Abstract: Novel compounds of the formula I in which D, W, X, Y, T and R1 are as defined in Patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumours.
Type:
Grant
Filed:
March 31, 2003
Date of Patent:
February 27, 2007
Assignee:
Merck Patent GmbH
Inventors:
Dieter Dorsch, Werner Mederski, Johannes Gleitz, Bertram Cezanne, Christos Tsaklakidis, Christopher Barnes
Abstract: Nkx2-C4 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Nkx2-C4 polypeptides and polynucleotides in diagnostic assays.
Abstract: The invention relates to liquid-crystalline phenol esters of the formula I in which R, A1, Z1, m, L and Y are as defined in Claim 1, to liquid-crystalline media comprising at least one phenol ester of the formula I, and to electro-optical displays containing such a liquid-crystalline medium.
Type:
Grant
Filed:
May 13, 2005
Date of Patent:
February 20, 2007
Assignee:
Merck Patent GmbH
Inventors:
Volker Reiffenrath, Michael Heckmeier, Eike Poetsch, Joachim Krause, Werner Binder, Brigitte Schuler, Achim Götz
Abstract: The present invention describes a process for preparing highly pure tris-ortho-metalled organoiridium compounds and pure organometallic compounds of this type, especially compounds of the d8 metals, which may find use as coloring components in the near future as active components (=functional materials) in a series of different types of application which can be classed within the electronics industry in its broadest sense.
Type:
Grant
Filed:
May 20, 2003
Date of Patent:
February 20, 2007
Assignee:
Merck Patent GmbH
Inventors:
Philipp Stössel, Ingrid Bach, Hubert Spreitzer, Heinrich Becker
Abstract: The present invention relates to a process for the reduction of aliphatic, aromatic or heterocyclic organic compounds by means of hydrides and/or derivatives thereof.
Abstract: PHPIP-120 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed, also disclosed are methods for utilizing PHPIP-120 polypeptides and polynucleotides in diagnostic assays.
Type:
Grant
Filed:
January 25, 2002
Date of Patent:
February 13, 2007
Assignee:
Merck Patent GmbH
Inventors:
Bjoern Hock, Klaus Duecker, Roland Kellner
Abstract: The invention relates to a liquid-crystalline medium based on a mixture of polar compounds of positive dielectric anisotropy, characterized in that it comprises one or more compounds of the formula I and one or more compounds of the formula IA in which R1, R2, ring A, ring B, L1-4, Z1, Z2, X1 and X2 are as defined in claim 1.
Type:
Grant
Filed:
September 30, 2003
Date of Patent:
February 13, 2007
Assignee:
Merck Patent GmbH
Inventors:
Michael Heckmeier, Sabine Schoen, Peer Kirsch
Abstract: The present invention relates to a method of preparing a film that includes at least one layer of anisotropic polymer material. The method can include polymerizing a mixture of a filtered polymerizable mesogenic material.
Type:
Grant
Filed:
October 25, 2004
Date of Patent:
February 13, 2007
Assignee:
Merck Patent GmbH
Inventors:
Mark Verrall, Jeremy Ward, James Hanmer, David Coates
Abstract: The present invention relates to the laser inscription of a flexible inner support layer of a multilayered support unit, which is distinguished by the fact that the laser inscription of the inner support layer is carried out through one or more flexible outer laser-inactive support layers which are separate or can be separated from one another.
Abstract: Liquid or pasty metallic printing inks which contain a mixture of at least one metal effect pigment and at least one partly optically transparent effect pigment and are used for finishing prints.
Type:
Application
Filed:
May 10, 2004
Publication date:
February 1, 2007
Applicants:
XSYS Print Solutions Deutschland GmbH, Merck Patent GmbH
Inventors:
Ulrich Kurze, Peter Schlichting, Thomas Leuschner, Uwe Baz, Burkhard Krietsch
Abstract: Multilayer interference pigment consisting of a transparent carrier material coated with alternating layers of metal oxides of low and high refractive index, the difference in the refractive indices being at least 0.1, which is obtainable by alternate coating of the transparent carrier material with a metal oxide of high refractive index and with a metal oxide of low refractive index in a wet process by hydrolysis of the corresponding water-soluble metal compounds, separation, drying and, if desired, calcination of the resulting pigment.
Type:
Grant
Filed:
July 11, 2005
Date of Patent:
January 30, 2007
Assignee:
Merck Patent GmbH
Inventors:
Hans-Dieter Brückner, Andrea Heyland, Christoph Schmidt, Christina Schank, Claudia Seibel
Abstract: An achromatic quarter wave film (AQWF) comprising at least one quarter wave film (QWF) and at least one half wave film (HWF), each of said QWF and HWF comprising polymerized or vitrified anisotropic material, to methods and materials for the preparation of the AQWF, its use in optical devices like compensators and liquid crystal displays, and to a liquid crystal display comprising such an AQWF.
