Abstract: The invention relates to ultrasmall, monodisperse nanoparticles comprising silicon dioxide to the surface of which at least one antigen is attached. The nanoparticles can be used for the immunoprophylaxis or immunotherapy of cancer. The invention also relates to a method for the targeting of antigens at antigen-presenting cells and for the activation of the immune system, where the efficiency of targeting and/or immunoactivation are set via the particle characteristics. The invention also relates to a method for the active and passive immunisation of a mammal.
Type:
Application
Filed:
October 6, 2017
Publication date:
March 15, 2018
Applicant:
Merck Patent GmbH
Inventors:
Markus Weigandt, Andrea Hanefeld, Armin Kuebelbeck, Gregor Larbig
Abstract: The present invention relates to a liquid crystal panel, a liquid crystal display device and to a liquid crystal medium having a negative dielectric anisotropy ??.
Type:
Grant
Filed:
October 31, 2011
Date of Patent:
March 13, 2018
Assignee:
MERCK PATENT GMBH
Inventors:
Eun-Kyu Lee, Seung-Eun Lee, Dong-Mee Song
Abstract: The present application relates to an electronic device comprising a hole-transport layer A, a doped hole-transport layer B and a hole-transport layer C, where hole-transport layers A, B and C are arranged between the anode and the emitting layer, and where hole-transport layer B is arranged on the cathode side of hole-transport layer A and hole-transport layer C is arranged on the cathode side of hole-transport layer B.
Type:
Grant
Filed:
September 11, 2013
Date of Patent:
March 13, 2018
Assignee:
Merck Patent GmbH
Inventors:
Frank Voges, Jonas Valentin Kroeber, Christof Pflumm, Joachim Kaiser, Arne Buesing
Abstract: The present invention relates compounds comprising a tetra-heteroaryl indacenodithiophene-based structural unit, the synthesis of such compounds as well as their use in organic electronic devices. The invention further relates to organic electronic devices comprising such compounds.
Type:
Grant
Filed:
June 26, 2015
Date of Patent:
March 13, 2018
Assignee:
Merck Patent GmbH
Inventors:
William Mitchell, Mansoor D'Lavari, Changsheng Wang, David Sparrowe
Abstract: The invention relates to bimesogenic compounds of formula I wherein R11, R12, MG11, MG12, X11, X12 and Sp1 have the meaning given in claim 1, to the use of bimesogenic compounds of formula I in liquid crystal media and particular to flexoelectric liquid crystal devices comprising a liquid crystal medium according to the present invention.
Type:
Grant
Filed:
June 14, 2013
Date of Patent:
March 13, 2018
Assignee:
Merck Patent GmbH
Inventors:
Kevin Adlem, Owain Llyr Parri, Rachel Tuffin, Patricia Eileen Saxton, Benjamin Snow, Mark John Goulding, Nathan Smith
Abstract: The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of Kv1.3 channels found in T cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis, pharmaceutical compositions containing these compounds and methods for their preparation.
Type:
Grant
Filed:
December 1, 2016
Date of Patent:
March 13, 2018
Assignees:
Bionomics Limited, Merck Patent GmbH
Inventors:
Andrew Harvey, Agnes Bombrun, Rachel Cooke, Isabelle Jeanclaude-Etter, Nathan Kuchel, Jerome Molette, Jorgen Mould, Dharam Paul, Rajinder Singh, Cristina Donini, Veronique Colovray, Thomas Avery, Julia Crossman, Justin Ripper
Abstract: The present invention relates to metal complexes having a metal atom of groups 13 to 15 and at least one ligand, where the ligand comprises at least one anionic coordination group having at least one oxygen and/or nitrogen atom via which the metal atom is coordinated, and the ligand comprises at least one triarylamine group, to processes for preparation thereof and to the use thereof in electronic devices, especially in organic electroluminescent devices, called OLEDs (OLED=organic light emitting diode). The present invention also further relates to organic electroluminescent devices comprising these metal complexes.
Type:
Application
Filed:
April 19, 2016
Publication date:
March 8, 2018
Applicant:
MERCK PATENT GMBH
Inventors:
Philipp Stoessel, Dominik Joosten, Beate Burkhart, Katja Stegmaier
Abstract: The present invention relates to alkaline earth aluminate phosphors, to a process for the preparation thereof and to the use thereof as conversion phosphors. The present invention also relates to an emission-converting material comprising at least the conversion phosphor according to the invention, and to the use thereof in light sources, in particular pc-LEDs (phosphor converted light emitting devices). The present invention furthermore relates to light sources, in particular pc-LEDs, and to lighting units which comprise a primary light source and the emission-converting material according to the invention.
