Abstract: The present invention relates to cyclic sulfone moiety-containing hydroxyethylamine protease inhibitor compounds and pharmaceutical or method of use therefor, particularly as an inhibitor of HIV protease.
Abstract: The present invention discloses a novel method and an information system for allowing a non-random selection of a genotype of a plant cultivar that yields a selected plant product with desired processing features. The method involves determining structural and functional variables of the selected plant product, genetic variables responsible for said structural and functional variables and processing variables of the selected plant, and correlating the structural and functional variables to the genetic variables and to the processing variables so as to make a non-random selection of the genotype of the plant cultivar that yields the plant product with desired processing features.
Abstract: The present invention relates to cyclic sulfone moiety-containing hydroxyethylamine protease inhibitor compounds and pharmaceutical or method of use therefor, particularly as an inhibitor of HIV protease.
Type:
Grant
Filed:
September 2, 2004
Date of Patent:
September 26, 2006
Assignees:
G.D. Searle & Co., Monsanto Company
Inventors:
Deborah E. Bertenshaw, Daniel P. Getman, Robert M. Heintz, John J. Talley, Kathryn L. Reed, Robert A. Chrusciel, Michael Clare
Abstract: N-heterocyclic moiety containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
Type:
Application
Filed:
January 13, 2006
Publication date:
July 27, 2006
Applicant:
Monsanto Company (now named Pharmacia Corporation, which is a wholly owned subsidiary of Pfizer, Inc
Inventors:
John Talley, Daniel Getman, Gary DeCrescenzo, Kathryn Reed, Ko-Chung Lin, John Freskos, Michael Clare, Donald Rogier, Robert Heintz, Michael Vazquez, Richard Mueller
Abstract: One or more agricultural active ingredients (such as fungicides or insecticides) are entrapped in polymeric matrixes to form particles having a diameter in the range from about 0.2 to about 200 microns. The particles are applied to soil, to seeds, or to plants and release the active ingredient(s) at a rate sufficiently low to avoid phytoxicity but at a rate sufficiently high to provide effective amounts of the active ingredient(s), preferably throughout the growing period of the plant.
Type:
Grant
Filed:
June 4, 1999
Date of Patent:
July 4, 2006
Assignee:
Monsanto Company
Inventors:
M. Francis Botts, Frank C. Kohn, Maria L. Miller
Abstract: The present invention generally relates to the field of plant genetics and protein biochemistry. More specifically, the present invention relates to modified proteins having an increased number of essential amino acids. The invention provides proteins modified to have an increased number of essential amino acids, nucleic acid sequences encoding the enhanced proteins, and methods of designing, producing, and using the same. The invention also includes compositions, transformed host cells, transgenic plants and seeds containing the enhanced proteins, and methods for preparing and using the same.
Type:
Grant
Filed:
September 17, 2002
Date of Patent:
August 30, 2005
Assignee:
Monsanto Company
Inventors:
William D. Rapp, Jiexin Peng, Gautham Nadig, Tyamagondlu Venkatesh
Abstract: This invention relates to plant fatty acyl hydroxylases. Methods to use conserved amino acid or nucleotide sequences to obtain plant fatty acyl hydroxylases are described. Also described is the use of cDNA clones encoding a plant hydroxylase to produce a family of hydroxylated fatty acids in transgenic plants. In addition, the use of genes encoding fatty acid hydroxylases or desaturases to alter the level of lipid fatty acid unsaturation in transgenic plants is described.
Type:
Grant
Filed:
June 21, 2001
Date of Patent:
August 30, 2005
Assignees:
Carnegie Institution of Washington, Monsanto Company, Inc.
Inventors:
Chris Somerville, Pierre Broun, Frank van de Loo, Sekhar S. Boddupalli
Abstract: The invention includes selected novel optically active ?-amino ketones which either are themselves useful or are intermediates for the preparation of known ketomethylene pseudopeptides useful as antibiotics, antibiotic enhancers, or enzyme inhibitors. Further, the present invention provides a method for dehydrogenation/asymmetrical hydrogenation to obtain essentially pure antipodes of ketomethylene pseudopeptides having two chiral centers.
Abstract: This invention is directed to a process for making a salt of a carboxylic acid. The process comprises contacting a catalyst with an alkaline mixture comprising a primary alcohol. In one embodiment, for example, the catalyst comprises a metal support (preferably a metal sponge support) having a copper-containing active phase at the surface thereof. The support is resistant to deformation under the conditions of the dehydrogenation reaction. In another embodiment, the catalyst comprises a metal sponge having a copper-containing active phase at the surface thereof and a supporting structure containing at least 10% non-copper metal. This invention is also directed to copper-containing catalysts which may, for example, be used in the above process. This invention is further directed to processes for making such catalysts.
Type:
Application
Filed:
January 4, 2005
Publication date:
July 21, 2005
Applicant:
Monsanto Company
Inventors:
David Morgenstern, Juan Arhancet, Howard Berk, William Moench, James Peterson
Abstract: A method is provided of enhancing the herbicidal activity of a glyphosate herbicide, comprising adding to the glyphosate herbicide a mixture of a first surfactant and a second surfactant at a weight ratio of total surfactant to glyphosate of about 1:30 to about 2:1, wherein the first surfactant has a chemical structure comprising a cationic or protonatable amino group and a C8-24 linear or branched, saturated or unsaturated hydrocarbyl group, and the second surfactant has the formula R—CO—NR?—(CR?2)n—COOM where R is a C7-23 linear or branched, saturated or unsaturated hydrocarbyl group, n is 1 to 4, M is hydrogen or a cationic counterion, and R? groups are each independently hydrogen, C1-4 alkyl or a group —(CH2)m—COOM where m is 1 to 4 and M is as defined immediately above, with the proviso that no more than one R? group is such a group —(CH2)m—COOM; the weight ratio of the first to the second surfactant being about 1:10 to about 10:1.
