Patents Assigned to Merck
  • Mono-, oligo- and poly-4-fluorothiophenes and their use as charge transport materials
    Patent number: 6676857
    Abstract: Mono-, oligo- and polymers comprising one or more identical or different recurring units of formula I —[(Y)a—(D)b—(Z)c]—  I wherein D is a 3-substituted-4-fluorothiophene group of formula II, wherein Y, Z, R1, a, b and c have the meanings defined herein, are useful as semiconductors or charge transport materials.
    Type: Grant
    Filed: July 25, 2002
    Date of Patent: January 13, 2004
    Assignee: Merck Patent Gesellschaft mit
    Inventors: Martin Heeney, Louise Farrand, Mark Giles, Marcus Thompson, Steven Tierney, Maxim Shkunov, David Sparrowe, Iain McCulloch
  • 1-biaryl-1,8-naphthyridin-4-one phosphodiesterase-4 inhibitors
    Patent number: 6677351
    Abstract: Compounds represented by Formula (I): or a pharmaceutically acceptable salt thereof, are phosphodiesterrase 4 inhibitors useful in the treatment of asthma and inflammation.
    Type: Grant
    Filed: May 24, 2002
    Date of Patent: January 13, 2004
    Assignee: Merck Frosst Canada & Co.
    Inventors: Chun Li, Mario Girard, Pierre Hamel, Sebastien Laliberte, Richard Friesen, Yves Girard, Daniel Guay
  • Polymer beads
    Patent number: 6677042
    Abstract: The invention relates to polymer beads comprising an anisotropic polymer material with helically twisted structure, to their use in reflective films, spraying or printing inks or as pigments, for optical or electrooptical, decorative or security applications, to a reflective film comprising one or more polymer beads in a transmissive binder, and to a security marking or security device comprising one or more polymer beads or comprising a reflective film.
    Type: Grant
    Filed: September 18, 2001
    Date of Patent: January 13, 2004
    Assignee: Merck Patent GmbH
    Inventors: Matthias Kuntz, David Coates, Simon Greenfield, John Patrick
  • Liquid-crystalline medium
    Patent number: 6677003
    Abstract: A liquid-crystalline medium based on a mixture of polar compounds of positive dielectric anisotropy, characterized in that it comprises one or more compounds of the formula I and one or more compounds of the formula IA in which are as defined herein, is suitable for use in MLC, TN and STN displays.
    Type: Grant
    Filed: October 19, 2001
    Date of Patent: January 13, 2004
    Assignee: Merck Patent Gesellschaft mit
    Inventors: Georg Lussem, Dagmar Klement, Volker Reiffenrath
  • Phenylcyclohexanes and a liquid-crystalline medium
    Patent number: 6677002
    Abstract: Novel phenylcyclohexanes of the formula I: in which n is 0 to 7, Q1 and Q2 are H, or one of these radicals is alternatively CH3, r is 0, 1, 2, 3, 4 or 5, A is trans-1,4-cyclohexylene, 1,4-phenylene, 3-fluoro-1,4-phenylene or a single bond, X is F, Cl, —CF3, —CN, —OCF3 or —OCHF2, and Y and Z are each, independently of one another, H or F, with the proviso that, in the case where A is a single bond, Q1═Q2═H and simultaneously X═CN, Y and/or Z are F.
    Type: Grant
    Filed: February 8, 2001
    Date of Patent: January 13, 2004
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Andreas Wächtler, Reinhard Hittich, Eike Poetsch, Herbert Plach, David Coates, Bernhard Rieger, Joachim Krause
  • Pb-Bi-Sr-Ca-Cu-oxide powder mix with enhanced reactivity and process for its manufacture
    Patent number: 6677278
    Abstract: An Oxide Precursor Powder from the Pb—Bi—Sr—Ca—Cu—O 2223 System can be produced by heat treating powder, produced using the Spray Pyrolysis Process as described in: GB2210605 or EP0681989 between 700° C. and 850° C. in an atmosphere containing between 0.1% and 21% O2. Heat Treatment of the pyrolysis powder under controlled conditions produces a powder with a particular phase composition, that is highly homogeneous and has a small particle size distribution, that is inherently more reactive than powders heat treated in the same way but produced using other processes.
    Type: Grant
    Filed: June 6, 2002
    Date of Patent: January 13, 2004
    Assignee: Merck Patent GmbH
    Inventors: Lee Woodall, Ru-Shi Liu, Ya-Wei Hsueh, Wolfgang Wilhelm Schmahl, Sebastian Raeth
  • Process for the preparation of ring compounds
    Publication number: 20040006235
    Abstract: In a process for the preparation of ring compounds via a combinatorial synthesis, the reaction procedure is based on a Suzuki coupling, subsequent halo-demetallation and finally a further Suzuki coupling. The Suzuki couplings are each carried out with a boronic acid or a boronic acid ester. The reaction procedure uses provides novel ring compounds and uses novel synthesis units used for this purpose. The novel ring compounds are suitable for use as constituents in liquid-crystalline mixtures.
