Patents Assigned to Monash University
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Patent number: 11335515Abstract: The invention provides a capacitive energy storage device comprising: at least one porous film infiltrated with an electrolyte; and one or more pairs of separated electrodes disposed on top of a first surface of the porous film, each electrode comprising a capacitive electrode material in ionic communication with the underlying porous film, wherein the electrolyte provides ionic communication between the separated electrodes via the internal porosity of the porous film.Type: GrantFiled: April 26, 2018Date of Patent: May 17, 2022Assignee: MONASH UNIVERSITYInventors: Parama Chakraborty Banerjee, Mainak Majumder, Derrek Evan Lobo, Abozar Akbarivakilabadi
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Patent number: 11331368Abstract: The present invention relates to compositions, methods and kits for the treatment of fibrosis. In particular, the compositions, methods and kits are particularly useful, but not limited to, the treatment of cardiac fibrosis. The invention provides a method of treating fibrosis in an individual comprising administering an AT2R selective agonist, thereby treating fibrosis.Type: GrantFiled: July 17, 2018Date of Patent: May 17, 2022Assignee: Monash UniversityInventors: Robert Widdop, Marie-Isabel Aguilar, Mark Del Borgo, Emma Jones, Baydaa Hirmiz, Yan Wang
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Publication number: 20220143038Abstract: The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, and methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.Type: ApplicationFiled: January 27, 2022Publication date: May 12, 2022Applicants: PureTech LYT, Inc., Monash UniversityInventors: Daniel Kenneth Bonner, Ketki Karanam, Sifei Han, Luojuan Hu, Christopher John Hamilton Porter, Tim Quach, Rishab R. Shyam, Jamie Simpson, Natalie Trevaskis
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Patent number: 11319343Abstract: The present invention relates generally to the field of immunomodulation. Taught herein is an agent for inhibiting immunostimulation mediated by a Toll-like receptor useful in the treatment of viral and microbial pathogenesis, diseases involving elements of autoimmunity and inflammation as well as cancer. The agent antagonizes disulfide bond formation between C98 and C475 of Toll-like receptor 7 (TLR7) thereby preventing TLR7 activation. Pharmaceutical compositions are also enabled herein.Type: GrantFiled: June 29, 2018Date of Patent: May 3, 2022Assignees: ROYAL MELBOURNE INSTITUTE OF TECHNOLOGY, UNIVERSITY OF SOUTH AUSTRALIA, THE PROVOST, FELLOWS, FOUNDATION SCHOLARS AND THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEEN ELIZABETH NEAR DUBLIN, MONASH UNIVERSITYInventors: Stavros Selemidis, Doug A. Brooks, John O'Leary
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Patent number: 11311512Abstract: The present invention relates to compounds and their uses, in particular, compounds in the form of prodrugs that promote transport of a pharmaceutical agent to the lymphatic system and subsequently enhance release of the parent drug.Type: GrantFiled: August 12, 2015Date of Patent: April 26, 2022Assignee: Monash UniversityInventors: Chris Porter, Jamie Simpson, Natalie Trevaskis, Tim Quach, Sifei Han, Luojuan Hu
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Publication number: 20220118247Abstract: An apparatus for performing bioelectric stimulation, the apparatus comprising: a stimulation unit; a measurement unit comprising an amplifier; first and second stimulation electrodes operable to apply electrical signals to tissue of a patient; first and second measurement electrodes operable to receive first and second measurement signals from the tissue of the patient; wherein the stimulation unit is configured to deliver a first stimulation signal to the first stimulation electrode and a second stimulation signal to the second stimulation electrode; wherein the first signal and the second signal are mirrored about a biasing voltage, the biasing voltage set in dependence of the dynamic range of the amplifier.Type: ApplicationFiled: October 25, 2019Publication date: April 21, 2022Applicant: MONASH UNIVERSITYInventors: Richard H. THOMSON, Paul B. FITZGERALD, Caley SULLIVAN, Mark HARRISON
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Patent number: 11304954Abstract: The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, and methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.Type: GrantFiled: December 19, 2018Date of Patent: April 19, 2022Assignees: PureTech LYT, Inc., Monash UniversityInventors: Daniel Kenneth Bonner, Ketki Karanam, Sifei Han, Luojuan Hu, Christopher John Hamilton Porter, Tim Quach, Rishab R. Shyam, Jamie Simpson, Natalie Trevaskis
