Patents Assigned to Merck Patent GmbH
  • Patent number: 7105210
    Abstract: A liquid-crystalline medium based on a mixture of polar compounds of positive dielectric anisotropy, which contains one or more compounds of the formula I and one or more compounds of the formula IA in which R1, R2, ring A, L1-8, Z1, X1 and X2 are as defined in claim 1.
    Type: Grant
    Filed: March 5, 2004
    Date of Patent: September 12, 2006
    Assignee: Merck Patent GmbH
    Inventors: Michael Heckmeier, Brigitte Schuler, Izumi Saito, Sabine Schoen, Peer Kirsch
  • Publication number: 20060199844
    Abstract: The present invention relates to methylene urea derivatives of formula (I), the use of the compounds of formula (I) as inhibitors of raf-kinase, the use of the compounds of formula (I) for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.
    Type: Application
    Filed: October 8, 2003
    Publication date: September 7, 2006
    Applicant: Merck Patent GmbH
    Inventors: Hans-Peter Buchstaller, Matthias Wiesner, Oliver Schadt, Christiane Amendt, Frank Zenke, Christian Sirrenberg, Matthias Grell, Dirk Finsinger
  • Publication number: 20060199926
    Abstract: The present invention relates to novel oxygen-containing organoaluminium complexes of the general formula (I) in which R1, independently of one another, denote branched or unbranched C1-C7-alkyl, -cycloalkyl, -alkenyl, -cycloalkenyl, -aryl or -alkynyl; R2 denotes unsubstituted, mono- or polyalkylated and/or mono- or polyfluorinated aromatic hydrocarbons from the group R3, R4, independently of one another, denote CH2, CF2 or C(R1)2; independently of one another, m denotes 0, 1, 2 n denotes 0, 1, 2. These compounds can serve as cocatalysts in olefinic polymerisation reactions. In particular, they can be employed for the preparation of novel Ziegler-Natta catalysts having improved properties, in particular having higher activities compared with conventional Ziegler-Natta catalysts with AlEt3, as cocatalyst, or of novel coordination catalyst systems which have higher activities than conventional Ziegler-Natta catalysts, even at low temperatures, such as 60° C., and a pressure of 2 bar.
    Type: Application
    Filed: September 13, 2002
    Publication date: September 7, 2006
    Applicant: Merck Patent GmbH
    Inventors: Katrin Koehler, Eike Poetsch, Jens Eichhorn, Herbert Schumann, Birgit Wassermann, Sebastiain Dechert, Markus Hummert, Stefan Schutte, Walter Kaminsky, Andrea Eisenhardt, Manfred Arnold
  • Patent number: 7098344
    Abstract: A novel process for carrying out reactions of carbonyl compounds with organometallic reagents, in particular with Grignard reagents, is described.
    Type: Grant
    Filed: January 10, 2001
    Date of Patent: August 29, 2006
    Assignee: Merck Patent GmbH
    Inventors: Ulrich Koop, Holger Krummradt, Michael Schwarz, Joeran Stoldt, Juergen Eckstein, Stefan Zehner, Wolfgang Melichar
  • Patent number: 7098357
    Abstract: The present invention relates to a process for the dehydration of organic compounds to give unsaturated compounds.
    Type: Grant
    Filed: March 1, 2001
    Date of Patent: August 29, 2006
    Assignee: Merck Patent GmbH
    Inventors: Hanns Wurziger, Guido Pieper, Norbert Schwesinger
  • Publication number: 20060189665
    Abstract: The present invention relates to oxamide derivatives of Formula (I), the use of the compounds of Formula (I) as inhibitors of raf-kinase, the use of the compounds of Formula (I) for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.
    Type: Application
    Filed: March 9, 2004
    Publication date: August 24, 2006
    Applicant: MERCK PATENT GMBH
    Inventors: Hans-Peter Buchstaller, Matthias Wiesner, Frank Zenke, Christiane Amendt, Matthias Grell, Christian Sirrenberg
  • Patent number: 7094328
    Abstract: The present invention relates to acids of the general formula [I], [RyPF6-y]?H+ [I], where y=1, 2 or 3, and in which the ligands R may be identical or different and R is a perfluorinated C1-8-alkyl or aryl group or R is a partially fluorinated C1-8-alkyl or aryl group, in which some of the F or H may have been substituted by chlorine. The present invention furthermore relates to a process for the preparation of the acids according to the invention, to salts comprising a cation and the anion of the acid according to the invention, and to a process for the preparation of the salts. The invention furthermore relates to the use of the acids and salts according to the invention.
