Abstract: The invention relates to a liquid-crystalline medium based on a mixture of polar compounds having positive dielectric anisotropy, characterized in that it comprises one or more compounds of the general formula I
in which R, Y and L1 are as defined in claim 1.
Type:
Grant
Filed:
July 26, 2000
Date of Patent:
June 18, 2002
Assignee:
Merck Patents Gesellschaft mit beschraenkter Haftung
Abstract: Aralkylpyridazinone derivatives of the formula I
and their physiologically acceptable salts in which
R1, R2, R3, R4, R5 and Q have the meanings indicated in claim 1, show inhibition of phosphodiesterase IV and can be employed for the treatment of inflammatory processes and of allergies, asthma and autoimmune disorders.
Type:
Grant
Filed:
April 19, 1996
Date of Patent:
June 4, 2002
Assignee:
Merck Patent Gesellschaft mit beschraenkter Haftung
Inventors:
Rochus Jonas, Michael Wolf, Norbert Beier
Abstract: The invention relates to a non-dusting homogeneous pigment preparation notable in that it comprises at least 40% by weight of one or more pearl lustre pigments.
Type:
Grant
Filed:
August 30, 1999
Date of Patent:
June 4, 2002
Assignee:
Merck Patent Gesellschaft mit Beschraenkter Haftung
Inventors:
Wolfgang Hechler, Gerhard Herget, Brigitte Husseini
Abstract: The invention relates to a highly orientated flaky pigment being excellent in plane orientation (leafing effect), wherein a hydrated metal oxide and one or more fluorine-containing phosphates represented by the general formulae (A) and (B) shown in below or salts thereof are covered on the surface of a flaky pigment with a pearl gloss.
The general formulae:
(A) (RfCnH2nO)mPO(OM)3−m
(B) (RfSO2NRCnH2nO)mPO(OM)3−m
wherein Rf is the same or different and represents linear or branched C3 to C21 perfluoroalkyl group or perfluoroxyalkyl group, n is 1 to 12, m is 1 to 3, M represents hydrogen, alkali metal, ammonium group or substituted ammonium group, and R represents hydrogen or C1 to C3 alkyl group. A process for producing said pigment in a wet process is also disclosed.
Type:
Grant
Filed:
October 5, 2000
Date of Patent:
January 22, 2002
Assignee:
Merck Patent Gesellschaft mit beschraenkter Haftung
Abstract: The invention describes the possibility of the biofunctionalization of biomaterials, in particular implants, by their made-to-measure coating with synthesized cell- or tissue-selective RGD peptides which in vitro stimulate the adhesion of mainly those cell species which in each case are intended to accomplish the tissue integration of the appropriate biomaterial.
Type:
Grant
Filed:
November 22, 1999
Date of Patent:
August 28, 2001
Assignee:
Merck Patent Gesellschaft mit beschraenkter Haftung
Inventors:
Jorg Meyer, Alfred Jonczyk, Berthold Nies, Horst Kessler, Dirk Finsinger, Martin Kantlehner
Abstract: The present invention relates to pigment mixtures containing at least two components, component A being Al2O3 flakes coated with one or more metals, metal oxides and/or metal sulfides and component B being special-effect pigments, and to their use in varnishes, paints, printing inks, masterbatches, plastics and cosmetic formulations.
Type:
Grant
Filed:
December 23, 1999
Date of Patent:
July 31, 2001
Assignee:
Merck Patent Gesellschaft mit beschraenkter Haftung
Inventors:
Gerhard Pfaff, Sabine Schoen, Nishimagi Atsuko
Abstract: Piperazine derivatives of the formula I
in which
R1, m, k and R2 have the meanings indicated in claim 1, are potent 5-HT1A agonists and exhibit 5-HT-reuptake-inhibiting actions and are suitable for the treatment and prophylaxis of anxiety states, depression, schizophrenia, obsessions, tardive dyskinesias, learning disorders, age-dependent memory disorders, for positively affecting obsessive-compulsive disorder, and also for the treatment and for the control of the sequelae of cerebral infarcts such as stroke and cerebral ischaemias.
