Patents Assigned to MiCell Technologies, Inc.
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Patent number: 8758429Abstract: A method for depositing a coating comprising a polymer and pharmaceutical agent on a substrate, comprising the following steps: discharging at least one pharmaceutical agent in a therapeutically desirable morphology in dry powder form through a first orifice; discharging at least one polymer in dry powder form through a second orifice; depositing the polymer and/or pharmaceutical particles onto said substrate, wherein an electrical potential is maintained between the substrate and the pharmaceutical and/or polymer particles, thereby forming said coating; and sintering said coating under conditions that do not substantially modify the morphology of said pharmaceutical agent.Type: GrantFiled: September 6, 2012Date of Patent: June 24, 2014Assignee: Micell Technologies, Inc.Inventors: Doug Taylor, Jim McClain, Clint Smoke, Mike Cole, James DeYoung
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Patent number: 8636767Abstract: The invention relates to increasing the strength of bio-absorbable surgical sutures. The invention allows for delayed bioabsorption of suture materials to allow maintenance of mechanical strength of the suture for example in ‘barbed’ form.Type: GrantFiled: October 2, 2007Date of Patent: January 28, 2014Assignee: Micell Technologies, Inc.Inventor: Jim McClain
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Publication number: 20130172853Abstract: Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on the substrate, wherein the coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within the coating and on the substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of the medical device in the body of the subject a portion of the pharmaceutical agent and/or active biological agent is delivered at the intervention site along with at least a portion of the polymer and/or a at least a portion of the pharmaceutical carrying agents.Type: ApplicationFiled: July 15, 2011Publication date: July 4, 2013Applicant: MICELL TECHNOLOGIES, INC.Inventors: James B. McClain, Charles Douglas Taylor, Brett G. Zani, John Neet, Timothy Charles Kiorpes
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Publication number: 20130006351Abstract: A method for depositing a coating comprising a polymer and pharmaceutical agent on a substrate, comprising the following steps: discharging at least one pharmaceutical agent in a therapeutically desirable morphology in dry powder form through a first orifice; discharging at least one polymer in dry powder form through a second orifice; depositing the polymer and/or pharmaceutical particles onto said substrate, wherein an electrical potential is maintained between the substrate and the pharmaceutical and/or polymer particles, thereby forming said coating; and sintering said coating under conditions that do not substantially modify the morphology of said pharmaceutical agent.Type: ApplicationFiled: September 6, 2012Publication date: January 3, 2013Applicant: MICELL TECHNOLOGIES, INC.Inventors: Doug Taylor, Jim McClain, Clint Smoke, Mike Cole, James DeYoung
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Publication number: 20120323311Abstract: Provided herein is a device comprising: a. stent; b. a plurality of layers on said stent framework to form said device; wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form.Type: ApplicationFiled: April 12, 2012Publication date: December 20, 2012Applicant: MICELL TECHNOLOGIES, INC.Inventors: James B. McCLAIN, Charles Douglas TAYLOR
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Patent number: 8298565Abstract: A method for depositing a coating comprising a polymer and pharmaceutical agent on a substrate, comprising the following steps: discharging at least one pharmaceutical agent in a therapeutically desirable morphology in dry powder form through a first orifice; discharging at least one polymer in dry powder form through a second orifice; depositing the polymer and/or pharmaceutical particles onto the substrate, wherein an electrical potential is maintained between the substrate and the pharmaceutical and/or polymer particles, thereby forming the coating; and sintering the coating under conditions that do not substantially modify the morphology of the pharmaceutical agent.Type: GrantFiled: July 14, 2006Date of Patent: October 30, 2012Assignee: Micell Technologies, Inc.Inventors: Doug Taylor, Jim McClain, Clint Smoke, Mike Cole, James DeYoung