Type:
Grant
Filed:
August 31, 2000
Date of Patent:
June 21, 2005
Assignee:
Monsanto Company
Inventors:
David Z. Becher, Al S. Wideman, James C. Forbes
Abstract: The present invention relates to cyclic sulfone moiety-containing hydroxyethylamine protease inhibitor compounds and pharmaceutical or method of use therefor, particularly as an inhibitor of HIV protease.
Abstract: This invention provides a method of preparing a polymeric delivery system for active ingredients. The delivery system is formed either by attaching the active ingredient to a linker through a hydrolyzable covalent bond, then forming a covalent bond between the linker and a portion of the subunits of a cross-linked polymer, or by attaching a linker to a portion of the subunits of a cross-linked polymer, then attaching the active ingredient to the polymer-linker combination through a hydrolyzable covalent bond. The invention also provides a delivery system comprising an active ingredient covalently bonded through a hydrolyzale covalent bond to a linker, which is in turn covalently bonded to a portion of subunits of a cross-linked polymer.
Abstract: The invention includes selected novel optically active ?-amino ketones which either are themselves useful or are intermediates for the preparation of known ketomethylene pseudopeptides useful as antibiotics, antibiotic enhancers, or enzyme inhibitors. Further, the present invention provides a method for dehydrogenation/asymmetrical hydrogenation to obtain essentially pure antipodes of ketomethylene pseudopeptides having two chiral centers.
Abstract: N-heterocyclic moiety containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
Type:
Application
Filed:
March 5, 2004
Publication date:
January 6, 2005
Applicant:
Monsanto Company (now named Pharmacia Corporation, which is a wholly owned subsidiary of Pfizer, Inc
Inventors:
John Talley, Daniel Getman, Gary DeCrescenzo, Kathryn Reed, Ko-Chung Lin, John Freskos, Michael Clare, Donald Rogier, Robert Heintz, Michael Vazquez, Richard Mueller
Abstract: This invention provides promoters capable of transcribing heterologous nucleic acid sequences in seeds, and methods of modifying, producing, and using the same.
Abstract: This invention relates to plant fatty acid hydroxylases. Methods to use conserved amino acid or nucleotide sequences to obtain plant fatty acid hydroxylases are described. As described is the use of cDNA clones encoding a plant hydroxylase to produce a family of hydroxylated fatty acids in transgenic plants. In addition, the use of genes encoding fatty acid hydroxylases or desaturases to alter the level of lipid fatty acid unsaturation in transgenic plants is described.
Type:
Application
Filed:
April 8, 2004
Publication date:
November 25, 2004
Applicants:
The Carnegie Institution of Washington, Monsanto Company, Inc.
Inventors:
Pierre Broun, Frank van de Loo, Sekhar S. Boddupalli, Chris Somerville
Abstract: Disclosed are constructs comprising sequences encoding 3-hydroxy-3methylglutaryl-Coenzyme A reductase and at least one other sterol synthesis pathway enzyme. Also disclosed are methods for using such constructs to alter sterol production and content in cells, plants, seeds and storage organs of plants. Also provided are oils and compositions containing altered sterol levels produced by use of the disclosed constructs. Novel nucleotide sequences useful in the alteration of sterol production are also provided. Also provided are cells, plants, seeds and storage organs of plants comprising sequences encoding 3-hydroxy-3methylglutaryl-Coenzyme A reductase, at least one other sterol synthesis pathway enzyme and at least one tocopherol synthesis enzyme.
Type:
Grant
Filed:
June 20, 2001
Date of Patent:
November 23, 2004
Assignee:
Monsanto Company
Inventors:
Balasulojini Karunanandaa, Martha Post-Beittenmiller, Mylavarapu Venkatramesh, Ganesh M. Kishore, Gregory M. Thorne, John R. LeDeaux
Abstract: An improved process for the manufacture of formylphosphonic acid derivatives is reported. An aminomethylphosphonic acid substrate is contacted with a reagent selected from the group consisting of water, an alcohol, a phenol compound, and mixtures thereof and an oxidizing gas in the presence of a catalyst to form a reaction product mixture containing a formylphosphonic acid derivative and the conditions under which said contacting is carried out are controlled so that no more than 50% of the formylphosphonic acid derivative formed in the reaction product mixture is consumed by reaction with the reagent.
Abstract: An improved process for the manufacture of formylphosphonic acid derivatives is reported. An aminomethylphosphonic acid substrate is contacted with a reagent selected from the group consisting of water, an alcohol, a phenol compound, and mixtures thereof and an oxidizing gas in the presence of a catalyst to form a reaction product mixture containing a formylphosphonic acid derivative and the conditions under which said contacting is carried out are controlled so that no more than 50% of the formylphosphonic acid derivative formed in the reaction product mixture is consumed by reaction with the reagent.
Abstract: N-heterocyclic moiety containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
Type:
Grant
Filed:
September 18, 2002
Date of Patent:
July 13, 2004
Assignee:
Monsanto Company
Inventors:
John J. Talley, Daniel P. Getman, Gary A. DeCrescenzo, Kathryn L. Reed, Ko-Chung Lin, John Nicholas Freskos, Michael Clare, Donald Joseph Rogier, Jr., Robert M. Heintz, Michael L. Vazquez, Richard A. Mueller