Patents Assigned to Monsanto Company
  • EVOLUTION OF BT TOXINS
    Publication number: 20230220016
    Abstract: The disclosure provides amino acid sequence variants of Bacillus thuringiensis (Bt) toxins and methods of producing the same. Some aspects of this disclosure provide methods for generating Bt toxin variants by continuous directed evolution. Some aspects of this disclosure provide compositions and methods for pest control using the disclosed variant Bt toxins.
    Type: Application
    Filed: October 26, 2022
    Publication date: July 13, 2023
    Applicants: President and Fellows of Harvard College, Monsanto Company
    Inventors: David R. Liu, Ahmed Hussein Badran, Victor Guzov, Tom Malvar, Prashanth Vishwanath, Jeff Nageotte, Qing Huai, Melissa Kemp
  • Evolution of toxins
    Patent number: 11524983
    Abstract: The disclosure provides amino acid sequence variants of Bacillus thuringiensis (Bt) toxins and methods of producing the same. Some aspects of this disclosure provide methods for generating Bt toxin variants by continuous directed evolution. Some aspects of this disclosure provide compositions and methods for pest control using the disclosed variant Bt toxins.
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: December 13, 2022
    Assignees: President and Fellows of Harvard College, Monsanto Company
    Inventors: David R. Liu, Ahmed Hussein Badran, Victor Guzov, Tom Malvar, Prashanth Vishwanath, Jeff Nageotte, Qing Huai, Melissa Kemp
  • Methods, devices, kits and compositions for detecting roundworm, whipworm and hookworm
    Patent number: 10942180
    Abstract: Methods, devices, kits and compositions for detecting the presence or absence of one or more helminthic coproantigens in a sample are disclosed herein. The methods, devices, kits and compositions of the present invention may be used to confirm the presence or absence of roundworm, whipworm and/or hookworm in a fecal sample from a mammal and may also be able to distinguish between one or more helminth infections. Confirmation of the presence or absence of roundworm, whipworm and/or hookworm in the mammal may be made, for example, for the purpose of selecting an optimal course of treating the mammal and/or for the purpose of determining whether the mammal has been rid of the infection after treatment has been initiated.
    Type: Grant
    Filed: August 13, 2019
    Date of Patent: March 9, 2021
    Assignees: Idexx Laboratories, Inc., Monsanto Company
    Inventors: David Allen Elsemore, Jinming Geng, Laurie A. Flynn, Michael Crawford
  • Methods, devices, kits and compositions for detecting roundworm, whipworm and hookworm
    Patent number: 10429388
    Abstract: Methods, devices, kits and compositions for detecting the presence or absence of one or more helminthic coproantigens in a sample are disclosed herein. The methods, devices, kits and compositions of the present invention may be used to confirm the presence or absence of roundworm, whipworm and/or hookworm in a fecal sample from a mammal and may also be able to distinguish between one or more helminth infections. Confirmation of the presence or absence of roundworm, whipworm and/or hookworm in the mammal may be made, for example, for the purpose of selecting an optimal course of treating the mammal and/or for the purpose of determining whether the mammal has been rid of the infection after treatment has been initiated.
    Type: Grant
    Filed: January 5, 2018
    Date of Patent: October 1, 2019
    Assignees: Idexx Laboratories, Inc., Monsanto Company
    Inventors: David Allen Elsemore, Jinming Geng, Laurie A Flynn, Michael Crawford
  • Methods, devices, kits and compositions for detecting roundworm, whipworm, and hookworm
    Patent number: 9746469
    Abstract: Methods, devices, kits and compositions for detecting the presence or absence of one or more helminthic coproantigens in a sample are disclosed herein. The methods, devices, kits and compositions of the present invention may be used to confirm the presence or absence of roundworm, whipworm and/or hookworm in a fecal sample from a mammal and may also be able to distinguish between one or more helminth infections. Confirmation of the presence or absence of roundworm, whipworm and/or hookworm in the mammal may be made, for example, for the purpose of selecting an optimal course of treating the mammal and/or for the purpose of determining whether the mammal has been rid of the infection after treatment has been initiated.
    Type: Grant
    Filed: April 23, 2015
    Date of Patent: August 29, 2017
    Assignees: IDEXX Laboratories, Inc., Monsanto Company
    Inventors: David Allen Elsemore, Jinming Geng, Laurie A Flynn, Michael Crawford
  • Nucleic acid sequences and methods of use for the production of plants with modified polyunsaturated fatty acids
    Patent number: 8097778
    Abstract: The present invention is directed to nucleic acid molecules and nucleic acid constructs, and other agents associated with fatty acid synthesis, particularly the ratios of saturated and unsaturated fats. Moreover, the present invention is directed to plants incorporating such agents where the plants exhibit altered ratios of saturated and unsaturated fats. In particular, the present invention is directed to plants incorporating such agents where the plants exhibit altered ratios of monounsaturated to polyunsaturated fatty acids.
