Patents Assigned to MiCell Technologies
-
Publication number: 20170136155Abstract: Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on said substrate, wherein said coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within said coating and on said substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of said medical device in the body of said subject a portion of said pharmaceutical agent and/or active biological agent is delivered at said intervention site along with at least a portion of said polymer and/or a at least a portion of said pharmaceutical carrying agents.Type: ApplicationFiled: October 4, 2016Publication date: May 18, 2017Applicant: Micell Technologies, Inc.Inventors: James B. McClain, Charles Douglas Taylor, John Neet
-
Patent number: 9636309Abstract: Provided is a drug delivery composition comprising at least one polymer and at least one active agent; wherein the active agent is present in crystalline form on at least one region of an outer surface of the composition and wherein active agent surface content is adjusted to provide a selected active agent release profile.Type: GrantFiled: September 9, 2011Date of Patent: May 2, 2017Assignee: Micell Technologies, Inc.Inventors: James B. McClain, Charles Douglas Taylor, Wenda C. Carlyle
-
Publication number: 20170080191Abstract: Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on the substrate, wherein the coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within the coating and on the substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of the medical device in the body of the subject a portion of the pharmaceutical agent and/or active biological agent is delivered at the intervention site along with at least a portion of the polymer and/or a at least a portion of the pharmaceutical carrying agents.Type: ApplicationFiled: December 1, 2016Publication date: March 23, 2017Applicant: Micell Technologies, Inc.Inventors: James B. McClain, Charles Douglas Taylor, John Neet, Brett G. Zani
-
Publication number: 20170065521Abstract: Drug delivery systems are disclosed which include a drug in dry powder form and a biodegradable or metabolizable carrier having an average particle size of less than about 1 mm for delivery of the drug to a particular location in the body and for providing for the timed elution of the drug at that location, preferably by exhibiting a linear drug elution profile for a sustained drug release period of at least 30 days. Methods for manufacturing these drug delivery systems are also disclosed.Type: ApplicationFiled: September 9, 2016Publication date: March 9, 2017Applicant: Micell Technologies, Inc.Inventor: Wenda C. Carlyle
-
Patent number: 9539593Abstract: A stent holder for mounting and electrically charging a stent during coating of the stent using dry particles, the particles comprising inert polymers, pharmaceutical or biological agents, is provided. An assembly for supporting and electrically charging a stent during the coating of the stent using dry particles, the particles comprising inert polymers, pharmaceutical or biological agents, is provided. A chamber for creating an electrical field around a stent and for supporting, electrically charging, and exposing the stent to dry particles, the particles comprising inert polymers, pharmaceutical or biological agents, is provided. A method for creating an electrical field around a stent and for supporting, electrically charging, and exposing the stent to dry particles comprising inert polymers, pharmaceutical or biological agents is provided.Type: GrantFiled: October 23, 2007Date of Patent: January 10, 2017Assignee: Micell Technologies, Inc.Inventors: James B. McClain, Doug Taylor, Ed Dickinson, Steve Worm
-
Patent number: 9510856Abstract: Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on the substrate, wherein the coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within the coating and on the substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of the medical device in the body of the subject a portion of the pharmaceutical agent and/or active biological agent is delivered at the intervention site along with at least a portion of the polymer and/or a at least a portion of the pharmaceutical carrying agents.Type: GrantFiled: July 16, 2010Date of Patent: December 6, 2016Assignee: Micell Technologies, Inc.Inventors: James B. McClain, Charles Douglas Taylor, John Neet, Brett G. Zani
-
Patent number: 9486338Abstract: Provided herein is a device comprising: a. stent; b. a plurality of layers on said stent framework to form said device; wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form.Type: GrantFiled: December 9, 2015Date of Patent: November 8, 2016Assignee: Micell Technologies, Inc.Inventors: James B. McClain, Charles Douglas Taylor