    Type: Grant
    Filed: June 11, 2002
    Date of Patent: August 22, 2006
    Assignee: Merck Patent GmbH
    Inventors: Nikolai Ignatyev, Michael Schmidt, Andreas Kühner, Volker Hilarius, Udo Heider, Andriy Kucheryna, Peter Sartori, Helge Willner
  • Patent number: 7095044
    Abstract: A field effect transistor in which a continuous semiconductor layer comprises: a) an organic semiconductor; and, b) an organic binder which has an inherent conductivity of less than 10?6Scm?1 and a permittivity at 1,000 Hz of less than 3.3 and a process for its production comprising: coating a substrate with a liquid layer which comprises the organic semiconductor and a material capable of reacting to form the binder; and, converting the liquid layer to a solid layer comprising the semiconductor and the binder by reacting the material to form the binder.
    Type: Grant
    Filed: November 21, 2001
    Date of Patent: August 22, 2006
    Assignee: Merck Patent GmbH
    Inventors: Beverley Anne Brown, Domenico Carlo Cupertino, Janos Veres, John David Schofield, Stephen William Leeming, Stephen George Yeates
  • Patent number: 7094905
    Abstract: The present invention relates to a gentle process for catalytic hydrogenation and to a process for the preparation of biotin using the hydrogenation step. The process according to the invention for the selective, catalytic hydrogenation of a C—C double bond on a thiazole ring system having at least one functional group which can be converted into a salt under basic conditions is characterised in that the hydrogenation is carried out in a protic solvent is a pH>7.
    Type: Grant
    Filed: August 9, 2001
    Date of Patent: August 22, 2006
    Assignee: Merck Patent GmbH
    Inventors: Stefan Lehmann, Thomas Koppe
  • Patent number: 7090986
    Abstract: A naturally occurring protein isolated from the saliva of the medicinal leech Hirudo medicinalis is described which strongly binds to collagen thus acting as an inhibitor of natural platelet adhesion to collagen. The protein has a molecular weight of about 12,000, an acidic isoelectric point and contains six cysteins. The protein was sequenced and the gene was cloned from a H. medicinalis cDNA-library. Procedures for producing such polypeptide by recombinant techniques are disclosed. The recombinant and the natural occurring proteins are potent inhibitors of collagen-dependent platelet adhesion and therefore useful for the therapeutic treatment of various conditions related to heart disease and diseases of the circulation system. Furthermore, the protein is useful for coating natural or artificial collagen surfaces in order to render them nonadhesive for cells and prevent the activation of cells.
    Type: Grant
    Filed: June 16, 2005
    Date of Patent: August 15, 2006
    Assignee: Merck Patent GmbH
    Inventors: Wolfgang Strittmatter, Detlef Güssow, Uwe Hofmann, Jürgen Hemberger, Zisi Fotev, Bernhard Scheuble
  • Patent number: 7090899
    Abstract: Liquid-crystalline medium having a dielectric anisotropy ?? of ?3, comprising compounds of the general formula (I), in which R is as defined herein, are suitable for use as liquid-crystalline media for, e.g., IPS, MLC, TN or STN displays, but in particular for LCoS displays. The media have very high specific resistance values, low threshold voltages, short response times and high birefringence values ?n, while maintaining other boundary conditions.
    Type: Grant
    Filed: September 10, 2003
    Date of Patent: August 15, 2006
    Assignee: Merck Patent GmbH
    Inventors: Atsutaka Manabe, Matthias Bremer, Elena Kress
  • Patent number: 7091022
    Abstract: MEKK3b polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing MEKK3b polypeptides and polynucleotides in diagnostic assays.
    Type: Grant
    Filed: August 7, 2001
    Date of Patent: August 15, 2006
    Assignee: Merck Patent GmbH
    Inventor: Burkhard Scharm
  • Patent number: 7087716
    Abstract: RGS8 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing RGS8 polypeptides and polynucleotides in diagnostic assays.
    Type: Grant
    Filed: May 10, 2001
    Date of Patent: August 8, 2006
    Assignee: Merck Patent GmbH
    Inventors: Claudia Wilm, Michael Gassen
  • Patent number: 7087272
    Abstract: The invention relates to fluorinated fluorene derivatives of negative DC anisotropy, of the formula I R1—(—A1—Z1—)k1—(—A2—Z2—)k2—W—(—Z3—A3—)k3—(—Z4—A4—)k4—R2I in which W denotes the sub-formula L1 and L2, independently of one another, are H, F, Cl, —CH2F, —CHF2 or —CF3, with the proviso that L1 and L2 are not both H, L3 and L4, independently of one another, are H or F, and R1, R2, A1, A2, A3, A4, Z1, Z2, Z3, Z4, k1, k2, k3 and k4 are as defined above. The invention furthermore relates to liquid-crystalline media and to optical and electro-optical display elements.