Type:
Application
Filed:
March 2, 2016
Publication date:
March 8, 2018
Applicant:
MERCK PATENT GMBH
Inventors:
Aleksander ZYCH, Mathias RAPPHAHN, Ralf PETRY, Ingo KOEHLER, Andreas BENKER, Stefan TEWS
Abstract: The present invention provides compounds of Formula (I) for the treatment of parasitic diseases including malaria, as well as neurodegenerative diseases. Formula (I) wherein R3, R4, X and Y have the meaning given in claim 1.
Abstract: The present invention relates to interference pigments based on multicoated flake-form substrates which have on the surface of the substrate a layer sequence comprising (A0) optionally a high-refractive-index coating consisting of a layer of TiO2, (A) a high-refractive-index coating consisting of a mixture of TiO2 and Fe2O3, which may optionally be doped with one or more further oxides, (B) a high-refractive-index layer consisting of SnO2, (C) a high-refractive-index coating which absorbs in the visible wavelength region, and optionally (D) an outer protective layer, and to the use thereof, in particular in paints, coatings, industrial coatings, automobile paints, automotive refinish paints, coil coating, powder coatings, printing inks, plastics, pigment pastes, pigment preparations and in dry preparations, such as, for example, granules.
Abstract: Claimed is a cyclometallated organometallic light emitting complex having two tridentate ligand portions sharing a central heterocycle “A” providing a binding-site for each of the two metals (formula I): Formula (I): A more illustrative embodiment is formula (XII): Characterizing for the invention is that either one of XI and X2 and either one of Y1 and Y2 is carbon. The dinuclear complexes are for use in OLEDs.
Abstract: The present invention relates to a novel printable paste in the form of a hybrid gel based on precursors of inorganic oxides which can be used in a simplified process for the production of solar cells, where the hybrid gel according to the invention functions both as doping medium and also as diffusion barrier.
Type:
Application
Filed:
March 24, 2016
Publication date:
March 1, 2018
Applicant:
Merck Patent GmbH
Inventors:
Oliver DOLL, Ingo KOEHLER, Sebastian BARTH
Abstract: The present invention relates to liquid-crystalline media (LC media) having negative or positive dielectric anisotropy, comprising a low-molecular-weight component and a polymerizable component. The polymerizable component comprises self-aligning, polymerizable mesogens (polymerizable self-alignment additives) which effect homeotropic (vertical) alignment of the LC media at a surface or the cell walls of a liquid-crystal display (LC display). The invention therefore also encompasses LC displays having homeotropic alignment of the LC medium without alignment layers. The invention discloses novel structures for self-alignment additives which have a certain position of the functional groups.
Abstract: Compounds of the formula I in which R1-R3 and Z have the meanings indicated in Claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
Abstract: The present invention relates to a novel printable medium in the form of a hybrid sol and/or gel based on precursors of inorganic oxides for use in a simplified process for the production of solar cells, in which the medium according to the invention functions both as doping medium and also as diffusion barrier.
Type:
Application
Filed:
March 24, 2016
Publication date:
February 22, 2018
Applicant:
Merck Patent GmbH
Inventors:
Oliver DOLL, Ingo KOEHLER, Sebastian BARTH
Abstract: The present invention relates to a compound of formula (I) or (II), which is suitable for use as functional material in an electronic device, in particular as emitter material in an organic electroluminescent device.
Abstract: The present invention provides a method for forming a siliceous film. According to the method, a siliceous film having a hydrophilic surface can be formed from a polysilazane compound at a low temperature. In the method, a composition containing a polysilazane compound and a silica-conversion reaction accelerator is applied on a substrate surface to form a polysilazane film, and then a polysilazane film-treatment solution is applied thereon so that the polysilazane compound can be converted into a siliceous film at 300° C. or less. The polysilazane film-treatment solution contains a solvent, hydrogen peroxide and an alcohol.
Abstract: The present invention relates to a photosensitive composition comprising at least one nanosized fluorescent material and polysiloxane, to a color conversion film, and to a use of the color conversion film in an optical device. The invention further relates to an optical device comprising the color conversion film and a method for preparing the color conversion film and the optical device.
Type:
Application
Filed:
February 5, 2016
Publication date:
February 15, 2018
Applicants:
Merck Patent GmbH, AZ Electronic Materials (Luxembourg) S.a.r.l.
Abstract: The present invention relates to a liquid crystal (LC) medium comprising a polymerizable compound, to a process for its preparation, to its use for optical, electro-optical and electronic purposes, in particular in LC displays, especially in an LC display of the polymer sustained alignment (PSA) type, and to an LC display, especially a PSA display, comprising it.