Patents Assigned to Merck
  • PNEUMOCOCCAL CONJUGATE VACCINE FORMULATIONS
    Publication number: 20200054740
    Abstract: The present invention provides pneumococcal conjugate vaccine formulations comprising surfactant systems incorporating polysorbate 20 or a combination of a poloxamer and a polyol.
    Type: Application
    Filed: February 20, 2018
    Publication date: February 20, 2020
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: William J. Smith, Cecilia Giovarelli, Denise K. Nawrocki
  • ENHANCING IMMUNOGENICITY OF STREPTOCOCCUS PNEUMONIAE POLYSACCHARIDE-PROTEIN CONJUGATES
    Publication number: 20200054733
    Abstract: The present invention provides immunogenic compositions having one or more polysaccharide-protein conjugates in which one or more polysaccharides from Streptococcus pneumoniae bacterial capsules are conjugated to a carrier protein in an aprotic solvent such as dimethylsulfoxide (DMSO). The present invention also provides methods for providing an enhanced immune response to a pneumococcal polysaccharide protein conjugate vaccine comprising administering to a human subject an immunogenic composition comprising polysaccharide-protein conjugates prepared in DMSO conditions.
    Type: Application
    Filed: February 20, 2018
    Publication date: February 20, 2020
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Jian He, John E. MacNair, William J. Smith, Michael A. Winters, Joseph G. Joyce, Chitrananda Abeygunawardana, Luwy Musey, Hari Pujar, Julie M. Skinner, Emily Wen, Patrick McHugh, John Michael Williams, Catherine Lancaster
  • Process for preparing recombinant insulin using microfiltration
    Patent number: 10562951
    Abstract: The use of two tandem microfiltration (MF) steps in a process for making recombinant insulin is described. The two MF steps in a single downstream purification unit operation reduce both soluble and insoluble impurities and exchange the insulin product into a suitable buffer for downstream purification.
    Type: Grant
    Filed: March 3, 2016
    Date of Patent: February 18, 2020
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Sean S. Gant, Michael J. Iammarino, Kristi Kerchner, Michael A. Rauscher, David J. Roush, Christopher H. Smith, Martin Chandler, Matthew Petroff
  • Process for producing nanoparticles laden with active ingredient
    Patent number: 10561733
    Abstract: The present invention relates to a novel process for the production of nanoparticles laden with active compounds and to the use thereof as medicaments. The process for the production of nanoparticles comprises the steps (a) dissolution of at least one active compound and at least one polymer in an organic solvent, (b) mixing of the solution prepared in step (a) with an aqueous phase, (c) evaporation of the organic solvent, (d) purification of the nanoparticles laden with active compound obtained in step (c) by means of dialysis against aqueous dialysis solution comprising the same active compound.
    Type: Grant
    Filed: February 11, 2013
    Date of Patent: February 18, 2020
    Assignee: Merck Patent GmbH
    Inventors: Markus Weigandt, Senta Voss, Tobias Miller, Achim Goepferich
  • Cell culture media
    Patent number: 10563169
    Abstract: The present invention relates to dry cell culture media comprising amino acid components of certain particle size. Some dry powder cell culture media show poor dissolving properties and result in turbid solutions when they are dissolved in aqueous solutions. Using amino acid components of certain particle sizes significantly reduces that problem.
    Type: Grant
    Filed: November 13, 2015
    Date of Patent: February 18, 2020
    Assignee: Merck Patent GmbH
    Inventor: Joerg Von Hagen
  • Bismuth perfluoroalkylphosphinates as lewis acid catalysts
    Patent number: 10562927
    Abstract: The invention relates to bismuth perfluoroalkylphosphinates as Lewis acid catalysts, the compounds, and processes for the preparation thereof. ArxBi[OP(O)(Rf)2]3-x??(Ia), Ar3Bi[OP(O)(Rf)2]2??(Ib).
    Type: Grant
    Filed: September 7, 2016
    Date of Patent: February 18, 2020
    Assignee: MERCK PATENT GMBH
    Inventors: Berthold Theo Hoge, Sven Joerg-Ruediger August Solyntjes, Nikolai (Mykola) Ignatiev
  • Preparation of nanoparticles-releasing enteric microparticles
    Patent number: 10561622
    Abstract: The present invention is directed to a process for the preparation of enteric microparticles comprising nanoparticles, wherein the nanoparticles comprise a matrix and an active ingredient. The microparticles obtained by such process are usable various multiparticulate pharmaceutical formulations such as extemporaneous dosage forms (powder for reconstitution).