-
Patent number: 9486431Abstract: Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on said substrate, wherein said coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within said coating and on said substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of said medical device in the body of said subject a portion of said pharmaceutical agent and/or active biological agent is delivered at said intervention site along with at least a portion of said polymer and/or a at least a portion of said pharmaceutical carrying agents.Type: GrantFiled: July 16, 2009Date of Patent: November 8, 2016Assignee: Micell Technologies, Inc.Inventors: James B. McClain, Douglas Taylor, John Neet
-
Publication number: 20160271303Abstract: Provided herein is a device comprising a stent and a coating on the stent; wherein the coating comprises at least one polymer and at least one active agent; wherein at least part of the active agent is in crystalline form.Type: ApplicationFiled: May 31, 2016Publication date: September 22, 2016Applicant: Micell Technologies, Inc.Inventors: James B. McClain, Charles Douglas Taylor, Wenda C. Carlyle
-
Patent number: 9433516Abstract: Provided herein is a device comprising: a. stent; b. a plurality of layers on said stent framework to form said device; wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form.Type: GrantFiled: April 16, 2010Date of Patent: September 6, 2016Assignee: Micell Technologies, Inc.Inventors: James B. McClain, Douglas Taylor
-
Patent number: 9415142Abstract: A method for depositing a coating comprising a polymer and at least two pharmaceutical agents on a substrate, comprising the following steps: providing a stent framework; depositing on said stent framework a first layer comprising a first pharmaceutical agent; depositing a second layer comprising a second pharmaceutical agent; Wherein said first and second pharmaceutical agents are selected from two different classes of pharmaceutical agents.Type: GrantFiled: August 29, 2014Date of Patent: August 16, 2016Assignee: Micell Technologies, Inc.Inventors: James DeYoung, Charles Douglas Taylor, James B. McClain, Clint Smoke, Mike Cole
-
Publication number: 20160030643Abstract: Provided herein is a coated coronary stent including a stent framework, heparin molecules attached to the stent framework and a rapamycin-polymer coating wherein at least part of rapamycin is a crystalline form. In one embodiment, the rapamycin-polymer coating comprises one or more resorbable polymers. Methods for preparing stents are also disclosed.Type: ApplicationFiled: May 21, 2015Publication date: February 4, 2016Applicant: MICELL TECHNOLOGIES, INC.Inventor: James B. McClain
-
Publication number: 20160015537Abstract: A coated coronary stent, comprising a stainless steel sent framework coated with a p1imer layer of Parylene C, and a rapamycin-polymer coating having substantially uniform thickness disposed on the stent framework, wherein the rapamycin-polymer coating comprises polybutyl methacrylate (PBMA), polyethylene-co-vinyl acetate (PEVA) and rapamycin, wherein substantially all of the rapamycin in the coating is in amorphous form and substantially unifom1ly dispersed within the rapamycin-polymer coating.Type: ApplicationFiled: May 21, 2015Publication date: January 21, 2016Applicant: Micell Technologies, Inc.Inventors: Charles Douglas Taylor, James DeYoung, James B. McClain
-
Publication number: 20150250926Abstract: A medical device that releases a pharmaceutical agent to a target site is disclosed. The medical device includes a balloon, and a coating on at least a portion of the balloon. The coating includes particles of a pharmaceutical agent. Each particle of the particles of the pharmaceutical agent is at least partially encapsulated in a polymer material. A method of releasing a pharmaceutical agent at a target site is also disclosed. The method includes the steps of providing a device including a balloon, and a coating on at least a portion of the balloon, the coating including particles of a pharmaceutical agent, and each particle of the pharmaceutical agent is at least partially encapsulated in a polymer material; positioning the device to allow the balloon to reach the target site; and inflating the balloon of the device.Type: ApplicationFiled: October 18, 2013Publication date: September 10, 2015Applicant: MICELL TECHNOLOGIES, INC.Inventors: James B. McClain, Charles Douglas Taylor, Meagan M. Fagan