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Publication number: 20120177742Abstract: Devices, coatings, and methods therefore comprise a medical device for delivering nanoparticles of an active agent to a treatment site. A coating on the medical device comprises active agent nanoparticles, which delivers coating to the treatment site and releases active agent nanoparticles into the treatment site over at least one day. A coating may comprise a polymer, a surfactant, and the nanoparticles. The coating may be prepared by forming a nanoemulsion. A coating may comprise encapsulated active agent nanoparticles which comprise active agent nanoparticles encapsulated in a polymer. The coating may have a positive surface charge. The coating may deliver active agent nanoparticles into the treatment site over at least about one day. The coating may be formed of a surfactant and nanoparticles mixture. The active agent nanoparticles may be deposited on the medical device using electrostatic capture.Type: ApplicationFiled: December 29, 2011Publication date: July 12, 2012Applicant: MICELL TECHNOLOGIES, INC.Inventors: James B. McCLAIN, Charles Douglas Taylor, Brett G. Zani, Timothy Charles Kiorpes
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Publication number: 20120172787Abstract: Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on the substrate, wherein the coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within the coating and on the substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of the medical device in the body of the subject a portion of the pharmaceutical agent and/or active biological agent is delivered at the intervention site along with at least a portion of the polymer and/or a at least a portion of the pharmaceutical carrying agents.Type: ApplicationFiled: July 16, 2010Publication date: July 5, 2012Applicant: MICELL TECHNOLOGIES, INC.Inventors: James B. McClain, Charles Douglas Taylor, John Neet, Brett G. Zani
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Publication number: 20120064124Abstract: Provided is a drug delivery composition comprising at least one polymer and at least one active agent; wherein the active agent is present in crystalline form on at least one region of an outer surface of the composition and wherein active agent surface content is adjusted to provide a selected active agent release profile.Type: ApplicationFiled: September 9, 2011Publication date: March 15, 2012Applicant: MICELL TECHNOLOGIES, INC.Inventors: James B. McClain, Charles Douglas Taylor, Wenda C. Carlyle
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Publication number: 20110264190Abstract: Provided herein are devices comprising a stent; and a coating on said stent comprising a polymer and an active agent, wherein the active agent comprises at least one of: extracellular matrix and an extracellular matrix component. Provided herein are methods of preparing a device comprising a stent and a coating on said stent; said method comprising: providing a stent; and forming a plurality of layers on said stent; wherein the coating comprises a polymer and at least one of said layers comprises one or more active agents; wherein at least a portion of the active agent comprises at least one of extracellular matrix and an extracellular matrix component.Type: ApplicationFiled: April 20, 2011Publication date: October 27, 2011Applicant: MICELL TECHNOLOGIES, INC.Inventors: James B. McClain, Arthur J. Benvenuto
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Publication number: 20110257732Abstract: Provided herein is a device comprising: a. stent; b. a plurality of layers on said stent framework to form said device; wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form.Type: ApplicationFiled: April 13, 2011Publication date: October 20, 2011Applicant: Micell Technologies, Inc.Inventors: James B. McClain, Douglas Taylor
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Publication number: 20110190864Abstract: Stent delivery systems having improved deliverability comprising an elongate member having an inflation lumen and a guidewire lumen therein; a balloon having an interior that is in fluid communication with the inflation lumen; and a stent comprising a coating mounted on the balloon. Methods for making stent delivery systems having improved deliverability. Methods for delivering two stent delivery systems concurrently through a guiding catheter, each stent delivery system comprising elongate member having an inflation lumen and a guidewire lumen therein, a balloon having an interior that is in fluid communication with the inflation lumen, and a stent comprising a coating mounted on the balloon. Stent coatings may comprise a pharmaceutical agent at least a portion of which is in crystalline form.Type: ApplicationFiled: January 26, 2011Publication date: August 4, 2011Applicant: Micell Technologies, Inc.Inventors: James B. McClain, Douglas Taylor, David Enscore
