose the next fabric in the stack to be elasticized; and repeating the steps for the next fabric.

Abstract: A pre-filled pharmaceutical package comprising a liquid formulation of a VEGF-antagonist, for example Ranibizumab, in a pre-filled pharmaceutical package, for example a syringe, cartridge, or vial, made in part or in whole of a thermoplastic polymer, coated on the interior with a tie coating or layer, a barrier coating or layer, a pH protective coating or layer, and optionally a lubricity coating or layer. Stability performance of the VEGF-antagonist packaged in the coated COP vessel comparable to or better than glass was obtained.

Abstract: Disclosed are plunger assemblies including various convertible plungers and methods of making the same. Each plunger assembly is configured for disposition within a barrel of a medical container, e.g., a syringe, and displaced within the barrel from an engagement position to a release position. The engagement position is configured to provide a compression seal between a storage sealing section of the plunger and an inner wall of the syringe barrel. In the release position, the compression seal is reduced or eliminated. Also disclosed are methods for making convertible plungers and assembling them into syringes, e.g., pre-filled syringes.

Abstract: An article or vessel is described including a vessel surface and a coating set comprising at least one tie coating, at least one barrier coating, and at least one pH protective coating. For example, the coating set can comprise a tie coating, a barrier coating, a pH protective coating and a second barrier coating; and in the presence of a fluid composition, the fluid contacting surface is the barrier coating or layer. The respective coatings can be applied by PECVD of a polysiloxane precursor. Such vessels can have a coated interior portion containing a fluid with a pH of 4 to 8. The barrier coating prevents oxygen from penetrating into the thermoplastic vessel, and the tie coating and pH protective coating together protect the barrier layer from the contents of the vessel. The second barrier coating is comparable to glass surface if needed.

Abstract: A support system for positioning a patient in lateral position during surgery procedures with a removable, adjustable support pad assembly, comprising a first support unit arranged for attachment to side rail on a lateral edge of an operating table, and a second support unit comprising an arm connected movably by the using of a movable connection with a pad plate adapted to position a support pad connected by a biasing connector to a support plate with degrees of freedom of angular rotational movement of the support pad in relation to the patient. The biasing connector comprises a channel formed between a base plate support segment and a projection clamping the pad plate apart from the support plate to allow flow of air and/or fluids from the support pad.

Abstract: In the field of radioimmunoguided surgical system instrumentation there is described and claimed a hand-held probe with a disposable power source as well as a visually perceptible indicator of detected counts of radiation. Also disclosed is a system comprising the hand-held probe and an instrumentation console. The handle includes a probe link that transmits a message containing gamma data relating to the low-level electrical signal. The instrumentation console may include a housing, a console link to receive the message transmitted by the probe link, a receiver electrically coupled to the console link to convert the message to corresponding electrical display signals, and a visually perceivable display electrically coupled to the receiver to convert the electrical display signals to a visually perceivable display relating to the amount of radiation detected.

Abstract: A biopsy device includes a body, a needle, a cutter, an analysis area, a valve, and a tissue sample holder. The cutter is movable relative to the needle and in communication with the needle for transporting tissue samples. The analysis area is disposed proximally of the cutter and in communication with the needle to receive a tissue sample cut by the cutter for analysis by a user. The valve is disposed proximally of the analysis area and configured to alternate between an open configuration and a closed configuration. The tissue sample holder is disposed proximally of the valve and fixedly attached to the body. The valve is configured to permit analysis of the sample disposed in the analysis area when the valve is in the closed configuration and to permit the tissue sample to be passed into the tissue sample holder when the valve is in the open configuration configuration.

Abstract: A biopsy device includes a cutter defining a cutter lumen and a tissue sample holder for collecting tissue samples. In one example, the tissue sample holder includes a rotatable manifold, and has a plurality of chambers that are each configured to separately hold tissue samples. A tissue sample holder rotation mechanism is operable to rotate the manifold to successively align each of the chambers with the cutter lumen. A controller in communication with the rotation mechanism is configured to rotate the manifold to a presentation position to present a collected tissue sample within a chamber to a user (e.g., at an angular position approximately 90 degrees from the cutter lumen). The controller is further configured to rotate the manifold align the next, empty chamber with the cutter lumen in response to a user input instructing the biopsy device to obtain another tissue sample.

Abstract: The present invention is an improved system for use of eye tracking including spatial mapping percepts in a visual prosthesis by presenting an electrically induced precept through a visual prosthesis, requesting a subject look to the direction of the percept and tracking their eye movement. Eye movement is both faster and more accurate than asking a visual prosthesis user to point to the location of a percept. This method can be beneficial in a retinal prosthesis, but is particularly useful in a cortical visual prosthesis where visual cortex does not match the retinotopic map. Methods are presented for calibrating an eye tracker. Eye tracking hardware may also be used for blanking video information base on the subject's natural blink reflex.

Abstract: A process is provided for making a walled structure using an injection molding apparatus. The apparatus has a molding space formed between a mold cavity and an inner core disposed within the mold cavity. The molding space defines a shape of the structure. The process includes injecting molding material into the molding space, moving or retaining a portion of a movable impression member protruding from the inner core within a portion of the molding space so as to create a recess within an inner wall of the structure, and retracting the impression member into the inner core such that the impression member is cleared from the molding space. Precision control in forming the impression member is provided by a closed-loop configuration using a sensor that measures a molding space parameter (e.g., temperature), optionally in combination with a servo drive for activating the impression member.

Abstract: The present inventive subject matter describes a device and system for positioning, adjusting, and stretching a patient's extremity for surgical procedures where alignment is critical and minute adjustments may be required repeatedly. The device helps in maintaining the patient's extremity stationary, once the physician has selected the precise position for the elected procedure. The device uses using a combination of an articulating and a rotating frame, support plates and support rings that are attached to the extremity surgical positioning system. The system acts as a limb splint that is firmly attached to the surgical table. The support plates are attached to the patient via a series of adjustable straps preventing the extremity from moving independently of the support plate. A locking rack and gear configuration has adjustable locking pivot points that are positioned along and within the outer/inner proximal tube and outer/inner distal tube that lengthens or rotates various portions of the extremity.

Abstract: A marker delivery device comprises a marker deployer cannula, a push rod, a biopsy site marker, and a ramped tip. The marker deployer cannula may have a marker exit in communication with an interior lumen of the cannula. The marker exit may comprise a distal end with a ramped surface. The biopsy site marker may be configured with a plurality of edges. The plurality of edges may be configured to engage at least a portion of the interior lumen of the cannula. The ramped tip may comprise a first ramped surface and a second ramped surface, the second ramped surface may align with the ramped surface of the distal end of the marker exit. The push rod may be used to push the biopsy site marker up the ramped tip and through the marker exit.

Abstract: A biopsy device including a body, a needle, a cutter, and a tissue sample holder. The needle extends distally from the body. The cutter is longitudinally translatable relative to the needle and defines a cutter lumen. The tissue sample holder includes an outer cup or cover, a rotatable member, a tissue receiving tray, and a bulk cup assembly. The rotatable member defines a plurality of passages and a first cylindrical portion. Each strip of the plurality of strips are insertable into a corresponding passage of the plurality of passages. The bulk cup assembly is insertable into the first cylindrical portion of the rotatable member.