Abstract: A tubular prosthesis comprises a tubular member having raised portions, which can be formed from and be part of the tubular member. The raised portions form a chamber or discrete space in a body passageway or lumen between the prosthesis and a portion of the passageway or lumen wall in which it is placed. A substance is delivered to the chamber to assist the prosthesis placement. The substance can comprise one or more substances that can enhance the seal and/or fixation characteristics between the prosthesis the passageway wall and/or provide therapeutic benefit. In another embodiment, the raised portions can be collars secured to the tubular member and in yet a further embodiment the raised portions can comprise inflatable collars.

Abstract: A method of manufacturing a stent includes forming a stent blank including a predetermined alloy composition, the alloy composition including at least base element and at least one sacrificial element and forming a stent framework from the stent blank. The method further includes removing at least a portion of the sacrificial element and forming at least one pore based on the removal. A method of manufacturing a vascular treatment system includes forming a stent blank including a predetermined alloy composition including at least one base element and at least one sacrificial element. The method further includes forming a stent framework and removing at least a portion of the sacrificial element. The method also includes forming at least one pore based on the removal, bending the stent framework to a delivery shape, and attaching the bent stent framework including the formed pores to a catheter.

Abstract: Disclosed are drug delivery systems comprising drugs admixed with polymers having drug solubility gradients and methods of making the polymers. Also disclosed are medical devices having coatings thereon comprising the drug solubility gradient-containing polymers and at least one drug.

Abstract: A drug elution stent includes a stent framework and a drug elution portion disposed on the stent framework. The drug elution portion includes a first sugar layer disposed on the stent framework, at least one therapeutic agent layer disposed on the first sugar layer and a second sugar layer disposed on the at least one therapeutic agent layer. A method of manufacturing a drug elution stent includes the steps of providing a stent having a stent framework and coating at least a portion of the stent framework with a drug elution portion.

Abstract: An implantable device capable of delivering drugs is disclosed. An example of the device is a stent that comprises at least one hypotube having a lumen and one or more pores. The lumen of the hypotube is configured to retain drugs that can be eluted through the one or more pores after deployment at a treatment site.

Abstract: In general, this disclosure describes techniques for capacitive digit-to-analog converter (CAPDAC) resetting in an implantable medical device (IMD) analog-to-digital converter (ADC). The CAPDAC of an IMD ADC may occasionally be reset to increase the accuracy of its output. The output of the CAPDAC may be disconnected from a negative feedback input of an integrator and connected to a pseudo load during the reset. Disconnecting the CAPDAC from the negative feedback input of the integrator reduces the affect of the reset on the integrator. During the reset of the CAPDAC, the negative feedback input of integrator is coupled to a sample and hold capacitor, which temporarily provides an input approximately equal to a previous, e.g., immediate, value of the output of CAPDAC prior to the reset. Thus, the resetting of the CAPDAC is done in such a manner that the affect of the reset on integrator is substantially reduced or eliminated.

Abstract: The disclosure provides techniques for parameter-directed shifting of electrical stimulation electrode combinations. An external programmer permits a user to shift electrode combinations, e.g., along the length of a lead or leads. The external programmer accepts shift input and causes an electrical stimulator to shift electrode combinations as indicated by the input. Different sets of electrodes may have different electrode counts. For example, an array of electrodes carried by one lead may have a greater number of electrodes than an array of electrodes carried on another lead. The disclosure provides techniques for shifting electrode combinations among leads with different electrode counts. For example, an external programmer may execute shifts in a series of shift operations, where the number of shift operations along the length of a lead having a greater electrode count is greater than the number of shift steps along the length of a lead having a lesser electrode count.

Abstract: A diabetes data management system selects variable threshold parameters to that are utilized in a report. A first low threshold glucose reading and a first high threshold glucose reading for a before meal event timeframe are selected. A second low threshold glucose reading and a second high threshold glucose reading are selected for an after meal event timeframe. The threshold readings are stored in a database. The diabetes data management system analyzes glucose behavior around meal events. The system receives a plurality of glucose readings for a time period, receives a first time range as a pre-meal analysis period for the first meal event and receives a second time range as a post-meal analysis period for the first meal event. The system creates a graph which highlights the pre-meal analysis period, the post-meal analysis period, and displays the plurality of glucose readings for the time period.

Abstract: A form for retaining a battery in implantable medical device includes outer edge and first and second opposing major surfaces. The first major surface of the form includes a recess, a ridge disposed between the recess and the outer edge, and a trough forming element disposed between the ridge and the outer edge. The ridge is configured to engage at least a portion of a major surface of the battery retained in the form. The trough forming element has first and second edge surfaces positioned to engage an edge surface of the retained battery to form a trough configured to receive adhesive. The recess is disposed adjacent the ridge and is configured to allow for expansion of the retained battery during recharge. The retention assembly is configured to secure the first major surface of the battery against the ridge to prevent adhesive from leaking from the trough into the recess.

Abstract: A connector header includes a housing formed from a plastic material having a modulus of rigidity of 100 ksi or greater. The housing defines an opening for insertion of a lead. The connector header further includes a lead receptacle having an electrically conductive element. The electrically conductive element is operably couplable to a feedthrough of the implantable medical device. The lead receptacle is in communication with the opening and is disposed within the housing such that an electrical contact of the lead is electrically couplable to the conductive element of the receptacle when the lead is inserted into the receptacle.

Abstract: The disclosure provides techniques for parameter-directed shifting of electrical stimulation electrode combinations having substantially similar electrode patterns. An external programmer permits a user to shift electrode combinations along the length of a lead or leads. The external programmer accepts parameter-directed shift input and causes an electrical stimulator to shift electrode combinations as indicated. The external programmer may present an electrode combination as a parameter that can be adjusted or selected to shift the electrode combination along the length of a lead. An electrode combination may be presented as a value that can be incremented, decremented, or otherwise adjusted to indicate a shift in a desired direction. An external programmer that permits a patient or other user to shift electrode combinations in a manner similar to adjustments of other parameters may enable the patient to maintain or improve therapeutic efficacy.

