Patents Assigned to Monash University
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Publication number: 20250147092Abstract: A method for estimating fault location in an electrical power line system (PLS) is provided. The method includes receiving an observed signal caused by a real fault in the PLS. The observed signal is measured at a real observation point in the PLS. The real fault has occurred at one of two or more real locations in the PLS; accessing a library representing model signals between model guessed fault locations and a model observation point in a network model of the PLS; selecting a model GFL by: (i) calculating metrics for the model signals by processing the model signals with the observed signal, and/or (ii) selecting the model GFL corresponding to a highest calculated metric; estimating a fault location of real locations in the PLS based on a corresponding location of the selected model GFL; and sending the estimated fault location to an external management system.Type: ApplicationFiled: February 10, 2023Publication date: May 8, 2025Applicant: Monash UniversityInventors: Reza Razzaghi, David Flynn, Lachlan Andrew
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Publication number: 20250099572Abstract: The invention relates to vaccine compositions for inducing an immune response to a coronavirus in a subject, and uses thereof. In particular, the vaccine comprises of a chimeric or fusion protein comprising a) a N-terminal secretion signal peptide; b) an amino acid sequence of the receptor binding domain (RBD) of a spike protein of a coronavirus; and c) a C-terminal domain comprising a transmembrane region and a cytoplasmic region. In a preferred embodiment, the signal peptide, RBD, transmembrane region, and cytoplasmic region are derived from SARS-CoV-2, and that the vaccine composition is formulated as a lipid nanoparticle (LNP).Type: ApplicationFiled: August 17, 2022Publication date: March 27, 2025Applicant: Monash UniversityInventors: Hareth Basim Ali AL-WASSITI, Colin William POUTON, Stewart Alastair FABB
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Publication number: 20250087691Abstract: Stability to long term charge and discharge cycles is the most formidable challenge for Lithium-Sulfur batteries. Therefore, a more holistic design of a durable cathode with minimal polysulfide escape to mitigate the corrosion of the lithium anode is required. A saccharide-based binder system—the monosaccharide (glucose) component, on account of being a strong reducing agent has a unique capacity for the regulation of polysulfide thereby dramatically enhancing the functionality of a polysaccharide (carboxymethyl cellulose) binder system. The two-component binder system promotes the formation of viscoelastic filaments during casting which endows sulfur cathode a desired web-like microstructure. The combination of these effects leads to 97% sulfur utilisation with an ultra-long cycle life of 1000 cycles (9 months) and a high capacity retention (around 700 mAhg?1 after 1000 cycles). A pouch cell prototype with a capacity of 1200 mAhg?1 demonstrates a promising transition from laboratory to manufacturing options.Type: ApplicationFiled: July 18, 2022Publication date: March 13, 2025Applicant: Monash UniversityInventors: Yingyi HUANG, Mahdokht SHAIBANI, Matthew HILL, Mainak MAJUMDER
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Publication number: 20250052024Abstract: A system including: a distance sensor system located/oriented/configured to measure a deformation of a geomaterial portion due to compaction of the geomaterial portion; and an electronic processing system configured to: receive signals from the distance sensor system representing the measured deformation, and automatically generate an estimate/measure of a geomaterial layer property of the geomaterial portion based on: the measured deformation; and a pre-defined relationship/model that associates deformation values with geomaterial layer property values (e.g., density values, stiffness values, modulus values, energy values, or layer thicknesses during compaction).Type: ApplicationFiled: December 17, 2021Publication date: February 13, 2025Applicant: Monash UniversityInventors: Amir Tophel, Jayantha K. Kodikara, Jeffrey P. Walker
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Publication number: 20250034222Abstract: This invention relates to polypeptides, including variants of interleukin-38 (IL-38), and related therapeutics and compositions. The invention also relates to the use of the polypeptides and compositions in methods of treating inflammatory diseases or conditions. The present invention provides a monomeric polypeptide comprising an amino acid sequence of an IL-38 monomer, the amino acid sequence having a mutation or modification for preventing the peptide from forming a homodimer and favouring the formation of a stable monomer.Type: ApplicationFiled: December 7, 2022Publication date: January 30, 2025Applicants: Monash University, Hudson Institute of Medical ResearchInventors: Claudia Annelie Nold, Andrew Malcolm Ellisdon, Marcel Friedrich Nold, James Whisstock
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Patent number: 12186361Abstract: This invention relates to drug delivery and in particular to the delivery of biologically active agents in the form of dry powders for inhalation. The invention also relates to methods for preparing such dry powder formulations and methods for their use.Type: GrantFiled: June 15, 2021Date of Patent: January 7, 2025Assignee: Monash UniversityInventors: Michelle McIntosh, David Morton, Tomas Sou, Livesey Olerile, Richard Prankerd
