Abstract: Disclosed are a sheath adjustable in multiple directions and a transcatheter interventional system. The sheath that can be adjusted in multiple directions includes: a body section, a bending section, connected with the distal end of the body section, the bending section is a multi-layer composite tube body and includes a plurality of segments, the middle layer of the multi-layer composite tube body is a woven mesh, and the density of the woven mesh of the plurality of segments is gradually reduced in the direction from the proximal end to the distal end; and at least a pair of traction mechanisms, each pair of the traction mechanism respectively passes through the bending section and the body section, to adjust the bending angle of the bending section to different directions.

Abstract: The present invention provides a catheter apparatus with a carrier comprising right-handed wire helixes and left-handed wire helixes that are plainly or bi-axially woven into a tubular structure. A therapeutic assembly wraps around one of the wire helixes to stabilize an associated interstice of the tubular structure. The regular shape of the carrier may be quickly recovered after the carrier is seriously bent or distorted in an intravascular treatment.

Abstract: The present invention provides a system and method for retaining, positioning and releasing a prosthetic heart valve. The system includes a valve holder, and a control handle. The valve holder includes a connection base and at least one holding arm. The holding arms are distributed around a periphery of the connection base, with the holding arms having positioning structures at the distal side thereof for engaging with an outflow side of the prosthetic heart valve. The control handle is coupled to the valve holder for controlling the valve holder.

Abstract: Provided herein is a method of treating, preventing, or alleviating one or more symptoms of Chagas disease in a subject, comprising administering to the subject: (i) ascorbic acid, or a single enantiomer, a mixture of enantiomers, or a mixture of diastereomers thereof; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; (ii) a quinone compound, or a single enantiomer, a mixture of enantiomers, or a mixture of diastereomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof; and (iii) an antiparasitic agent.

Abstract: Disclosed are a valve clamping device with an adjustable bearing force and a valve clamping system. The valve clamping device with an adjustable bearing force comprises: a support portion comprising a connecting end and a free end disposed oppositely; a hollow adjustment portion made of a shape memory material, one end of which is sleeved outside the connecting end and connected to the support portion, and another end of which hangs in air; a clamping portion enclosed outside the adjustment portion; and a driving portion connected to the clamping portion to drive the clamping portion to open or close around the adjustment portion; wherein the free end of the support portion is within the adjustment portion, and a proximal end of the adjustment portion is spaced apart from a proximal end of the support portion.

Abstract: The present invention discloses a core assembly, a sheath assembly, a sheath, a sheath processing method and an interventional instrument delivery system and method. A core assembly for delivering an interventional instrument according to the present invention comprises a core tube, a locking member fixed at a distal end of the core tube for connecting the interventional instrument, and a bendable adjustable tube mounted around an outer periphery of the core tube, wherein the distal ends of the bendable adjustable tube and the core tube are fixedly connected to each other, and the proximal ends can slide relative to each other.

Abstract: A lead assembly and associated process include a lead and an integrated feature that facilitates extraction of the lead from the associated body passage. The integrated feature in one embodiment is a sheath received between the associated body passage and received over the lead. The sheath has a first portion extending from adjacent the proximal end to adjacent the distal end of the lead, where the first portion has an inner surface facing with the lead outer surface and the first portion having an outer surface facing radially outward from the lead outer surface. A second portion of the sheath extends from adjacent the distal end to adjacent the proximal end of the lead. The second portion has an inner surface received over the outer surface of the first portion, and the second portion further having an outer surface abutting an inner surface of the associated body passage that receives the lead therein. The integrated feature is alternatively a wire, band, or spoke assembly.

Abstract: The present invention relates to products and methods for modulating cardiac function.

Abstract: An extraocular muscle clip (22) for correcting strabismus includes upper and lower plates (24, 26) which are couplable together to sandwich and grasp extraocular muscle (42). A delivery tool (50) delivers the clip (22) and includes a shaft (52) and a muscle hook (56) that is slidable underneath the extraocular muscle (42) to position the lower plate (26) of the clip (22) underneath the muscle (42). An integrated blade (60) of the tool (50) cuts the extraocular muscle (42) subsequently to grasping of the muscle (42) by the upper and lower plates (24, 26) of the clip (22). One or more sutures (30) are coupled to the upper plate (24) and/or the lower plate (26) of the clip (22) and facilitate recoupling of the extraocular muscle (42) to a globe of the eye (40) following cutting of the extraocular muscle (42). Other embodiments are also described.

Abstract: A method for depositing a coating comprising a polymer and at least two pharmaceutical agents on a substrate, comprising the following steps: providing a stent framework; depositing on said stent framework a first layer comprising a first pharmaceutical agent; depositing a second layer comprising a second pharmaceutical agent; Wherein said first and second pharmaceutical agents are selected from two different classes of pharmaceutical agents.

Abstract: An ocular clip implant (22) used for securing an intraocular lens (IOL) (62) in an eye of a patient is provided which includes an IOL-engaging portion (26) disposed at a first end of the ocular clip implant (22). The IOL-engaging portion (26) is configured to grasp a portion of the IOL (62). An ocular-wall-engaging portion (28) is integrated with and disposed at a second end of the ocular clip implant (22). The ocular-wall-engaging portion (28) includes an anchor (29) transitionable from a first, straightened configuration to a second, non-straightened configuration to anchor the ocular clip implant (22) to a wall of the eye in order to secure the IOL (62) to the eye. Other embodiments are also described.

