Patents Assigned to Merck
  • N-heteroaryl indazole derivatives as LRRK2 inhibitors, pharmaceutical compositions, and uses thereof
    Patent number: 12030872
    Abstract: The present invention is directed to substituted certain N-heteroaryl indazole derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, X, Y, and Z are as defined herein, which are potent inhibitors of LRRK2 kinase and may be useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease and other diseases and disorders described herein. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of diseases, such as Parkinson's disease, in which LRRK-2 kinase is involved.
    Type: Grant
    Filed: October 25, 2019
    Date of Patent: July 9, 2024
    Assignee: Merck Sharp & Dohme LLC
    Inventors: Vladimir Simov, William P. Kaplan, John J. Acton, III, Michael J. Ardolino, Joanna L Chen, Peter H. Fuller, Hakan Gunaydin, Derun Li, Ping Liu, Kaitlyn Marie Logan, Joey Methot, Gregori J. Morriello, Santhosh F. Neelamkavil, Luis Torres, Xin Yan, Hua Zhou
  • System and method for controlling the state of two or more liquid-crystal-based switchable elements
    Patent number: 12031378
    Abstract: A method for controlling the state of two or more liquid crystal-based switchable elements is proposed, wherein the switchable elements are configured as smart windows and/or as switchable subunits of smart windows, wherein in a first step a), at least two keyframes are defined, wherein each keyframe comprises setting values defining the intended state of a group of switchable elements. In a subsequent step b), a display frame is computed, wherein the display frame comprises setting values for the state of the group of switchable elements based on at least one of the defined keyframes. In a subsequent step c), the state of each of the switchable elements of the group of switchable elements is set as defined by the setting values of the computed display frame. Also, a master controller for use with the method, and a system implementing the method.
    Type: Grant
    Filed: October 27, 2021
    Date of Patent: July 9, 2024
    Assignee: Merck Patent GmbH
    Inventors: Ties de Jong, Heiko Christ, Jasper van den Muijsenberg, Jens Osterodt, Abraham Karel Riemens
  • Compounds with diazadibenzofurane or diazadibenzothiophene structures
    Patent number: 12030890
    Abstract: The present invention describes diazadibenzofuran or diazadibenzothiophene derivatives substituted by carbazole, fluorene, phenanthrene, benzofuran and/or benzothiophene groups, especially for use in electronic devices. The invention further relates to a process for preparing the compounds of the invention and to electronic devices comprising these.
    Type: Grant
    Filed: October 31, 2022
    Date of Patent: July 9, 2024
    Assignee: Merck Patent GmbH
    Inventors: Amir Parham, Thomas Eberle, Anja Jatsch, Tobias Grossmann, Jonas Kroeber
  • Method for producing an electronic component which includes a self-assembled monolayer
    Patent number: 12035546
    Abstract: The invention relates to a process for the production of an electronic component comprising a self-assembled monolayer (SAM) using compounds of the formula I R1-(A1-Z1)r—(B1)n—(Z2-A2)s-Sp-G??(I) in which the groups occurring have the meanings defined in Claim 1; the present invention furthermore relates to the use of the components in electronic switching elements and to compounds for the production of the SAM.
    Type: Grant
    Filed: June 11, 2019
    Date of Patent: July 9, 2024
    Assignee: MERCK PATENT GMBH
    Inventors: Peer Kirsch, Sebastian Resch, Henning Seim, Marc Tornow, Takuya Kamiyama, Gerd-Volker Roeschenthaler, Romana Pajkert, Jacob Woodruff, Charith Nanayakkara
  • Polymerisable LC medium and polymer film with flat optical dispersion
    Patent number: 12031079
    Abstract: The invention relates to a polymerisable LC medium with flat, negative or positive optical dispersion, a polymer film with flat, negative or positive optical dispersion obtainable from such a material, and the use of the polymerisable LC medium and polymer film in optical, electro optical, electronic, semiconducting or luminescent components or devices.