    Type: Grant
    Filed: October 15, 2015
    Date of Patent: February 18, 2020
    Assignee: Merck Patent GmbH
    Inventors: Andrea Hanefeld, Markus Weigandt, Stefan Schiller, Marc Schneider, Michael C. Lehr
  • Formulation containing an organic semiconductor and a metal complex
    Patent number: 10566550
    Abstract: The present invention relates to formulations which comprise at least one organic semiconductor, at least one metal complex and at least one solvent and the use of these formulations in electronic devices, in particular organic electroluminescent devices.
    Type: Grant
    Filed: May 4, 2016
    Date of Patent: February 18, 2020
    Assignee: Merck Patent GmbH
    Inventors: Fabrice Eckes, Katja Scheible, Holger Heil, Dietmar Kunkel, Henning Seim
  • METHODS FOR MAKING POLYSACCHARIDE-PROTEIN CONJUGATES
    Publication number: 20200046821
    Abstract: The present invention provides methods for making polysaccharide-protein conjugates in which polysaccharides, typically from bacteria, are conjugated to a carrier protein by reductive amination under conditions which improve conjugation reaction consistency, increase consumption of protein during conjugation reaction, generate conjugates of higher molecular weight, and/or reduce the levels of free cyanide in the conjugate reaction product. The polysaccharide-protein conjugates obtained using these methods are useful for inclusion in multivalent vaccines.
    Type: Application
    Filed: January 30, 2018
    Publication date: February 13, 2020
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Jitin Bajaj, Michael Albert Winters, Emily Wen, Jian He
  • ORGANIC SEMICONDUCTING COMPOUNDS
    Publication number: 20200052227
    Abstract: The invention relates to novel organic semiconducting compounds containing a polycyclic unit, to methods for their preparation and educts or intermediates used therein, to compositions, polymer blends and formulations containing them, to the use of the compounds, compositions and polymer blends as organic semiconductors in, or for the preparation of, organic electronic (OE) devices, especially organic photovoltaic (OPV) devices, perovskite-based solar cell (PSC) devices, organic photodetectors (OPD), organic field effect transistors (OFET) and organic light emitting diodes (OLED), and to OE, OPV, PSC, OPD, OFET and OLED devices comprising these compounds, compositions or polymer blends.
    Type: Application
    Filed: October 2, 2017
    Publication date: February 13, 2020
    Applicant: Merck Patent GmbH
    Inventors: Graham MORSE, Lana NANSON, William MITCHELL, Michal KROMPIEC, Mansoor D'LAVARI, Agnieszka PRON
  • PROCESS FOR PREPARING ORTHO-METALLATED METAL COMPOUNDS
    Publication number: 20200048289
    Abstract: The present invention describes a process for producing tris-orthometalated metal compounds which can be used as coloring components as functional materials in a number of diverse applications that can be broadly attributed to the electronics industry.
    Type: Application
    Filed: February 13, 2018
    Publication date: February 13, 2020
    Applicant: Merck Patent GmbH
    Inventors: Philipp Stoessel, Tobias Brueckl, Verena Buback
  • ORGANIC PHOTODETECTOR
    Publication number: 20200052216
    Abstract: The invention relates to an organic photodetector (OPD) comprising a photoactive layer that contains an electron acceptor and an electron donor, the acceptor being an n-type semiconductor which is a small molecule that does not contain a fullerene moiety, and the electron donor being a p-type semiconductor which is a conjugated copolymer comprising donor and acceptor units.
    Type: Application
    Filed: October 2, 2017
    Publication date: February 13, 2020
    Applicant: Merck Patent GmbH
    Inventors: William MITCHELL, Lichun CHEN, Toby CULL
  • BINUCLEAR METAL COMPLEXES AND ELECTRONIC DEVICES, IN PARTICULAR ORGANIC ELECTROLUMINESCENT DEVICES CONTAINING SAID METAL COMPLEXES
    Publication number: 20200052213
    Abstract: The present invention relates to binuclear metal complexes and electronic devices, in particular organic electroluminescent devices containing said metal complexes.
