Patents Assigned to Merck
  • NOVEL DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 INHIBITORS
    Publication number: 20240059700
    Abstract: Invented are compounds of formula I and the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are DGAT2 inhibitors. Also provided are methods of making compounds of Formula I, pharmaceutical compositions comprising compounds of Formula I, and methods of using these compounds to treat hepatic steatosis, nonalcoholic steatohepatitis (NASH), fibrosis, type-2 diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, atherosclerosis, cognitive decline, dementia, cardiorenal diseases such as chronic kidney diseases and heart failure and related diseases and conditions, comprising administering a compound of Formula I to a patient in need thereof.
    Type: Application
    Filed: September 12, 2023
    Publication date: February 22, 2024
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Yeon-Hee Lim, Jianming Bao, Faben A. Cruz, Fa-Xiang Ding, Cedric Lorenz Hugelshofer, Victor W. Mak, James Patrick Roane, Jillian R. Sanzone, Samantha E. Shockley, Rose Yen
  • Luminescent film, organic electroluminescent element, organic material composition and method for producing organic electroluminescent element
    Patent number: 11910628
    Abstract: A luminescent film includes a host compound, a blue phosphorescent compound, and a blue fluorescent compound, in which an emission spectrum of the blue phosphorescent compound and an absorption spectrum of the blue fluorescent compound have portions overlapping with each other; shortest wavelength-side maximum emission wavelengths of the blue phosphorescent compound (abbreviated as “BPM” in the expression) and the blue fluorescent compound (abbreviated as “BFM” in the expression) satisfy the following expression (1): ?BFM??BPM: expression (1) in which ?BFM represents the shortest wavelength-side maximum emission wavelength of the blue fluorescent compound and ?BPM represents the shortest wavelength-side maximum emission wavelength of the blue phosphorescent compound; and light emission derived from the blue fluorescent compound is detected.
    Type: Grant
    Filed: March 4, 2022
    Date of Patent: February 20, 2024
    Assignee: MERCK PATENT GMBH
    Inventors: Kenichi Tabata, Yuta Nakamura, Taketo Namikawa, Satoru Inoue, Yasuo Miyata, Hiromoto II
  • Liquid crystal mixture and liquid crystal display
    Patent number: 11905450
    Abstract: The invention relates to a compound of formula I, wherein R11, R21, A11, A, Z, X11, X21, Y11, Y12, Sp11, Sp21, o and p have one of the meanings as given in claim 1. The invention further relates to method of production of a compound of formula I, to the use of said compounds in LC media and to LC media comprising one or more compounds of formula I. Further, the invention relates to a method of production of such LC media, to the use of such media in LC devices, and to LC device comprising a LC medium according to the present invention. The present invention further relates to a process for the fabrication such liquid crystal display and to the use of the liquid crystal mixtures according to the invention for the fabrication of such liquid crystal display.
    Type: Grant
    Filed: April 18, 2019
    Date of Patent: February 20, 2024
    Assignee: MERCK PATENT GMBH
    Inventors: Lars Lietzau, Simon Siemianowski, Izumi Saito, Rocco Fortte
  • Liquid-crystal medium comprising polymerizable compounds
    Patent number: 11905448
    Abstract: The present invention relates to a liquid-crystal (LC) medium comprising polymerizable compounds, to its use for optical, electro-optical and electronic purposes, in particular in LC displays, especially in LC displays of the PSA (polymer sustained alignment) or SA (self-aligning) mode, to an LC display of the PSA or SA mode comprising the LC medium, and to a process of manufacturing the LC display.
    Type: Grant
    Filed: October 20, 2022
    Date of Patent: February 20, 2024
    Assignee: MERCK PATENT GMBH
    Inventors: Hye-Ryung Park, Eun-Kyu Lee, Yen-Kai Huang
  • LIPID NANOPARTICLE COMPOSITIONS CONTAINING MONOESTER CATIONIC LIPIDS
    Publication number: 20240050378
    Abstract: The present disclosure provides, among other things, lipid nanoparticle formulations that include monoester cationic lipids. The present invention also provides compositions that include monoester cationic lipid nanoparticles and nucleic acids. The present disclosure also provides lipid nanoparticles encapsulating agents. The present disclosure further provides methods of producing lipid nanoparticles with encapsulated nucleic acids.
    Type: Application
    Filed: December 1, 2021
    Publication date: February 15, 2024
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Marian E. Gindy, Andrew Bett, Izzat Tiedje Raheem, Ronald M. Kim
  • FUSED [7,5] BICYCLIC PYRAZOLE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF HERPESVIRUSES
    Publication number: 20240051963
    Abstract: The present invention relates to novel Fused [7,5] Bicyclic Pyrazole Derivatives of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein X, R1, R2, R3, and R4 are as defined herein. The present invention also relates to compositions comprising at least one Fused [7,5] Bicyclic Pyrazole Derivative, and methods of using the Fused [7,5] Bicyclic Pyrazole Derivatives for treating or preventing a herpesvirus infection in a patient.
