Abstract: An implantable medical device communication system communicates information between an implantable medical device and at least one slave device by way of a two-wire bus. Slave devices may include remote sensors, actuators and other implantable medical devices. The implantable medical device includes a communication unit to output commands and power pulses, and receive information from the slave devices over the two-wire bus. The implantable medical device and slaves communicate over the bus by selectively changing one of the lines of the bus between a first and second voltage, the second voltage substantially equal to a reference voltage of the second line, e.g., zero volts. In some embodiments, the power pulses take the form of bipolar pulse pairs. The slave device includes a recovery unit to recover power from the power pulses.

Abstract: A system and method for reducing the amount of noise causes by inductive elements within an implantable medical device. In particular, the invention provides a system for gradually initiating and terminating the current flow within inductive elements such as transformers that are used to charge energy storage devices such as high-voltage capacitors of an implantable cardio/defibrillator. This more gradual change in the rate of current flow prevents ground shifts and subsequent noise spikes within the device. This, in turn, allows cardiac signals to be sensed more accurately by sensing circuits, preventing oversensing, and minimizing the occurrence of inappropriate shock delivery.

Abstract: An implantable system having a left ventricular pacing lead for implantation in the great cardiac vein via the coronary sinus of a patient's heart. The pacing lead includes a sensor for measuring the velocity of blood flowing through the coronary sinus. An implantable medical device (IMD) coupled to the pacing lead monitors the blood flow signal from the sensor and delivers pacing pulses to the patient's heart as a function of the blood flow signal. The IMD integrates the blood flow signal to estimate blood flow volume and adjusts a pacing parameter of the pacing pulses to maximize the blood flow. In a multi-chamber pacing system, the IMD continuously adjusts the atrial and ventricular (AV) delay in order to maximize the integral of the velocity signal received from pacing lead. In a multisite pacing system, where the IMD includes a plurality of ventricular pacing leads, the IMD adjusts the interventricular delay.

Abstract: A method and apparatus provides a sensed AV delay and/or a paced AV delay following an atrial sensed event and/or an atrial paced event, respectively. The AV delay is a predetermined time period initiated by the respective occurrence of the atrial sensed event or atrial paced event. A ventricular safety pacing window is defined during at least an initial portion of the AV delay. Ventricular events are sensed during the AV delay. If a ventricular event is sensed during the ventricular safety pacing window, then a commitment is made to the delivery of a ventricular safety pace upon expiration of the AV delay.

Abstract: A pacing system and method for providing multiple chamber pacing of a patient's heart, and in particular, pacing programmed for treatment of various forms of heart failure. The system utilizes impedance sensing for determining optimum pacing parameters, e.g., for pacing the left ventricle so that left heart output is maximized. The impedance sensing also is used for determination of arrhythmias or progression of heart failure. Impedance sensing is provided for between selected pairs of the four chambers, to enable optimizing of information for control and diagnosis. In a preferred embodiment of the invention, impedance measurements are obtained for determining the timing of right heart valve closure or right ventricular contractions, and the timing of delivery of left ventricular pace pulses is adjusted so as to optimally synchronize left ventricular pacing with the right ventricular contractions.

Abstract: A system and method for providing automated self-identification information of a remote medical component of an implantable medical device system to a centralized computer is disclosed. The system includes a memory component of the remote medical component containing self-identification information. An information network of the centralized expert data center is globally located relative to the programmer. An interface between the programmer and the information network is established for transmitting the self-identification information from the programmer component to the information network. An information identification module located in the information network recognizes the self-identification information of the components of the programmer.

