Patents Assigned to Monash University
  • Publication number: 20250147092
    Abstract: A method for estimating fault location in an electrical power line system (PLS) is provided. The method includes receiving an observed signal caused by a real fault in the PLS. The observed signal is measured at a real observation point in the PLS. The real fault has occurred at one of two or more real locations in the PLS; accessing a library representing model signals between model guessed fault locations and a model observation point in a network model of the PLS; selecting a model GFL by: (i) calculating metrics for the model signals by processing the model signals with the observed signal, and/or (ii) selecting the model GFL corresponding to a highest calculated metric; estimating a fault location of real locations in the PLS based on a corresponding location of the selected model GFL; and sending the estimated fault location to an external management system.
    Type: Application
    Filed: February 10, 2023
    Publication date: May 8, 2025
    Applicant: Monash University
    Inventors: Reza Razzaghi, David Flynn, Lachlan Andrew
  • Publication number: 20250099572
    Abstract: The invention relates to vaccine compositions for inducing an immune response to a coronavirus in a subject, and uses thereof. In particular, the vaccine comprises of a chimeric or fusion protein comprising a) a N-terminal secretion signal peptide; b) an amino acid sequence of the receptor binding domain (RBD) of a spike protein of a coronavirus; and c) a C-terminal domain comprising a transmembrane region and a cytoplasmic region. In a preferred embodiment, the signal peptide, RBD, transmembrane region, and cytoplasmic region are derived from SARS-CoV-2, and that the vaccine composition is formulated as a lipid nanoparticle (LNP).
    Type: Application
    Filed: August 17, 2022
    Publication date: March 27, 2025
    Applicant: Monash University
    Inventors: Hareth Basim Ali AL-WASSITI, Colin William POUTON, Stewart Alastair FABB
  • Publication number: 20250087691
    Abstract: Stability to long term charge and discharge cycles is the most formidable challenge for Lithium-Sulfur batteries. Therefore, a more holistic design of a durable cathode with minimal polysulfide escape to mitigate the corrosion of the lithium anode is required. A saccharide-based binder system—the monosaccharide (glucose) component, on account of being a strong reducing agent has a unique capacity for the regulation of polysulfide thereby dramatically enhancing the functionality of a polysaccharide (carboxymethyl cellulose) binder system. The two-component binder system promotes the formation of viscoelastic filaments during casting which endows sulfur cathode a desired web-like microstructure. The combination of these effects leads to 97% sulfur utilisation with an ultra-long cycle life of 1000 cycles (9 months) and a high capacity retention (around 700 mAhg?1 after 1000 cycles). A pouch cell prototype with a capacity of 1200 mAhg?1 demonstrates a promising transition from laboratory to manufacturing options.
    Type: Application
    Filed: July 18, 2022
    Publication date: March 13, 2025
    Applicant: Monash University
    Inventors: Yingyi HUANG, Mahdokht SHAIBANI, Matthew HILL, Mainak MAJUMDER
  • Publication number: 20250052024
    Abstract: A system including: a distance sensor system located/oriented/configured to measure a deformation of a geomaterial portion due to compaction of the geomaterial portion; and an electronic processing system configured to: receive signals from the distance sensor system representing the measured deformation, and automatically generate an estimate/measure of a geomaterial layer property of the geomaterial portion based on: the measured deformation; and a pre-defined relationship/model that associates deformation values with geomaterial layer property values (e.g., density values, stiffness values, modulus values, energy values, or layer thicknesses during compaction).
    Type: Application
    Filed: December 17, 2021
    Publication date: February 13, 2025
    Applicant: Monash University
    Inventors: Amir Tophel, Jayantha K. Kodikara, Jeffrey P. Walker
  • Publication number: 20250034222
    Abstract: This invention relates to polypeptides, including variants of interleukin-38 (IL-38), and related therapeutics and compositions. The invention also relates to the use of the polypeptides and compositions in methods of treating inflammatory diseases or conditions. The present invention provides a monomeric polypeptide comprising an amino acid sequence of an IL-38 monomer, the amino acid sequence having a mutation or modification for preventing the peptide from forming a homodimer and favouring the formation of a stable monomer.
    Type: Application
    Filed: December 7, 2022
    Publication date: January 30, 2025
    Applicants: Monash University, Hudson Institute of Medical Research
    Inventors: Claudia Annelie Nold, Andrew Malcolm Ellisdon, Marcel Friedrich Nold, James Whisstock
  • Patent number: 12186361
    Abstract: This invention relates to drug delivery and in particular to the delivery of biologically active agents in the form of dry powders for inhalation. The invention also relates to methods for preparing such dry powder formulations and methods for their use.
    Type: Grant
    Filed: June 15, 2021
    Date of Patent: January 7, 2025
    Assignee: Monash University
    Inventors: Michelle McIntosh, David Morton, Tomas Sou, Livesey Olerile, Richard Prankerd
  • Patent number: 12178875
    Abstract: The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a provided lipid prodrug or a pharmaceutical composition thereof.
