Abstract: The present invention relates to thiadiazolopyridine polymers, their synthesis and their use. The present invention further relates to organic electronic devices comprising such thiadiazolopyridine polymers.
Abstract: The invention relates to a filling device (1) for dispensing a fluid into at least one container, where the filling device (1) has a weighing system (2) and a filling-needle system (3). The weighing system (2) has a positioning device (4) which can be adapted to a container diameter and which may have an annular design. The weighing system (2) is arranged on an accommodation platform (7) which can be moved vertically by means of a linear unit. The filling-needle system (3) is arranged on a displacement unit in a position at a distance in the axial direction above the positioning device (4).
Abstract: The present invention relates to compounds of the formula (1) which are suitable for use in electronic devices, in particular organic electroluminescent devices, and to electronic devices which comprise these compounds.
Type:
Grant
Filed:
March 3, 2016
Date of Patent:
April 17, 2018
Assignee:
Merck Patent GmbH
Inventors:
Christof Pflumm, Amir Hossain Parham, Constanze Brocke, Elvira Montenegro, Frank Voges, Holger Heil, Arne Buesing
Abstract: The present invention relates to microspheres and to their use, preferably as laser absorbing additive, and to a process for their production.
Type:
Grant
Filed:
October 16, 2013
Date of Patent:
April 17, 2018
Assignee:
Merck Patent GmbH
Inventors:
Franciscus Wilhelmus Maria Gelissen, Franciscus Gerardus Henricus Van Duijnhoven
Abstract: Compounds of the formula I in which W, R1, R2 and R3 have the meanings indicated in claim 1, are inhibitors of ALK1, AL2 and ALK5, and can be employed for the treatment of diseases such as cancer.
Type:
Application
Filed:
March 22, 2016
Publication date:
April 12, 2018
Applicant:
MERCK PATENT GMBH
Inventors:
Dieter DORSCH, Alfred JONCZYK, Mireille KRIER
Abstract: The present invention relates to liquid-crystalline media (LC media), characterised in that they comprise one or more compounds of the formula I, and one or more compounds of the formula II, where the parameters have the meaning indicated in claim 1, to the use thereof in electro-optical displays, and to LC displays which contain these LC media.
Type:
Application
Filed:
March 3, 2016
Publication date:
April 12, 2018
Applicant:
MERCK PATENT GMBH
Inventors:
Mark GOEBEL, Rocco FORTTE, Lars LIETZAU, Christian HOCK
Abstract: Disclosed are C-ring modified tricyclic benzonaphthiridinone compounds and analogs thereof, pharmaceutical compositions comprising such compounds and processes for preparing the same. The compounds are useful in the treatment of diseases amenable to protein kinase signal transduction inhibition, regulation and/or modulation.
Type:
Grant
Filed:
December 2, 2009
Date of Patent:
April 10, 2018
Assignee:
Merck Patent GmbH
Inventors:
Yufang Xiao, Bayard R. Huck, Amanda E. Sutton, Thomas E. Richardson, Srinivasa R. Karra
Abstract: Novel benzamide derivatives of formula (I) wherein W1, W2, R1 to R7, R6, X and Y have the meaning according to the claims, are positive allosteric modulators of the FSH receptor, and can be employed, inter alia, for the treatment of fertility disorders.
Type:
Grant
Filed:
October 3, 2016
Date of Patent:
April 10, 2018
Assignee:
Merck Patent GmbH
Inventors:
Henry Yu, Andreas Goutopoulos, Thomas E. Richardson, Jiezhen Li, Brian H. Heasley, Pandi Bharathi
Abstract: The present invention relates to a liquid-crystal medium which comprises a component A which consists of one or more compounds selected from the group of the formulae I-M and I-U in which the parameters have the respective meanings given in the claims or in the text, and to the corresponding, novel mesogenic compounds and to the preparation thereof. The present invention likewise relates to the use of these liquid-crystal media, in particular in components for high-frequency technology, and to components of this type which contain media according to the invention, and to the production and use of these components. The components according to the invention are suitable, in particular, as phase shifters in the microwave and millimeter wave region, for microwave and millimeter wave array antennae and very particularly for so-called tuneable “reflectarrays”.
Abstract: The present invention relates to a process for the vacuum purification of chemical compounds and to an apparatus for carrying out this process.
Abstract: The instant invention relates to mesogenic media comprising one or more compounds of formula G wherein the parameters are as specified in the text, preferably to mesogenic media showing a blue phase, preferably stabilised by a polymer, and their use in electro-optical light modulation elements and their respective use in displays, as well as to such devices.
