Abstract: The present invention is directed to carrier systems comprising ether-lipids conjugated to one or more bioactive ligands and exposed on the surface of the carrier system for use in targeted delivery and/or antigen display systems. Optionally one or more further bioactive agents may be encapsulated or embedded within or attached to or adsorbed onto the carrier system. The present invention is further directed to methods of their preparation and their uses in medical applications, such as targeted delivery of bioactive agents to specific tissues or cells and antigen display systems for the study, diagnosis, and treatment of traits, diseases and conditions that respond to said bioactive agents.
Type:
Grant
Filed:
March 11, 2013
Date of Patent:
January 30, 2018
Assignee:
MERCK PATENT GMBH
Inventors:
Michael Wilhelm Platscher, Raymond Behrendt, Viola Groehn, Simone Rachel Hoertner, Marco Silvio Passafaro, Finn Bauer
Abstract: Compounds of formula (I) wherein X1, X2, W, R1 to R5, L and m have the meaning according to the claims, are glucosidase inhibitors, and can be employed, inter alia, for the treatment of Alzheimer's disease.
Type:
Grant
Filed:
March 10, 2014
Date of Patent:
January 30, 2018
Assignee:
Merck Patent GmbH
Inventors:
Henry Yu, Lesley Liu-Bujalski, Theresa L. Johnson
Abstract: A formulation comprising at least one solvent and at least two different functional compounds of formula (I) AB]k??(I) wherein A is a functional structural element, the structural element serving as a host material, as a unit that has hole-injection and/or hole-transport properties, as a unit that has electron-injection and/or electron-transport properties, as a unit which has light-emitting properties, or as a unit which improves the transfer from the singlet state to the triplet state of light-emitting compounds; B is a solubility-promoting structural element; and k is an integer in the range from 1 to 20; the molecular weight of the functional compound is at least 550 g/mol, and the solubility-promoting structural element B conforms to the general formula (L-I)
Type:
Grant
Filed:
August 27, 2015
Date of Patent:
January 30, 2018
Assignee:
Merck Patent GmbH
Inventors:
Rémi Manouk Anémian, Susanne Heun, Thomas Eberle, Philipp Stoessel, Aurélie Ludemann, Dietmar Kunkel
Abstract: The present invention relates to an electro-optical switching element comprising at least one light source, and a light converting layer, and to a use of the electro-optical switching element in an optical device. The invention further relates to an optical device comprising the electro-optical switching element.
Abstract: The invention relates to bimesogenic compounds of formula I wherein R11, R12, MG11, MG12 and CG1 have the meaning given in claim 1, to the use of bimesogenic compounds of formula I in liquid crystal media and particular to flexoelectric liquid crystal devices comprising a liquid crystal medium according to the present invention.
Type:
Application
Filed:
November 23, 2015
Publication date:
January 25, 2018
Applicant:
Merck Patent GmbH
Inventors:
Kevin ADLEM, Hassan ARASI, Owain Llyr PARRI, Rachel TUFFIN
Abstract: The present invention relates to metal complexes and to electronic devices, especially organic electroluminescent devices, comprising these metal complexes, especially as emitters.
Type:
Application
Filed:
January 7, 2016
Publication date:
January 25, 2018
Applicant:
Merck Patent GmbH
Inventors:
Philipp Stoessel, Nils Koenen, Philipp Harbach, Christian Ehrenreich
Abstract: The present invention relates to a powder formulation comprising at least one insect repellent and magnesium hydroxide carbonate, and to a process for the preparation of the formulation and to the use of the formulation for repelling insects.
Type:
Application
Filed:
January 8, 2016
Publication date:
January 25, 2018
Applicant:
MERCK PATENT GMBH
Inventors:
Michael TERMER, Frank PFLUECKER, Lilia HEIDER, Alexandra AXT-HEIDEMANN, Jutta ZUR LAGE
Abstract: Compounds of the formula I in which R, W, R1, R4, X1, X2, X3, X4 and q have the meanings indicated in Claim 1, are inhibitors of fatty acid synthase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
Type:
Application
Filed:
September 6, 2017
Publication date:
January 25, 2018
Applicant:
Merck Patent GmbH
Inventors:
Christos TSAKLAKIDIS, Wolfgang STAEHLE, Birgitta LEUTHNER
Abstract: The present invention relates to electron-deficient heteroaromatic compounds which are substituted by dibenzofuran or dibenzothiophene derivatives and by carbazoles or amines, in particular for use as triplet matrix materials in organic electroluminescent devices. The invention furthermore relates to a process for the preparation of the compounds according to the invention and to electronic devices comprising these compounds.
Type:
Grant
Filed:
July 15, 2015
Date of Patent:
January 23, 2018
Assignee:
Merck Patent GmbH
Inventors:
Amir Hossain Parham, Thomas Eberle, Anja Jatsch, Tobias Grossmann, Jonas Valentin Kroeber, Rémi Manouk Anémain
Abstract: The present invention relates to an electronic device comprising one or more compounds of a formula (I) or (II). Furthermore, the invention encompasses the use of a compound of the formula (I) or (II) in an electronic device, and the provision of certain compounds of the formula (I) or (II).
