Abstract: The present application relates to methods of producing exosomes. The application also provides a method for preparing a protein composition comprising culturing an exosome-producing cell expressing a Nef-fusion protein comprising a Nef-derived peptide fused to a protein of interest; isolating exosomes from the exosome-producing cell culture; and purifying the protein of interest from the isolated exosomes. The application further discloses compositions that comprise exosomes containing the Nef-fusion protein, as well as methods of using the Nef-fusion protein and exosomes containing the Nef-fusion protein.
Type:
Grant
Filed:
July 1, 2019
Date of Patent:
August 24, 2021
Assignee:
MOREHOUSE SCHOOL OF MEDICINE
Inventors:
Vincent C. Bond, Michael Powell, Ming Bo Huang, Syed Ali
Abstract: A method for formulating a cleaning composition contains the step of coating a granular absorbent material with a coating agent to produce a coated absorbent material and mixing the coated absorbent material with a sanitation agent, wherein the coated absorbent material absorbs the sanitation agent to form the cleaning composition. The resulting cleaning composition may be used for cleaning up pathogens or hazardous materials. The cleaning composition may also functions as a liquefiable dry cleaning powder for public areas in response to bodily fluid incidents. A coating method of a non-toxic bio static film on a high surface area solid is disclosed.
Type:
Grant
Filed:
June 21, 2019
Date of Patent:
July 13, 2021
Assignees:
MOREHOUSE SCHOOL OF MEDICINE, DEVMAR PRODUCTS, LLC, INNOVATIVE ENVIRONMENTAL COMPANIES
Inventors:
Walter Hawkins, Sharon W. Reynolds, James W. Lillard, Jr.
Abstract: A nutritional supplement composition for treating nutritional deficiencies caused by a medical condition in subjects is disclosed. The present application further discloses a method of using a nutritional supplements composition for treating a subject with complications resulting from sickle cell anemia. The method comprises administering to a subject an effective amount of the nutritional supplement.
Type:
Grant
Filed:
November 10, 2015
Date of Patent:
July 13, 2021
Assignee:
MOREHOUSE SCHOOL OF MEDICINE
Inventors:
Jacqueline Hibbert, Jonathan K. Stiles, Kayellen Umeakunne, Hyacinth I. Hyacinth
Abstract: A method for formulating a cleaning composition contains the step of coating a granular absorbent material with a coating agent to produce a coated absorbent material and mixing the coated absorbent material with a sanitation agent, wherein the coated absorbent material absorbs the sanitation agent to form the cleaning composition. The resulting cleaning composition may be used for cleaning up pathogens or hazardous materials. The cleaning composition may also function as a liquefiable dry cleaning powder for public areas in response to bodily fluid incidents. A coating method of a non-toxic bio static film on a high surface area solid is disclosed.
Type:
Grant
Filed:
June 11, 2018
Date of Patent:
May 4, 2021
Assignees:
MOREHOUSE SCHOOL OF MEDICINE, DEVMAR PRODUCTS, LLC, INNOVATIVE ENVIRONMENTAL COMPANIES
Inventors:
Walter Hawkins, Sharon W. Reynolds, James W. Lillard, Jr.
Abstract: This application discloses a composition comprising an amiloride and/or an amiloride analog which can be used for reducing nerve injury or nervous system injury in a subject. The formulation of such composition is also disclosed. The application further directs to methods for treating nerve injury or nervous system injury by administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising amiloride, an amiloride analog or a pharmaceutically acceptable salt thereof.
Abstract: The present application relates to methods of treating HIV-associated nephropathy (HIVAN) and/or focal segmental glomerulosclerosis (FSGS) using endothelin-1 (ET-1) antagonists. The application further relates to a composition for the treatment of HIVAN and/or FSGS. A kit for detecting the presence of ET-1 or ET-1-associated biomarker in a biological sample is also disclosed.