Abstract: A method includes (i) placing about a first alignment pin a first lead receptacle having a conductive portion, and (ii) placing about a second alignment pin a second lead receptacle having a conductive portion. The method further includes placing the first and second lead receptacles on a restraining fixture and attaching and electrically coupling a first conductor of a one piece lead frame pin assembly to the conductive portion of the first receptacle. The lead frame pin assembly has a tab element connecting the first conductor to a second conductor. The first and second conductors each include a feedthrough coupling portion. The method also includes attaching and electrically coupling the second conductor of the lead frame assembly to the conductive portion of the second receptacle. The lead receptacle and pin assembly may be inserted into a connector header.

Abstract: A connector circuit assembly for use in an implantable medical device, and a method of making the assembly that includes a core portion formed of a thermoplastic material using either an injection molding process or a machining process. This core portion is adapted to be fitted with at least one electrically-conductive circuit component such as a connector member, a set-screw block, or a conductive jumper member. In one embodiment of the invention, the core portion includes multiple receptacles or other spaces that are adapted to be loaded with the various circuit components. The core assembly is positioned into a second-shot mold assembly, and a second thermoplastic material is injected into the mold so that the second thermoplastic material extends over and adheres to the core portion and the circuit component.

Abstract: A system for applying a polymer (hydrogel) to the inner surface of a vessel by photopolymerization includes an inner catheter received within an outer catheter and a fluid channeling structure mounted on the catheters with its proximal end attached to the outer catheter and its distal end attached to the inner catheter. The fluid channeling structure includes an elastomeric sleeve sandwiched between an inner elastic coil and an outer light emission coil. Light emission coil loops are interspaced with elastic coil loops. The light emission coil has a smaller diameter than the elastic coil, drawing the elastomeric sleeve down between loops of the elastic coil to form a helical channel. The coils and sleeve are stretched to provide a narrowed crossing profile for delivery, and are contracted at a treatment site to form a helical cavity between the sleeve and the vessel wall within which to perform interfacial photopolymerization.

Abstract: A valve repair system, preferably including an annuloplasty prosthesis and a holder for the prosthesis. The holder includes a first component having a central opening, a circumferential surface and an outwardly extending member. The annuloplasty prosthesis is located adjacent to the circumferential surface, above the outwardly extending member. The holder further includes a second component movable upwardly relative to the first holder component and includes a rigid penetrating member extending downward from the second component into the prosthesis, holding it adjacent the circumferential surface. The holder also includes a suturing guide for assisting a physician in valve repair surgery, which may be a cuttable suture extending across the central opening along a path approximating a desired line of leaflet coaption. The cuttable suture may additionally secure the first and second components to one another.

Abstract: Methods and apparatus are provided for manufacturing a medical device. An implantable medical device includes a semiconductor substrate, an epitaxial layer, and a power transistor. The epitaxial layer overlies the semiconductor substrate. The power transistor is formed in the epitaxial layer and includes a first electrode, a control electrode, and a second electrode. The power transistor has a voltage breakdown greater than 100 volts. The current flow of the power transistor is vertical through the epitaxial layer to the semiconductor substrate. A backside contact couples to the first electrode of the power transistor. A method of manufacturing a medical device includes a power transistor formed in an epitaxial layer overlying a semiconductor substrate. A deep trench is etched through the epitaxial layer exposing the semiconductor substrate. A first electrode contact region couples to an exposed area of the semiconductor substrate in the deep trench.

Abstract: A device to determine the level of a substance of interest in a patient's body and provide a therapeutic amount of medicament is disclosed. The level of a substance of interest in the patient's body is determined by iontopheretically sampling the patients' blood and then analyzing the resulting sample to determine the level of the substance of interest. The information about the level of a substance of interest is transmitted to an implanted drug pump in the patient's body. The preferred method of transmitting information about the level of a substance of interest determined by the sensor is transmitted to an implanted drug pump in the patient's body is via a so called “body bus”. The “body bus” is a telemetry system where the patient's own body provides the interconnection between the iontopheretic device and the implanted drug pump.

Abstract: A system can be used to determine a position of a boney structure in physical space. The system can include a laser emitting device that can emit a laser beam that transmits through soft tissue and reflects off of a boney surface. The system can then determine the position of the reflection point and correlate the reflection point to image data acquired of a patient.

Abstract: Universal modular stented graft assemblies are assembled, on site, and often in a patient's parent artery, from at least two components; a first component and a second component. The first and second components each include a window, or fenestration. The second component couples with the first component by fitting at least partially in the first component to form the universal modular stent graft assembly with an adjustable collateral opening. As the first and second components are assembled, the first and second components are adjusted relative to each other so that the first and second component windows overlap to form a collateral opening whose size is selectable, depending on the overlap, with the desired position and dimensions in the universal modular stent graft assembly.

Abstract: In general, this disclosure is related to detecting overload within an analog-to-digital converter (ADC) of an implantable medical device (IMD). The IMD may include an overload detection module that determines whether the ADC is operating in an overload condition. When the overload detection module determines the ADC is operating in the overload condition for a particular period of time, the ADC may send an overload signal to a processor that processes the output of the ADC. The overload signal notifies the processor that the ADC is operating in or is close to operating in the overload condition. In response to the indication from the ADC, the processor of the IMD may disregard the output of the ADC. The processor may continue to disregard the output of the ADC until the overload signal is deactivated, thereby indicating that the ADC is no longer in an overloaded condition.