Abstract: The invention provides novel quinazoline carboxamide azetidine compounds according to Formula (I) and use for the treatment of hyperproliferative diseases, such as cancer.
Type:
Grant
Filed:
November 11, 2011
Date of Patent:
February 3, 2015
Assignee:
Merck Patent GmbH
Inventors:
Bayard R. Huck, Reinaldo Jones, Yufang Xiao, Constantin Neagu, Donald Bankston, Andreas Goutopoulos
Abstract: The present invention relates to an apparatus and a process for manufacturing cell culture media. A specific cooling in combination with a certain type of mill lead to a production process that reduces decrease in the performance of the culture media. Preferably, the process is run continuously.
Type:
Grant
Filed:
November 3, 2011
Date of Patent:
February 3, 2015
Assignee:
Merck Patent GmbH
Inventors:
Jochen Bausch, Joerg von Hagen, Tanino Scaramuzza
Abstract: The invention relates to an electro-optical liquid-crystal display which contains, as dielectric, a liquid-crystalline medium having negative dielectric anisotropy and includes a backlight which essentially only emits light having a wavelength of 400 nm or more or has, between the liquid-crystal layer and the backlight, a cut-off filter which essentially only allows light having a wavelength of 420 nm or more to pass through. In particular, the liquid-crystalline medium comprises a) a (first) dielectrically negative component (component A) which consists of one or more dielectrically negative compounds of the formula I in which the parameters have the meanings indicated in claim 2, and a further (second) dielectrically negative component (component B).
Abstract: The present invention is directed to carrier systems comprising ether-lipids conjugated to one or more bioactive ligands and exposed on the surface of the carrier system for use in targeted delivery and/or antigen display systems. Optionally one or more further bioactive agents may be encapsulated or embedded within or attached to or adsorbed onto the carrier system. The present invention is further directed to methods of their preparation and their uses in medical applications, such as targeted delivery of bioactive agents to specific tissues or cells and antigen display systems for the study, diagnosis, and treatment of traits, diseases and conditions that respond to said bioactive agents.
Type:
Application
Filed:
March 11, 2013
Publication date:
January 29, 2015
Applicant:
MERCK PATENT GMBH
Inventors:
Michael Wilhelm Platscher, Raymond Behrendt, Viola Groehn, Simone Rachel Hoertner, Marco Silvio Passafaro, Finn Bauer
Abstract: Compounds of the formula (I), in which R1, R3, R5, R6, R7, R, X and Y have the meanings indicated in Claim 1, are inhibitors of methionine aminopeptidase and can be employed for the treatment of tumours.
Type:
Application
Filed:
March 21, 2013
Publication date:
January 29, 2015
Applicant:
MERCK PATENT GmbH
Inventors:
Timo Heinrich, Frank Zenke, Mireille Krier, Manja Friese-Hamim, Jeyaprakashnarayanan Seenisamy
Abstract: The present invention is directed to a new class of lipids, more specifically ether-lipids having a polar headgroup, as well as vesicles comprising these lipids, methods of their preparation as well as their uses in medical applications, wherein the ether-lipids are represented by general formula I
Type:
Application
Filed:
March 11, 2013
Publication date:
January 29, 2015
Applicant:
MERCK PATENT GmbH
Inventors:
Michael Wilhelm Platscher, Raymond Behrendt, Viola Groehn, Simone Rachel Hoertner, Marco Silvio Passafaro, Finn Bauer
Abstract: The present invention relates to white-emitting organic electroluminescent devices which have a fluorescent emitter layer and a phosphorescent emitter layer.
Type:
Grant
Filed:
April 13, 2011
Date of Patent:
January 27, 2015
Assignee:
Merck Patent GmbH
Inventors:
Joachim Kaiser, Horst Vestweber, Simone Leu, Holger Heil
Abstract: The present invention relates to the improvement of organic electronic devices, in particular electroluminescent devices, by using compounds which can have a plurality of isomers, where one of these isomers is present in excess.
Type:
Grant
Filed:
November 3, 2005
Date of Patent:
January 27, 2015
Assignee:
Merck Patent GmbH
Inventors:
Philipp Stoessel, Esther Breuning, Horst Vestweber, Holger Heil
Abstract: The present invention relates to intensely colored and/or optically variable pigments which have a flake-form transparent or semitransparent electrically conductive core and at least one coloring dielectric layer surrounding the core, to a process for the preparation of such pigments, and to the use thereof.
