Abstract: The present invention relates to the preparation and use of recombinant variants of group 6 allergens of the Poaceae (true grasses), which are characterised by reduced IgE reactivity compared with known wild-type allergens and at the same time substantially retained reactivity with T-lymphocytes.
Type:
Application
Filed:
November 18, 2014
Publication date:
March 12, 2015
Applicant:
MERCK PATENT GMBH
Inventors:
Martin WALD, Andreas NANDY, Helmut FIEBIG, Bernhard WEBER, Helga KAHLERT, Gerald REESE, Oliver CROMWELL
Abstract: The present invention relates to electro-optical switching elements and displays comprising them. In particular, it relates to electro-optical switching elements comprising at least a light reflecting layer, a light switching layer, and a light conversion layer, which comprises one or more light emitting substances, in particular, a light reflecting layer, which selectively reflects visible light, a light controlling element that controls the amount of transmitted and/or reflected light, and a light converting layer that shifts the wavelength of the transmitted light to longer values. The displays give bright images under either bright or dark conditions with small power consumption. They are particularly suitable for so called liquid crystal, electronic paper (e-paper) and MEMS switching applications.
Abstract: The invention relates to novel fullerene derivatives, to methods for their preparation and educts or intermediates used therein, to mixtures and formulations containing them, to the use of the fullerene derivatives, mixtures and formulations as organic semiconductors in, or for the preparation of, organic electronic (OE) devices, especially organic photovoltaic (OPV) devices and organic photodetectors (OPD), and to OE, OPV and OPD devices comprising, or being prepared from, these fullerene derivatives, mixtures or formulations.
Type:
Application
Filed:
September 11, 2014
Publication date:
March 12, 2015
Applicants:
Nano-C, Inc., MERCK PATENT GMBH
Inventors:
Nicolas BLOUIN, Stephane BERNY, Edward A. JACKSON, Henning RICHTER, Feng HE
Abstract: The present invention relates to thermally conductive pigments which consist of a substrate and a coating applied thereto comprising aluminium oxide and/or aluminium oxide hydrate, to a process for the preparation of these pigments, and to the use thereof.
Abstract: The present invention relates to a holder for monolithic sorbents in which a radial pressure can be exerted over the entire length of the sorbent by a conically tapering clamping tube.
Type:
Application
Filed:
March 22, 2013
Publication date:
March 12, 2015
Applicant:
Merck Patent GmbH
Inventors:
Karin Cabrera Perez, Klaus Kreher, Willi Neuroth, Michael Ukelis
Abstract: The present invention relates to a liquid crystal (LC) medium comprising a polymerizable compound, to a process for its preparation, to its use for optical, electro-optical and electronic purposes, in particular in an LC display, especially in an LC display of the PSA (“polymer sustained alignment”) type, and to an LC display comprising the LC medium.
Type:
Application
Filed:
September 11, 2014
Publication date:
March 12, 2015
Applicant:
Merck Patent GmbH
Inventors:
Eveline BARON, Julian VOGT, Qiong TONG, Stephan DEROW
Abstract: The present invention relates to novel formulations comprising an organic semiconductor (OSC) and one or more organic solvents. The formulation comprises a dimethyl anisole solvent. Furthermore, the present invention describes the use of these formulations as inks for the preparation of organic electronic (OE) devices, especially organic photovoltaic (OPV) cells and OLED devices, to methods for preparing OE devices using the novel formulations, and to OE devices, OLED devices and OPV cells prepared from such methods and formulations.
Type:
Grant
Filed:
December 22, 2010
Date of Patent:
March 10, 2015
Assignee:
Merck Patent GmbH
Inventors:
Philip Edward May, Mark James, Susanne Heun, Magda Goncalves-Miskiewicz, Katie Court
Abstract: The invention relates to co-activated silicate based phosphors. The invention further relates to the method of preparing these phosphors and to the use of these phosphors in electronic and electrooptical devices, in particular in light emitting diodes (LEDs) and solar cells. The invention further relates to illumination units comprising said phosphors.
Abstract: The present invention relates to a liquid-crystalline medium, characterized in that it contains a polymerizable component (A) containing one more polymerizable compounds and a liquid-crystalline component (B) containing one more compounds of the general formula I in which R, rings A1 and A2, Z1, Z2, Y1, Y2, X0 and r are as defined in Claim 1.