    Type: Grant
    Filed: March 7, 2002
    Date of Patent: August 8, 2006
    Assignee: Merck Patent GmbH
    Inventors: Matthias Bremer, Detlef Pauluth, Melanie Klasen-Memmer
  • Patent number: 7084143
    Abstract: The invention relates to compounds of formula (I) wherein R1, R2, R4 and R5 have the meaning given in Claim 1. Said compounds are potent 5-HT2A-antagonists and are suitable for the treatment of psychosis, schizophrenia, depression, neurological disorders, memory disorders. Parkinson's disease, amytrophic lateral sclerosis, Alzheimer's disease, Huntington's disease, eating disorders, e.g. nervous bulimia and anorexia and premenstrual syndrome and/or for positively influencing compulsive behaviors (obsessive-compulsive disorder, OCD).
    Type: Grant
    Filed: December 17, 2004
    Date of Patent: August 1, 2006
    Assignee: Merck Patent GmbH
    Inventors: Henning Boettcher, Christoph Seyfried
  • Patent number: 7084290
    Abstract: The invention relates to a method for producing perfluoroalkanesulfonic acid esters and for further transforming the same into the salts thereof. The invention also relates to the use of the produced compounds in electrolytes, batteries, capacitors, supercapacitors, and galvanic cells.
    Type: Grant
    Filed: May 4, 2002
    Date of Patent: August 1, 2006
    Assignee: Merck Patent GmbH
    Inventors: Nikolai Ignatyev, Michael Schmidt, Udo Heider, Peter Sartori, Andry Kucheryna
  • Patent number: 7083834
    Abstract: An anisotropic polymer film with improved alignments prepared by coating onto a substrate with a structured surface. The polymer films thereby obtained are useful in optical and electrooptical devices for decorative and security applications.
    Type: Grant
    Filed: December 10, 2004
    Date of Patent: August 1, 2006
    Assignee: Merck Patent GmbH
    Inventors: Matthias Kuntz, John Patrick, Guy Gregory, Tony Bleasdale, Rodney Riddle, Robert Hammond-Smith, Peter Howarth, Allan Marshall
  • Publication number: 20060166033
    Abstract: The invention relates to new polymerizable, luminescent compounds of formula I wherein R1, R2, Q and L1 have the meanings given in claim 1. Furthermore the invention relates to polymerizable mixtures containing compounds according to the invention and preferably at least one polymerizable mesogenic compound. Polymer materials obtainable by polymerizing such mixtures are also described. These compounds, mixtures and materials show advantageous photoluminescent and/or electroluminescent properties and may be used in light emitting devices and optical- or electrooptical display elements.
    Type: Application
    Filed: June 18, 2003
    Publication date: July 27, 2006
    Applicant: MERCK Patent GmbH
    Inventors: Eike Poetsch, Thomas Jacob, Jose Serrano, Milagros Pinol, Raquel Gimenez, Joachim Stumpe, Thomas Fischer, Regina Rosenhauer, Burkhard Schulz
  • Patent number: 7081280
    Abstract: A liquid-crystalline medium containing a mixture of polar compounds of positive dielectric anisotropy. The mixture contains one or more compounds of formula I in which: R is H, an alkyl or alkenyl radical having 1 to 15 carbon atoms which is unsubstituted, monosubstituted by CN or CF3 or at least monosubstituted by halogen, where one or more CH2 groups in these radicals are optionally, in each case independently of one another, replaced by —O—, —S—, —CO—, —CO—O—, —O—CO— or —O—CO—O in such a way that O atoms are not linked directly to one another; is a trans-1,4-cyclohexylene ring, in which one or two CH2 groups are optionally replaced by —O— and/or —S—, or a cyclohexenylene ring; Y is halogenated alkyl, halogenated alkenyl, halogenated alkoxy or halogenated alkenyloxy having 1 to 6 carbon atoms; Z is —OCH2—, —CH2CH2—, —CH?CH—, —CF2O—, —OCF2—, —C2F4— or a single bond; and n is 1 or 2.
    Type: Grant
    Filed: July 2, 2004
    Date of Patent: July 25, 2006
    Assignee: Merck Patent GmbH
    Inventors: Michael Heckmeier, Brigitte Schuler, Kazuaki Tarumi, Peer Kirsch, Volker Reiffenrath
  • Patent number: 7081282
    Abstract: The invention relates to an optically variable marking comprising a semiopaque substrate with a first surface that is covered with an optically variable layer that is for example a liquid crystal polymer layer or a layer comprising pearlescent pigments, and a second surface that is partially covered with a metal layer in the shape of a pattern, to methods of its preparation and to its use for decorative or security applications.
    Type: Grant
    Filed: July 1, 2002
    Date of Patent: July 25, 2006
    Assignee: Merck Patent GmbH
    Inventors: Matthias Kuntz, Reiner Delp, Rodney Riddle, John Patrick, Robert Hammond-Smith