Abstract: An intraocular lens material disclosed in the present description includes an aromatic ring-containing acrylate structural unit, an alkoxyalkyl methacrylate structural unit including an alkoxy group having 4 or less carbon atoms, a hydrophilic structural unit based on a hydrophilic monomer, and a cross-linking structural unit based on a cross-linkable monomer.

Abstract: A diffractive multi-focal ophthalmic lens includes a novel structure and manufacturing method in which improvement in optical characteristics such as halo reduction is obtained. A diffractive multi-focal ophthalmic lens in which a plurality of focal points are set by a diffraction grating including a blaze shaped phase function in which a plurality of zone sequences are overlapped, wherein adopted is a structure expressed by a phase function in which an inclination of a blaze of a specific adjustment zone in a standard profile is reversed.

Abstract: To provide a contact lens with novel structure that is able to achieve both stability of the lens circumferential position in the worn state and improved wearing comfort at a high level. A first thick part and a second thick part are provided on a peripheral zone at both left and right sides such that each center-of-gravity position of both the first thick part and the second thick part is positioned below a horizontal diametrical line. A third thick part is provided on the peripheral zone below an optical zone. An upper thin part and a lower thin part are provided respectively at an upper peripheral zone positioned above the optical zone and a lower peripheral zone positioned below the optical zone and at an outer circumference side of the third thick part.

Abstract: An object of the present invention is to provide a process capable of producing a self-assembling peptide derivative that is useful in the fields of regenerative medicine and surgery in large quantities and in an economical and efficient manner. In particular, provided is a production process employing a combination of (i) a step of convergently constructing a sequence with use of a common repeating unit consisting of a specific amino acid sequence and (ii) a step of first isolating the peptide derivative as a disulfuric acid salt, a tetramethanesulfonic acid salt or a tetra(trifluoroacetic acid (TFA) salt), and then subjecting the peptide salt to a salt exchange reaction to yield a tetrahydrochloric acid salt.

Abstract: A presbyopia contact lens set especially for a user who has worn spherical contact lenses, a designing method for a presbyopia contact lens, and a manufacturing method for a presbyopia contact lens that uses such design method. The presbyopia contact lens set configured by combining a plurality of types of presbyopia contact lens having different specifications lens powers, includes the plurality of types of presbyopia contact lenses in which the radial lens power profile in a near-use region and that in a far-use region are defined using mutually different functions, the function for defining the radial lens power profile in the far-use region is set in accordance with a specifications lens power, and the radial lens power rate-of-change in the far-use region is made larger for lenses having a small specifications lens power than for lenses having a large specifications lens power.

Abstract: A polymer produced by polymerizing a polymerizable composition including a hydrophilic monomer and a crosslinkable monomer. The A×B value that is the product of the molar fraction A of the hydrophilic monomer and the molar fraction B of the crosslinkable monomer is more than 2.1×10?3 and less than 3.6×10?3. The molar fraction B of the crosslinkable monomer is less than 2.4×10?2. The polymer has a refractive index n of 1.5 or more in a state of hydration.

Abstract: Provided are a lens power measurement device and a lens power measurement method whereby lens power measurement results of a contact lens can be displayed in a manner which is easy to view, while maintaining fully satisfactory precision of the lens power measurement results. From lens power distribution information determined based on optical property measurement information of a contact lens, correction target information including positive and negative abnormal peaks on both sides of a lens central axis in a lens central area is selected. Lens power distribution measurement results are then obtained by applying substitution using a correction function that smoothes out the abnormal peaks to the selected correction target information to smooth the lens power measurement values.

Abstract: A diffractive multi-focal lens having a diffractive structure comprising a plurality of concentric circular zones, wherein: at least a portion of the diffractive structure is provided with an overlapping region in which at least two zone profiles overlap in the same region; in the overlapping region, at least a portion of a first zone profile has a zone pitch represented by a prescribed equation, and at least a portion of a second zone profile has a zone pitch represented by another prescribed equation; and an addition power P1 given by the first zone profile and an addition power P2 given by the second zone profile are determined by a prescribed relational expression, in which a and b are mutually different real numbers, and a value of a/b cannot be expressed by a natural number X or by 1/X.

Abstract: A method for manufacturing a diffractive multi-focal ophthalmic lens capable of generating at least three focal points in an optical axis direction using a diffractive structure comprising a plurality of zones in a concentric circle form. A composite profile is generated by overlapping at least two starting profiles comprising a plurality of zones in a concentric circle form, and an adjusted profile is generated in which at least one of phase and amplitude is adjusted by employing a zone of the composite profile as a subject in order to set an intensity distribution in the optical axis direction and determine optical characteristics, to manufacture the diffractive multi-focal ophthalmic lens for which the adjusted profile is provided in at least a portion of the diffractive structure.

Abstract: A contact lens is provided as hydrate of a copolymer of at least three components including (I) both terminal-polymerizable silicone oligomer exhibiting viscosity of at least 200 mPa·s at room temperature, (II) a hydrophilic monomer component having ethylenically unsaturated group, and (III) a hydrophobic monomer component having molecular weight of at most 700, wherein the lens exhibits an elastic-modulus ratio determined as ratio of a rupture elastic modulus to an initial elastic modulus in range of 0.8-1.2. The contact lens is transparent and by combination of high oxygen permeability and balance between softness and mechanical properties. The lens is produced through a process including steps of stirring material-liquid including at least three components of the above-mentioned (I), (II) and (III) under stirring power of 5-10000 W/m3 per unit volume of the material-liquid for at least 10 minutes, and injecting stirred material-liquid into a lens mold to polymerize material-liquid.