Abstract: Disclosed are an endoscope handle and a driving apparatus. The driving apparatus includes a motor module, the motor module being provided with a protruding motor shaft; a starting sliding block connected to the motor shaft and capable of being driven by the motor shaft to move along a straight line, the starting sliding block being provided with a first coupling portion, and the first coupling portion being in coupling contact with a follow-up sliding block externally disposed so as to drive, by the follow-up sliding block, a bending control wire of an endoscope to be tightened and released; a force sensor disposed on the motor module and configured to measure a tensile force borne by the bending control wire and generate a stress signal; and a controller communicatively connected to the motor module and the force sensor and configured to adjust the output of the motor module.

Abstract: A leaflet positioning and fixing clip and a narrow-environment orientation system thereof are provided. The clip includes a fixing element, a lower gripping arm assembly sleeved outside the fixing element, an upper gripping arm assembly sleeved outside the lower gripping arm assembly, a pull rope controlling the upper gripping arm assembly to move, and an occlusive film attached below the lower gripping arm assembly. The upper gripping arm assembly includes an upper central fixing plate and upper gripping arms radially distributed around the upper central fixing plate. The lower gripping arm assembly includes a lower central fixing plate and lower gripping arms. There are at least two upper gripping arms mated with at least two lower gripping arms to form grippers for gripping a tricuspid valve. The occlusive film is stably positioned in a center of the tricuspid valve through the grippers.

Abstract: An artificial chordae tendineae implantation system, including a clamping device, puncture device, a pushing device, and a clamp assistance device. The pushing device includes a pushing catheter. The puncture device and the clamping device respectively are movably insertedly mounted within the pushing catheter. An artificial chordae tendineae is accommodated in the clamping device. The clamp assistance device includes a clamp assistance arm movably insertedly mounted within the pushing catheter and a clamp assistance member provided at the distal end of the clamp assistance arm. The clamp assistant member is made of a flexible and/or soft material. The clamp assistance member and the clamp assistance arm are accommodated together in the pushing catheter. The clamp assistance arm pushes the clamp assistance member to pass out from the distal end of the pushing catheter or the distal end of the clamping device.

Abstract: A medical system comprises an operation table, a magnetic navigation apparatus, a medical image apparatus, and an optical positioning apparatus. The magnetic navigation apparatus is configured to navigate a positioning medical tool to a lesion region on the medical path. The optical positioning apparatus comprises an imaging module and at least three first markers provided on the medical image apparatus. The optical positioning apparatus is configured to acquire the position of the medical image apparatus relative to the imaging module. The medical image apparatus is configured to move according to the position of the medical image apparatus relative to the imaging module to scan a head end region of the positioning medical tool to acquire an image, and reconstruct a two-dimensional image and/or a three-dimensional model of the head end region of the positioning medical tool.

Abstract: The present disclosure provides a neutron capture therapy system, including a neutron generator to generate neutrons after irradiation by charged particles, and a beam shaping assembly includes a moderator and a reflector surrounding the moderator. A vacuum tube connected to the accelerator is provided at an accommodating portion. The vacuum tube transmits the charged particles accelerated by the accelerator to the neutron generator to generate neutrons. The neutron generator moves between a first position and a second position, at the first position, the neutron generator react with the charged particle beam to generate neutrons, at the second position, the neutron generator falls off the beam shaping assembly. The vacuum tube is detached to make the neutron generator fall off the beam shaping assembly, to reduce direct contact of a worker with the neutron generator after nuclear reactions, thereby reducing radioactive hazards for workers.

Abstract: A medical system, comprises an operation table, a magnetic navigation apparatus and a medical image apparatus. The magnetic navigation apparatus and the medical image apparatus are respectively provided beside the operation table, and the operation table can be transmitted by rays of the medical image apparatus. The magnetic navigation apparatus is configured to navigate, according to a medical path, a positioning medical tool to a lesion region on the medical path. The medical image apparatus is configured to scan a head end region of the positioning medical tool to acquire a medical image, and to reconstruct a two-dimensional image and/or a three-dimensional model of the head end region of the positioning medical tool, so as to confirm the surrounding condition of the positioning medical tool and whether the positioning medical tool reaches a correct position.

Abstract: The present invention provides a valve material having a long-acting antithrombosis property and a preparation method therefor. The preparation method therefor comprises the following steps: performing glutaraldehyde cross-linking treatment on an animal-derived biological valve material, so that the valve material can resist decomposition for a long time; soaking the treated valve material in a formulation solution containing a cross-linking agent and a modifier for 10-60 min, then increasing the temperature to 30-60° C., and performing heat treatment for 1-12 h; and rinsing the valve material after heat treatment, so as to obtain the valve material. The valve material prepared by the method has excellent antithrombosis and anti-calcification properties, and can effectively solve the problem of calcification and thrombosis in the valve material treated by existing means of glutaraldehyde cross-linking.

Abstract: The present disclosure provides a clip device. The clip device may include a clip and a storage tube. The clip may include clip arms including a first clip arm and a second clip arm; the storage tube including a channel, a proximal end of the first clip arm, and a proximal end of the second clip arm being stowable within the channel; the clip being capable of being switched from a locked state to an unlocked state; wherein in the locked state, the distal end of the first clip arm and the distal end of the second clip arm are closed and the storage tube restricts a movement of the clip relative to the storage tube toward the distal end of the first clip arm and the distal end of the second clip arm; in the unlocked state, a movement restriction of the clip by the storage tube is released and the distal end of the first clip arm and the distal end of the second clip arm are able to be reopened.

Abstract: Methods, systems and devices for applying energy to tissue, and more particularly relates to a system for ablating or modifying structures in a body with systems and methods that generate a flow of vapor at a controlled flow rate for applying energy to the body structure.