    Type: Application
    Filed: March 17, 2003
    Publication date: January 8, 2004
    Applicant: Merck Patent GmbH
    Inventors: Detlef Pauluth, Peer Kirsch, Peter Baeuerle, Oliver Deeg
  • Conjugate, its preparation and use
    Patent number: 6673336
    Abstract: The invention relates to a conjugate which can be used for preparing dermatological and cosmetic compositions. The invention also relates to processes for preparing such conjugate and to its use.
    Type: Grant
    Filed: November 7, 2001
    Date of Patent: January 6, 2004
    Assignee: Merck Patent, GmbH
    Inventors: Herwig Buchholz, Eike Poetsch, Ralf Rosskopf, Ralf Anselmann, Michael Kirschbaum, Frank Pflücker
  • 5-chloro-3-(4-methanesulfonylphenyl)-6?-methyl-[2,3?]bipyridinyl in pure crystalline form and process for synthesis
    Patent number: 6673935
    Abstract: This invention encompasses the Form V polymorph of Compound A of structural formula: which is useful in the treatment of cyclooxygenase-2 mediated diseases. The invention encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising the Form V polymorph of Compound A. The invention also encompasses a process for synthesizing the Form V polymorph of Compound A.
    Type: Grant
    Filed: January 14, 2003
    Date of Patent: January 6, 2004
    Assignee: Merck & Co., Inc.
    Inventors: Louis S. Crocker, Ian W. Davies, Richard G. Osifchin, Andrew Kotliar
  • Liquid-crystalline medium
    Patent number: 6673268
    Abstract: A MIM-liquid crystal display comprising a MIM diode array, a pair of parallel substrates and a nematic liquid crystalline medium disposed between the pair of substrates, characterized in that the nematic liquid crystalline medium is based on a) a component A comprising one or more compounds of the formula I b) a component B comprising one or more compounds of the formula II in which R1, R2, R3, Z1, Z2, Z3, Z4, Q, X, L1, L2, m and n have the meaning given herein.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: January 6, 2004
    Assignee: Merck Patent Gesellschaft mit beschränkter Haftung
    Inventors: Bernhard Rieger, Atsushi Sawada, Hideo Ichinose, Herbert Plach
  • Method of producing n-(4,5-bis-methanesulfonyl-2-methyl-benzoyl)-guanidine, the hydrochloride thereof
    Patent number: 6673968
    Abstract: The present invention relates to an NHE-1 selective Na+/H+ antiporter inhibitor N-(4,5-bismethanesulfonyl-2-methylbenzoyl)guanidine, hydrochloride, to its hydrochloride hydrate, and to a process for the preparation.
    Type: Grant
    Filed: September 4, 2002
    Date of Patent: January 6, 2004
    Assignee: Merck Patent Gesellschaft mit beschränkter Haftung
    Inventors: Rolf Gericke, Manfred Baumgarth, Hans Markus Bender, Bernhard Ladstetter
  • Process for the preparation of 1,2,4-triazolin-5-one derivatives
    Patent number: 6673939
    Abstract: The present invention relates to a process for the preparation of a compound of formula (I) wherein R represents hydrogen, C1-10alkyl, haloC1-10alkyl or aryl; which are useful intermediates in the preparation of morpholine derivatives of formula (A). Compounds of formula (A) are useful as therapeutic agents.
    Type: Grant
    Filed: February 5, 2003
    Date of Patent: January 6, 2004
    Assignee: Merck Sharp & Dohme Ltd.
    Inventor: Cameron John Cowden
  • Combination therapy for reducing the risks associated with cardiovascular disease
    Patent number: 6673831
    Abstract: The instant invention provides methods for preventing or reducing the risk of developing atherosclerosis, as well as for halting or slowing the progression of atherosclerotic disease once it has become clinically evident, comprising the administration of a therapeutically effective amount of an HMG-CoA RI in combination with folic acid or a pharmaceutically acceptable salt or ester thereof to a person who is at risk of developing atherosclerosis or who already has atherosclerotic disease.
    Type: Grant
    Filed: April 27, 1998
    Date of Patent: January 6, 2004
    Assignee: Merck & Co., Inc.