    Type: Grant
    Filed: August 13, 2018
    Date of Patent: July 9, 2024
    Assignee: MERCK PATENT GMBH
    Inventors: Eduardo Beltran Gracia, Kevin Adlem, Naomi Weare, Hassan Norouzi-Arasi
  • NOVEL FORMS OF CYCLIC DINUCLEOTIDE COMPOUNDS
    Publication number: 20240218009
    Abstract: Novel forms of 2-amino-9-[(2R,5R,7R,8S,10R,12aR, 14R,15S,15aR,16R)-14-(6-amino-9H-purin-9-yl)-15,16-difluoro-2,10-dihydroxy-2,10-disulfidooctahydro-12H-5,8-methanofuro[3,2-1][1,3,6,9,11,2,10]pentaoxadiphospha-cyclotetradecin-7-yl]-1,9-dihydro-6H-purin-6-one, which include adducts of 2-amino-9-[(2R,5R,7R,8S,10R,12aR, 14R,15S,15aR,16R)-14-(6-amino-9H-purin-9-yl)-15,16-difluoro-2,10-dihydroxy-2,10-disulfidooctahydro-12H-5,8-methanofuro[3,2-1][1,3,6,9,11,2,10]pentaoxadiphospha-cyclotetradecin-7-yl]-1,9-dihydro-6H-purin-6-one and L-histidine, may be useful as inductors of type I interferon production, specifically as STING active agents.
    Type: Application
    Filed: April 18, 2022
    Publication date: July 4, 2024
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Stephanus Axnanda, Andrew Patrick Jude Brunskill, Erin N. Guidry, Eric A. Kemp, Courtney K. Maguire, Mikhail Reibarkh, Matthew S. Winston
  • Isomerically pure F-labelled tetrahydrofolates
    Patent number: 12023390
    Abstract: The present invention is directed towards isomerically pure 18F-labelled (6S)- or (6R)-5-methyltetrahydrofolate radiopharmaceuticals, wherein the phenyl group within the folate structure, has been replaced by an 18F-labelled N-heterocycle, for use in diagnostic imaging of a cell or population of cells expressing a folate-receptor in vitro or in vivo or for use in monitoring of cancer or inflammatory and autoimmune diseases and therapy thereof.
    Type: Grant
    Filed: March 19, 2018
    Date of Patent: July 2, 2024
    Assignee: Merck Patent GmbH
    Inventors: Rudolf Moser, Viola Groehn, Cristina Mueller, Roger Schibli, Simon Ametamey, Silvan Boss
  • RFID label
    Patent number: 12026568
    Abstract: The invention concerns a RFID label for marking containers or equipment, preferably in a laboratory environment and including in particular cylindrical bottles, vials, syringes, etc., by adhering the RFID layer to a surface thereof. The RFID label has a flat flexible support material base (11), at least one RFID microelectronic device (5c) included in the flat support material base (11), and at least one antenna (5a,5b) connected with the at least one RFID microelectronic device (5c) and included in the flat support material base (11). The flat support material base (11) has a number of predefined cuts (8) distributed about its outer periphery and/or the at least one RFID microelectronic device (5c) includes a tamper detection function and a conductive loop (5d) connected with tamper detection function terminals of the RFID microelectronic device (5c) is included in the flat support material base (11).
    Type: Grant
    Filed: November 18, 2020
    Date of Patent: July 2, 2024
    Assignee: MERCK PATENT GMBH
    Inventors: Christian-Hubertus Kuechenthal, Roja Azees, Dan Kvelstad, Sven Erfurth
  • OXAZOLIDINONE COMPOUND AND METHODS OF USE THEREOF AS AN ANTIBACTERIAL AGENT
    Publication number: 20240208958
    Abstract: The present invention relates to the oxazolidinone compound of Formula (I): and pharmaceutically acceptable salts thereof. The present invention also relates to compositions containing the compound of Formula (I). The invention also provides methods for inhibiting growth of mycobacterial cells as well as a method of treating mycobacterial infections by Mycobacterium tuberculosis by administering a therapeutically effective amount of Formula (I) and/or a pharmaceutically acceptable salt thereof, or a composition comprising such compound and/or salt.
