Abstract: A device for temporarily protecting a neck of an aneurysm of a blood vessel is provided. The device includes a plurality of wires coiled to form a collapsible frame configured to expand and substantially conform to a shape of an inside surface of the blood vessel while the aneurysm is being treated. The device includes a retention wire disposed at a proximal end of the frame of the plurality of wires. The device includes a cover comprising at least a first portion configured to be disposed directly against a neck of the aneurysm while the aneurysm is being treated, the first portion having a first porosity to blood flow. Related methods of use and manufacturing are also provided.

Abstract: A valve leaflet obstruction repair clip and a repair system thereof include a clamping component and a flow obstruction component. The clamping component and the flow obstruction component are assembled and clamped to fix the incomplete closure between the valve leaflets. The upper clamping arm and the lower clamping arm are engaged together in a natural state, and the upper clamping arm undergoes unilateral movement in an extended state. The present application enables edge-to-edge repair of the valve leaflets and adopts unilateral clamping, effectively preventing the problem of valve leaflet stenosis caused by the implantation of the repair device.

Abstract: A bendable sheath and a delivery system using the bendable sheath. The bendable sheath comprises a tube body (3). The tube body (3) comprises a distal end and a proximal end. A tube wall of the tube body (3) is connected to a pull wire (8). One end of the pull wire (8) extends towards the proximal end of the tube body (3), and the other end is connected to the tube body (3) near the distal end of the tube body (3). The pull wire (8) comprises at least a section thereof disposed freely outside the tube body (3) and near the distal end of the tube body (3). The pull wire (8) in the bendable sheath comprises the section disposed freely outside the sheath tube body (3) and, when pulled, the section is disposed so as to facilitate the application of force. The section moves relative to the tube body (3), such that a force application point is adaptively changed.

Abstract: A sheath for loading and retrieving a prosthetic implant is disclosed, which includes a tube. The tube has opposing distal and proximal ends in its axial direction, and the distal end has a plurality of support rods arranged at intervals in a circumferential direction of the tube and having relative converged and flared configurations. A plurality of connecting strips are provided in the axial direction between two adjacent support rods, and each connecting strip is folded back and forth in the converged configuration and tends to be straightened in the flared configuration relative to the converged configuration. The straightened lengths of the connecting strips increase sequentially from the proximal end to the distal end, and two ends of each connecting strip are connected to the support rods on the corresponding sides and the connecting portions have the same axial level.

Abstract: The present invention provides a probe device comprising an inner cutting probe and an outer cutting probe. wherein the outer cutting probe has a first side cutting and sucking port in communication with a sliding channel thereof, and the inner probe is slidable within the sliding channel of the outer cutting probe and shaped to have a first end blade edge, a second side port with a second side blade edge and a third side blade edge opposite to the second side blade edge in a cross-sectional view thereof. When the inner cutting probe is slidable within the sliding channel of the outer cutting probe in the forward and backward direction of one cutting cycle, three cuttings are achieved in the forward and backward direction of one cutting cycle, thereby improving the cutting efficiency of the operation.

Abstract: M Disclosed is a valve clamp for preventing leaflet injury, a valve clamping system, and a method for repairing a valve. The valve clamp for preventing leaflet injury comprises a fixed base and a pair of clamp arms that are openably and closeably disposed on opposite sides of the fixed base, wherein each of the clamp arms has a connection end connected to the fixed base, a free end opposite to the connection end, and a gripping section between the connection end and the free end, the gripping section is at least partially recessed inwardly to form a capture zone, and the capture zone extends toward the free end and then extends toward a direction away from the capture zone of the other clamp arm to form a first flanging section.

Abstract: A stent device with skirt folds and a processing method thereof, a skirt folding method, and a heart valve. The stent device comprises a stent (1, 105) and a flexible skirt (2, 107), the skirt (2, 107) having an expanded state, in which the skirt is axially extended and surrounds the stent (1, 105) before release thereof, and a folded state, in which the skirt is driven by the deformation caused when the stent (1, 105) is released, collapses and folds axially along the released stent (1, 105) so as to form an annular peripheral leakage-blocking portion. The peripheral leakage prevention technology enables an interventional stent to fit to the inner wall of a vessel more snugly, such that the stent does not easily move and is more stable, thereby being suitable for more people, reducing additional risks of surgery and preventing complications such as peripheral leakage and thrombus.

Abstract: A sheath facilitating retraction of prosthetic implant is provided. The sheath includes a tubular body, and the distal end of the body is connected with an expandable section. The expandable section has relative converged configuration and flared configuration and includes a primary expandable area and a secondary expandable area. The primary expandable area includes a plurality of first expandable pieces arranged at intervals in a circumferential direction of the body. The secondary expandable area includes a plurality of second expandable pieces arranged at intervals in the circumferential direction of the body, and all the second expandable pieces include two alternating groups consisting of a first group formed by further extending the first expandable pieces to the distal end and a second group formed by connecting strips wound between two adjacent first expandable pieces.

Abstract: The present invention discloses a dry biological tissue material and a method of preparing the material.

