Abstract: The invention relates to compounds of the formula I, and to a liquid-crystalline medium, preferably having a nematic phase and negative dielectric anisotropy, which comprises one or more compounds of formula I, defined herein, for use in an electro-optical display, particularly in an active-matrix display based on the VA, ECB, PALO, FFS or IPS effect, and to the use of the compounds of the formula I for the stabilization of a liquid-crystalline medium which comprises one or more compounds of the formula II and one or more compounds of the formulae III-1 to III-4, defined herein.
Type:
Grant
Filed:
April 20, 2012
Date of Patent:
February 24, 2015
Assignee:
MERCK PATENT GmbH
Inventors:
Mark Goebel, Rocco Fortte, Detlef Pauluth
Abstract: The present invention relates to a novel process for the production of nanoparticles laden with active compounds and to the use thereof as medicaments. The process for the production of nanoparticles comprises the steps (a) dissolution of at least one active compound and at least one polymer in an organic solvent, (b) mixing of the solution prepared in step (a) with an aqueous phase, (c) evaporation of the organic solvent, (d) purification of the nanoparticles laden with active compound obtained in step (c) by means of dialysis against aqueous dialysis solution comprising the same active compound.
Type:
Application
Filed:
February 11, 2013
Publication date:
February 19, 2015
Applicant:
Merck Patent GmbH
Inventors:
Markus Weigandt, Senta Voss, Tobias Miller, Achim Goepferich
Abstract: Compounds of the formula I in which R1, R2 and R4 have the meanings indicated in Claim 1, are inhibitors of GCN2, and can be employed, inter alia, for the treatment of cancer.
Type:
Application
Filed:
February 14, 2013
Publication date:
February 19, 2015
Applicant:
Merck Patent GmbH
Inventors:
Kai Schiemann, Carl Deutsch, Guenter Hoelzemann, Daniel Kuhn, Ansgar Wegener, Dominique Swinnen, Horacio Comas
Abstract: The invention relates to the use of propanol and propenol derivatives as antioxidants, to compositions comprising propanol and propenol derivatives and the preparation thereof, and to certain propanol and propenol derivatives and the preparation thereof.
Abstract: The invention relates to novel conjugated polymers containing one or more repearting units derived from indacenodibenzothiophene or dithia-dicyclopenta-dibenzothiophene, to methods for their preparation and educts or intermediates used therein, to polymer blends, mixtures and formulations containing them, to the use of the polymers, polymer blends, mixtures and formulations as organic semiconductors in organic electronic (OE) devices, especially in organic photovoltaic (OPV) devices, and to OE and OPV devices comprising these polymers, polymer blends, mixtures or formulations.
Type:
Application
Filed:
April 2, 2013
Publication date:
February 19, 2015
Applicant:
MERCK PATENT GMBH
Inventors:
William Mitchell, Mansoor D'Lavari, Changsheng Wang, Steven Tierney, Jingyao Song
Abstract: The invention relates to a process for preparing benzo[1,2-b;4,5-b?]dithiophene-4,8-dicarboxylic acid or its 2,3-dihydro derivative, and to novel products prepared by this process.
Abstract: The invention relates to a liquid-crystalline medium comprising at least one compound of the formula I, in which R1 has the meanings indicated in Claim 1, and to the use thereof in liquid-crystalline media and in electro-optical liquid-crystal displays.
Type:
Application
Filed:
August 13, 2014
Publication date:
February 19, 2015
Applicant:
Merck Patent GmbH
Inventors:
Mark GOEBEL, Lars LIETZAU, Sabine SCHOEN, Andreas POHLE
Abstract: The present invention relates to a liquid-crystalline medium, characterised in that it contains a polymerisable component (A) containing one more polymerisable compounds and a liquid-crystalline component (B) containing one more compounds of the general formula I in which R, rings A1 and A2, Z1, Z2, Y1, Y2, X0 and r are as defined in Claim 1.
Type:
Grant
Filed:
August 20, 2013
Date of Patent:
February 17, 2015
Assignee:
Merck Patent GmbH
Inventors:
Seung-Eun Lee, Eun Young Kim, Dong-Mee Song, Kyung-Ah Park, Sang-Hyun Park, Eun-Kyu Lee
Abstract: The present invention relates to a liquid-crystalline medium, characterized in that it contains a polymerizable component (A) containing one more polymerizable compounds and a liquid-crystalline component (B) containing one more compounds of the general formula I in which R, rings A1 and A2, Z1, Z2, Y1, Y2, X0 and r are as defined in Claim 1.
Type:
Grant
Filed:
August 20, 2013
Date of Patent:
February 17, 2015
Assignee:
Merck Patent GmbH
Inventors:
Seung-Eun Lee, Eun Young Kim, Dong-Mee Song, Kyung-Ah Park, Sang-Hyun Park, Eun-Kyu Lee
Abstract: Anti-CD19 B4 antibodies with modified variable regions are disclosed. The modified anti-CD19 variable region polypeptides have alterations to one or more framework regions or complementarity determining regions of the heavy chain variable region or light chain variable region, thereby to reduce a T-cell response.