    Type: Application
    Filed: December 9, 2021
    Publication date: February 15, 2024
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Andrew J. Cooke, JR., Jeffrey W. Schubert, Jason W. Skudlarek
  • PROCESS MANAGEMENT OF MEDIA PREPARATION
    Publication number: 20240053372
    Abstract: System for performing a media preparation process controlled by a computer (7) further comprising a Media Preparation Module (12), a media bag (2) for storing the media in an unprepared state (13), a Dispensing Module (9, 9a) for storing the media in a finally prepared state (17), and a water providing system which connects the Media Preparation Module (12) with the media bag (2) and the Dispensing Module (9, 9a) and provides them with temperature adjustable water using a water sterilization filter set (4) wherein, the system (6) additionally comprises an attachable machine readable data storage (3) which contains information about the current state and/or operating parameters of the system parts, which are read, processed and used by the computer (7) to operate the system (6) according to required conditions.
    Type: Application
    Filed: December 20, 2021
    Publication date: February 15, 2024
    Applicant: Merck Patent GmbH
    Inventors: Stephane OLIVIER, Gaetan BOUR
  • FORMULATIONS OF ANTI-LAG3 ANTIBODIES AND CO-FORMULATIONS OF ANTI-LAG3 ANTIBODIES AND ANTI-PD-1 ANTIBODIES
    Publication number: 20240052036
    Abstract: The present invention provides formulations of anti-LAG3 antibodies, and co-formulations of anti-PD-1 antibodies and anti-LAG3 antibodies, and their use in treating various disorders.
    Type: Application
    Filed: October 12, 2023
    Publication date: February 15, 2024
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Preeti G. Desai, Shuai Shi, Valentyn Antochshuk, Rubi Burlage, Smita Raghava
  • POSITIVE TONE PHOTORESIST FORMULATION USING CROSSLINKABLE SILOXANE COMPOUNDS
    Publication number: 20240053681
    Abstract: The present invention relates to novel positive tone photoresist formulations comprising using crosslinkable siloxane polymers. The siloxane polymers used in the positive tone photoresist formulations are crosslinkable and comprise a first repeating unit, which contains at least one maleimide group, and a second repeating unit, which does not contain a maleimide group. The present invention further provides a manufacturing method for a microelectronic structure using a positive tone photoresist formulation according to the present invention and to an electronic device comprising a microelectronic structure, which is obtained or obtainable by said manufacturing method.
    Type: Application
    Filed: October 9, 2020
    Publication date: February 15, 2024
    Applicant: MERCK PATENT GMBH
    Inventors: Karsten KOPPE, Naofumi YOSHIDA
  • LIQUID CRYSTALLINE MEDIUM AND ELECTRO-OPTICAL DEVICE
    Publication number: 20240052242
    Abstract: The new media exhibit a ferroelectric nematic phase preferably at ambient temperature. They preferably comprise one or more compounds selected from the group of compounds of formulae IA, IB and IC, in which the variable groups have the meanings indicated in the text and in the claims. Use of the media for providing ferroelectric nematic materials and a method of operation of an electro-optical device are presented. The media may be useful for energy-saving displays and electrical appliances.
    Type: Application
    Filed: November 30, 2021
    Publication date: February 15, 2024
    Applicant: MERCK PATENT GMBH
    Inventors: Matthias BREMER, Atsutaka MANABE, Martin KRASKA
  • Fluorine compounds
    Patent number: 11898058
    Abstract: The present invention relates to novel compounds containing fluorinated end groups and to the use thereof in, for example, dirt-repellent coatings.
    Type: Grant
    Filed: July 16, 2021
    Date of Patent: February 13, 2024
    Assignee: Merck Patent GmbH
    Inventor: Reiner Friedrich
  • Methods for providing a homogenous solution of lyophilized mutant diptheria toxin in dimethylsulfoxide
    Patent number: 11896656
    Abstract: A method is described for reconstituting lyophilized mutant diphtheria toxin in dimethyl sulfoxide for use in producing pneumococcal capsular polysaccharide mutant diphtheria toxin conjugates.
    Type: Grant
    Filed: April 25, 2019
    Date of Patent: February 13, 2024
    Assignee: MERCK SHARP & DOHME LLC
    Inventors: Patrick Leonard Ahl, Akhilesh Bhambhani, Christopher Jon Farrell, Patrick McHugh, Morrisa C. Jones, Daniel D. Roth, Jessica R. Sinacola, Justin Stanbro, Matthew P. Watson, Emily Wen, Michael A. Winters
  • Anti-ILT4 antibodies and antigen-binding fragments
    Patent number: 11897956
    Abstract: The present invention provides antibodies and antigen-binding fragments thereof that bind to ILT4 (immunoglobulin-like transcript 4) and combinations thereof, e.g., with an anti-PD1 antibody. Also provided are methods of use thereof, for example, for treating or preventing cancer in a subject; and methods of making such antibodies and fragments.