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Patent number: 11306066Abstract: The present disclosure relates generally, but not exclusively, to compounds and their use in therapy, to compositions and agents comprising said compounds, to methods of treatment using said compounds, and their use in the manufacture of medicaments. The disclosure further relates to inhibitors of IRAP and their use in the treatment or prevention of Alzheimer's disease and the treatment and prevention of memory and cognitive disorders.Type: GrantFiled: May 6, 2016Date of Patent: April 19, 2022Assignee: Monash UniversityInventors: Siew Yeen Chai, Philip Thompson, Simon Mountford, Michael W. Parker
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Patent number: 11273166Abstract: The present invention generally relates to methods and compositions for the treatment of overweight or obese individuals. In particular, the invention relates to reducing adiposity of an overweight or obese individual. The present invention provides a method for reducing adiposity or treating obesity in an individual, the method comprising inhibiting TCPTP and/or PTP1B in the hypothalamus of the individual, thereby reducing adiposity or treating obesity in the individual.Type: GrantFiled: June 13, 2018Date of Patent: March 15, 2022Assignee: Monash UniversityInventors: Garron Dodd, Tony Tiganis
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Publication number: 20220073580Abstract: This invention relates to polypeptides, including variants of interleukin-37 (IL-37), and related therapeutics and compositions. The invention also relates to the use of the polypeptides and compositions in methods of treating inflammatory diseases or conditions. The present invention provides a monomeric anti-inflammatory polypeptide comprising an amino acid sequence of an IL-37 monomer, the amino acid sequence having a mutation or modification for preventing the anti-inflammatory peptide from forming a homodimer.Type: ApplicationFiled: June 30, 2021Publication date: March 10, 2022Applicants: Monash University, Hudson Institute of Medical ResearchInventors: Marcel Nold, Claudia Nold, Andrew Ellisdon, James Whisstock
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Patent number: 11239073Abstract: Dirac semimetals, methods for modulating charge carrying density and/or band gap in a Dirac semimetal, devices including a Dirac semimetal layer, and methods for forming a Dirac semimetal layer on a substrate are described.Type: GrantFiled: October 31, 2018Date of Patent: February 1, 2022Assignee: MONASH UNIVERSITYInventors: Michael Sears Fuhrer, John Thery Hellerstedt, Mark Thomas Edmonds, James Lee Richard Jessee Collins, Chang Liu
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Patent number: 11225505Abstract: The present invention relates to antimicrobial polymyxin derivative compounds and their uses, and in particular to peptide polymyxin antibiotics which may be used in the treatment of bacterial infections such as Gram negative bacterial infections, particularly those caused by multidrug-resistant (MDR) Gram negative bacterial infections.Type: GrantFiled: September 29, 2016Date of Patent: January 18, 2022Assignee: Monash UniversityInventors: Kade D. Roberts, Jian Li, Tony Velkov, Roger L. Nation, Philip E. Thompson
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Publication number: 20210399277Abstract: A method of producing Sulfur cathodes for Li—S batteries utilising dry mixing of constituents (sulphur, carbon and binder) or semi-dry mixing. The resultant structure binds the neighbouring particles without covering them, i.e. by attaching a few parts of a particle to other neighbouring particles provides a solution for the successful cycling of thick and ultra-thick sulfur cathodes. Such an approach provides a robust thick cathode where particles are strongly bonded with minimal surface coverage with the polymer providing sufficient room to expand during lithiation. Bridging bonds are formed within the cathodes.Type: ApplicationFiled: November 10, 2019Publication date: December 23, 2021Applicant: Monash UniversityInventors: Mahdokht SHAIBANI, Mainak MAJUMDER
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Publication number: 20210388363Abstract: An isolated or purified AON for modifying pre-mRNA splicing in the Receptor for Advanced Glycation End-products (RAGE) to modulate splicing of the RAGE gene transcript or part thereof is provided.Type: ApplicationFiled: August 25, 2021Publication date: December 16, 2021Applicants: MONASH UNIVERSITY, MURDOCH UNIVERSITYInventors: Stephen WILTON, Merlin Christopher THOMAS, Carlos ROSADO, Raelene Jane PICKERING
