Patents Assigned to Merck Patents GmbH
  • Patent number: 8946247
    Abstract: The invention provides novel quinazoline carboxamide azetidine compounds according to Formula (I) and use for the treatment of hyperproliferative diseases, such as cancer.
    Type: Grant
    Filed: November 11, 2011
    Date of Patent: February 3, 2015
    Assignee: Merck Patent GmbH
    Inventors: Bayard R. Huck, Reinaldo Jones, Yufang Xiao, Constantin Neagu, Donald Bankston, Andreas Goutopoulos
  • Patent number: 8944352
    Abstract: The present invention relates to an apparatus and a process for manufacturing cell culture media. A specific cooling in combination with a certain type of mill lead to a production process that reduces decrease in the performance of the culture media. Preferably, the process is run continuously.
    Type: Grant
    Filed: November 3, 2011
    Date of Patent: February 3, 2015
    Assignee: Merck Patent GmbH
    Inventors: Jochen Bausch, Joerg von Hagen, Tanino Scaramuzza
  • Patent number: 8945420
    Abstract: The invention relates to an electro-optical liquid-crystal display which contains, as dielectric, a liquid-crystalline medium having negative dielectric anisotropy and includes a backlight which essentially only emits light having a wavelength of 400 nm or more or has, between the liquid-crystal layer and the backlight, a cut-off filter which essentially only allows light having a wavelength of 420 nm or more to pass through. In particular, the liquid-crystalline medium comprises a) a (first) dielectrically negative component (component A) which consists of one or more dielectrically negative compounds of the formula I in which the parameters have the meanings indicated in claim 2, and a further (second) dielectrically negative component (component B).
    Type: Grant
    Filed: January 17, 2011
    Date of Patent: February 3, 2015
    Assignee: Merck Patent GmbH
    Inventors: Atsutaka Manabe, Kazuaki Tarumi, Hubert Spreitzer, Axel Jansen, Melanie Klasen-Memmer
  • Publication number: 20150030669
    Abstract: The present invention is directed to carrier systems comprising ether-lipids conjugated to one or more bioactive ligands and exposed on the surface of the carrier system for use in targeted delivery and/or antigen display systems. Optionally one or more further bioactive agents may be encapsulated or embedded within or attached to or adsorbed onto the carrier system. The present invention is further directed to methods of their preparation and their uses in medical applications, such as targeted delivery of bioactive agents to specific tissues or cells and antigen display systems for the study, diagnosis, and treatment of traits, diseases and conditions that respond to said bioactive agents.
    Type: Application
    Filed: March 11, 2013
    Publication date: January 29, 2015
    Applicant: MERCK PATENT GMBH
    Inventors: Michael Wilhelm Platscher, Raymond Behrendt, Viola Groehn, Simone Rachel Hoertner, Marco Silvio Passafaro, Finn Bauer
  • Publication number: 20150031670
    Abstract: Compounds of the formula (I), in which R1, R3, R5, R6, R7, R, X and Y have the meanings indicated in Claim 1, are inhibitors of methionine aminopeptidase and can be employed for the treatment of tumours.
    Type: Application
    Filed: March 21, 2013
    Publication date: January 29, 2015
    Applicant: MERCK PATENT GmbH
    Inventors: Timo Heinrich, Frank Zenke, Mireille Krier, Manja Friese-Hamim, Jeyaprakashnarayanan Seenisamy
  • Publication number: 20150030670
    Abstract: The present invention is directed to a new class of lipids, more specifically ether-lipids having a polar headgroup, as well as vesicles comprising these lipids, methods of their preparation as well as their uses in medical applications, wherein the ether-lipids are represented by general formula I
    Type: Application
    Filed: March 11, 2013
    Publication date: January 29, 2015
    Applicant: MERCK PATENT GmbH
    Inventors: Michael Wilhelm Platscher, Raymond Behrendt, Viola Groehn, Simone Rachel Hoertner, Marco Silvio Passafaro, Finn Bauer
  • Patent number: 8941297
    Abstract: The present invention relates to white-emitting organic electroluminescent devices which have a fluorescent emitter layer and a phosphorescent emitter layer.
    Type: Grant
    Filed: April 13, 2011
    Date of Patent: January 27, 2015
    Assignee: Merck Patent GmbH
    Inventors: Joachim Kaiser, Horst Vestweber, Simone Leu, Holger Heil
  • Patent number: 8940407
    Abstract: The present invention relates to the improvement of organic electronic devices, in particular electroluminescent devices, by using compounds which can have a plurality of isomers, where one of these isomers is present in excess.
    Type: Grant
    Filed: November 3, 2005
    Date of Patent: January 27, 2015
    Assignee: Merck Patent GmbH
    Inventors: Philipp Stoessel, Esther Breuning, Horst Vestweber, Holger Heil
  • Patent number: 8940189
    Abstract: The present invention relates to intensely colored and/or optically variable pigments which have a flake-form transparent or semitransparent electrically conductive core and at least one coloring dielectric layer surrounding the core, to a process for the preparation of such pigments, and to the use thereof.
    Type: Grant
    Filed: December 11, 2008
    Date of Patent: January 27, 2015
    Assignee: Merck Patent GmbH
    Inventors: Burkhard Krietsch, Matthias Kuntz, Reinhold Rueger
  • Patent number: 8940184
    Abstract: The present invention relates to polymerizable compounds, to processes and intermediates for the preparation thereof, and to the use thereof for optical, electro-optical and electronic purposes, in particular in liquid-crystal (LC) media and LC displays, especially in LC displays of the PS (“polymer sustained”) or PSA (“polymer sustained alignment”) type.