Abstract: The invention relates to novel organic semiconducting polymers containing one or more monomers derived from s-indacene fused symmetrically on each terminus with dithieno[3,2-b;2?,3?-d]thiophene (IDDTT), cyclopenta[2,1-b;3,4-b?]dithiophene (IDCDT), or derivatives thereof, to methods for their preparation and educts or intermediates used therein, to polymer blends, mixtures and formulations containing them, to the use of the polymers, polymer blends, mixtures and formulations as semiconductors in organic electronic (OE) devices, especially in organic photovoltaic (OPV) devices and organic photodetectors (OPD), and to OE, OPV and OPD devices comprising these polymers, polymer blends, mixtures or formulations.
Type:
Application
Filed:
January 18, 2013
Publication date:
February 12, 2015
Applicant:
MERCK PATENT GMBH
Inventors:
Changsheng Wang, William Mitchell, Nicolas Blouin, Jingyao Song, Mansoor D'Lavari, Steven Tierney
Abstract: The present invention relates to compounds suitable for use in electronic devices, and to electronic devices, especially organic electroluminescent devices, comprising these compounds.
Type:
Application
Filed:
February 28, 2013
Publication date:
February 12, 2015
Applicant:
Merck Patent GmbH
Inventors:
Philipp Stoessel, Elvira Montenegro, Arne Buesing, Teresa Mujica-Fernaud, Joachim Kaiser
Abstract: A pharmaceutical composition of 3-(1-{3-[5-(1-Methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile or a pharmaceutically acceptable salt and/or solvate thereof in combination with a compound selected from the group erlotinib, cetuximab, aflibercept, bevacizumab.
Abstract: The present invention relates to a composite ceramic which comprises a conversion phosphor and a further material, characterised in that the further material has a negative coefficient of thermal expansion, and to a process for the preparation thereof. Furthermore, the present invention also relates to the use of the composite ceramic according to the invention as emission-converting material, preferably in a white light source, and to a light source, a lighting unit and a display device.
Type:
Application
Filed:
March 2, 2013
Publication date:
February 12, 2015
Applicant:
Merck Patent GmbH
Inventors:
Holger Winkler, Thomas Juestel, Julian Plewa
Abstract: The invention relates to a process for the preparation of alkyl phosphinates, alkenyl phosphinates, alkynyl phosphinates or phenyl phosphinates by reaction of a corresponding phosphine oxide with an alcohol or phenol in the presence of alkali-metal fluoride or tetraalkylammonium fluoride.
Type:
Application
Filed:
February 12, 2013
Publication date:
February 12, 2015
Applicant:
MERCK PATENT GmbH
Inventors:
Nikolai Mykola Ignatyev, Michael Schulte, Christoph Alexander Jablonka, Karsten Koppe, Walter Frank
Abstract: The present invention relates to organic electroluminescent devices which comprise fluorene derivatives and spirobifluorene derivatives as matrix material for phosphorescent emitters.
Type:
Grant
Filed:
July 8, 2009
Date of Patent:
February 10, 2015
Assignee:
Merck Patent GmbH
Inventors:
Amir Hossain Parham, Joachim Kaiser, Anja Gerhard, Jonas Valentin Kroeber
Abstract: The invention relates to a liquid-crystalline medium which contains at least two polymerisable compounds or reactive mesogens (RM) and at least one compound selected from the group of compounds of the formula IIA, IIB and IIC, in which R2A, R2B, R2C, L1-6, ring B, Z2, Z2, p, q and v have the meanings indicated in Claim 1, and to the use thereof for an active-matrix display, in particular based on the VA, PSA, PS-VA, PALC, FFS, PS-FFS, IPS or PS-IPS effect, especially for the use in LC displays of the PS (polymer stabilised) or PSA (polymer sustained alignment) type.
Type:
Application
Filed:
February 12, 2013
Publication date:
February 5, 2015
Applicant:
Merck Patent GmbH
Inventors:
Ji-Won Jeong, Yong-Kuk Yun, Dong-Mee Song, Jung-Min Lee
Abstract: Compounds of the formula I in which R1, R2 and R4 have the meanings indicated in Claim 1, are inhibitors of Syk, and can be employed, inter alia, for the treatment of cancer, rheumatoid arthritis and/or systemic lupus
Type:
Application
Filed:
January 22, 2013
Publication date:
February 5, 2015
Applicant:
Merck Patent GmbH
Inventors:
Lars Burgdorf, Tatjana Ross, Carl Deutsch
Abstract: The invention relates to coated phosphor particles comprising luminescent particles and at least one, preferably substantially transparent, metal, transition-metal or semimetal oxide coating, and to a process for the production thereof.
Abstract: The present invention relates to the provision of a DNA sequence of the major grass pollen allergen Lol p 4. The invention also encompasses fragments, new combinations of partial sequences and point mutants having a hypoallergenic action. The recombinant DNA molecules and the derived polypeptides, fragments, new combinations of partial sequences and variants can be utilised for the therapy of pollen-allergic diseases. The proteins prepared by recombinant methods can be employed for in vitro and in vivo diagnosis of pollen allergies.
Type:
Grant
Filed:
December 6, 2010
Date of Patent:
February 3, 2015
Assignee:
Merck Patent GmbH
Inventors:
Andreas Nandy, Helmut Fiebig, Oliver Cromwell