    Type: Grant
    Filed: January 29, 2024
    Date of Patent: December 31, 2024
    Assignees: Seaport Therapeutics, Inc., Monash University
    Inventors: Daniel Kenneth Bonner, Ketki Karanam, James Tendai Mutamba, Rishab R. Shyam, Jamie Simpson, Sifei Han, Luojuan Hu, Christopher John Hamilton Porter, Tim Quach, Natalie Trevaskis
  • Patent number: 12161610
    Abstract: This invention relates to methods of treating or preventing viral infections caused by flaviviruses, such as dengue virus, yellow fever virus, West Nile virus or Japanese encephalitis virus or infections caused by Chikungunya virus (CHIKV). The methods involve the administration of retinoic acid analogues to subjects who have, are suspected of having a flavivirus infection or infection with CHIKV, or to those who are at risk of becoming infected with a flavivirus or becoming infected with CHIKV.
    Type: Grant
    Filed: July 20, 2023
    Date of Patent: December 10, 2024
    Assignee: Monash University
    Inventors: Johanna Elisabeth Fraser, David Andrew Jans, Kylie Michelle Wagstaff
  • Publication number: 20240402121
    Abstract: The invention relates generally to a method of detecting and/or analysing target polymers, especially target polynucleotides, using a biological pore. The invention also relates to a novel system for carrying out the method. The method has many uses. In particular, the method may be used for diagnosis, detection of polymorphisms and V(D)J repertoire analysis.
    Type: Application
    Filed: October 4, 2022
    Publication date: December 5, 2024
    Applicants: Oxford Nanopore Technologies PLC, Monash University
    Inventors: Lakmal Nishantha Jayasinghe, Elizabeth Jayne Wallace, Richard Alexander Gutierrez, Michelle Anne Dunstone, Bradley Alan Spicer
  • Publication number: 20240358652
    Abstract: The present invention is directed to lipid nanoparticles, formulations containing lipid nanoparticles and methods of treating diseases or conditions with said lipid nanoparticles and formulations thereof. A lipid nanoparticle comprising (a) an active agent; (b) a cationic and/or ionisable lipid comprising from about 40 mol % to about 60 mol % of the total lipid present in the nanoparticle; (c) a phospholipid comprising from about 5 mol % to about 20 mol % of the total lipid present in the nanoparticle; (d) a structural lipid comprising from about 30 mol % to about 50 mol % of the total lipid present in the nanoparticle; (e) a PEGylated lipid comprising from about 0.05 mol % to less than 0.5 mol % of the total lipid present in the nanoparticle.
    Type: Application
    Filed: August 17, 2022
    Publication date: October 31, 2024
    Applicant: Monash University
    Inventors: Hareth Basim Ali AL-WASSITI, Colin William POUTON, Kha Tu Joan HO
  • Patent number: 12097366
    Abstract: An apparatus for performing bioelectric stimulation, the apparatus comprising: a stimulation unit; a measurement unit comprising an amplifier; first and second stimulation electrodes operable to apply electrical signals to tissue of a patient; first and second measurement electrodes operable to receive first and second measurement signals from the tissue of the patient; wherein the stimulation unit is configured to deliver a first stimulation signal to the first stimulation electrode and a second stimulation signal to the second stimulation electrode; wherein the first signal and the second signal are mirrored about a biasing voltage, the biasing voltage set in dependence of the dynamic range of the amplifier.
    Type: Grant
    Filed: October 25, 2019
    Date of Patent: September 24, 2024
    Assignee: MONASH UNIVERSITY
    Inventors: Richard H. Thomson, Paul B. Fitzgerald, Caley Sullivan, Mark Harrison
  • Publication number: 20240278194
    Abstract: Disclosed herein is a phenolic-graphene oxide composition comprising phenolic-graphene oxide having a carbon to oxygen (C:O) ratio of 2.1 or greater and 5 or less.
    Type: Application
    Filed: June 15, 2022
    Publication date: August 22, 2024
    Applicant: Monash University
    Inventors: Mainak MAJUMDER, Abozar AKBARIVAKILABADI, Sally EL MERAGAWI, Petar JOVANOVIC
  • Patent number: 12060408
    Abstract: A method of screening candidate agents for their ability to modulate RAGE activity where such RAGE activity is induced by an active co-located GPCR, the method comprising the steps of: contacting a RAGE polypeptide with a GPCR polypeptide in the presence of a candidate agent where the GPCR polypeptide is constitutively active and/or is activated by addition of an agonist, partial agonist or allosteric modulator of that GPCR; and detecting whether the candidate agent is a modulator of RAGE ligand-independent activation of RAGE by activated co-located GPCR by detecting an effect indicative of modulation of RAGE activation by the presence of the candidate agent and/or by detecting RAGE-dependent signalling that is modulated by the presence of the candidate agent.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: August 13, 2024
    Assignees: Monash University, The University of Western Australia
    Inventors: Kevin Donald George Pfleger, Merlin Christopher Thomas, Raelene Jane Pickering, Carlos Rosado, Christos Tikellis
  • Patent number: 12060581
    Abstract: The invention provides methods and compositions for producing a multi-layered cellular structure or blastocyst-like structure from a cell population of reprogrammed somatic cells.