Abstract: An implantable device having enhanced capabilities for monitoring a patient's heart rate and respiration trends over extended periods of time is disclosed. The information collected by the implantable device may be stored and telemetered to an associated external device such as a device programmer for display and analysis. Heart rates are measured by measuring the time intervals between sensed depolarizations of a chamber of the patient's heart and preceding sensed depolarizations or delivered pacing pulses. Intervals may be measured in the ventricle and/or atrium of the patient's heart. According to another aspect of the invention, an implanted impedance sensor is employed to monitor minute ventilation. The heart rate and minute ventilation data is used to develop long-term trend data used for diagnostic purposes. In one embodiment of the invention, heart interval and minute ventilation measurements are taken only during defined time periods of the night and/or day when the patient is at rest.

Abstract: In a fluid delivery system for delivering a fluid into an individual's body, a leak detection system indicates that the fluid has leaked outside a normal fluid path of the fluid delivery system, such as near an infusion site or a fluid-filled reservoir. Preferably, the leak detection system includes a chemical positioned near the infusion site that reacts with preservatives in the leaking fluid to generate a highly visible, brightly colored, chemical complex. Alternatively, mechanical, electro-optical, electrochemical, electrical or other chemical systems may be used to detect the presence of fluid that is leaking near the infusion site. Further, the leak detection systems may be used to detect the presence of fluid that is leaking from or near other locations within the fluid delivery system, such as on or near a fluid-filled reservoir, or a flexible tube coupled between the reservoir and the infusion site.

Abstract: A holster is provided with a clip portion for clipping to a user's belt or other suitable location and a harness portion for holding an electronic device, such as, but not limited to, a medical infusion pump. The holster may include a rotation mechanism that allows the holster to be rotated in a manner, to position and maintain the electronic device in any one of a plurality of selectable rotational orientations, while the holster is clipped to the user's belt. Alternatively or in addition, the clip portion is pivotally connected by a hinge to the harness portion, to allow the harness portion to pivot upward relative to the clip portion. The pivotal connection of the clip portion to the harness portion allows the user pivot the harness portion (and, thus, a medical device received in the harness portion) upward, for example, to better accommodate the user's view or access to displays, indicators, compartments, buttons or other manual operators on the medical device.

Abstract: An implantable medical device with internal processor is configured for diagnostic emulation with an external processor to enhance diagnostic testing with capabilities such as faster testing and more realistic testing. The implantable medical device can be a wide variety of implantable devices such as neuro stimulators, pacemakers, defibrillators, drug delivery pumps, diagnostic recorders, cochlear implants, and the like. The external processor is coupleable to the medical device to execute software involving medical device components with a bus switch coupled to the address bus, the data bus, and the internal processor. The bus switch has a bus switch external connector that when activated is configured to couple an external processor through the address bus external connection to the address bus and the external processor through the data bus external connector to the data bus.

Abstract: The present invention is directed to a defibrillator having both a manual and an AED mode with corresponding user commands for both modes. The defibrillator includes a door which conceals manual mode commands, such that opening of the door puts the defibrillator in the manual mode and simultaneously reveals the manual mode command buttons. In one actual embodiment, the door includes apertures which allow access to the AED command buttons. When the door is in the open position, a keypad is revealed having manual commands which preferably take the form of buttons. In another actual embodiment, the door includes a switch which senses when the door is opened and sends the defibrillator into manual mode. The door includes a front side having AED command buttons, and a back side having manual mode command buttons. The door conceals a keypad having further manual mode command buttons.

Abstract: A reusable external infusion device infuses a fluid into an individual's body. The infusion device controls the rate that fluid flows from a reservoir inside a housing, through an external tube, and into the individual's body. Essentially, the infused fluid is insulin. However, many other fluids may be administered through infusion such as, HIV drugs, drugs to treat pulmonary hypertension, iron chelation drugs, pain medications, anti-cancer treatments, vitamins, hormones, and others.

