Abstract: The present invention relates to compositions, methods and kits for the treatment of fibrosis. In particular, the compositions, methods and kits are particularly useful, but not limited to, the treatment of cardiac fibrosis. The invention provides a method of treating fibrosis in an individual comprising administering an inhibitor of insulin-regulated aminopeptidase (IRAP), thereby treating fibrosis.
Type:
Grant
Filed:
August 4, 2020
Date of Patent:
August 3, 2021
Assignee:
MONASH UNIVERSITY
Inventors:
Siew Yeen Chai, Robert Widdop, Tracey Gaspari, Huey Wen Lee
Abstract: The present disclosure provides a coating composition for forming a coating that at least partially mobilizes in response to UV light, the composition comprising a monomer selected from acrylates, methacrylates and mixtures thereof, a cross-linking agent comprising two sub-units covalently bonded together, each sub-unit comprising an unsaturated group which is co-polymerisable with the monomer, wherein the two sub-units are adapted to dissociate in response to irradiation by UV light. The cross-linking agent may be present in the coating composition in an amount of less than 15 mol % of the total of the monomer and cross-linking agent.
Type:
Grant
Filed:
September 5, 2018
Date of Patent:
August 3, 2021
Assignee:
Monash University
Inventors:
Mustafa Abdallh, Milton Thomas William Hearn, George Simon, Kei Saito
Abstract: This invention relates to drug delivery and in particular to the delivery of biologically active agents in the form of dry powders for inhalation. The invention also relates to methods for preparing such dry powder formulations and methods for their use.
Type:
Grant
Filed:
November 4, 2016
Date of Patent:
July 20, 2021
Assignee:
MONASH UNIVERSITY
Inventors:
Michelle McIntosh, David Morton, Tomas Sou, Livesey Olerile, Richard Prankerd
Abstract: Closed-loop transcranial stimulation and monitoring is disclosed that includes generating a stimulation signal having a set of first oscillation parameters; applying the stimulation signal transcranially to a patient; monitoring the stimulation signal as applied to the patient; receiving a brain activity signal from the patient; generating a feedback signal based on the monitored stimulation signal as applied to the patient; and generating a modified activity signal by subtracting the feedback signal from the brain activity signal; determining one or more second oscillation parameters of the modified activity signal; and adjusting the set of first oscillation parameters of the stimulation signal based on the one or more second oscillation parameters of the modified activity signal. Closed-loop transcranial stimulation and monitoring is also disclosed in which the patient is engaged in a cognitive task.
Type:
Grant
Filed:
April 10, 2017
Date of Patent:
July 20, 2021
Assignee:
Monash University
Inventors:
Paul B Fitzgerald, Caley M. Sullivan, Richard H. Thomson
Abstract: A carbon monolith and a process of producing same, the process comprising the steps of: (i) mixing a carbonaceous precursor material with an alkali salt to form a first mixture; (ii) extruding the first mixture produced in step (i) into the shape of a monolith; and (iii) carbonizing the monolith produced in step (ii).
Abstract: The invention relates to a membrane, and method of manufacture of a membrane for reverse osmosis having a porous substrate, and a layer adjacent the porous substrate comprising a two dimensional nanosheet material and crosslinked polymer. The two dimensional nanosheet material is preferably chosen from the group comprising graphene oxide including reduced graphene oxide, holey graphene, holey graphene oxide, laminated graphene oxide and holey reduced graphene oxide.
Abstract: The invention relates to CXCR2, to antibodies and related fragments thereof for binding to CXCR2, to production of said antibodies and fragments and to use of said antibodies and fragments for detection and therapy of various conditions.
Type:
Grant
Filed:
February 27, 2018
Date of Patent:
July 6, 2021
Assignee:
Monash University
Inventors:
Charles Reay Mackay, Remy Michel Robert
Abstract: This invention relates to methods of treating or preventing viral infections caused by flaviviruses, such as dengue virus, yellow fever virus, West Nile virus or Japanese encephalitis virus or infections caused by Chikungunya virus (CHIKV). The methods involve the administration of retinoic acid analogues to subjects who have, are suspected of having a flavivirus infection or infection with CHIKV, or to those who are at risk of becoming infected with a flavivirus or becoming infected with CHIKV.
Type:
Grant
Filed:
April 16, 2014
Date of Patent:
May 18, 2021
Assignee:
Monash University
Inventors:
Johanna Elisabeth Fraser, David Andrew Jans, Kylie Michelle Wagstaff
Abstract: An imaging apparatus and method, the apparatus comprising: a semiconductor die; a photosensitive array of photodiodes and single photon avalanche diodes (SPADs), the photodiodes comprising reverse biased diodes; and a front-end circuit coupled to the photosensitive array; and an output for outputting image data from the front-end circuit. The photosensitive array and the front-end circuit are provided in the semiconductor die.
Type:
Application
Filed:
May 31, 2018
Publication date:
April 29, 2021
Applicant:
Monash University
Inventors:
Simon Kennedy, Daniel Morrison, Jean-Michel Redoute, Mehmet Rasit Yuce
Abstract: A sodium-ion electrolyte composition for use in an electrochemical cell, the electrolyte composition comprising a mixture of a phosphonium salt and a sodium salt, wherein the electrolyte composition presents as a solid up to at least 25° C.
