Patents Assigned to MiCell Technologies, Inc.
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Publication number: 20190111190Abstract: A method for depositing a coating comprising a polymer and at least two pharmaceutical agents on a substrate, comprising the following steps: providing a stent framework; depositing on said stent framework a first layer comprising a first pharmaceutical agent; depositing a second layer comprising a second pharmaceutical agent; Wherein said first and second pharmaceutical agents are selected from two different classes of pharmaceutical agents.Type: ApplicationFiled: December 18, 2018Publication date: April 18, 2019Applicant: Micell Technologies, Inc.Inventors: James P. DeYoung, Charles Douglas Taylor, James B. McClain, Clint Smoke, Mike Cole
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Patent number: 10232092Abstract: Provided herein are devices comprising a stent; and a coating on said stent comprising a polymer and an active agent, wherein the active agent comprises at least one of: extracellular matrix and an extracellular matrix component. Provided herein are methods of preparing a device comprising a stent and a coating on said stent; said method comprising: providing a stent; and forming a plurality of layers on said stent; wherein the coating comprises a polymer and at least one of said layers comprises one or more active agents; wherein at least a portion of the active agent comprises at least one of extracellular matrix and an extracellular matrix component.Type: GrantFiled: April 20, 2011Date of Patent: March 19, 2019Assignee: Micell Technologies, Inc.Inventors: James B. McClain, Arthur J. Benvenuto
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Publication number: 20190046695Abstract: Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on the substrate, wherein the coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within the coating and on the substrate until implantable device is deployed a an intervention site inside the body of a subject and wherein upon deployment of the medical device in the body of the subject a portion of the pharmaceutical agent and/or active biological agent is delivered at the intervention site along with at least a portion of the polymer and/or a at least a portion of the pharmaceutical carrying agents.Type: ApplicationFiled: October 15, 2018Publication date: February 14, 2019Applicant: Micell Technologies, Inc.Inventors: James B. McClain, Charles Douglas Taylor, Brett G. Zani, John Neet, Timothy Charles Kiorpes
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Patent number: 10188772Abstract: A medical device that releases a pharmaceutical agent to a target site is disclosed. The medical device includes a balloon, and a coating on at least a portion of the balloon. The coating includes particles of a pharmaceutical agent. Each particle of the particles of the pharmaceutical agent is at least partially encapsulated in a polymer material. A method of releasing a pharmaceutical agent at a target site is also disclosed. The method includes the steps of providing a device including a balloon, and a coating on at least a portion of the balloon, the coating including particles of a pharmaceutical agent, and each particle of the pharmaceutical agent is at least partially encapsulated in a polymer material; positioning the device to allow the balloon to reach the target site; and inflating the balloon of the device.Type: GrantFiled: October 18, 2013Date of Patent: January 29, 2019Assignee: Micell Technologies, Inc.Inventors: James B. McClain, Charles Douglas Taylor, Meagan M. Fagan
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Patent number: 10117972Abstract: Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on the substrate, wherein the coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within the coating and on the substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of the medical device in the body of the subject a portion of the pharmaceutical agent and/or active biological agent is delivered at the intervention site along with at least a portion of the polymer and/or a at least a portion of the pharmaceutical carrying agents.Type: GrantFiled: July 12, 2012Date of Patent: November 6, 2018Assignee: Micell Technologies, Inc.Inventors: James B. McClain, Charles Douglas Taylor, Brett G. Zani, John Neet, Timothy Charles Kiorpes
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Publication number: 20180272043Abstract: Provided herein is a coated coronary stent, comprising: a. stent; b. a plurality of layers deposited on said stent to form said coronary stent; wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form.Type: ApplicationFiled: April 24, 2018Publication date: September 27, 2018Applicant: Micell Technologies, Inc.Inventors: Charles Douglas Taylor, James B. McClain
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Publication number: 20180228371Abstract: An implantable device including a sensing element, transmitter and power element is disclosed. The device may allow for monitoring of one or more body conditions in a minimally invasive manner, while a receiver may receive such information. Methods of utilizing device are also disclosed.Type: ApplicationFiled: August 3, 2016Publication date: August 16, 2018Applicant: Micell Technologies, Inc.Inventor: James B. McClain
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Patent number: 9981072Abstract: Provided herein is a coated coronary stent, comprising: a. stent; b. a plurality of layers deposited on said stent to form said coronary stent; wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form.Type: GrantFiled: March 31, 2010Date of Patent: May 29, 2018Assignee: Micell Technologies, Inc.Inventors: Douglas Taylor, James B. McClain
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Patent number: 9981071Abstract: Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on said substrate, wherein said coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within said coating and on said substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of said medical device in the body of said subject a portion of said pharmaceutical agent and/or active biological agent is delivered at said intervention site along with at least a portion of said polymer and/or a at least a portion of said pharmaceutical carrying agents.Type: GrantFiled: October 4, 2016Date of Patent: May 29, 2018Assignee: Micell Technologies, Inc.Inventors: James B. McClain, Charles Douglas Taylor, John Neet