    Type: Grant
    Filed: April 7, 2009
    Date of Patent: January 17, 2012
    Assignee: Monsanto Company
    Inventor: Joanne J. Fillatti
  • Yield and stress tolerance in transgenic plants II
    Patent number: 8071846
    Abstract: Polynucleotides and polypeptides incorporated into expression vectors have been introduced into plants and were ectopically expressed. The polypeptides of the invention have been shown to confer at least one regulatory activity and confer increased yield, greater height, greater early season growth, greater canopy coverage, greater stem diameter, greater late season vigor, increased secondary rooting, more rapid germination, greater cold tolerance, greater tolerance to water deprivation, reduced stomatal conductance, altered C/N sensing, increased low nitrogen tolerance, increased low phosphorus tolerance, or increased tolerance to hyperosmotic stress as compared to the control plant as compared to a control plant.
    Type: Grant
    Filed: March 31, 2010
    Date of Patent: December 6, 2011
    Assignees: Monsanto Company, Mendel Biotechnology, Inc.
    Inventors: Robert A. Creelman, Neal I. Gutterson, Oliver J. Ratcliffe, T. Lynne Reuber, R. Eric Cerny, Kimberly Faye Zobrist Duff, Susanne Kjemtrup-Lovelace, Robert J. Meister, Marie E. Petracek, Thomas Ruff, Qingzhang Xu
  • Production of hydroxylated fatty acids in genetically modified plants
    Patent number: 8003855
    Abstract: This invention relates to plant fatty acyl hydroxylases. Methods to use conserved amino acid or nucleotide sequences to obtain plant fatty acyl hydroxylases are described. Also described is the use of cDNA clones encoding a plant hydroxylase to produce a family of hydroxylated fatty acids in transgenic plants. In addition, the use of genes encoding fatty acid hydroxylases or desaturases to alter the level of lipid fatty acid unsaturation in transgenic plants is described.
    Type: Grant
    Filed: September 27, 2007
    Date of Patent: August 23, 2011
    Assignees: Carnegie Institution of Washington, Monsanto Company, Inc.
    Inventors: Chris Somerville, Pierre Broun, Frank van de Loo, Sekhar S. Boddupalli
  • Transgenic plants containing altered levels of steroid compounds
    Patent number: 7906710
    Abstract: Disclosed are constructs comprising sequences encoding 3-hydroxy-3methylglutaryl-Coenzyme A reductase and at least one other sterol synthesis pathway enzyme. Also disclosed are methods for using such constructs to alter sterol production and content in cells, plants, seeds and storage organs of plants. Also provided are oils and compositions containing altered sterol levels produced by use of the disclosed constructs. Novel nucleotide sequences useful in the alteration of sterol production are also provided. Also provided are cells, plants, seeds and storage organs of plants comprising sequences encoding 3-hydroxy-3methylglutaryl-Coenzyme A reductase, at least one other sterol synthesis pathway enzyme and at least one tocopherol synthesis enzyme.
    Type: Grant
    Filed: June 3, 2009
    Date of Patent: March 15, 2011
    Assignee: Monsanto Company
    Inventors: Balasulojini Karunanandaa, Martha Post-Beittenmiller, Mylavarapu Venkatramesh, Ganesh M. Kishore, Gregory M. Thorne, John R. LeDeaux
  • POULTRY MEAT AND EGGS COMPRISING BENEFICIAL FATTY ACIDS
    Publication number: 20100233313
    Abstract: The present disclosure provides for improved poultry products and methods of producing such poultry products by incorporating healthy lipids containing stearidonic acid into animal feed products. Furthermore, the present disclosure provides methods for producing said products. In one embodiment of the disclosure, a poultry animal may be fed feed comprising a transgenic plant product. In other embodiments of the disclosure, poultry white meat and dark meat products comprising SDA, EPA, DPA, and DHA are disclosed. In further embodiments of the disclosure, poultry eggs comprising SDA, EPA, DHA, and DPA are disclosed.
    Type: Application
    Filed: March 16, 2009
    Publication date: September 16, 2010
    Applicant: Monsanto Company
    Inventors: Gary F. Hartnell, Virginia M. Ursin
  • Production of Hydroxylated Fatty Acids in Genetically Modified Plants
    Publication number: 20100168455
    Abstract: This invention relates to plant fatty acyl hydroxylases. Methods to use conserved amino acid or nucleotide sequences to obtain plant fatty acyl hydroxylases are described. Also described is the use of cDNA clones encoding a plant hydroxylase to produce a family of hydroxylated fatty acids in transgenic plants. In addition, the use of genes encoding fatty acid hydroxylases or desaturases to alter the level of lipid fatty acid unsaturation in transgenic plants is described.
