Abstract: The applicants have discovered that by simultaneously administering particular combinations of drugs at particular dosage levels by means of a transdermal delivery system, anesthesia may be induced in patients requiring such treatment. It has been found that profound sedation or an analgesic effect may be produced by means of a particular combination of pharmacologic agents which are administered simultaneously by transdermal administration. A patch system has been devised which is useful for reversing anesthesia.

Abstract: The present application is directed to a method for distinguishing between normally differentiated and benign or malignantly transformed cells in human colonic tissue. It is also directed to a method for monitoring the state of premalignant or malignant human colonic tissue. In both methods, a 50F1 complementary DNA standard probe is utilized which hybridizes to the RNA in the test sample and to a second sample, which is a predetermined sample of colonic tissue, and the amount of hybridization of the 50F1 complementary DNA to the test sample is compared to the hybridization of the 50F1 complementary DNA with the second sample.

Abstract: A composition comprising 5-ethoxy-2'-deoxyuridine is disclosed which is useful as an antiviral agent.

Abstract: A new process is disclosed for the preparation of esters of polyhydroxy compounds having three or more hydroxy compounds. The process is based on the reaction with an alkyl chloroformate to form a mixed anhydride which is contacted with a polyol.

Abstract: The applicants have discovered a method of treating malignancies which comprises administering effective amounts of 5-fluorouracil, interferon-.alpha. and a compound formula (I): ##STR1## wherein R is selected is selected from the group consisting of alkyl of 1 to 5 carbon atoms, alkene of 2 to 5 carbon atoms and alkynyl of 2 to 5 carbon atoms; R.sub.1 is 2'-deoxyribofuranosyl.

Abstract: The present invention is concerned with a method for treating hemoglobin or blood in vivo or in vitro to modify the affinity of hemoglobin for oxygen, said method comprising causing an effective amount of a substituted arylureidophenoxymethyl propionic acid to come in contact with hemoglobin.

Abstract: The present invention provides a method for the treatment of a malignancy sensitive to a treatment regimen which comprises administering by injection to a host afflicted with said malignancy 5-fluorouracil at a dose of 600-100 mg/m.sup.2 /day followed by the administration of from 2-40 million international units of alpha-2a-interferon.

Abstract: A novel method for the treatment of hyperlipidemia/high serum cholesterol is disclosed which is based on the parenteral administration of granulocyte colony stimulating factor.

Abstract: The invention provides a method and composition for preserving platelets which is based on the use of a composition which includes apyrase and an antioxidant. Preferred compositions will also include a protease inhibitor and optionally a solvent.

Abstract: The disclosure is directed to an apparatus and method for producing a three-dimensional image representation of a body. The body can be animate or inanimate; i.e. the invention can be used to obtain 3D image representations of for example, parts of the human body or any object that one wishes to view or measure. The 3D image representations can be used to produce 2D displays of sections, contours, etc., or displays having 3D perspective, such as wire-frame type illustrations. This facilitates automatic computation of areas or volumes. In a disclosed embodiment, an ultrasonic imaging subsystem is provided for producing signals representative of two-dimensional images of sections of the body, the subsystem including a scanning transducer that is moveable to determine the section of the body to be imaged. The image representative signals are stored as arrays of digital pixel values.

Abstract: The present invention is concerned with a process for the synthesis of substituted arylureidophenoxymethyl propionic acids and an analogous benzamides series of compounds which have activity in the dissociation of oxygen from hemoglobin. In addition the process may be utilized to prepare compounds which are known.

Abstract: Novel compounds are disclosed which have the formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 may be the same or different and independently selected from the group consisting of hydrogen, halogen, straight and branched chain alkyl of from 1-6 carbon atoms, aryl, cycloalkyl of 4 to 7 carbon atoms; and alkoxy of 1 to 6 carbon atoms; R.sub.5 and R.sub.6 may be the same or different and are selected from the group consisting of hydrogen, halogen, straight and branched chain alkyl groups of from 1-6 carbon atoms, aralkyl groups wherein the alkyl portion has from 1-6 carbon atoms cycloalkyl of from 4-7 carbon atoms and aryl; R.sub.7 is hydrogen or a straight or branched chain alkyl group of 1-6 carbon atoms and the pharmaceutically acceptable salts thereof.These compounds are useful for the treatment of hyperlipidemia and for the in vivo and in vitro treatment of hemoglobin or blood to modify the affinity of hemoglobin for oxygen.

Abstract: The present invention is concerned with a process for the synthesis of substituted arylureidophenexymethyl propionic acids and an analogous benzamides series of compounds which have activity in the dissociation of oxygen from hemoglobin. In addition the process may be utilized to prepare compounds which are known.

Abstract: A method is disclosed for the analysis of gene expression in human biopsy that is useful in the diagnosis and prognosis of disease and evaluation of risk for disease. The method comprises the steps of compiling data regarding the level of expression of certain individual cloned gene sequences from patients having defined pathological conditions and from normal patients and thereafter identifying sequences that characterize the pathological condition.The data regarding the expression of the individual cloned genes are stored in a defined pattern or array. Replicas of this array are hybridized to radioactive probes made using the RNA isolated from biopsy tissue. The extent of hybridization of the probe to each of the cloned sequences is proportional to the level of expression of the cloned sequence in the tissue from which the probe was made. This may be done by exposing the hybridized clones to x-ray film and scanning the x-ray films to quantify the cloned sequences.

Abstract: The present invention is concerned with a process for the synthesis of substituted arylureidophenexymethyl propionic acids and an analogous benzamides series of compounds which have activity in the dissociation of oxygen from hemoglobin. In addition, the process may be utilized to prepare compounds which are known.

Abstract: The invention relates to the preparation of an ester or an amide from an anhydride with an alcohol or an amine, wherein the anhydride is first prepared by reacting an acid and an alkyl chloroformate in a 100% aqueous medium, that is, 100% water.

Abstract: A method for detecting the presence of Mycobacteria in a fluid or tissue which comprises mixing the fluid or tissue containing a secretory product of Mycobacteria with a complex of a tracer-containing molecule and a binding macromolecule having reversible binding affinity for the tracer-containing molecule detecting the tracer-containing molecule, wherein the tracer-containing molecule is a charcoal-adsorbable protein from Mycobacterium tuberculosis which has a molecular weight of 20,000-30,000 and which is immunochemically stable from 4.degree. C. to 250.degree. C. and has a pH range from 3.0 to 9.0. The method is particularly applicable to the detection of infectious tuberculosis in humans and determining the antibiotic sensitivity of infecting Mycobacteria.

Abstract: A composition comprising a nucleosidic anti-tumor agent esterified with a carboxylic acid-containing steroid is described. These steroid ester derivatives of, for example, a deoxyuridine compound provide enhanced anti-tumor effects in chemotherapy as compared to the corresponding nucleosides alone.

Abstract: A method for detecting the presence of Mycobacteria in a fluid or tissue which comprises mixing the fluid or tissue containing a secretory product of Mycobacteria with a complex of a tracer-containing molecule and a binding macromolecule having reversible binding affinity for the tracer-containing molecule and detecting the tracer-containing molecule, wherein the tracer-containing molecule is a charcoal-adsorbable protein from Mycobacterium tuberculosis which has a molecular weight of 20,000-30,000 and which is immunochemically stable from 4.degree.0 C. to 250.degree. C. and has a pH range from 3.0 to 9.0. The method is particularly applicable to the detection of infectious tuberculosis in humans and determining the antibiotic sensitivity of infecting Mycobacteria.