Abstract: A contact lens is provided as a hydrate of a copolymer of at least three components including (I) a both terminal-polymerizable silicone oligomer component that forms a hydrophobic region (A) in the copolymer, (II) a hydrophilic component that forms a hydrophilic region (C) in the copolymer, and (III) a hydrophobic monomer component having a molecular weight of at most 700 that forms the hydrophilic region (C) together with the component (II) and also contributes to form an intermediate region (B) which does not solvate with a hydrophilic solvent between the hydrophobic region (A) and hydrophilic region (C), wherein the intermediate region (B) shows a volume rate of 5 to 40% with respect to the region (A) in the copolymer, and the contact lens is transparent and free from bubbles therein.

Abstract: The purpose of the present invention is to provide novel contact lens manufacturing method and contact lens capable of giving a lens inner surface shape reflecting a cornea shape of a contact lens wearer more easily than before with sufficient accuracy to reflect the cornea shape, thereby improving comfort during use. By using statistical information on a corneal surface shape obtained from a population of target eyes having a feature to be treated, a fitting for a rotationally-symmetric shape is performed based on a definitional equation using a radius of curvature (R) and a conic constant (C.C.) while a fitting for a rotationally-asymmetric shape is performed based on a definitional equation using a Zernike function. A shape of a lens rear surface (20) corresponding to the corneal surface shape specified by these definitional equations is adopted for a rear surface of a peripheral area of a contact lens (10).

Abstract: An ophthalmic lens which gives excellent wearing comfort required for its use as a contact lens, and which has sufficiently high flexibility and an adequate degree of deformation recovery property required for its use as an intraocular lens. The ophthalmic lens is formed of a polymer having a young's modulus of 0.3-1.0 MPa and a stress relaxation rate of 10-20%.

Abstract: In order to reduce halos that occur in multifocal ophthalmic lenses, the mechanism of the phenomenon was elucidated and a solution was found based on the results. Thus provided are a multifocal ophthalmic lens having a structure and a manufacturing method for the same which can effectively reduce halos. A multifocal ophthalmic lens having a focal point formation region provided to an optical portion of a lens, which forms at least two focal points, wherein a cancellation region is provided to the optical portion, the cancellation region providing diffracted light of an amplitude distribution that reduces, on the image plane of the first focal point among the focal points, the amplitudes of light other than the light that forms the first focal point.

Abstract: A polysiloxane-based macromonomer for an ophthalmic lens, which exhibits excellent compatibility with respect to a hydrophilic component such as a hydrophilic monomer. The polysiloxane-based macromonomer has at least one polymerizable group, a polysiloxane chain having a siloxane unit as a repeating unit, a polyoxyethylene chain in which a number of repetition of an oxyethylene group is two or more, and a polyoxyalkylene chain having an oxyalkylene group other than the oxyethylene group as a repeating unit, wherein an HLB value calculated according to a formula: [HLB value]=E/5 is within a range from 0.7 to 6.0, wherein E represents a weight fraction (wt %) of the oxyethylene group in a molecule of the polysiloxane-based macromonomer.

Abstract: The present invention provides a bone formation promoter having high biological safety and capable of promoting bone formation. The bone formation promoter of the present invention includes a self-assembling peptide capable of forming a ?-sheet structure in an aqueous solution having a neutral pH; and a bone chip. A sum of charges of amino acid residues constituting the self-assembling peptide at pH 7.0 is unequal to 0.

Abstract: A decentered type contact lens including: an optical zone provided in a center part of the contact lens; a peripheral zone provided on an outer circumference of the optical zone; an optical center of the optical zone being set to deviate from a lens geometric center; and a circumferential direction alignment mechanism for setting a lens circumferential direction position in a worn state, the contact lens being characterized in that: a center-of-gravity deviation in relation to the lens geometric center is set for the peripheral zone, and a center-of-gravity position shift accompanying deviation of the optical center of the optical zone in relation to the lens geometric center is corrected by offset using the center-of-gravity deviation of the peripheral zone.

Abstract: The present invention provides a contact lens having novel myopia progression suppression capability, while enabling a good QOV to be obtained and ensuring myopia is kept from progressing. A contact lens having a refractive correction power for correcting myopia and myopic astigmatism set in a central region of an optical part, wherein a positive addition power in comparison with a power in the central region is set in a peripheral region of the optical part so that progression of the myopia or myopic astigmatism is suppressed, a positioning member is provided that specifies a circumferential position of the lens under a worn condition, and a lens optical axis of the optical part is set offset from a lens geometric center to align with a line of sight of a human eye under the worn condition produced by the positioning member.

Abstract: Provided is a diffraction-type multifocal ophthalmic lens for which halos are reduced. Also provided is a diffraction-type multifocal ophthalmic lens having three or more focal points, which is implemented on the basis of the discovery that the diffraction-type multifocal ophthalmic lens has a characteristic whereby multiple focal points can be generated in the intermediate region as well as the near and far regions. Also provided is a method for manufacturing a diffraction-type multifocal ophthalmic lens which provides a simple design and manufacturing method by means of a simple diffraction structure and by replacing a cumbersome computer simulation with a simple method. This diffraction-type multifocal ophthalmic lens has a diffraction structure (20) where a plurality of diffraction zones are formed concentrically on the lens (10), and an equal-pitch region is provided where pitches of at least two zones among the diffraction zones are made equal.