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Patent number: 12178875Abstract: The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a provided lipid prodrug or a pharmaceutical composition thereof.Type: GrantFiled: January 29, 2024Date of Patent: December 31, 2024Assignees: Seaport Therapeutics, Inc., Monash UniversityInventors: Daniel Kenneth Bonner, Ketki Karanam, James Tendai Mutamba, Rishab R. Shyam, Jamie Simpson, Sifei Han, Luojuan Hu, Christopher John Hamilton Porter, Tim Quach, Natalie Trevaskis
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Patent number: 12161610Abstract: This invention relates to methods of treating or preventing viral infections caused by flaviviruses, such as dengue virus, yellow fever virus, West Nile virus or Japanese encephalitis virus or infections caused by Chikungunya virus (CHIKV). The methods involve the administration of retinoic acid analogues to subjects who have, are suspected of having a flavivirus infection or infection with CHIKV, or to those who are at risk of becoming infected with a flavivirus or becoming infected with CHIKV.Type: GrantFiled: July 20, 2023Date of Patent: December 10, 2024Assignee: Monash UniversityInventors: Johanna Elisabeth Fraser, David Andrew Jans, Kylie Michelle Wagstaff
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Publication number: 20240402121Abstract: The invention relates generally to a method of detecting and/or analysing target polymers, especially target polynucleotides, using a biological pore. The invention also relates to a novel system for carrying out the method. The method has many uses. In particular, the method may be used for diagnosis, detection of polymorphisms and V(D)J repertoire analysis.Type: ApplicationFiled: October 4, 2022Publication date: December 5, 2024Applicants: Oxford Nanopore Technologies PLC, Monash UniversityInventors: Lakmal Nishantha Jayasinghe, Elizabeth Jayne Wallace, Richard Alexander Gutierrez, Michelle Anne Dunstone, Bradley Alan Spicer
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Publication number: 20240358652Abstract: The present invention is directed to lipid nanoparticles, formulations containing lipid nanoparticles and methods of treating diseases or conditions with said lipid nanoparticles and formulations thereof. A lipid nanoparticle comprising (a) an active agent; (b) a cationic and/or ionisable lipid comprising from about 40 mol % to about 60 mol % of the total lipid present in the nanoparticle; (c) a phospholipid comprising from about 5 mol % to about 20 mol % of the total lipid present in the nanoparticle; (d) a structural lipid comprising from about 30 mol % to about 50 mol % of the total lipid present in the nanoparticle; (e) a PEGylated lipid comprising from about 0.05 mol % to less than 0.5 mol % of the total lipid present in the nanoparticle.Type: ApplicationFiled: August 17, 2022Publication date: October 31, 2024Applicant: Monash UniversityInventors: Hareth Basim Ali AL-WASSITI, Colin William POUTON, Kha Tu Joan HO
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Patent number: 12097366Abstract: An apparatus for performing bioelectric stimulation, the apparatus comprising: a stimulation unit; a measurement unit comprising an amplifier; first and second stimulation electrodes operable to apply electrical signals to tissue of a patient; first and second measurement electrodes operable to receive first and second measurement signals from the tissue of the patient; wherein the stimulation unit is configured to deliver a first stimulation signal to the first stimulation electrode and a second stimulation signal to the second stimulation electrode; wherein the first signal and the second signal are mirrored about a biasing voltage, the biasing voltage set in dependence of the dynamic range of the amplifier.Type: GrantFiled: October 25, 2019Date of Patent: September 24, 2024Assignee: MONASH UNIVERSITYInventors: Richard H. Thomson, Paul B. Fitzgerald, Caley Sullivan, Mark Harrison
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Publication number: 20240278194Abstract: Disclosed herein is a phenolic-graphene oxide composition comprising phenolic-graphene oxide having a carbon to oxygen (C:O) ratio of 2.1 or greater and 5 or less.Type: ApplicationFiled: June 15, 2022Publication date: August 22, 2024Applicant: Monash UniversityInventors: Mainak MAJUMDER, Abozar AKBARIVAKILABADI, Sally EL MERAGAWI, Petar JOVANOVIC
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Patent number: 12060408Abstract: A method of screening candidate agents for their ability to modulate RAGE activity where such RAGE activity is induced by an active co-located GPCR, the method comprising the steps of: contacting a RAGE polypeptide with a GPCR polypeptide in the presence of a candidate agent where the GPCR polypeptide is constitutively active and/or is activated by addition of an agonist, partial agonist or allosteric modulator of that GPCR; and detecting whether the candidate agent is a modulator of RAGE ligand-independent activation of RAGE by activated co-located GPCR by detecting an effect indicative of modulation of RAGE activation by the presence of the candidate agent and/or by detecting RAGE-dependent signalling that is modulated by the presence of the candidate agent.Type: GrantFiled: August 21, 2018Date of Patent: August 13, 2024Assignees: Monash University, The University of Western AustraliaInventors: Kevin Donald George Pfleger, Merlin Christopher Thomas, Raelene Jane Pickering, Carlos Rosado, Christos Tikellis