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Publication number: 20180092762Abstract: A method for depositing a coating comprising a polymer and pharmaceutical agent on a substrate, comprising the following steps: discharging at least one pharmaceutical agent in a therapeutically desirable morphology in dry powder form through a first orifice; discharging at least one polymer in dry powder form through a second orifice; depositing the polymer and/or pharmaceutical particles onto said substrate, wherein an electrical potential is maintained between the substrate and the pharmaceutical and/or polymer particles, thereby forming said coating; and sintering said coating under conditions that do not substantially modify the morphology of said pharmaceutical agent.Type: ApplicationFiled: September 15, 2017Publication date: April 5, 2018Applicant: Micell Technologies, Inc.Inventors: Charles Douglas Taylor, James B. McClain, Mike Cole, James P. DeYoung, Clint Smoke
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Publication number: 20180085498Abstract: A drug-eluting product is disclosed comprising an at least partially bioabsorbable element and an active pharmaceutical agent having a morphology, a solubility, and an average particle size which are selected so that the active pharmaceutical agent continues to dissolve during the biodegradation of the bioabsorbable element. The morphology is a crystalline, semi-crystalline or amorphous morphology, the solubility is less than 100 ?g/ml and the average particle size is grater that about 100 nm.Type: ApplicationFiled: September 23, 2016Publication date: March 29, 2018Applicant: Micell Technologies, Inc.Inventors: Timothy Charles Kiorpes, James B. McClain
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Publication number: 20180071438Abstract: Provided herein is a composition comprising a poly(alpha-hydroxycarboxylic acid) substantially free of acidic impurities wherein the poly(alpha-hydroxycarboxylic acid) is selected from poly(D,L-lactic-co-glycolic acid), poly(L-lactic acid), poly(D-lactic acid) and poly(D,L-lactic acid). Also provided is a device comprising: a substrate, and a coating wherein the coating comprises poly(D,L-lactic-co-glycolic acid) substantially free of acidic impurities.Type: ApplicationFiled: November 14, 2017Publication date: March 15, 2018Applicant: Micell Technologies, Inc.Inventors: Charles Douglas Taylor, James B. McClain, Edward Schmitt
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Publication number: 20180000996Abstract: A method for preparing a laminate coronary stent comprising: providing a stent framework; and depositing a plurality of layers on said stent framework to form said laminate coronary stent; wherein at least one of said layers comprises a bioabsorbable polymer.Type: ApplicationFiled: June 27, 2017Publication date: January 4, 2018Applicant: Micell Technologies, Inc.Inventors: James B. McClain, Charles Douglas Taylor, Robert Rabiner
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Patent number: 9827117Abstract: A method for depositing a coating comprising a polymer and pharmaceutical agent on a substrate, comprising the following steps: discharging at least one pharmaceutical agent in a therapeutically desirable morphology in dry powder form through a first orifice; discharging at least one polymer in dry powder form through a second orifice; depositing the polymer and/or pharmaceutical particles onto said substrate, wherein an electrical potential is maintained between the substrate and the pharmaceutical and/or polymer particles, thereby forming said coating; and sintering said coating under conditions that do not substantially modify the morphology of said pharmaceutical agent.Type: GrantFiled: April 25, 2014Date of Patent: November 28, 2017Assignee: Micell Technologies, Inc.Inventors: Doug Taylor, Jim McClain, Clint Smoke, Mike Cole, James DeYoung
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Patent number: 9789233Abstract: Provided herein is a device comprising: a. stent; b. a plurality of layers on said stent framework to form said device; wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form.Type: GrantFiled: April 17, 2009Date of Patent: October 17, 2017Assignee: Micell Technologies, Inc.Inventors: James B. McClain, Douglas Taylor
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Patent number: 9775729Abstract: Provided herein is a drug delivery system comprising: a. substrate; b. a plurality of components combined with the substrate to form the drug delivery system; wherein at least one components comprises a bioabsorbable polymer and at least one other component comprises one or more active agents; wherein at least part of the active agent is in crystalline form.Type: GrantFiled: August 19, 2016Date of Patent: October 3, 2017Assignee: Micell Technologies, Inc.Inventors: James B. McClain, Charles Douglas Taylor
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Publication number: 20170239399Abstract: A method for depositing a coating comprising a polymer and at least two pharmaceutical agents on a substrate, comprising the following steps: providing a stent framework; depositing on said stent framework a first layer comprising a first pharmaceutical agent; depositing a second layer comprising a second pharmaceutical agent; Wherein said first and second pharmaceutical agents are selected from two different classes of pharmaceutical agents.Type: ApplicationFiled: May 10, 2017Publication date: August 24, 2017Applicant: Micell Technologies, Inc.Inventors: James P. DeYoung, Charles Douglas Taylor, James B. McClain, Clint Smoke, Mike Cole
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Patent number: 9737642Abstract: A method for preparing a laminate coronary stent comprising: providing a stent framework; and depositing a plurality of layers on said stent framework to form said laminate coronary stent; wherein at least one of said layers comprises a bioabsorbable polymer.Type: GrantFiled: January 8, 2008Date of Patent: August 22, 2017Assignee: Micell Technologies, Inc.Inventors: James B. McClain, C. Douglas Taylor, Robert Rabiner
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Patent number: 9737645Abstract: A method for depositing a coating comprising a polymer and at least two pharmaceutical agents on a substrate, comprising the following steps: providing a stent framework; depositing on said stent framework a first layer comprising a first pharmaceutical agent; depositing a second layer comprising a second pharmaceutical agent; Wherein said first and second pharmaceutical agents are selected from two different classes of pharmaceutical agents.Type: GrantFiled: December 15, 2015Date of Patent: August 22, 2017Assignee: Micell Technologies, Inc.Inventors: James P. DeYoung, Charles Douglas Taylor, James B. McClain, Clint Smoke, Mike Cole
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Publication number: 20170196982Abstract: Provided is a drug delivery composition comprising at least one polymer and at least one active agent; wherein the active agent is present in crystalline form on at least one region of an outer surface of the composition and wherein active agent surface content is adjusted to provide a selected active agent release profile.Type: ApplicationFiled: March 28, 2017Publication date: July 13, 2017Applicant: Micell Technologies, Inc.Inventors: James B. McClain, Wenda C. Carlyle, Charles Douglas Taylor