    Type: Application
    Filed: March 20, 2021
    Publication date: June 27, 2024
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Brendan M. CROWLEY, Philippe NANTERMET, David B. OLSEN, Takao SUZUKI, Lihu YANG, Lanying YOU
  • PHENYL AZEPINES AS RIPK1 INHIBITORS AND METHODS OF USE THEREOF
    Publication number: 20240208986
    Abstract: Described herein are compounds of Formula I: (I), or a pharmaceutically acceptable salt thereof. The compounds of Formula I act as RIPK1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for RIPK1-related diseases.
    Type: Application
    Filed: April 21, 2022
    Publication date: June 27, 2024
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Joanna L. Chen, Erin F. DiMauro, Kevin D. Dykstra, Xavier Fradera, Peter H. Fuller, Charles A. Lesburg, Min Lu, Joey L. Methot, Matthew J. Mitcheltree, Jing Su
  • AURISTATIN LINKER-PAYLOADS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF
    Publication number: 20240207425
    Abstract: The present disclosure is directed to linker-payloads, and pharmaceutically acceptable salts, solvates, or stereoisomer thereof, comprising a structure of formula I: The disclosure is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds, intermediates thereof, and compositions in the prevention or treatment of cancers and/or tumors.
    Type: Application
    Filed: December 12, 2023
    Publication date: June 27, 2024
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Manoj B. Charati, John A. Flygare, Rebecca Elizabeth Johnson, Simon B. Lang, W. Michael Seganish
  • PLASMA KALLIKREIN INHIBITORS
    Publication number: 20240208994
    Abstract: The present invention provides a compound of Formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing one or more disease states that could benefit from inhibition of plasma kallikrein, including hereditary angioedema, uveitis, posterior uveitis, wet age-related macular degeneration, diabetic macular edema, diabetic retinopathy and retinal vein occlusion. The compounds are selective inhibitors of plasma kallikrein.
    Type: Application
    Filed: April 18, 2022
    Publication date: June 27, 2024
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Alan C. Cheng, Ying-Duo Gao, Song Yang, Mihir Mandal, Jiafang He, Jovan Alexander Lopez, Maoqun Tian
  • EXATECAN-DERIVED ADC LINKER-PAYLOADS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF
    Publication number: 20240208987
    Abstract: The present disclosure is directed to linker-payloads, and salts (including pharmaceutically acceptable salts), solvates, or stereoisomers thereof, comprising a structure of formula I: The disclosure is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds, intermediates thereof, and compositions in the prevention or treatment of cancers and/or tumors.
    Type: Application
    Filed: October 23, 2023
    Publication date: June 27, 2024
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Vlad Bacauanu, Manoj B. Charati, Sijie Chen, Rebecca Elizabeth Johnson, Simon B. Lang, Christian L. Morales, Ryan Quiroz, W. Michael Seganish, Nancy Zepeda
  • POLYMERISABLE OLIGOMERIC LIQUID CRYSTAL, POLYMERISABLE MEDIUM AND POLYMERISED LIQUID CRYSTAL FILM
    Publication number: 20240209264
    Abstract: A polymerisable oligomeric liquid crystal (LC) and a polymerisable LC medium comprising the polymerisable oligomeric LC together with one or more mono-, di- or multireactive mesogenic compounds. Furthermore, a method for the preparation of the oligomeric LC, a birefringent polymer film obtainable from the polymerisable LC medium, and a method of preparation of such a polymer film. Also, the use of the polymer film as optical component, in particular as ultra-thin polariser (UTP) in a liquid crystal display (LCD), for contrast enhancement in an organic light emitting device (OLED), or for AR/AV/VR applications.
    Type: Application
    Filed: December 7, 2023
    Publication date: June 27, 2024
    Applicant: Merck Patent GmbH
    Inventors: Danqing Liu, Yuanyuan Zhan, Efstathios Barmpoutsis, Dirk Jan Broer
  • Container system and method for freezing and thawing a liquid product
    Patent number: 12016330
    Abstract: Container system and method for freezing (and subsequently thawing) a liquid such as a drug substance, such that all containers in a set have a uniform width, hence uniform freeze-path length, in the widthwise direction and perpendicular to major walls of the containers, irrespective of the particular length, height, and volumetric capacity of the various containers in the set. This leads to uniform freezing performance and thereby reduces cryoconcentration. The system also eliminates or reduces ice-bridging, and the potential for containers rupturing during freezing and thawing operations.