Type:
Grant
Filed:
April 3, 2000
Date of Patent:
June 26, 2001
Assignee:
Merck Patent Gesellschaft mit beschraenkter Haftung
Inventors:
Henning Böttcher, Gerd Bartoszyk, Hartmut Greiner, Christoph Seyfried
Abstract: Halovinyl ethers of the general formula I ##STR1## in which R, A.sup.1, A.sup.2, A.sup.3, Z.sup.1, Z.sup.2, X.sup.1, X.sup.2, l, m and n are as defined herein are suitable as components of liquid-crystalline media.
Type:
Grant
Filed:
November 20, 1997
Date of Patent:
June 15, 1999
Assignee:
Merck Patent Gesellschaft mit beschraenkter Haftung
Inventors:
Peer Kirsch, Joachim Krause, Kazuaki Tarumi
Abstract: New anisotropic compounds of the formula (1) are useful in liquid crystal mixtures for electrooptical displays; at least one of the end groups of the compounds (1) is an alkyl group which carries cyano or halogen in a terminal or non-terminal position. This offers advantages for longitudinal polarization and/or cross-polarization of the anisotropic compounds with the aid of the comparatively highly polarizing cyano or halogen substituents, in particular high clear points, low ##EQU1## values and/or negative .DELTA..epsilon. values.
Type:
Grant
Filed:
May 15, 1992
Date of Patent:
October 12, 1993
Assignee:
Merck Patent Gesellschaft mit beschraenkter Haftung
Abstract: The invention relates to the use of stabilised organometallic adduct compounds for the production of thin films and epitaxic layers by gas phase deposition.
Type:
Grant
Filed:
September 6, 1991
Date of Patent:
August 10, 1993
Assignee:
Merck Patent Gesellschaft mit Beschraenkter Haftung
Inventors:
Martin Hostalek, Matthias Lokai, Ludwig Pohl
Abstract: The invention relates to the use of organometallic compounds containing, as metals, aluminum, gallium or indium for the deposition of thin films or epitactic layers from the gas phase.
Type:
Grant
Filed:
September 6, 1991
Date of Patent:
May 11, 1993
Assignee:
Merck Patent Gesellschaft mit beschraenkter Haftung
Inventors:
Dietrich Erdmann, Ludwig Pohl, Martin Hostalek
Abstract: The invention relates to an electrooptical display element which can be multiplexed, has two support plates which, with an edging, form a cell containing a pneumatic liquid crystal material with positive dielectric anisotropy, and at least one chiral additive, and has a small surface tilt angle and a twist angle with a value between 150.degree. and 250.degree., wherein the ratio of the elastic constants for bending and twisting K.sub.3 /K.sub.2 of the liquid crystal material and the twist angle are such that when using liquid crystal material with the ratio of the elastic constants K.sub.3 /K.sub.1 for mending and spreading, which is in the order of the maximum possible, the steepness of the characteristic line is approved by the characteristic line is bi-stable or when using liquid crystal material with the ratio of the elastic constants K.sub.3 /K.sub.
Type:
Grant
Filed:
May 15, 1989
Date of Patent:
February 23, 1993
Assignee:
Merck Patent Gesellschaft mit beschraenkter Haftung
Inventors:
Gunter Baur, Bernhard Scheuble, Waltraud Fehrenbach
Abstract: A chiral, tilted, smectic liquid crystal phase comprising a mixture of at least two compounds, wherein at least one compound is an achiral fluorinated biphenyldiole compound of formula I ##STR1## whereinR.sup.1 and R.sup.2 are each independently alkoxy or alkanoyloxy with 1 to 15 C atoms, ##STR2## denotes a 4,4-phenylene group optionally substituted by up to four F atoms, and is 1.