Type:
Grant
Filed:
December 11, 2008
Date of Patent:
January 27, 2015
Assignee:
Merck Patent GmbH
Inventors:
Burkhard Krietsch, Matthias Kuntz, Reinhold Rueger
Abstract: The present invention relates to polymerizable compounds, to processes and intermediates for the preparation thereof, and to the use thereof for optical, electro-optical and electronic purposes, in particular in liquid-crystal (LC) media and LC displays, especially in LC displays of the PS (“polymer sustained”) or PSA (“polymer sustained alignment”) type.
Abstract: The present invention relates to a liquid-crystal (LC) display of the PS (polymer stabilized) or PSA (polymer sustained alignment) type, and to polymerizable compounds and LC media for use in PS (polymer stabilized) and PSA displays.
Abstract: Compounds of the formula I in which R1, R2 and R4 have the meanings indicated in Claim 1, are inhibitors of Syk, and can be employed, inter alia, for the treatment of cancer, rheumatoid arthritis and/or systemic lupus
Type:
Application
Filed:
January 22, 2013
Publication date:
January 22, 2015
Applicant:
MERCK PATENT GMBH
Inventors:
Carl Deutsch, Daniel Kuhn, Tatjana Ross, Lars Burgdorf
Abstract: Compounds of the formula I in which U, V and W have the meanings indicated in claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
Type:
Application
Filed:
January 14, 2013
Publication date:
January 22, 2015
Applicant:
MERCK PATENT GMBH
Inventors:
Hans-Peter Buchstaller, Christina Esdar, Birgitta Leuthner
Abstract: Compounds of the formula I in which A, L1, L2, X and Y have the meanings indicated in Claim 1, are inhibitors of Syk, and can be employed, inter alia, for the treatment of rheumatoid arthritis.
Abstract: The present invention relates to a pigment mixture based on spherical particles having a defined particle-size distribution, and to the use thereof in paints, coatings, printing inks, security printing inks, plastics, ceramic materials, glasses, in cosmetic formulations, as tracer, as filler and for the preparation of pigment preparations and dry preparations.
Abstract: The present invention relates to liquid crystal media and to high frequency components comprising same, especially microwave components for high-frequency devices, such as devices for shifting the phase of microwaves.
Type:
Application
Filed:
December 10, 2012
Publication date:
January 15, 2015
Applicant:
MERCK PATENT GMBH
Inventors:
Atsutaka Manabe, Christian Jasper, Volker Reiffenrath, Constanze Brocke, Detlef Pauluth, Dagmar Klass
Abstract: The invention provides modified forms of bouganin protein having biological activity and a reduced propensity to activate human T cells as compared to the non-modified bouganin protein. The invention also provides T-cell epitope peptides of bouganin, and modified T-cell epitope peptides of bouganin which have a reduced propensity to activate human T cells as compared to the non-modified T-cell epitope peptide. The invention also provides cytotoxins having the having a ligand that binds to a cancer cells attached to the modified bouganin proteins. Also provided are methods of inhibiting or destroying mammalian cancer cells using the cytotoxins of the invention and pharmaceutical compositions for treating human cancer.
Type:
Application
Filed:
April 1, 2014
Publication date:
January 15, 2015
Applicant:
Merck Patent GmbH
Inventors:
Matthew BAKER, Francis J. CARR, Koen HELLENDOORN, Jeannick CIZEAU, Glen C. MACDONALD, Joycelyn ENTWISTLE, Denis G. BOSC, Nicholas R. GLOVER
Abstract: This invention relates to electrowetting fluids, the use of these fluids for the preparation of an electrowetting displays devices, and electrowetting display devices comprising such fluids.
Type:
Application
Filed:
February 12, 2013
Publication date:
January 15, 2015
Applicant:
Merck Patent GmbH
Inventors:
Louise Diane Farrand, Nathan Smith, Roshan Kumar, Anthony Lawrence
Abstract: The invention relates to polymers containing dibenzocycloheptene structural units, to a method for the production thereof, and to blends and formulations containing said polymers. The invention further relates to the use of the polymers or blends according to the invention in electronic devices and to electronic devices, in particular OLEDs, containing the polymers or blends according to the invention.
Type:
Application
Filed:
January 26, 2013
Publication date:
January 15, 2015
Applicant:
Merck Patent GmbH
Inventors:
Anna Hayer, Niels Schulte, Eva Maria Reis