Type:
Grant
Filed:
November 30, 2016
Date of Patent:
March 23, 2021
Assignees:
Deakin University, Monash University
Inventors:
Maria Forsyth, Matthias Hilder, Patrick C. Howlett, Faezeh Makhlooghiazad, Douglas Robert MacFarlane
Abstract: The invention relates to IL-21, to antibodies and related fragments thereof for binding to IL-21, to production of said antibodies and fragments and to use of said antibodies and fragments for detection and therapy of various conditions, in particular inflammation, infection and oncology.
Type:
Grant
Filed:
December 18, 2015
Date of Patent:
March 9, 2021
Assignee:
MONASH UNIVERSITY
Inventors:
Charles Reay Mackay, Di Yu, Remy Robert
Abstract: A serum-free media composition for maintenance or directed differentiation of human embryonic stem cells (HESCs) toward particular cell lineages is disclosed. The media comprises one or more cell nutrient media, a recombinant human albumin or equivalent thereof and optionally at least one agent involved in HESC differentiation. The media composition is substantially free of any human or animal derived products.
Type:
Grant
Filed:
April 8, 2010
Date of Patent:
January 19, 2021
Assignee:
Monash University
Inventors:
Andrew George Elefanty, Edouard Guy Stanley, Elizabeth Siewsun Ng
Abstract: The present disclosure provides proteins comprising antigen binding sites of antibodies that bind to interleukin-21 (IL-21) and uses thereof, e.g., in therapy.
Abstract: The invention relates to disulfide-rich peptides derived from spider venom and their use, particularly as neuroprotective agents. The invention also relates to nucleic acid molecules encoding the peptides as well as constructs and host cells comprising those nucleic acid molecules.
Type:
Grant
Filed:
October 11, 2019
Date of Patent:
January 5, 2021
Assignees:
The University of Queensland, Monash University
Inventors:
Glenn Frederick King, Lachlan Douglas Rash, Irene Chassagnon, Sandy Steffany Pineda Gonzalez, Robert Edward Widdop, Claudia Ann Ireland
Abstract: A soundless cracking demolition agent (SCDA) comprising quicklime, water, a viscosity enhancing agent (VEA), a high range water reducing admixture (HRWR) and an anhydrous accelerator component. A method for in-situ leaching and a method for the recovery of unconventional oil or gas utilising the SCDA of the present invention are also described.
Type:
Grant
Filed:
November 16, 2018
Date of Patent:
November 17, 2020
Assignee:
Monash University
Inventors:
Ranjith Pathegama Gamage, Radhika Shehan Vidanage De Silva
Abstract: An improved method for concentrating dispersions of graphene oxide, coating a substrate with a layer of a graphene oxide solution, and producing a supported graphene membrane stabilised by controlled deoxygenation; and graphene-based membranes that demonstrate ultra-fast water transport, precise molecular sieving of gas and solvated molecules, and which show great promise as novel separation platforms.
Abstract: Compound of formula I: wherein: A is selected from: (i) where RF1 is H or F; (ii) (iii) a N-containing C6 heteroaryl group; and B is where X1 is either CRF2 or N, where RF2 is H or F; X2 is either CR3 or N, where R3 is selected from H, Me, Cl, F OMe; X3 is either CH or N; X4 is either CRF3 or N, where RF3 is H or F; where only one or two of X1, X2, X3 and X4 may be N; and R4 is selected from I, optionally substituted phenyl, optionally substituted C5-6 heteroaryl; optionally substituted C1-6 alkyl and optionally substituted C1-6 alkoxy, which are useful in the treatment of a condition ameliorated by the inhibition of MOZ.
Type:
Grant
Filed:
June 9, 2016
Date of Patent:
November 10, 2020
Assignees:
MONASH UNIVERSITY, The Walter and Eliza Hall Institute of Medical Research
Inventors:
Anne Kathrin Voss, Jonathan Baell, Huu Nghi Nguyen, David J. Leaver, Benjamin L. Cleary, H. Rachel Lagiakos, Bilal Nadeem Sheikh, Timothy John Thomas
Abstract: Methods of reducing chemical degradant formation, such as those resulting from dimer formation in disulfide bridge-closed ring-bearing polypeptides, such as oxytocin, in a solid-state; to heat stable pharmaceutical compositions having improved physio- or chemical stability, to inhalers and dosage forms of such compositions, to methods of production of and treatment of diseases and or conditions, such as post partum hemhorrage, with such compositions.
Abstract: The present invention relates to a method for the treatment of fibrosis, in particular cardiac fibrosis, comprising the administration of an inhibitor of insulin-regulated aminopeptidase (IRAP). Preferable the IRAP inhibitor is chosen from the group including HFI-419, HA-08, AL-40, HFI-437, Val-Tyr-Ile-His-Pro-Phe (otherwise known as angiotensin IV or ANG IV), c[Cys-Tyr-Cys]-His-Pro-Phe, and c[Hcy-Tyr-Hcy]-His-Pro-Phe.
Type:
Grant
Filed:
September 6, 2018
Date of Patent:
September 29, 2020
Assignee:
MONASH UNIVERSITY
Inventors:
Siew Yeen Chai, Robert Widdop, Tracey Gaspari, Huey Wen Lee
Abstract: The present invention relates to antimicrobial compounds and their uses, and in particular to peptide antibiotics which may be used in the treatment of bacterial infections such as Gram-negative bacterial infections, particularly those caused by multidrug-resistant (MDR) pathogens.
Type:
Grant
Filed:
September 27, 2018
Date of Patent:
December 1, 2020
Assignee:
Monash University
Inventors:
Jian Li, Roger Nation, Tony Velkov, Philip Thompson, Kade D. Roberts