Type:
Grant
Filed:
July 14, 1989
Date of Patent:
January 26, 1993
Assignee:
Merck Patent Gesellschaft mit beschraenkter Haftung
Inventors:
David Coates, Ian C. Sage, Simon Greenfield
Abstract: The invention relates to a process for the preparation of racemic pilosinine derivatives as precursor for the alkaloid pilocarpine of pharmacological importance from a 5-formyl-1-alkylimidazole of the formula I ##STR1## in which R.sup.1 is a straight-chain or branched alkyl chain with 1-6 C atoms which, via the stage of the thioacetal, is added onto .gamma.-crotonolactone.
Type:
Grant
Filed:
October 23, 1991
Date of Patent:
January 19, 1993
Assignee:
Merck Patent Gesellschaft mit beschraenkter Haftung
Inventors:
Ulrich Heywang, Michael Casutt, Michael Schwarz
Abstract: Supertwist liquid crystal display elements with excellent steepness of the characteristic are obtained, if the nematic liquid crystal mixture satisfies the following conditions:a nematic phase range of at least 60.degree. C.,a viscosity of 30 mPa.s or lower, and.DELTA..epsilon./.epsilon..perp.<2.0, where .DELTA..epsilon. is the dielectric anisotropy and .epsilon..perp. is the dielectric constant in the direction of the short axis of the liquid crystal molecules.
Type:
Grant
Filed:
May 15, 1989
Date of Patent:
January 12, 1993
Assignee:
Merck Patent Gesellschaft mit beschraenkter Haftung
Inventors:
Georg Weber, Herbert Plach, Volker Reiffenrath, Reinhard Hittich
Abstract: Disclosed is a process for the preparation of multi-element metal oxide, high temperature superconductor precursor powder comprising spraying a homogenous solution of a multi-element metal salt solution mixed in a stoichiometric ratio corresponding to the desired superconducting composition into a horizontal tube-like furnace being heated to a temperature of 800.degree.-1000.degree. C., transporting resulting sprayed mist along the main axis of the furnace tube by the aid of hot air and collecting resultant finely divided metal oxide powder by the aid of a filter, whereby the resultant mixed metal oxide powder is a precursor for the preparation of a high temperature superconducting ceramic.
Type:
Grant
Filed:
June 1, 1989
Date of Patent:
January 5, 1993
Assignee:
Merck Patent Gesellschaft mit beschraenkter Haftung
Inventors:
Barry E. Kinsman, Rodney Riddle, Anthony R. Wilson
Abstract: The invention relates to a liquid-crystal matrix display having integrated nonlinear components and containing a liquid-crystal mixture having particularly high specific resistance.
Type:
Grant
Filed:
December 12, 1991
Date of Patent:
December 15, 1992
Assignee:
Merck Patent Gesellschaft mit beschraenkter Haftung
Inventors:
Reinhard Hittich, Georg Weber, Herbert Plach, Andreas Wachtler, Bernard Scheuble
Abstract: The invention relates to a bluish green pigment comprising a flaky fine powder as a substrate, in which the substrate is coated with a metal oxide composite composed of oxides of magnesium, calcium, cobalt and titanium in a coated amount of from 5 to 70% by weight on the basis of the total pigment.
Type:
Grant
Filed:
May 24, 1991
Date of Patent:
December 8, 1992
Assignee:
Merck Patent Gesellschaft mit beschraenkter Haftung
Abstract: 2,5-Disubstituted heterocycles of the formula I ##STR1## in which R.sup.1 and R.sup.2, each independently of one another, are alkyl, alkenyl or oxaalkyl having up to 12 C atoms,L.sup.1 and L.sup.2, each independently of one another are H or F,Y is --O--, --CO--O--, --O--CO-- or a single bond,m is 1 or 2,Z is H, F, OH or alkyl having up to 5 C atoms, andQ is --O--, --O--CO--, or if Z is fluorine or hydroxyl, is also be a single bondare suitable as components of ferroelectric mixtures.
Type:
Grant
Filed:
December 21, 1989
Date of Patent:
December 1, 1992
Assignee:
Merck Patent Gesellschaft Mit Beschraenkter Haftung
Inventors:
Andreas Wachtler, Thomas Geelhaar, Hans-Adolf Kurmeier, Detlef Pauluth