    Type: Application
    Filed: July 15, 2009
    Publication date: July 1, 2010
    Applicants: Carnegie Institution of Washington, Monsanto Company, Inc.
    Inventors: Chris SOMERVILLE, Pierre BROUN, Frank VAN DE LOO, Sekhar S. BODDUPALLI
  • Yield and stress tolerance in transgenic plants
    Patent number: 7692067
    Abstract: Polynucleotides and polypeptides incorporated into expression vectors have been introduced into plants and were ectopically expressed. The polypeptides of the invention have been shown to confer at least one regulatory activity and confer increased yield, greater height, greater early season growth, greater canopy coverage, greater stem diameter, greater late season vigor, increased secondary rooting, more rapid germination, greater cold tolerance, greater tolerance to water deprivation, reduced stomatal conductance, altered C/N sensing, increased low nitrogen tolerance, increased low phosphorus tolerance, or increased tolerance to hyperosmotic stress as compared to the control plant as compared to a control plant.
    Type: Grant
    Filed: June 22, 2007
    Date of Patent: April 6, 2010
    Assignees: Mendel Biotechnology, Inc., Monsanto Company
    Inventors: Robert Creelman, Neal I. Gutterson, Oliver Ratcliffe, T. Lynne Reuber, R. Eric Cerny, Kimberly Faye Zobrist Duff, Susanne Kjemtrup-Lovelace, Robert Meister, Marie Petracek, Thomas Ruff, Qingzhang Xu
  • AQUACULTURE FEED, PRODUCTS, AND METHODS COMPRISING BENEFICIAL FATTY ACIDS
    Publication number: 20090202672
    Abstract: Embodiments of the present invention provide improved aquaculture products and methods of producing such aquaculture products by incorporating healthier lipids containing stearidonic acid and gamma linolenic acid into the aquaculture feed. This in turn improves the health profile of the aquatic animals promoting growth and limiting commercial losses. Furthermore, embodiments of the present invention provide methods for producing said products. In one embodiment of the invention, an aquaculture animal may be fed a feed comprising a transgenic plant product. In other embodiments of the invention, cold water fish meat, warm water fish meat, and crustacean meat products comprising SDA, GLA, EPA, and DHA are disclosed. In further embodiments of the invention, other aquaculture feed products comprising SDA, and GLA are disclosed.
    Type: Application
    Filed: January 29, 2009
    Publication date: August 13, 2009
    Applicant: Monsanto Company
    Inventor: Gary F. Hartnell
  • METHODS OF IMPROVING DHA DEPOSITION AND RELATED FUNCTION AND/OR DEVELOPMENT
    Publication number: 20090197955
    Abstract: The present invention provides for improved deposition of DHA in human or animal tissues by incorporating healthy lipids containing stearidonic acid into humans or animal through prolonged food or feed, as well as through supplements, and therapeutics. Improved deposition of DHA through consumptions of edible compositions comprising stearidonic acid can be used to improve numerous indicators of health and development, including indicators of heart health, neurological function and development, and the Omega-3 Index in tissues.
    Type: Application
    Filed: January 29, 2009
    Publication date: August 6, 2009
    Applicant: Monsanto Company
    Inventors: Shawna L. Lemke, Gary F. Hartnell
  • METHODS OF FEEDING PIGS AND PRODUCTS COMPRISING BENEFICIAL FATTY ACIDS
    Publication number: 20090196950
    Abstract: The present invention provides for improved pork products for human consumption and methods of producing such pork products by incorporating healthy lipids containing stearidonic acid into swine feed products. Furthermore, the present invention provides methods for producing said products. In one embodiment of the invention, an animal may be fed feed comprising a transgenic plant product. In other embodiments of the invention, pork meat products for human consumption, such meat products comprising SDA, EPA, and DHA are disclosed. In further embodiments of the invention, pork products comprising novel fatty acid profiles are disclosed.
    Type: Application
    Filed: January 29, 2009
    Publication date: August 6, 2009
    Applicant: Monsanto Company
    Inventors: Gary F. Hartnell, Virginia M. Ursin, Donald M. Lucas
  • Transgenic plants with enhanced agronomic traits
    Publication number: 20090100536
    Abstract: This invention provides transgenic plant cells with recombinant DNA for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. This invention also provides transgenic plants and progeny seed comprising the transgenic plant cells where the plants are selected for having an enhanced trait selected from the group of traits consisting of enhanced water use efficiency, enhanced cold tolerance, increased yield, enhanced nitrogen use efficiency, enhanced seed protein and enhanced seed oil. Also disclosed are methods for manufacturing transgenic seed and plants with enhanced traits.