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Patent number: 12060581Abstract: The invention provides methods and compositions for producing a multi-layered cellular structure or blastocyst-like structure from a cell population of reprogrammed somatic cells.Type: GrantFiled: November 24, 2021Date of Patent: August 13, 2024Assignee: MONASH UNIVERSITYInventors: Jose Polo, Xiaodong Liu, Jia Ping Tan
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Publication number: 20240245788Abstract: The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.Type: ApplicationFiled: January 10, 2024Publication date: July 25, 2024Applicants: PureTech LYT, Inc., Monash UniversityInventors: Daniel Kenneth Bonner, Rishab R. Shyam, Jamie Simpson, Christopher John Porter, Natalie Trevaskis, Tim Quach, Sifei Han, Luojuan Hu
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Patent number: 12031220Abstract: The invention provides a cathode for the nitrogen reduction reaction, comprising an electrically conductive substrate and an electrocatalytic composition on the substrate, wherein the electrocatalytic composition comprises: a support material present in one or more crystalline phases; and metallic clusters dispersed on the support material, the metallic clusters comprising at least one metal selected from ruthenium, iron, rhodium, iridium and molybdenum, wherein at least 80 mass % of the support material is present in a semiconductive crystalline phase having a conduction band minimum energy below (more positive than) ?0.3 V relative to the normal hydrogen electrode (NHE).Type: GrantFiled: June 27, 2019Date of Patent: July 9, 2024Assignee: MONASH UNIVERSITYInventors: Douglas R. MacFarlane, Bryan Harry Rahmat Suryanto, Dabin Wang, Hoang-Long Du
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Publication number: 20240174927Abstract: Disclosed herein is a method for co-pyrolysis of a polyolefin and a rubber containing material comprising: operating at least a pyrolysis stage of a pyrolysis reactor at an operating temperature at or above the temperature at which pyrolysis of both the polyolefin and the rubber containing material commences and up to about 600° C. under a substantially inert atmosphere; feeding a mixture comprising the polyolefin and the rubber containing material into the pyrolysis reactor; co-pyrolysing the mixture in the pyrolysis reactor to produce a pyrolysis gas comprising volatile pyrolysis products of the polyolefin and the rubber, wherein the volatile pyrolysis product of the olefin comprises at least a short chain olefin and the volatile product of the rubber comprises at least a diene; and facilitating a gas phase reaction between the short chain olefin and the diene to produce a volatile gas comprising single-ring aromatic hydrocarbons.Type: ApplicationFiled: March 25, 2022Publication date: May 30, 2024Applicant: Monash UniversityInventors: Chandan KUNDU, Umer CHAUDHRY, Mahmud Arman KIBRIA, Sankar BHATTACHARYA
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Publication number: 20240151710Abstract: The invention relates to the field of medical diagnostics. In particular, it relates to compositions, methods and kits for detecting immune cells for diagnosis of allergy, for monitoring of vaccination responses, for determining immune response to pathogens and of treatment efficacy of allergen immunotherapy. For example, the invention provides a method of determining allergic reactivity in a subject, the method comprising, providing a sample from a subject, contacting the sample with a recombinant or synthetic allergen linked to a detectable label in conditions for permitting the binding of the allergen to an IgE molecule present in the sample, determining the binding of the allergen to an IgE molecule in the sample by detecting the label, wherein the detection of the label indicates the subject has allergic reactivity.Type: ApplicationFiled: October 16, 2020Publication date: May 9, 2024Applicants: MONASH UNIVERSITY, ALFRED HEALTH, THE MACFARLANE BURNET INSTITUTE FOR MEDICAL RESEARCH AND PUBLIC HEALTH LTDInventors: MENNO VAN ZELM, ROBYN O'HEHIR, MARK HOGARTH
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Patent number: 11976343Abstract: An aluminium based alloy, and a method for production of components by additive manufacturing (AM) or other rapid solidification process with the alloy, is based on the alloy having a composition with from 2.01 wt % to 15.0 wt % manganese, from 0.3 wt % to 2.0 wt % scandium, with a balance apart from minor alloy elements and incidental impurities of aluminium.Type: GrantFiled: July 28, 2023Date of Patent: May 7, 2024Assignee: MONASH UNIVERSITYInventors: Paul Rometsch, Xinhua Wu, Qingbo Jia
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Patent number: 11975073Abstract: The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.Type: GrantFiled: June 26, 2023Date of Patent: May 7, 2024Assignees: PureTech LYT, Inc., Monash UniversityInventors: Daniel Kenneth Bonner, Rishab R. Shyam, Jamie Simpson, Christopher John Porter, Natalie Trevaskis, Tim Quach, Sifei Han, Luojuan Hu