Abstract: The invention relates to a liquid-crystalline medium having a nematic phase and negative dielectric anisotropy which comprises a) one or more compounds of formula I b) one or more compounds of formula II and c) one or more compounds selected from the compounds of formulae III-1 to III-4 in which the parameters have the meanings indicated herein, to the use thereof in an electro-optical display, particularly in an active-matrix display based on the VA, ECB, PALC, FFS or IPS effect, to displays of this type which contain a liquid-crystalline medium of this type, and to the use of the compounds of the formula I for the stabilisation of a liquid-crystalline medium which comprises one or more compounds of formula II and one or more compounds selected from the compounds of formulae III-1 to III-4.
Type:
Grant
Filed:
November 11, 2011
Date of Patent:
January 23, 2018
Assignee:
MERCK PATENT GMBH
Inventors:
Mark Goebel, Elvira Montenegro, Atsutaka Manabe
Abstract: The present invention relates to a process for printing multicoloured printed images in which exclusively interference pigments are used for the coloured pigmentation of the printing inks, to printed products produced using a process of this type, to the use thereof, and to suitable interference pigments.
Type:
Application
Filed:
January 25, 2016
Publication date:
January 18, 2018
Applicant:
Merck Patent GmbH
Inventors:
Peter CLAUTER, Cairon PLATZER, Kirsten FRITSCHE, Marc-Dieter WEINGART, Lorenz BOEGLI, Christoph SCHMIDT
Abstract: The present invention relates to a conjugate containing at least one kidney-selective carrier molecule and at least one active compound which has a protective action for the kidney against nephrotoxic active compounds, to a process for the preparation of the conjugate, to the use thereof for the protection of the kidney against nephrotoxic active compounds, and to a medicament comprising the conjugate.
Type:
Application
Filed:
October 3, 2017
Publication date:
January 18, 2018
Applicant:
Merck Patent GmbH
Inventors:
Armin KUEBELBECK, Gregor LARBIG, Stefan ARNOLD, Walter MIER, Uwe HABERKORN
Abstract: The invention relates to a light modulation element comprising a cholesteric liquid crystalline medium sandwiched between two substrates (1), provided with a common electrode structure (2) and a driving electrode structure (3) individually, wherein the substrate with driving and/or common electrode structure is additionally provided with an alignment electrode structure (4) which is separated from the driving and or common electrode structure on the same substrate by a dielectric layer (5). The invention is further related to a method of production of said light modulation element and to the use of said light modulation element in various types of optical and electro-optical devices, such as electro-optical displays, liquid crystal displays (LCDs), non-linear optic (NLO) devices, and optical information storage devices.
Abstract: This invention relates to colored polymer, a process for their preparation, electrophoretic fluids comprising such particles, and electrophoretic display devices comprising such fluids.
Type:
Grant
Filed:
May 7, 2013
Date of Patent:
January 16, 2018
Assignee:
Merck Patent GmbH
Inventors:
Louise Diane Farrand, Nils Greinert, Claire Topping, Jonathan Henry Wilson, Simon Biggs, Olivier Cayre, Simon Lawson, Alexandre Richez, Simone Stuart-Cole
Abstract: The present invention relates to the use of aromatic boronic acid or borinic acid derivatives in organic electronic devices, in particular electroluminescent devices.
Type:
Grant
Filed:
June 20, 2016
Date of Patent:
January 16, 2018
Assignee:
Merck Patent GmbH
Inventors:
Philipp Stoessel, Esther Breuning, Arne Buesing, Amir Hossain Parham, Holger Heil, Horst Vestweber
Abstract: The invention provides novel heterocyclic amines according to Formula (I) their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
Type:
Grant
Filed:
August 24, 2016
Date of Patent:
January 16, 2018
Assignee:
Merck Patent GmbH
Inventors:
Ruoxi Lan, Xiaoling Chen, Yufang Xiao, Bayard R. Huck, Andreas Goutopoulos
Abstract: The application relates to an electronic device comprising anode, cathode, at least one emitting layer between anode and cathode, at least one p-doped layer A which comprises a monotriarylamine as host, and at least one layer B comprising a monotriarylamine. The invention furthermore relates to a p-doped mixture comprising a monotriarylamine of the formula (II), (III) or (IV) as host and an electron-acceptor compound as dopant and to the use of the mixture in an electronic device.
Type:
Grant
Filed:
March 5, 2013
Date of Patent:
January 16, 2018
Assignee:
Merck Patent GmbH
Inventors:
Christof Pflumm, Frank Voges, Jonas V. Kroeber, Philipp Stoessel, Joachim Kaiser
Abstract: Compounds containing at least one C—C triple bond of the formula I R1-[A1-Z1]m-A2A3-[Z2-A4]n-[Z3-A5]o-R2??I, which have neutral dielectric anisotropy, to the use thereof for high-frequency components, to liquid-crystalline media comprising the compounds, and to high-frequency components, in particular antennae, especially for the giga- and terahertz region, comprising these media. The liquid-crystalline media serve, for example, for the phase shifting of microwaves for tuneable phased-array antennae.
Type:
Grant
Filed:
September 3, 2013
Date of Patent:
January 16, 2018
Assignee:
MERCK PATENT GMBH
Inventors:
Constanze Brocke, Christian Jasper, Detlef Pauluth, Atsutaka Manabe