Abstract: A method for depositing a coating comprising a polymer and pharmaceutical agent on a substrate, comprising the following steps: discharging at least one pharmaceutical agent in a therapeutically desirable morphology in dry powder form through a first orifice; discharging at least one polymer in dry powder form through a second orifice; depositing the polymer and/or pharmaceutical particles onto said substrate, wherein an electrical potential is maintained between the substrate and the pharmaceutical and/or polymer particles, thereby forming said coating; and sintering said coating under conditions that do not substantially modify the morphology of said pharmaceutical agent.

Abstract: An implant delivery tube fitting (12) and an implant delivery system. The implant delivery tube fitting (12) is used for loading and delivering an implant, and the implant delivery tube fitting (12) comprises, sequentially from a proximal end to a distal end, an outer tube (122) and a capsule (121). The inner lumen of the capsule (121) is adapted to receive an implant, and the capsule (121) is provided at the distal end of the outer tube (122). The capsule (121) has a telescopic structure, and the outer tube (122) can drive the capsule (121) to make a telescopic movement so that the capsule (121) is lengthened or shortened.

Abstract: An expandable sheath for transcatheter delivery system is disclosed, including a tube having opposing distal and proximal ends in its axial direction. The distal end is provided with a plurality of support rods arranged at intervals in a circumferential direction of the tube, and the support rods extending axially and having relative converged and flared configurations. More than two connecting strips are provided in the axial direction between two adjacent support rods. The connecting strip extends in a curved path and undulates in the circumferential direction, and undulation degrees of the connecting strips increase sequentially from the proximal end to the distal end. The connecting strip has a first connecting portion and a second connecting portion respectively connected with two adjacent support rods in the circumferential direction, and the first connecting portion and the second connecting portion are located at different axial levels of the tube.

Abstract: The present invention provides a guidewire adjuster and a delivery-system control handle provided with the guidewire adjuster. The guidewire adjuster includes a support mechanism which has a lumen for a guidewire to extend therethrough; and a driving mechanism for driving the guidewire to move back and forth in the lumen. The guidewire adjuster is able to drive the guidewire to move with respect to a sheath of the delivery system. The support mechanism is connected to the control handle of the delivery system and forms a lumen for accommodating the guidewire. A proximal end of the sheath together with the stent can be driven to move upwardly, due to the relative movement between the guidewire and the sheath of the delivery system. Therefore, the position of the stent can be adjusted by advancing the guidewire forward when the stent has been deployed at a lower position than expected.

Abstract: Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on the substrate, wherein the coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within the coating and on the substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of the medical device in the body of the subject a portion of the pharmaceutical agent and/or active biological agent is delivered at the intervention site along with at least a portion of the polymer and/or a at least a portion of the pharmaceutical carrying agents.

Abstract: A control handle for a steerable catheter. A housing with a hollow interior region has a rotatable lever mechanism. Features are formed in the housing and on the lever mechanism for routing and affixing the catheter guidewire and to provide tension on the guidewire in a push/pull operation.

Abstract: The present application discloses an implant loading apparatus comprising a guider and a guide base. The guider is sleeved on the exterior of the guide base. The guide base comprises a guide column, a connecting section, and a base connected in the axial direction. Fixing sections are provided on either end of the connecting section. The guide base is removably connected to the guider via the fixing sections. The guide base is provided with the two fixing sections that fit the guider to implement twice removable fixing, thus favoring a coaxial operation. A valve stent is neither twisted nor tilted during a compression process, thus increasing loading efficiency, greatly reducing the operation difficulty of a surgery, and allowing the implementation of a single person operation.

Abstract: A bicycle-mountable carrier assembly includes a mounting assembly attachable to a rail of the bicycle's saddle. At least one payload support is joined, e.g., pivotably, to the mounting assembly. The payload support defines a structure for mounting at least one payload carrier attachment in a secure but removable fashion. One or more payload supports may be provided, and one or more mounting structures may be provided on each payload support. The mounting structures may be provided in a rear-and side-facing positions and in different angular orientations, for carrying of payloads in a variety of different positions and orientations. The carrier further includes at least one payload carrier attachment defining a mounting structure complementary to the payload support's mounting structure. The payload carrier may be adapted to function as a fishing rod holder, a fishing rod case holder, a water bottle, a fishing tackle box, or another payload as desired.

Abstract: Electronic apparatus (100) for delivering Coherent Sine Burst Irreversible Electroporation energy to a biological tissue (1) comprises at least one electrode (3) positionable on or near the biological tissue (1), a power generator (2) for supplying electric energy to the electrode (3), and to generate a respective electric signal (S) to energize the electrode (3). The electric signal (S) is formed by alternating over time a first electric signal (S1) with a second electric signal (S2), with each first electric signal (S1) being the same. The first electric signal (S1) is supplied to electrode (3) during a first time interval (T1) and the second electric signal (S2) is supplied to electrode (3) during a second time interval (T2), subsequent to the first time interval (T1). The first electric signal (S1) is a continuous bipolar signal which comprises two or more basic sine waves (SB) in the first time interval (T1).