Type:
Grant
Filed:
May 9, 2003
Date of Patent:
January 30, 2007
Assignees:
Merck Patent GmbH, LG Chemical Ltd.
Inventors:
Jeong Su Yu, Moon Soo Park, Byoung Kun Jeon, Karl Skjonnemand, Kim Slaney, Mark Verrall
Abstract: The present invention relates to effect pigments having a color flop comprising metal oxide-coated SiO2 flakes having a uniform layer thickness, where the color flop runs through all four quadrants of the a,b color coordinate system (CIELAB L,a,b system). The present invention likewise relates to processes for the preparation of these pigments in which SiO2 flakes having a uniform layer thickness are coated with metal oxides, and to the use of these pigments in cosmetics, paints, coatings, plastics, films, in security printing, in security features in documents and identity papers, for coloring seed, for coloring foods or in medicament coatings and for the preparation of pigment compositions and dry preparations.
Type:
Grant
Filed:
January 17, 2006
Date of Patent:
January 30, 2007
Assignee:
Merck Patent GmbH
Inventors:
Gerhard Pfaff, Cornelia Foerderer, Doreen Warthe, Johann Dietz
Abstract: The invention relates to an optical compensator for liquid crystal displays comprising at least one O plate retarder, and at least one twisted A plate retarder with a twist angle ? of more than 90°, and further relates to a liquid crystal display comprising such a compensator.
Type:
Grant
Filed:
February 17, 2005
Date of Patent:
January 30, 2007
Assignee:
Merck Patent GmbH
Inventors:
David Coates, Owain Llyr Parri, Mark Verrall, Peter Le Masurier
Abstract: A liquid crystal display device produced through the steps of injecting a polymerizable monomer-containing liquid crystal composition between two substrates and, while applying a voltage between opposing transparent electrodes of the substrates, polymerizing the monomer, wherein the polymerizable monomer contained in the liquid crystal composition has one or more ring or condensed ring structures and functional groups bonded directly to the ring or condensed ring structure. The monomer is preferably represented by the following general formula: P1-A1-(Z1-A2)n-P2 wherein P1 and P2 are acrylates or the like, A1 and A2 are 1,4-phenylenes or the like, Z1 is —COO— or the like, and n is 0 to 2.
Abstract: Homeotropically oriented layers and films of liquid crystals especially on polymeric substrates. The layers and films, which also can be multi-layered films comprising a homeotropically aligned anisotropic film, are preparable by application of an orientation layer to the substrate. The orientation layer can be either an organic surfactant which is fixed in a matrix of a polymeric material or an inorganic thin layer such as aluminum or Al2O3.
Type:
Grant
Filed:
August 25, 2004
Date of Patent:
January 30, 2007
Assignee:
Merck Patent GmbH
Inventors:
David Coates, Owain Llyr Parri, Jeremy Lewis Ward, David Joicey, Keith Wilbourn, Colum Dickson, John Scott
Abstract: Novel compounds of formula (I) are disclosed, where R1, R1?, L, Y, m and p have the meanings given in claim 1, which are inhibitors of tyrosine kinases, in particular, TIE-2 and Raf kinases and can be used for the treatment of tumors.
Type:
Application
Filed:
July 19, 2004
Publication date:
January 25, 2007
Applicant:
MERCK PATENT GMBH
Inventors:
Francesc Mitjans, Elisabet Rosel-Vives, Jaume Adan, Marta Soler, Guenter Hoelzemann, Helene Crassier, Karl-August Ackermann, Wolfgang Staehle, Alfred Jonczyk, Wilfried Rautenberg
Abstract: An ionic liquid of the formula K+A?, wherein K and A are as defined herein, can be used in such things as electrochemical cells, supercapacitors, hydraulic liquids, solvents, organic syntheses.
Type:
Grant
Filed:
May 30, 2001
Date of Patent:
January 23, 2007
Assignee:
Merck Patent GmbH
Inventors:
Volker Hilarius, Udo Heider, Michael Schmidt
Abstract: Survivin Interacting Protein 1 and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing SIP-1 polypeptides and polynucleotides in diagnostic assays.
Type:
Grant
Filed:
March 21, 2001
Date of Patent:
January 23, 2007
Assignee:
Merck Patent GmbH
Inventors:
Bernd Hentsch, Klaus Dücker, Björn Hock
Abstract: The invention relates to novel 9- and/or 10-substituted anthracenes, to their use in liquid crystal, light-emitting or semiconducting materials and devices, in anisotropic polymers, optical, electrooptical, decorative, security, cosmetic, diagnostic, electric, electronic, charge transport, semiconductor, optical recording, electroluminescent, photoconductor or electrophotographic applications, and to liquid crystal, light-emitting and semiconducting materials, polymers and devices comprising them.
Type:
Application
Filed:
June 30, 2004
Publication date:
January 18, 2007
Applicant:
MERCK PATENT GMBH
Inventors:
Mark Goulding, Marcus Thompson, Warren Duffy, Martin Heeney, Iain McCulloch