Type:
Grant
Filed:
August 20, 2013
Date of Patent:
March 10, 2015
Assignee:
Merck Patent GmbH
Inventors:
Seung-Eun Lee, Eun Young Kim, Dong-Mee Song, Kyung-Ah Park, Sang-Hyun Park, Eun-Kyu Lee
Abstract: The present invention relates to a liquid-crystalline medium based on a mixture of polar compounds having negative dielectric anisotropy (??), which is distinguished by the fact that it has a value for the ratio ?1/?n2 in the range 6-45 with a clearing point of >60° C. and a ?? of ??2.3. Media of this type are particularly suitable for electro-optical displays having active-matrix addressing based on the ECB, PA LCD, FFS or IPS effect.
Abstract: Photoactive polymers are provided, as well as related photovoltaic cells, articles, systems, and methods comprising these photoactive polymers.
Type:
Grant
Filed:
February 26, 2013
Date of Patent:
March 3, 2015
Assignee:
Merck Patent GmbH
Inventors:
Li Wen, David P. Waller, Paul Byrne, Nicolas Drolet, Gilles Herve Regis Dennler, Kap-Soo Cheon
Abstract: Compounds of the formula I, in which R1, R2, X and Y have the meanings indicated in Claim 1, are inhibitors of TBK1 and IKK? and can be employed, inter alia, for the treatment of cancer and inflammatory diseases.
Abstract: Disclosed are bispecific aptamers binding with high specifity to a tumour specific antigen (TSA) and a effector cell specific antigen (ESA) for treatment of cancer.
Type:
Grant
Filed:
December 12, 2011
Date of Patent:
March 3, 2015
Assignee:
Merck Patent GmbH
Inventors:
Lars Toleikis, Ralf Guenther, Bjoern Hock, Achim Doerner
Abstract: The present invention relates to polymers which contain at least one carbazole structural unit of the general formula (I) where Ar1, Ar2, Ar3 is each, independently of one another, an aryl or heteroaryl group, which may be substituted by one or more radicals R of any desired type; m, o is, independently of one another, 0 or 1; n is 1, 2 or 3 and the dashed lines represent the linking in the polymer; and at least one arylamine structural unit of the general formula (II) and/or (III) where Ar4, Ar5, Ar7, Ar8 is each, independently of one another, an aryl or heteroaryl group, which may be substituted by one or more radicals R of any desired type; Ar6 is an aryl or heteroaryl group, which may be substituted by one or more radicals R of any desired type, or represents a group of the formula Ar9-Y—Ar9, where Ar9 is in each case, independently, an aryl or heteroaryl group, which is substituted by one or more radicals R of any desired type or which may be linked to one another, and Y is a spacer group or a direct bon
Type:
Grant
Filed:
August 1, 2011
Date of Patent:
March 3, 2015
Assignee:
Merck Patent GmbH
Inventors:
Niels Schulte, Anna Hayer, Aurélie Ludemann
Abstract: The present invention relates to the provision of a DNA sequence of the major grass pollen allergen Lol p 4. The invention also encompasses fragments, new combinations of partial sequences and point mutants having a hypoallergenic action. The recombinant DNA molecules and the derived polypeptides, fragments, new combinations of partial sequences and variants can be utilised for the therapy of pollen-allergic diseases. The proteins prepared by recombinant methods can be employed for in vitro and in vivo diagnosis of pollen allergies.
Type:
Application
Filed:
November 7, 2014
Publication date:
February 26, 2015
Applicant:
MERCK PATENT GMBH
Inventors:
Andreas NANDY, Helmut FIEBIG, Oliver CROMWELL
Abstract: Compounds of the formula I in which R1, X and Y have the meanings indicated in Claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
Abstract: The invention relates to a process for the preparation of tris(perfluoroalkyl)phosphine oxides by reaction of tris(perfluoroalkyl)difluorophosphorane with alkaline-earth metal oxides, alkaline-earth metal carbonates, zinc oxide, copper(I) oxide, copper(II) oxide, silver oxide, mercury(II) oxide, cadmium oxide or cadmium carbonate.
Type:
Grant
Filed:
February 17, 2011
Date of Patent:
February 24, 2015
Assignee:
MERCK PATENT GmbH
Inventors:
Nikolai Mykola Ignatyev, Waldemar Wiebe, Helge Willner