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Patent number: 11160873Abstract: Expression of proteolytically active, high molecular weight ADAM10 protease is relatively increased in tumour cells that also express the putative tumour stem cell marker CD133. A recombinant humanized antibody or antibody fragment based on 8C7 monoclonal antibody may be used to selectively bind to proteolytically active, high molecular weight ADAM10 protease to thereby detect tumour cells and also as a therapeutic agent for treating cancers, tumours and other malignancies inclusive of leukemia, lymphoma, lung cancer, colon cancer, adenoma, neuroblastoma, brain tumour, renal tumour, prostate cancer, sarcoma and/or melanoma.Type: GrantFiled: July 5, 2018Date of Patent: November 2, 2021Assignees: Monash University, Memorial Sloan-Kettering Cancer Centre, Ludwig Institute for Cancer Research Ltd., Olivia Newton-John Cancer Research InstituteInventors: Martin Lackmann, Peter W. Janes, Lakmali Atapattu Mudiyanselage, Andrew M. Scott, Dimitar B. Nikolov, Nayanendu Saha
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Patent number: 11137390Abstract: A diagnostic device for analysing properties of an analyte in a sample liquid including: a distribution zone having at least two hydrophilic layers placed one on top of the other, wherein one layer is a top layer (12) and the other is a bottom layer (13); and a detection zone located under the distribution zone, the detection zone having a detection layer (14), wherein: the top layer has one or more openings (15) through which the sample liquid is introduced into the device; the bottom layer having one or more openings (16) connecting the distribution zone to the detection zone; the bottom layer also having a means by which the sample liquid is distributed from the top layer's opening to the detection layer through the bottom layer's opening; and a visual indication results on the detection layer when the sample liquid comes into contact with the detection layer.Type: GrantFiled: June 17, 2016Date of Patent: October 5, 2021Assignee: MONASH UNIVERSITYInventors: Junfei Tian, Wei Shen, Gil Garnier, David Bashforth, Heather McLiesh
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Publication number: 20210299447Abstract: Closed-loop transcranial stimulation and monitoring is disclosed that includes generating a stimulation signal having a set of first oscillation parameters; applying the stimulation signal transcranially to a patient; monitoring the stimulation signal as applied to the patient; receiving a brain activity signal from the patient; generating a feedback signal based on the monitored stimulation signal as applied to the patient; and generating a modified activity signal by subtracting the feedback signal from the brain activity signal; determining one or more second oscillation parameters of the modified activity signal; and adjusting the set of first oscillation parameters of the stimulation signal based on the one or more second oscillation parameters of the modified activity signal. Closed-loop transcranial stimulation and monitoring is also disclosed in which the patient is engaged in a cognitive task.Type: ApplicationFiled: June 14, 2021Publication date: September 30, 2021Applicant: MONASH UNIVERSITYInventors: Paul B FITZGERALD, Caley M. Sullivan, Richard H. THOMSON
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Patent number: 11123376Abstract: The present disclosure relates generally to the methods of treatment of mammalian subjects by an enhanced cell-based therapeutic approach in order to facilitate tissue and neuronal repair, regeneration and/or reparation. Medicaments useful in the treatment of mammalian subjects and methods of production of the medicaments are also encompassed by the present disclosure.Type: GrantFiled: June 10, 2016Date of Patent: September 21, 2021Assignees: MONASH UNIVERSITY, HUDSON INSTITUTE OF MEDICAL RESEARCHInventors: Euan Wallace, Rebecca Lim
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Publication number: 20210244825Abstract: The invention relates to IL-21, to antibodies and related fragments thereof for binding to IL-21, to production of said antibodies and fragments and to use of said antibodies and fragments for detection and therapy of various conditions, in particular inflammation, infection and oncology.Type: ApplicationFiled: January 22, 2021Publication date: August 12, 2021Applicant: Monash UniversityInventors: Charles Reay MACKAY, Di YU, Remy ROBERT
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Publication number: 20210244692Abstract: The present invention relates to methods for treating or preventing or delaying the progression or onset of autoimmune disease, comprising the use of dietary metabolites.Type: ApplicationFiled: February 17, 2021Publication date: August 12, 2021Applicants: MONASH UNIVERSITY, COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATIONInventors: CHARLES REAY MACKAY, Eliana Marino Moreno, Trevor Lockett, Julie Clarke, David Topping