Abstract: A GI tract stimulator and/or monitor IMD comprising a housing enclosing electrical stimulation and/or monitoring circuitry and a power source and an elongated flexible member extending from the housing to an active fixation mechanism adapted to be fixed into the GI tract wall is disclosed. After fixation is effected, the elongated flexible member bends into a preformed shape that presses the housing against the mucosa so that forces that would tend to dislodge the fixation mechanism are minimized. The IMD is fitted into an esophageal catheter lumen with the fixation mechanism aimed toward the catheter distal end opening whereby the bend in the flexible member is straightened. The catheter body is inserted through the esophagus into the GI tract cavity to direct the catheter distal end to the site of implantation and fix the fixation mechanism to the GI tract wall.

Abstract: Implantable medical device telemetry is provided between an implantable medical device and an external communication device. The implantable medical device includes a device transmitter and/or a device receiver. The external communication device includes a moveable communication head including an antenna therein connected to at least one of an external transmitter and/or an external receiver for communication with the device transmitter and/or the device receiver of the implantable medical device. A user moves the moveable head apparatus relative to the implantable medical device. Tactile feedback is provided to the user via the moveable head apparatus upon movement of the moveable head apparatus to a position where valid telemetry can be performed.

Abstract: The present invention provides active agent delivery systems for use in medical devices, wherein the active agent delivery systems include an active agent and a miscible polymer blend that includes a hydrophobic cellulose derivative and a polyvinyl homopolymer or copolymer selected from the group consisting of a polyvinyl alkylate homopolymer or copolymer, a polyvinyl alkyl ether homopolymer or copolymer, a polyvinyl acetal homopolymer or copolymer, and combinations thereof.

Abstract: A medical device known as a catheter is configured with a variable infusion rate to deliver a therapeutic substance such as pharmaceutical compositions, genetic materials, and biologics to treat a variety of medical conditions such as pain, spastisity, cancer, and other diseases in humans and other animals. The variable infusion rate catheter provides clinician with increased flexibility, versatility, and many other improvements. The variable infusion rate catheter has a Micro Electro Mechanical System (MEMS) flow restriction with a variable infusion rate. The MEMS flow restriction is fluidly coupled to the catheter to receive therapeutic substance dispensed from a therapeutic substance delivery device and restrict the therapeutic substance flow to a desired infusion rate. Many embodiments of the variable infusion rate catheter and its methods of operation are possible.

Abstract: An autoinflating catheter and balloon assembly having an autoregulating structure to prevent overinflation of the balloon as a result of variable fluid flow rates through the catheter lumen. A tight-fitting elastomeric balloon is provided on the distal end of the catheter body, and the assembly is constructed so that at least a portion of the fluid flow through the lumen is directed to the balloon to inflate it. As the balloon is inflated, more and more of the fluid flow through the catheter is discharged from the catheter, thereby preventing overinflation of the balloon.

Abstract: A method of making a temporary medical electrical lead for pacing or defibrillating a heart of a patient.

Abstract: The present invention is directed to a defibrillator having both a manual and an AED mode with corresponding user commands for both modes. The defibrillator includes a door which conceals manual mode commands, such that opening of the door puts the defibrillator in the manual mode and simultaneously reveals the manual mode command buttons. In one actual embodiment, the door includes apertures which allow access to the AED command buttons. When the door is in the open position, a keypad is revealed having manual commands which preferably take the form of buttons. In another actual embodiment, the door includes a switch which senses when the door is opened and sends the defibrillator into manual mode. The door includes a front side having AED command buttons, and a back side having manual mode command buttons. The door conceals a keypad having further manual mode command buttons.

Abstract: A device useful for localized delivery of a therapeutic material is provided. The device includes a structure including a porous material; and a water-insoluble salt of a therapeutic material dispersed in the porous material. The water-insoluble salt is formed by contacting an aqueous solution of a therapeutic salt with a heavy metal water-soluble salt dispersed throughout a substantial portion of the porous material. The heavy metal water-soluble salt can be dispersed in the porous material so that the device can be sterilized and the therapeutic material can be loaded in the device in situ, for example, just prior to use. The therapeutic material is preferably a heparin or heparin derivative or analog which renders the material antithrombotic as an implantable or invasive device.