-
Publication number: 20150025620Abstract: A method for depositing a coating comprising a polymer and pharmaceutical agent on a substrate, comprising the following steps: discharging at least one pharmaceutical agent in a therapeutically desirable morphology in dry powder form through a first orifice; discharging at least one polymer in dry powder form through a second orifice; depositing the polymer and/or pharmaceutical particles onto said substrate, wherein an electrical potential is maintained between the substrate and the pharmaceutical and/or polymer particles, thereby forming said coating; and sintering said coating under conditions that do not substantially modify the morphology of said pharmaceutical agent.Type: ApplicationFiled: April 25, 2014Publication date: January 22, 2015Applicant: Micell Technologies, Inc.Inventors: Doug Taylor, Jim McClain, Clint Smoke, Mike Cole, James DeYoung
-
Patent number: 8900651Abstract: A method for depositing a coating comprising a polymer and impermeable dispersed solid on a substrate, comprising the following steps: discharging at least one impermeable dispersed solid in dry powder form through a first orifice; discharging at least one polymer in dry powder form through a second orifice; depositing the polymer and/or impermeable dispersed solid particles onto said substrate, wherein an electrical potential is maintained between the substrate and the impermeable dispersed solid and/or polymer particles, thereby forming said coating; and sintering said coating under conditions that do not disrupt the activity and/or function of the substrate. A similar method is provided for depositing a coating comprising a hydrophobic polymer and a water-vapor-trapping material on a substrate.Type: GrantFiled: December 4, 2008Date of Patent: December 2, 2014Assignee: Micell Technologies, Inc.Inventors: James McClain, Douglas Taylor
-
Publication number: 20140350522Abstract: Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on the substrate, wherein the coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within the coating and on the substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of the medical device in the body of the subject a portion of the pharmaceutical agent and/or active biological agent is delivered at the intervention site along with at least a portion of the polymer and/or a at least a portion of the pharmaceutical carrying agents.Type: ApplicationFiled: July 12, 2012Publication date: November 27, 2014Applicant: Micell Technologies, Inc.Inventors: James B. McClain, Charles Douglas Taylor, Brett G. Zani, John Neet, Timothy Charles Kiorpes
-
Publication number: 20140343667Abstract: A bioabsorbable biomedical implant is disclosed. The implant includes a tubular scaffold comprising a plurality of interconnected polymer struts. The interconnected polymer struts defines a plurality of deformable cells. The polymer struts have an average thickness of no more than 150 ?m. Methods for making the bioabsorbable biomedical implant, including the methods for making the fiber-reinforced polymer composite materials for the tubular scaffold, are also disclosed.Type: ApplicationFiled: May 15, 2014Publication date: November 20, 2014Applicant: MICELL TECHNOLOGIES, INC.Inventor: James B. McClain
-
Patent number: 8852625Abstract: A method for depositing a coating comprising a polymer and at least two pharmaceutical agents on a substrate, comprising the following steps: providing a stent framework; depositing on said stent framework a first layer comprising a first pharmaceutical agent; depositing a second layer comprising a second pharmaceutical agent; Wherein said first and second pharmaceutical agents are selected from two different classes of pharmaceutical agents.Type: GrantFiled: April 26, 2007Date of Patent: October 7, 2014Assignee: Micell Technologies, Inc.Inventors: James DeYoung, Doug Taylor, Jim McClain, Clint Smoke, Mike Cole
-
Publication number: 20140277401Abstract: A bioabsorbable biomedical implant is disclosed. The implant includes a tubular scaffold comprising a plurality of interconnected polymer struts. The interconnected polymer struts defines a plurality of deformable cells. The polymer struts have an average thickness of no more than 120 ?m. Methods for making the bioabsorbable biomedical implant, including the methods for making the polymer materials for the tubular scaffold, are also disclosed.Type: ApplicationFiled: March 12, 2014Publication date: September 18, 2014Applicant: MICELL TECHNOLOGIES, INC.Inventors: James B. McClain, Charles Douglas Taylor