    Type: Grant
    Filed: December 8, 2021
    Date of Patent: June 25, 2024
    Assignee: Merck Sharp & Dohme LLC
    Inventors: Jeffrey Charles Johnson, Anthony Flammino, Mark Anton Petrich, Scott McFeaters, John H. Roosa, Jr., Robert Ian Alpern, Joseph W. Locurcio, Matthew H. Flamm
  • Process for the manufacture of a solid pharmaceutical administration form
    Patent number: 12016827
    Abstract: The present invention relates to a process for the preparation of a solid pharmaceutical administration form using a 3D printing process as well. The process is a printing process that allows the production of solid pharmaceutical administration forms in a flexible manner and in conformity with the high quality standards required for the production of pharmaceuticals.
    Type: Grant
    Filed: December 22, 2021
    Date of Patent: June 25, 2024
    Assignee: MERCK PATENT GMBH
    Inventors: Stefan Schiller, Andrea Hanefeld, Gerhard Jonschker
  • Materials for organic electroluminescent devices
    Patent number: 12022732
    Abstract: The present invention relates to carbazole derivatives, in particular for use as triplet matrix materials in organic electroluminescent devices. The invention further relates to a method for producing the compounds according to the invention and to electronic devices comprising same.
    Type: Grant
    Filed: March 24, 2021
    Date of Patent: June 25, 2024
    Assignee: Merck Patent GmbH
    Inventors: Amir Hossain Parham, Thomas Eberle, Anja Jatsch, Christof Pflumm, Jonas Valentin Kroeber
  • Compositions comprising polysaccharide-protein conjugates and methods of use thereof
    Patent number: 12016914
    Abstract: The invention is related to multivalent immunogenic compositions comprising more than one S. pneumoniae polysaccharide protein conjugates, wherein each of the conjugates comprises a polysaccharide from an S. pneumoniae serotype conjugated to a carrier protein, wherein the serotypes of S. pneumoniae are as defined herein. Also provided are methods for inducing a protective immune response in a human patient comprising administering the multivalent immunogenic compositions of the invention to the patient. The multivalent immunogenic compositions are useful for providing protection against S. pneumoniae infection and/or pneumococcal diseases caused by S. pneumoniae.
    Type: Grant
    Filed: March 23, 2023
    Date of Patent: June 25, 2024
    Assignee: Merck Sharp & Dohme LLC
    Inventors: Chitrananda Abeygunawardana, Yadong Adam Cui, Romulo Ferrero, Jian He, Luwy Musey, Tanaz Petigara, Julie M. Skinner
  • Glazing comprising a switchable device, laminated structure and method for manufacturing of a glazing
    Patent number: 12017431
    Abstract: A glazing (10) comprising a switchable optical device (26) is proposed. The switchable optical device (26) has a layer structure comprising in this order a first substrate (12), a switchable layer (18) and a second substrate (24). Further, at least one of the first substrate (12) and the second substrate (24) is attached to a further sheet (30) by means of an adhesive tape (40) or an optically clear adhesive (48). Further aspects of the invention relate to a laminated structure and an insulated glazing unit comprising such a glazing (10) and a method for manufacturing of such a glazing (10).
    Type: Grant
    Filed: December 17, 2019
    Date of Patent: June 25, 2024
    Assignee: MERCK PATENT GMBH
    Inventors: Rainer Neeff, Michael Junge
  • Radar-Compatible Plastic Part
    Publication number: 20240199896
    Abstract: A radar-compatible plastic part that has a surface provided with a colouring coating that is free from metal-effect pigments; a process for the production of a radar-compatible plastic part of this type; and the use thereof in vehicle construction. The radar-compatible, coated plastic part is suitable for use for cover parts of radar devices, omits conventional metal-effect pigments in its colouring coating, and has a silver-coloured metallic appearance, high hiding power, and a strong lightness flop, and at the same time, a good radar wave transparency.
    Type: Application
    Filed: April 25, 2022
    Publication date: June 20, 2024
    Applicant: Merck Patent GmbH
    Inventors: Udo Gumsheimer, Kevin Kaiser