Abstract: Methods and devices for delivering therapeutic or diagnostic energy (e.g., light, ultrasound, ionizing radiation (e.g., x-ray), vibration, heat energy, etc.) into the eye. An energy emitting device is positioned on the eye and used to deliver energy into the eye. The device may be constructed to allow the subject's eyelids to open and close while the device is positioned on the eye. The device is useable for various energy based or energy-mediated therapies, including crosslinking of corneal collagen, light therapy, photodynamic therapy, photo-activation of drugs, etc.

Abstract: Patients having exercise limiting conditions and those at risk of developing such conditions are exposed to a regimen of hypoxic conditions that simulate various altitude conditions. The exposure is of a temporary nature, being from a few hours to most of a day or night in any one day and repeated on a personally worked out regimen of from a series of consecutive days to a regular number of “on” and “off” days, to a random number of days. An alternate regimen is such exposure for a few minutes at a time followed by normoxic rest period of a few minutes, with the cycle repeated multiple times over the course of a treatment session. The conditioning treatment strengthens the cardiac tissue and skeletal muscle and the results extend beyond the treatment periods whereby the patient's condition is substantially improved.

Abstract: The invention relates to methods of obtaining an expanded population of mammalian ex vivo cells and/or for treating a mammalian subject by (a) administering to a subject an effective amount of an agent that confers a growth disadvantage to at least a subset of endogenous cells at the site of engraftment; (b) administering to the subject an effective amount of a mitogenic stimulus for the ex vivo cells; and (c) administering the ex vivo cells to the subject, wherein the ex vivo cells engraft at the site and proliferate to a greater extent than the subset of endogenous cells, to repopulate at least a portion of the engraftment site with the ex vivo cells. The repopulated cells can be harvested for further use or be left at the engraftment site of a subject to be treated. The invention also provides methods of treating brain injury in a subject by engrafting ex vivo cells at the site of injury.

Abstract: Attachments for a manual wheelchair are provided for navigating a wheelchair over obstacles and uneven terrain, such as a typical curb on a street. The attachments provide for regulating the movement of the wheelchair as the wheelchair descends the curb and to prevent the wheelchair from flipping over during such movement. The attachments include a belt support frame, at least two rollers mounted on the belt support frame and a belt mounted around the at least two rollers. The belt support frame is adapted for mounting on the frame of the wheelchair such that as the wheelchair descends from the upper surface to the lower surface, the belt engages an edge of the upper surface and rolls around the at least two rollers slowing a descent of the wheelchair from the upper surface to the lower surface.

Abstract: Attachments for a manual wheelchair are provided for navigating a wheelchair over obstacles and uneven terrain, such as a typical curb on a street. The attachments provide for regulating the movement of the wheelchair as the wheelchair descends the curb and to prevent the wheelchair from flipping over during such movement. The attachments include a front caster wheel slider assembly on each side of the wheelchair, a follower wheel assembly and a track belt damping bar. The front caster wheel slider assembly includes a piston that will quickly push the front caster wheels down after they roll over the top edge of the curb. The follower wheel assembly acts as a sensor that will release the piston in the assembly after the front caster wheels roll over the top edge of the curb. As the back wheels of the wheelchair roll over and down the curb, the track belt damping bar slows the descent of the wheelchair.

Abstract: A method of determining if a cancer patient is amenable to treatment with EGFR inhibitors including but not limited to cetuximab, panitumumab or erlotinib by the following steps: (a) Obtaining cells from a cancer patient's tumor; (b) Determining if said cells contain a biomarker that is predictive of a therapeutic response to response to treatment with cetuximab or panitumumab. The biomarker is the mutation status of the PIK3CA gene and the expression status of the PTEN gene. Tumors that harbor activating mutations in Exon 9 and 20 of the PIK3CA gene or which show loss of PTEN protein expression will be considered not likely to benefit from EGFR targeting therapies.

Abstract: Systems and methods are provided for facilitating management of health care in medical facilities such as hospitals, clinics, emergency rooms, etc., for example by monitoring and assessing the quality of patient care. Data is collected and operated on relating to medical conditions, treatment, cost, care, events, outcomes and results of treatments, and data representing the collective experience of similar patients is mined to discover opportunities to improve the quality of health care. Statistical and comparative data and reports including such and other information indicate a quality of care and provide epidemiologically cogent information. Quality of care may be considered as achieving desired or expected norms of performance, including success, in a timely fashion, and can be judged not just by what functionally happens during a patient instigated encounter, but also by long term outcomes evidenced by the patient's passage through the health care delivery system.

Abstract: A scaled head frame positioner and tabletop adapter are provided. The positioner may be employed for any neurosurgical procedure that requires fixed positioning of the stereotactic head frame or ring onto a patient's skull. The positioner employs a generally triangular shaped member with Velcro tapes fixed at each corner. The tapes have measurement markings, such as measurement tapes. The positioner supports the head frame with the tapes engaging means on the frame and fastened back to themselves, with markings indicating distances to adjust the position of the frame about the patient's head. Furthermore, the tabletop adapter clamps the patient with a stereotactic head frame onto a CT or treatment table. The tabletop adapter includes a generally U-shaped bracket secured to a support to be placed on the tabletop. The bracket is attachable to the head frame of the patient to hold his head in a desired position.

Abstract: Attachments for a manual wheelchair are provided for navigating a wheelchair over obstacles and uneven terrain, such as a typical curb on a street. The attachments provide for regulating the movement of the wheelchair as the wheelchair descends the curb and to prevent the wheelchair from flipping over during such movement. The attachments include a front caster wheel slider assembly on each side of the wheelchair, a follower wheel assembly and a track belt damping bar. The front caster wheel slider assembly includes a piston that will quickly push the front caster wheels down after they roll over the top edge of the curb. The follower wheel assembly acts as a sensor that will release the piston in the assembly after the front caster wheels roll over the top edge of the curb. As the back wheels of the wheelchair roll over and down the curb, the track belt damping bar slows the descent of the wheelchair.