Type:
Grant
Filed:
December 3, 2014
Date of Patent:
April 10, 2018
Assignee:
Merck Patent GmbH
Inventors:
Michael Wittek, Matthias Bremer, Erdal Durmaz
Abstract: The present invention relates to polymerizable compounds, to processes and intermediates for the preparation thereof, to liquid-crystal (LC) media comprising them, and to the use of the polymerizable compounds and LC media for optical, electro-optical and electronic purposes, in particular in LC displays, especially in LC displays of the polymer sustained alignment type.
Abstract: The present invention relates to indolizine compounds, and pharmaceutically acceptable compositions thereof, useful as antagonists of P2X7, and for the treatment of P2X7-related disorders.
Type:
Grant
Filed:
December 6, 2016
Date of Patent:
April 3, 2018
Assignee:
Merck Patent GmbH
Inventors:
Srinivasa R. Karra, Andreas Goutopoulos
Abstract: An apparatus for performing sonication on liquid samples comprises a rack for holding an array of sample vials, an ultrasonic probe with an arrangement of recesses corresponding to the array of sample vials and adapted to respectively receive and contact an outer surface of a bottom portion of a respective one of the sample vials, and a counter-holder with an arrangement of pushing members corresponding to the array of sample vials and adapted to respectively apply a force to a respective one of the sample vials so as to push the bottom portion of each vial into contact with the associated recess of the probe. The apparatus can be used in a method of preparing a sample for detection of cell components (e.g. cell analyte, proteins, nucleid acids etc.) and applying sonication within certain parameter ranges which can provide a universal lysis method that can be applied to a large variety of cells or organisms like all bacteria, viruses, spores, yeast and mold within the same apparatus and process.
Type:
Grant
Filed:
February 20, 2014
Date of Patent:
April 3, 2018
Assignee:
MERCK PATENT GMBH
Inventors:
Luc Felden, David Lehmann, Marisa Hohnadel, Sebastien Jouette
Abstract: The present invention relates to methods for the production of enantiopure or enantioenriched Praziquantel precursors and to methods for the production of enantiopure or enantioenriched Praziquantel comprising the methods for the production of the Praziquantel precursors. The present invention further relates to compounds or intermediates useful in such methods.
Type:
Grant
Filed:
November 19, 2015
Date of Patent:
April 3, 2018
Assignee:
Merck Patent GmbH
Inventors:
David Maillard, Andreas Waechtler, Jeremy Maurin, Ewgenij Wakaresko, Christian Jasper
Abstract: A support apparatus for a filter membrane comprises a base support and a disc-shaped porous support member. The member is removably received in a seat portion of the base support in fluid communication with a drain. A bottom side of the disc-shaped porous support member is supported in a support plane. The bottom side of the member is unsupported in an area and the unsupported area is adjacent to a space in the seat portion of the base support that is located and dimensioned such that application of a force, onto the top side of the member at a location substantially within the boundaries of the unsupported area at the bottom side will cause the member to pivot/tilt into the space and lift above the support plane at a diagonally opposite side from the location where the force is applied so that it can be easily grasped and removed.
Abstract: The invention relates to a liquid-crystalline medium, preferably having a nematic phase and dielectric anisotropy of 0.5 or more, which comprises one or more compounds of formula Y in which the parameters have the meanings given in the text, to the use thereof in an electro-optical display, particularly in an active-matrix display based on the IPS or FFS effect, to displays of this type which contain a liquid-crystalline medium of this type, and to the use of the compounds of formula Y for the improvement of the transmission and/or response times of a liquid-crystalline medium which comprises one or more additional mesogenic compounds.
Abstract: The present invention relates to compounds suitable for use in electronic devices, and to electronic devices, especially organic electroluminescent devices, comprising these compounds.
Type:
Grant
Filed:
July 20, 2016
Date of Patent:
March 27, 2018
Assignee:
Merck Patent GmbH
Inventors:
Philipp Stoessel, Elvira Montenegro, Arne Buesing, Teresa Mujica-Fernaud, Joachim Kaiser
Abstract: The present invention relates to the isolation of recombinant and/or biotherapeutic proteins for capture or clarification from cell culture fluid using copolymers. The copolymers used according to the process of the present invention comprise hydrophobic and anionic residues.
Type:
Grant
Filed:
November 25, 2013
Date of Patent:
March 27, 2018
Assignee:
Merck Patent GmbH
Inventors:
Johann Bauer, Almut Rapp, Bernd Stanislawski, Florian Capito
Abstract: The present invention relates to a liquid crystal (LC) medium comprising a polymerizable compound, one or more compounds of formula Q, and one or more compounds of formula AN1 to a process for its preparation, to its use for optical, electro-optical and electronic purposes, in particular in LC displays, especially in an LC display of the polymer sustained alignment (PSA) type, and to an LC display, especially a PSA display, comprising it.
Type:
Grant
Filed:
August 17, 2015
Date of Patent:
March 27, 2018
Assignee:
MERCK PATENT GMBH
Inventors:
Dong-Mee Song, Eun-Kyu Lee, Seung-Eun Lee