    Type: Grant
    Filed: June 3, 2021
    Date of Patent: February 13, 2024
    Assignees: Merck Sharp & Dohme LLC, Agenus Inc.
    Inventors: Milan Blanusa, Barbara Joyce-Shaikh, Andrea Claudia Schuster, Kornelia Schultze, Luis A. Zuniga
  • Theoretical modeling and mechanism of drug release from controlled release implants by microstructural image characterization
    Patent number: 11900025
    Abstract: Embodiments disclosed herein relate to a model for predicting the release profile of a controlled release device. The implant modeling system and models disclosed herein allow the accurate prediction of a release profile for a controlled release device based on features extracted from micro-resolution imagery. The models combine microstructural features that can be extracted at the XRCT resolution, including pore volume and connectivity, using erosion-dilation image analysis. This strategy allows prediction of release curves of the controlled release device using XRCT despite its resolution limitations.
    Type: Grant
    Filed: March 4, 2019
    Date of Patent: February 13, 2024
    Assignee: Merck Sharp & Dohme LLC
    Inventors: Roberto Irizarry, Antong Chen, Daniel Skomski
  • Anti-ILT4 antibodies and antigen-binding fragments
    Patent number: 11897957
    Abstract: The present invention provides antibodies and antigen-binding fragments thereof that bind to ILT4 (immunoglobulin-like transcript 4) and combinations thereof, e.g., with an anti-PD1 antibody. Also provided are methods of use thereof, for example, for treating or preventing cancer in a subject; and methods of making such antibodies and fragments.
    Type: Grant
    Filed: June 3, 2021
    Date of Patent: February 13, 2024
    Assignees: Merck Sharp & Dohme LLC, Agenus Inc.
    Inventors: Milan Blanusa, Barbara Joyce-Shaikh, Andrea Claudia Schuster, Kornelia Schultze, Luis A. Zuniga
  • Photosensitive siloxane composition and pattern forming method using the same
    Patent number: 11899365
    Abstract: To provide a photosensitive siloxane composition capable of forming a pattern having a desired taper angle and a desired linewidth. [Means] The present invention provides a photosensitive siloxane composition comprising: a polysiloxane having a structure represented by the following formula (ia?): (L is an alkylene or phenylene), a photoactive agent, and a solvent.
    Type: Grant
    Filed: December 27, 2018
    Date of Patent: February 13, 2024
    Assignee: Merck Patent GmbH
    Inventors: Naofumi Yoshida, Takashi Fuke, Megumi Takahashi, Katsuto Taniguchi, Toshiaki Nonaka
  • LIQUID CRYSTAL COMPOUNDS
    Publication number: 20240043747
    Abstract: New compounds and their mixtures enable the formation of the ferroelectric nematic liquid crystalline phase at ambient temperature. Compounds of the formula I are presented, in which the variable groups have the meanings indicated in claim 1. Liquid crystal media comprise at least one compound of the formula I.
    Type: Application
    Filed: November 30, 2021
    Publication date: February 8, 2024
    Applicant: MERCK PATENT GMBH
    Inventors: Matthias BREMER, Atsutaka MANABE, Martin KRASKA
  • IL-2 MUTEINS FOR TREATING AUTOIMMUNE AND INFLAMMATORY DISEASES
    Publication number: 20240043491
    Abstract: Provided herein are IL-2 muteins that bind to IL-2 receptor subunit but do not have measurable binding to IL-2 receptor subunit. Also provided are compositions, kits, methods, and uses involving such IL-2 muteins.
    Type: Application
    Filed: December 21, 2021
    Publication date: February 8, 2024
    Applicant: MERCK SHARP & DOHME LLC
    Inventors: Stephen E. ALVES, Glareh AZADI, Maribel BEAUMONT, Lia BENSO, Alan C. CHENG, Peter GEORGIEV, Brian E. HALL, Veronica M. JUAN, Renee MOORE, Venkataraman SRIRAMAN, Jie ZHANG-HOOVER
  • ENTEROVIRUS PURIFICATION WITH CATION EXCHANGE CHROMATOGRAPHY
    Publication number: 20240043813
    Abstract: The present invention relates to a cation exchange chromatography process for the purification of enteroviruses.
    Type: Application
    Filed: December 16, 2021
    Publication date: February 8, 2024
    Applicant: MERCK SHARP & DOHME LLC
    Inventors: Spyridon KONSTANTINIDIS, Murphy POPLYK, Andrew Ryan SWARTZ
  • Add-on unit for a media preparation apparatus
    Patent number: D1014464
    Type: Grant
    Filed: April 4, 2022
    Date of Patent: February 13, 2024
    Assignee: Merck Patent GmbH
    Inventors: Diana Spitznagel, Gaétan Bour, Stéphane Olivier