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Publication number: 20100298928Abstract: Provided herein is a coated coronary stent, comprising: a stent framework; heparin molecules attached to the stent framework; and a rapamycin-polymer coating wherein at least part of rapamycin is in crystalline form. In one embodiment, the rapamycin-polymer coating comprises one or more resorbable polymers.Type: ApplicationFiled: October 17, 2008Publication date: November 25, 2010Applicant: MICELL TECHNOLOGIES, INC.Inventors: James B. McClain, Douglas Taylor
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Publication number: 20100272778Abstract: Provided herein is a device comprising: a. stent; b. a plurality of layers on said stent framework to form said device; wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form.Type: ApplicationFiled: April 16, 2010Publication date: October 28, 2010Applicant: MICELL TECHNOLOGIES, INC.Inventors: James B. McClain, Douglas Taylor
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Publication number: 20100256748Abstract: Provided herein is a coated coronary stent, comprising: a. stent; b. a plurality of layers deposited on said stent to form said coronary stent; wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form.Type: ApplicationFiled: March 31, 2010Publication date: October 7, 2010Applicant: MICELL TECHNOLOGIES, INC.Inventors: Douglas Taylor, James B. McClain
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Publication number: 20100256746Abstract: Provided herein is a composition comprising a poly(alpha-hydroxycarboxylic acid) substantially free of acidic impurities wherein the poly(alpha-hydroxycarboxylic acid) is selected from poly(D,L-lactic-co-glycolic acid), poly(L-lactic acid), poly(D-lactic acid) and poly(D,L-lactic acid). Also provided is a device comprising: a substrate, and a coating wherein the coating comprises poly(D,L-lactic-co-glycolic acid) substantially free of acidic impurities.Type: ApplicationFiled: March 23, 2010Publication date: October 7, 2010Applicant: MICELL TECHNOLOGIES, INC.Inventors: Douglas Taylor, James B. McClain, Edward E. Schmitt
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Publication number: 20100239635Abstract: Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on said substrate, wherein said coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within said coating and on said substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of said medical device in the body of said subject a portion of said pharmaceutical agent and/or active biological agent is delivered at said intervention site along with at least a portion of said polymer and/or a at least a portion of said pharmaceutical carrying agents.Type: ApplicationFiled: March 23, 2010Publication date: September 23, 2010Applicant: MICELL TECHNOLOGIES, INC.Inventors: James B. McClain, Douglas Taylor, John Neet
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Publication number: 20100228348Abstract: A method for depositing a coating comprising a polymer and impermeable dispersed solid on a substrate, comprising the following steps: discharging at least one impermeable dispersed solid in dry powder form through a first orifice; discharging at least one polymer in dry powder form through a second orifice; depositing the polymer and/or impermeable dispersed solid particles onto said substrate, wherein an electrical potential is maintained between the substrate and the impermeable dispersed solid and/or polymer particles, thereby forming said coating; and sintering said coating under conditions that do not disrupt the activity and/or function of the substrate. A similar method is provided for depositing a coating comprising a hydrophobic polymer and a water-vapor-trapping material on a substrate.Type: ApplicationFiled: May 23, 2008Publication date: September 9, 2010Applicant: MICELL TECHNOLOGIES, INC.Inventors: James McClain, Douglas Taylor
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Publication number: 20100030261Abstract: The invention relates to increasing the strength of bio-absorbable surgical sutures. The invention allows for delayed bioabsorption of suture materials to allow maintenance of mechanical strength of the suture for example in ‘barbed’ form.Type: ApplicationFiled: October 2, 2007Publication date: February 4, 2010Applicant: Micell Technologies, Inc.Inventor: Jim McClain
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Publication number: 20100015200Abstract: Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on said substrate, wherein said coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within said coating and on said substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of said medical device in the body of said subject a portion of said pharmaceutical agent and/or active biological agent is delivered at said intervention site along with at least a portion of said polymer and/or a at least a portion of said pharmaceutical carrying agents.Type: ApplicationFiled: July 16, 2009Publication date: January 21, 2010Applicant: MICELL TECHNOLOGIES, INC.Inventors: James B. McClain, Douglas Taylor, John Neet