Type:
Grant
Filed:
May 30, 2013
Date of Patent:
December 15, 2020
Assignee:
MOREHOUSE SCHOOL OF MEDICINE
Inventors:
Gale W. Newman, Barbara A. Jacob-Mungin, Chamberlain Obialo
Abstract: A method for treating a cancer comprises administering to a subject in need of such treatment an effective amount of a pharmaceutical composition comprising an anti-cancer agent having at least one secretion modifying region (SMR) peptide from HIV-1 Nef fused to at least one cell-penetrating peptide (CPP) or at least one Clusterin (Clu)-binding peptide (Clu-BP).
Type:
Grant
Filed:
December 19, 2018
Date of Patent:
October 13, 2020
Assignee:
MOREHOUSE SCHOOL OF MEDICINE
Inventors:
Vincent C. Bond, James W. Lillard, Jr., Ming Bo Huang
Abstract: A method for formulating a cleaning composition contains the step of coating a granular absorbent material with a coating agent to produce a coated absorbent material and mixing the coated absorbent material with a sanitation agent, wherein the coated absorbent material absorbs the sanitation agent to form the cleaning composition. The resulting cleaning composition may be used for cleaning up pathogens or hazardous materials. The cleaning composition may also function as a liquefiable dry cleaning powder for public areas in response to bodily fluid incidents. A coating method of a non-toxic bio static film on a high surface area solid is disclosed.
Type:
Grant
Filed:
June 12, 2018
Date of Patent:
July 7, 2020
Assignees:
Morehouse School of Medicine, DevMar Products, LLC, Innovative Envirornmental Companies
Inventors:
Walter Hawkins, Sharon W. Reynolds, James W. Lillard, Jr.
Abstract: A composition and method for preventing or reducing the incidence of a transient ischemic attack in a subject at risk for developing a stroke comprises orally administering to the subject a prophylactically effective amount of a pharmaceutical composition comprising an ASIC1a inhibitor capable of penetrating the blood-brain barrier. Preferred ASIC1a inhibitors for use in the disclosed methods include amiloride and amiloride analogs.
Abstract: A method for formulating a composition contains the step of coating a granular absorbent material with a coating agent to produce a coated absorbent material and mixing the coated absorbent material with a sanitation agent, wherein the coated absorbent material absorbs the sanitation agent to form the liquid loading composition. Liquid-loading compositions that can absorb liquids in many applications, including clean-up and farming, are also disclosed.
Type:
Grant
Filed:
May 21, 2018
Date of Patent:
March 31, 2020
Assignees:
MOREHOUSE SCHOOL OF MEDICINE, DEVMAR PRODUCTS, LLC, INNOVATIVE ENVIRONMENTAL COMPANIES
Inventors:
Walter Hawkins, Sharon W. Reynolds, James W. Lillard, Jr.
Abstract: A multipartite peptide that inhibits release of exosomes in a cell, comprising an N-terminal end and a C-terminal end and comprising at least one secretion modifying region (SMR) peptide from HIV-1 Nef and at least one Clusterin (Clu)-binding peptide (Clu-BP). Pharmaceutical compositions comprising these peptides alone or in synergistic combinations with other active agents in methods for treating cancers and/or infectious diseases are further provided herein.
Type:
Grant
Filed:
July 9, 2018
Date of Patent:
January 28, 2020
Assignee:
MOREHOUSE SCHOOL OF MEDICINE
Inventors:
Vincent Craig Bond, James W. Lillard, Jr., Ming Bo Huang
Abstract: A method for detecting HIV infection in a mammal is disclosed. The method contains the steps of isolating exosomes from a urine sample of a mammal and detecting the presence of HIV-specific biomarker in said isolated exosomes. A method for diagnosing a mammal with an HIV-associated disease, in particular, HIV-associated nephropathy is also disclosed.