Abstract: Systems and methods are provided for facilitating management of health care in medical facilities such as hospitals, clinics, emergency rooms, etc., for example by monitoring and assessing the quality of patient care. Data is collected and operated on relating to medical conditions, treatment, cost, care, events, outcomes and results of treatments, and data representing the collective experience of similar patients is mined to discover opportunities to improve the quality of health care. Statistical and comparative data and reports including such and other information indicate a quality of care and provide epidemiologically cogent information. Quality of care may be considered as achieving desired or expected norms of performance, including success, in a timely fashion, and can be judged not just by what functionally happens during a patient instigated encounter, but also by long term outcomes evidenced by the patient's passage through the health care delivery system.

Abstract: A method of determining if a cancer patient is amenable to treatment with EGFR inhibitors including but not limited to cetuximab, panitumumab or erlotinib by the following steps: (a) Obtaining cells from a cancer patient's tumor; (b) Determining if said cells contain a biomarker that is predictive of a therapeutic response to response to treatment with cetuximab or panitumumab. The biomarker is the mutation status of the PIK3CA gene and the expression status of the PTEN gene. Tumors that harbor activating mutations in Exon 9 and 20 of the PIK3CA gene or which show loss of PTEN protein expression will be considered not likely to benefit from EGFR targeting therapies.

Abstract: An ambulatory suspension system for gait rehabilitation has a parallel pair of rails bordering the sides of a training area and a bridge extending between and movable along the rails. A trolley is movable along the bridge and includes a motor driven hoist with a cable extending thereabout and depending from the trolley. The hoist is operable to vary the length of the cable depending from the trolley, and a harness is suspended by the cable. Motors move the bridge along the rails and the trolley along the bridge as the sensors sense the direction of movement of the patient in X and Y directions. The falling motion of a patient supported in the harness is sensed and will immediately disable the system. A computer control receives signals from the sensors and operates the motors so that the patient is held in an upright position.

Abstract: The invention relates to methods of obtaining an expanded population of mammalian ex vivo cells and/or for treating a mammalian subject by (a) administering to a subject an effective amount of an agent that confers a growth disadvantage to at least a subset of endogenous cells at the site of engraftment; (b) administering to the subject an effective amount of a mitogenic stimulus for the ex vivo cells; and (c) administering the ex vivo cells to the subject, wherein the ex vivo cells engraft at the site and proliferate to a greater extent than the subset of endogenous cells, to repopulate at least a portion of the engraftment site with the ex vivo cells. The repopulated cells can be harvested for further use or be left at the engraftment site of a subject to be treated. The invention also provides methods of treating brain injury in a subject by engrafting ex vivo cells at the site of injury.

Abstract: The present invention relates to a method for decreasing elevated serum/plasma LDL-cholesterol levels or LDL-cholesterol levels and CRP levels in a mammal in need thereof. The methods comprises administering an effective amount of a tetracycline formulation. In one embodiment, the tetracycline formulation is a non-antibacterial tetracycline. In another embodiment, the tetracycline formulation is an antibacterial tetracycline at a sub-antibacterial amount.

Abstract: The claims define a method which is based on the use of baclofen to suppress the cough of a patient who is afflicted with a cough that is induced by the administration of an ACE inhibitor. The usual dose of baclofen is from 10 to 30 mg daily. A pharmaceutical composition which comprises an effective amount of an ACE inhibitor is also disclosed which is a combination of an ACE inhibitor and an amount of baclofen which is effective to suppress the cough which is caused by the administration of the therapeutic dose of an ACE inhibitor.

Abstract: The present invention provides a chemically modified form of hemoglobin that is stabilized and can efficiently bind and release oxygen. In addition the chemically modified hemoglobin may be polymerized to increase its molecular weight and increase its stability so that it will have a longer half life in the circulatory system and may be used as a stable oxygen transport mediator which is useful as the basis of a blood substitute.

Abstract: A method for inducing neuromuscular blockade is described which is based on the administration to a surgical patient of an amount of a drug comprising tetrabutylammonium or a mixture of tetrabutylammonium and tetrapropylammonium which is effective to induce a neuromuscular block. In addition, there is disclosed the method of combining a non depolarizing muscle relaxant with the tetrabutylammonium or tetraproplyammonium compound to provide a neuromuscular block which requires a reduced dosage of both drugs.

Abstract: The present invention provides a chemically modified form of hemoglobin that is stabilized and can efficiently bind and release oxygen. In addition the chemically modified hemoglobin may be polymerized to increase its molecular weight and increase its stability so that it will have a longer half life in the circulatory system and may be used as a stable oxygen transport mediator which is useful as the basis of a blood substitute.

Abstract: A novel technique is disclosed for the prevention of false positive reactions in immunological testing which are caused by interference of C.sub.1 and C.sub.1q. The method is based on heating a sample of a body fluid at a temperature of 59.degree.-64.degree. C. in the presence of a particular neutral salt. A method for screening for rheumatoid factor is also disclosed.

Abstract: The present invention provides a method for the treatment of carcinoma. Those carcinomas include those of visceral origin and in particular gastrointestinal malignancies. The method comprises administering an amount of 5-fluorouracil and an amount of interferon which is effective in the palliation of said carcinoma or malignancy. Alpha, beta or gamma interferon may be used but recombinant alpha-2a-interferon is preferred.