    Type: Application
    Filed: July 18, 2007
    Publication date: April 16, 2009
    Applicant: Monsanto Company
    Inventors: Thomas Adams, Ameeta K. Agarwa, Jeffrey Ahrens, James A. Ball, Amarjit Basra, Erin Bell, Terry L. Bradshaw, Paul S. Chomet, James H. Crowley, Jill Deikman, Molian Deng, Meghan Donnarummo, Kimberly Faye Zobrist Duff, Stephen Duff, Michael D. Edgerton, Banu Gopalan, Xiaoping He, Mackenzie Heal, Brendan S. Hinchey, Shihshieh Huang, Richard G. Johnson, Vincent Jung, Keith Kretzmer, Lucille B. Laccetti, Chao Qiang Lai, Garrett J. Lee, Michael H. Luethy, Timothy J. Leland, Jingdong Liu, Bin Lu, Adrian A. Lund, Linda L. Madson, Kathleen P. Malloy, Marcus Paul McNabnay, Manchikanti Padmavati, Thomas Ruff, William Start, Daniel Tennessen, Carl P. Urwin, Gabriela Vaduva, K.R. Vidya, Steven Thomas Voss, Christine Voyles, Zhango Xin, Nanfei Xu, Qingzhang Xu, Qiang Zhang, Yajuan Zhao, Li Zhou
  • Production of hydroxylated fatty acids in genetically modified plants
    Publication number: 20090070902
    Abstract: This invention relates to plant fatty acyl hydroxylases. Methods to use conserved amino acid or nucleotide sequences to obtain plant fatty acyl hydroxylases are described. Also described is the use of cDNA clones encoding a plant hydroxylase to produce a family of hydroxylated fatty acids in transgenic plants. In addition, the use of genes encoding fatty acid hydroxylases or desaturases to alter the level of lipid fatty acid unsaturation in transgenic plants is described.
    Type: Application
    Filed: September 27, 2007
    Publication date: March 12, 2009
    Applicants: Carnegie Institution of Washington, Monsanto Company, Inc.
    Inventors: Chris Somerville, Pierre Broun, Frank van de Loo, Sekhar S. Boddupalli
  • Plants with Multiple Transgenes on a Chromosome
    Publication number: 20080256669
    Abstract: A transgenic seed or plant of a corn, cotton, rapeseed or soybean species having a recombinant chromosome with multiple transgenes for imparting traits to said seed or its plant. Useful traits include herbicide tolerance, insect resistance, nematode resistance, viral resistance, tolerance to water deficit, tolerance to nitrogen deficit, enhanced amino acid level in seed, enhanced starch level in seed, enhanced oil level in seed, modified oil composition, and increased yield. Useful recombinant chromosomes are produced with centromere DNA from the plant targeted for transformation or from truncated native chromosomes.
    Type: Application
    Filed: April 16, 2008
    Publication date: October 16, 2008
    Applicant: MONSANTO COMPANY
    Inventors: Bradon Fabbri, Stefan Bledig
  • Methods, systems and computer program products for dynamic scheduling and matrix collecting of data about samples
    Patent number: 7356417
    Abstract: Data is collected about samples that possess characteristics that change over time and that are contained in any array of containers arranged in a container spatial relationship. A matrix of cells is displayed in a cell spatial relationship corresponding to the container spatial relationship. The matrix user interface allows a user to enter a large number of data points per minute, compared to conventional systems, which may require a user to swipe a bar code, enter an indicia, or enter a row/column position prior to entering data. Data collection of characteristics of samples also can be scheduled, by storing past values of the characteristics of the samples and also storing rules in a rule base. The rules determine whether a characteristic of a sample is to be data collected and, if so, identify the characteristic which is to be data collected, based on the past values of characteristics of samples.
    Type: Grant
    Filed: March 27, 2001
    Date of Patent: April 8, 2008
    Assignee: Monsanto Company
    Inventors: Thomas H. Barrett, Jr., Corey D. DeHaven
  • ?- and ?-amino acid hydroxyethlamino sulfonyl urea derivatives useful as retroviral protease inhibitors
    Patent number: 7232817
    Abstract: ?- and ?-amino acid hydroxyethylamino sulfonyl urea derivative compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
    Type: Grant
    Filed: September 27, 2005
    Date of Patent: June 19, 2007
    Assignees: G.D. Searle & Co., Monsanto Company
    Inventors: Michael L. Vazquez, Richard A. Mueller, John J. Talley, Daniel P. Getman, Gary A. DeCrescenzo, Eric T. Sun