Type:
Grant
Filed:
October 2, 2009
Date of Patent:
January 28, 2020
Assignee:
MOREHOUSE SCHOOL OF MEDICINE
Inventors:
Gale W. Newman, Mike Powell, Akins Doherty, Chamberlain Obialo, Claudette Mitchell-Ali, Khalid Bashir, Mafuz Khan
Abstract: A method for diagnosing hepatitis virus infection or a hepatitis disease condition in a subject based on hepatitis virus-associated biomarkers present on exosomes in a bodily fluid sample from the subject is disclosed. Also disclosed are a method for monitoring the course of a hepatitis virus infection or a hepatitis disease condition in a subject and a method for-monitoring effectiveness of treatment to a subject with an anti-hepatitis virus agent based on hepatitis virus-associated biomarkers present on exosomes in bodily fluid samples from the subject, as well as a kit for diagnosing hepatitis virus infection and/or a hepatitis disease condition in a subject based on hepatitis virus-associated biomarkers on exosomes in bodily fluid samples from the subject.
Abstract: A method for formulating a cleaning composition contains the step of coating a granular absorbent material with a coating agent to produce a coated absorbent material and mixing the coated absorbent material with a sanitation agent, wherein the coated absorbent material absorbs the sanitation agent to form the cleaning composition. The resulting cleaning composition may be used for cleaning up pathogens or hazardous materials. The cleaning composition may also functions as a liquefiable dry cleaning powder for public areas in response to bodily fluid incidents. A coating method of a non-toxic bio static film on a high surface area solid is disclosed.
Type:
Grant
Filed:
September 19, 2018
Date of Patent:
October 29, 2019
Assignees:
Morehouse School of Medicine, DevMar Products, LLC, Innovative Environmental Companies
Inventors:
Walter Hawkins, Sharon W. Reynolds, James W. Lillard, Jr.
Abstract: A method for diagnosing hepatitis virus infection or a hepatitis disease condition in a subject based on hepatitis virus-associated biomarkers present on exosomes in a bodily fluid sample from the subject is disclosed. Also disclosed are a method for monitoring the course of a hepatitis virus infection or a hepatitis disease condition in a subject and a method for monitoring effectiveness of treatment to a subject with an anti-hepatitis virus agent based on hepatitis virus-associated biomarkers present on exosomes in bodily fluid samples from the subject, as well as a kit for diagnosing hepatitis virus infection and/or a hepatitis disease condition in a subject based on hepatitis virus-associated biomarkers on exosomes in bodily fluid samples from the subject.
Abstract: The present application relates to methods of producing exosomes. The application also provides a method for preparing a protein composition comprising culturing an exosome-producing cell expressing a Nef-fusion protein comprising a Nef-derived peptide fused to a protein of interest; isolating exosomes from the exosome-producing cell culture; and purifying the protein of interest from the isolated exosomes. The application further discloses compositions that comprise exosomes containing the Nef-fusion protein, as well as methods of using the Nef-fusion protein and exosomes containing the Nef-fusion protein.
Type:
Grant
Filed:
July 12, 2018
Date of Patent:
September 17, 2019
Assignee:
MOREHOUSE SCHOOL OF MEDICINE
Inventors:
Vincent Craig Bond, Michael Powell, Ming Bo Huang, Syed Ali
Abstract: This application discloses a composition comprising an amiloride and/or an amiloride analog which can be used for reducing nerve injury or nervous system injury in a subject. The formulation of such composition is also disclosed. The application further directs to methods for treating nerve injury or nervous system injury by administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising amiloride, an amiloride analog or a pharmaceutically acceptable salt thereof.
Abstract: A method for formulating a cleaning composition contains the step of coating a granular absorbent material with a coating agent to produce a coated absorbent material and mixing the coated absorbent material with a sanitation agent, wherein the coated absorbent material absorbs the sanitation agent to form the cleaning composition. The resulting cleaning composition may be used for cleaning up pathogens or hazardous materials. The cleaning composition may also function as a liquefiable dry cleaning powder for public areas in response to bodily fluid incidents. A coating method of a non-toxic bio static film on a high surface area solid is disclosed.
Type:
Grant
Filed:
September 6, 2017
Date of Patent:
August 6, 2019
Assignees:
MOREHOUSE SCHOOL OF MEDICINE, DEVMAR PRODUCTS, LLC, INNOVATIVE ENVIRONMENTAL COMPANIES
Inventors:
Walter Hawkins, Sharon W. Reynolds, James W. Lillard, Jr., Qing He, Harry Michael Jones