    Type: Grant
    Filed: November 24, 2021
    Date of Patent: August 13, 2024
    Assignee: MONASH UNIVERSITY
    Inventors: Jose Polo, Xiaodong Liu, Jia Ping Tan
  • Publication number: 20240245788
    Abstract: The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.
    Type: Application
    Filed: January 10, 2024
    Publication date: July 25, 2024
    Applicants: PureTech LYT, Inc., Monash University
    Inventors: Daniel Kenneth Bonner, Rishab R. Shyam, Jamie Simpson, Christopher John Porter, Natalie Trevaskis, Tim Quach, Sifei Han, Luojuan Hu
  • Patent number: 12031220
    Abstract: The invention provides a cathode for the nitrogen reduction reaction, comprising an electrically conductive substrate and an electrocatalytic composition on the substrate, wherein the electrocatalytic composition comprises: a support material present in one or more crystalline phases; and metallic clusters dispersed on the support material, the metallic clusters comprising at least one metal selected from ruthenium, iron, rhodium, iridium and molybdenum, wherein at least 80 mass % of the support material is present in a semiconductive crystalline phase having a conduction band minimum energy below (more positive than) ?0.3 V relative to the normal hydrogen electrode (NHE).
    Type: Grant
    Filed: June 27, 2019
    Date of Patent: July 9, 2024
    Assignee: MONASH UNIVERSITY
    Inventors: Douglas R. MacFarlane, Bryan Harry Rahmat Suryanto, Dabin Wang, Hoang-Long Du
  • Publication number: 20240174927
    Abstract: Disclosed herein is a method for co-pyrolysis of a polyolefin and a rubber containing material comprising: operating at least a pyrolysis stage of a pyrolysis reactor at an operating temperature at or above the temperature at which pyrolysis of both the polyolefin and the rubber containing material commences and up to about 600° C. under a substantially inert atmosphere; feeding a mixture comprising the polyolefin and the rubber containing material into the pyrolysis reactor; co-pyrolysing the mixture in the pyrolysis reactor to produce a pyrolysis gas comprising volatile pyrolysis products of the polyolefin and the rubber, wherein the volatile pyrolysis product of the olefin comprises at least a short chain olefin and the volatile product of the rubber comprises at least a diene; and facilitating a gas phase reaction between the short chain olefin and the diene to produce a volatile gas comprising single-ring aromatic hydrocarbons.
    Type: Application
    Filed: March 25, 2022
    Publication date: May 30, 2024
    Applicant: Monash University
    Inventors: Chandan KUNDU, Umer CHAUDHRY, Mahmud Arman KIBRIA, Sankar BHATTACHARYA
  • Publication number: 20240151710
    Abstract: The invention relates to the field of medical diagnostics. In particular, it relates to compositions, methods and kits for detecting immune cells for diagnosis of allergy, for monitoring of vaccination responses, for determining immune response to pathogens and of treatment efficacy of allergen immunotherapy. For example, the invention provides a method of determining allergic reactivity in a subject, the method comprising, providing a sample from a subject, contacting the sample with a recombinant or synthetic allergen linked to a detectable label in conditions for permitting the binding of the allergen to an IgE molecule present in the sample, determining the binding of the allergen to an IgE molecule in the sample by detecting the label, wherein the detection of the label indicates the subject has allergic reactivity.
    Type: Application
    Filed: October 16, 2020
    Publication date: May 9, 2024
    Applicants: MONASH UNIVERSITY, ALFRED HEALTH, THE MACFARLANE BURNET INSTITUTE FOR MEDICAL RESEARCH AND PUBLIC HEALTH LTD
    Inventors: MENNO VAN ZELM, ROBYN O'HEHIR, MARK HOGARTH
  • Patent number: 11976343
    Abstract: An aluminium based alloy, and a method for production of components by additive manufacturing (AM) or other rapid solidification process with the alloy, is based on the alloy having a composition with from 2.01 wt % to 15.0 wt % manganese, from 0.3 wt % to 2.0 wt % scandium, with a balance apart from minor alloy elements and incidental impurities of aluminium.
    Type: Grant
    Filed: July 28, 2023
    Date of Patent: May 7, 2024
    Assignee: MONASH UNIVERSITY
    Inventors: Paul Rometsch, Xinhua Wu, Qingbo Jia
  • Patent number: 11975073
    Abstract: The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.
    Type: Grant
    Filed: June 26, 2023
    Date of Patent: May 7, 2024
    Assignees: PureTech LYT, Inc., Monash University
    Inventors: Daniel Kenneth Bonner, Rishab R. Shyam, Jamie Simpson, Christopher John Porter, Natalie Trevaskis, Tim Quach, Sifei Han, Luojuan Hu