    Type: Application
    Filed: October 9, 2017
    Publication date: February 13, 2020
    Applicant: Merck Patent GmbH
    Inventors: Philipp Stoessel, Christian Ehrenreich, Philipp Harbach, Anna Hayer, Esther Breuning
  • METAL PREPARATION AND COATINGS MADE THEREFROM
    Publication number: 20200048777
    Abstract: The present invention is directed to metal preparations containing metal particles, in particular noble metal particles, to the use of such metal preparations for the production of attractive metallic decorative elements on articles having an outer silicatic surface such as of porcelain, ceramic, china, bone china, glass or enamel, to metallic coatings on such substrates and to a process for the production of coatings of this kind.
    Type: Application
    Filed: March 12, 2018
    Publication date: February 13, 2020
    Applicant: MERCK PATENT GMBH
    Inventor: Khwan Khung LIM
  • KDM5 INHIBITORS
    Publication number: 20200048258
    Abstract: The present invention provides a compound of Formula (I) (represented as tautomers Ia and Ib) or the pharmaceutically acceptable salts thereof, which are KDM5 inhibitors.
    Type: Application
    Filed: October 6, 2017
    Publication date: February 13, 2020
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: UMAR FARUK MANSOOR, Christian Fischer, Phieng Siliphaivanh, Luis Torres, Hakan Gunaydin, David L. Sloman
  • KDM5 INHIBITORS
    Publication number: 20200048259
    Abstract: The present invention provides a compound of Formula (I) (represented as tautomers Ia and Ib): (I) or the pharmaceutically acceptable salts thereof, which are KDM5 inhibitors.
    Type: Application
    Filed: October 6, 2017
    Publication date: February 13, 2020
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: UMAR FARUK MANSOOR, Christian Fischer, Phieng Siliphaivanh, Hakan Gunaydin
  • Liquid crystal medium
    Patent number: 10557083
    Abstract: The present invention relates to a liquid crystal (LC) medium comprising a terphenyl compound and at least two polymerisable compounds, to a process for its preparation, to its use for optical, electro-optical and electronic purposes, in particular in LC displays, especially in an LC display of the polymer sustained alignment (PSA) type, and to an LC display, especially a PSA display, comprising it.
    Type: Grant
    Filed: December 1, 2015
    Date of Patent: February 11, 2020
    Assignee: MERCK PATENT GMBH
    Inventors: Hyun-Jin Yoon, Ji-Won Jeong, Eun-Kyu Lee, Min-Ok Jin, Yong-Kuk Yun
  • Materials for electronic devices
    Patent number: 10559756
    Abstract: The invention relates to compounds with benzindenofluorene base bodies having a structure of formula (I): and to the use thereof in electronic devices, in particular in organic electroluminescent devices.
    Type: Grant
    Filed: April 29, 2014
    Date of Patent: February 11, 2020
    Assignee: Merck Patent GmbH
    Inventors: Holger Heil, Lara-Isabel Rodriguez, Beate Burkhart, Amandine Darsy
  • Humanized antibody for treating or preventing cognitive disorders, process for producing the same, and agent for treating or preventing cognitive disorders using the same
    Patent number: 10556950
    Abstract: The invention provides methods for using and compositions of humanized antibodies that bind tau protein that is phosphorylated at the serine at position 413.
    Type: Grant
    Filed: February 27, 2018
    Date of Patent: February 11, 2020
    Assignees: TEIJIN PHARMA LIMITED, MERCK SHARP & DOHME CORP.
    Inventors: Hiroshi Eguchi, Takashi Murakami, Naoko Namiki, Akira Tanokura, Jeanne E. Baker, Sophie Parmentier Batteur, Angela Marie Jablonski, Daniel Stephen Malashock, Carl Mieczkowski, Gopalan (Raghu) Raghunathan
  • Light-converting material
    Patent number: 10557081
    Abstract: The present invention relates to light-converting materials which comprise semiconductor nanoparticles and an unactivated crystalline material, where the semiconductor nanoparticles are located on the surface of the unactivated crystalline material. The present invention furthermore relates to the use of the light-converting material in a light source. The present invention furthermore relates to a light-converting mixture, to a light source, to a lighting unit which contains the light-converting material according to the invention, and to a process for the production of the light source.
    Type: Grant
    Filed: August 17, 2016
    Date of Patent: February 11, 2020
    Assignee: Merck Patent GmbH
    Inventors: Norbert Stenzel, Andrea Opolka, Bernhard Rieger, Stefan Tews