    Type: Grant
    Filed: August 30, 2010
    Date of Patent: January 27, 2015
    Assignee: MERCK PATENT GmbH
    Inventors: Andreas Taugerbeck, Achim Goetz
  • Patent number: 8940375
    Abstract: The present invention relates to a liquid-crystal (LC) display of the PS (polymer stabilized) or PSA (polymer sustained alignment) type, and to polymerizable compounds and LC media for use in PS (polymer stabilized) and PSA displays.
    Type: Grant
    Filed: July 3, 2008
    Date of Patent: January 27, 2015
    Assignee: Merck Patent GmbH
    Inventors: Matthias Bremer, Georg Bernatz
  • Patent number: 8940907
    Abstract: The present invention relates to a process for the preparation of phosphoric esters, and to selected compounds.
    Type: Grant
    Filed: October 8, 2010
    Date of Patent: January 27, 2015
    Assignee: Merck Patent GmbH
    Inventor: Karl Heinz Gluesenkamp
  • Publication number: 20150025058
    Abstract: Compounds of the formula I in which R1, R2 and R4 have the meanings indicated in Claim 1, are inhibitors of Syk, and can be employed, inter alia, for the treatment of cancer, rheumatoid arthritis and/or systemic lupus
    Type: Application
    Filed: January 22, 2013
    Publication date: January 22, 2015
    Applicant: MERCK PATENT GMBH
    Inventors: Carl Deutsch, Daniel Kuhn, Tatjana Ross, Lars Burgdorf
  • Publication number: 20150025071
    Abstract: Compounds of the formula I in which U, V and W have the meanings indicated in claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
    Type: Application
    Filed: January 14, 2013
    Publication date: January 22, 2015
    Applicant: MERCK PATENT GMBH
    Inventors: Hans-Peter Buchstaller, Christina Esdar, Birgitta Leuthner
  • Publication number: 20150025066
    Abstract: Compounds of the formula I in which A, L1, L2, X and Y have the meanings indicated in Claim 1, are inhibitors of Syk, and can be employed, inter alia, for the treatment of rheumatoid arthritis.
    Type: Application
    Filed: December 18, 2012
    Publication date: January 22, 2015
    Applicant: Merck Patent GmbH
    Inventors: Henry Yu, Lizbeth Celeste Deselm
  • Publication number: 20150023899
    Abstract: The present invention relates to a pigment mixture based on spherical particles having a defined particle-size distribution, and to the use thereof in paints, coatings, printing inks, security printing inks, plastics, ceramic materials, glasses, in cosmetic formulations, as tracer, as filler and for the preparation of pigment preparations and dry preparations.
    Type: Application
    Filed: July 17, 2014
    Publication date: January 22, 2015
    Applicant: MERCK PATENT GMBH
    Inventors: Sylke KLEIN, Lilia HEIDER, Carsten LORENZ, Sabine SCHOEN
  • Publication number: 20150014584
    Abstract: The present invention relates to liquid crystal media and to high frequency components comprising same, especially microwave components for high-frequency devices, such as devices for shifting the phase of microwaves.
    Type: Application
    Filed: December 10, 2012
    Publication date: January 15, 2015
    Applicant: MERCK PATENT GMBH
    Inventors: Atsutaka Manabe, Christian Jasper, Volker Reiffenrath, Constanze Brocke, Detlef Pauluth, Dagmar Klass
  • Publication number: 20150018526
    Abstract: The invention provides modified forms of bouganin protein having biological activity and a reduced propensity to activate human T cells as compared to the non-modified bouganin protein. The invention also provides T-cell epitope peptides of bouganin, and modified T-cell epitope peptides of bouganin which have a reduced propensity to activate human T cells as compared to the non-modified T-cell epitope peptide. The invention also provides cytotoxins having the having a ligand that binds to a cancer cells attached to the modified bouganin proteins. Also provided are methods of inhibiting or destroying mammalian cancer cells using the cytotoxins of the invention and pharmaceutical compositions for treating human cancer.
    Type: Application
    Filed: April 1, 2014
    Publication date: January 15, 2015
    Applicant: Merck Patent GmbH
    Inventors: Matthew BAKER, Francis J. CARR, Koen HELLENDOORN, Jeannick CIZEAU, Glen C. MACDONALD, Joycelyn ENTWISTLE, Denis G. BOSC, Nicholas R. GLOVER
  • Publication number: 20150015931
    Abstract: This invention relates to electrowetting fluids, the use of these fluids for the preparation of an electrowetting displays devices, and electrowetting display devices comprising such fluids.
    Type: Application
    Filed: February 12, 2013
    Publication date: January 15, 2015
    Applicant: Merck Patent GmbH
    Inventors: Louise Diane Farrand, Nathan Smith, Roshan Kumar, Anthony Lawrence
  • Publication number: 20150014598
    Abstract: The invention relates to polymers containing dibenzocycloheptene structural units, to a method for the production thereof, and to blends and formulations containing said polymers. The invention further relates to the use of the polymers or blends according to the invention in electronic devices and to electronic devices, in particular OLEDs, containing the polymers or blends according to the invention.
    Type: Application
    Filed: January 26, 2013
    Publication date: January 15, 2015
    Applicant: Merck Patent GmbH
    Inventors: Anna Hayer, Niels Schulte, Eva Maria Reis