    Inventor: Jonathan A. Tobert
  • Liquid-crystalline medium
    Patent number: 6669998
    Abstract: The invention relates to a liquid-crystalline medium based on a mixture of polar compounds having positive dielectric anisotropy, characterized in that it comprises one or more compounds of the general formula I: in which R, A1, Z1, Y and L are as defined herein.
    Type: Grant
    Filed: November 2, 2001
    Date of Patent: December 30, 2003
    Assignee: Merck Patent Gesellschaft
    Inventors: Kazuaki Tarumi, Brigitte Schuler, Eike Poetsch, Volker Reiffenrath, Yukiomi Tanaka
  • Liquid crystal display device
    Patent number: 6669865
    Abstract: A liquid crystal display device containing a liquid crystal cell and at least one reflective polarizer or a polarizer combination having at least one reflective polarizer as a means to generate circular polarized light. The reflective polarizer includes an optically active layer of an anisotropic polymer material with a helically twisted planar molecular orientation. The material is oriented so that the axis of the molecular helix extends transversely to the layer, and the pitch of the molecular helix is varied in such a manner that the difference between the maximum pitch and the minimum pitch is at least 100 nm.
    Type: Grant
    Filed: October 26, 2000
    Date of Patent: December 30, 2003
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: David Coates, Simon Greenfield, Mark Goulding, James Hanmer, Shirley Marden, Owain Llyr Parri
  • Method of preparing alpha-and-beta-tricalcium phosphate powders
    Publication number: 20030235622
    Abstract: The invention describes a wet-chemical process for the preparation of alpha- and beta-tricalcium phosphate (TCP) powders. The procedure simply comprises immediate addition of di-ammonium hydrogen phosphate to an aqueous solution of calcium nitrate tetrahydrate, or vice versa. Calcination of the recovered precursor powders at 800° C. in air produces beta-TCP, whereas the calcination of the same at 1200° C., followed by rapid cooling to room temperature yields submicron-particulated alpha-TCP powders. These powders can be the raw materials for bioceramics, such as artificial bones, artificial joints, artificial tooth roots, and calcium phosphate-based self-setting, self-hardening cements.
    Type: Application
    Filed: June 20, 2003
    Publication date: December 25, 2003
    Applicant: Merck Patent GmbH
    Inventor: Ahmet Cuneyt Tas
  • Pyrazinones, compositions containing such compounds and methods of use
    Publication number: 20030236402
    Abstract: Compounds represented by formula I: 1
    Type: Application
    Filed: July 25, 2002
    Publication date: December 25, 2003
    Applicant: Merck Frosst Canada & Co.
    Inventors: Yongxin Han, Andre Giroux, Robert Zamboni, Daniel J. McKay, Christopher I. Bayly, Erich L. Grimm, John Colucci
  • Liquid-crystalline medium
    Publication number: 20030234384
    Abstract: The invention relates to a liquid-crystalline medium based on a mixture of polar compounds of positive dielectric anisotropy, characterised in that it comprises one or more ester compounds of the formula I 1
    Type: Application
    Filed: February 6, 2003
    Publication date: December 25, 2003
    Applicant: Merck Patent GmbH
    Inventors: Michael Heckmeier, Sabine Schoen, Peer Kirsch, Brigitte Schuler, Izumi Saito
  • Broadband liquid crystal pigments
    Patent number: 6667793
    Abstract: Liquid crystal pigments comprising at least one layer of liquid crystalline polymer material with a helically twisted molecular structure wherein the helical axis is oriented substantially perpendicular to the plane of the layer and which show reflection of circularly polarized light, some prepared in which the bandwidth of the reflected wavelength band is at least 100 nm. These pigments are suitable for use in reflective films or coatings for decorative applications, cosmetic compositions, and pharmaceutical compositions, optical elements, and security applications.
    Type: Grant
    Filed: March 16, 2001
    Date of Patent: December 23, 2003
    Assignee: Merck Patent Gesellschaft
    Inventors: Mark Goulding, Matthias Kuntz, Mark Verrall, David Coates
  • Polynucleotide sequences encoding mouse sphingosine-1-phosphate phosphatase
    Patent number: 6667163
    Abstract: The present invention provides polynucleotides and polypeptides of a murine sphingosine-1-phosphate phosphatase, referred to herein as mSPP1. The polynucleotides and polypeptides are used to further provide expression vectors, host cells comprising the vectors, probes and primers, antibodies against the mSPP1 protein and polypeptides thereof, assays for the presence or expression of mSPP1 and assays for the identification of compounds that interact with mSPP1.
    Type: Grant
    Filed: February 7, 2001
    Date of Patent: December 23, 2003
    Assignee: Merck & Co., Inc.
    Inventors: Suzanne M. Mandala, Rosemary A. Thornton