Patents Assigned to Morehouse School of Medicine
  • COMPOSITIONS AND METHODS FOR EXOSOME TARGETED EXPRESSION
    Publication number: 20140004181
    Abstract: The present application relates to methods of producing exosomes. The application also provides a method for preparing a protein composition comprising culturing an exosome-producing cell expressing a Nef-fusion protein comprising a Nef-derived peptide fused to a protein of interest; isolating exosomes from the exosome-producing cell culture; and purifying the protein of interest from the isolated exosomes. The application further discloses compositions that comprise exosomes containing the Nef-fusion protein, as well as methods of using the Nef-fusion protein and exosomes containing the Nef-fusion protein.
    Type: Application
    Filed: September 6, 2013
    Publication date: January 2, 2014
    Applicant: Morehouse School of Medicine
    Inventors: Vincent Craig BOND, Michael Powell, Ming Bo Huang, Syed Ali
  • CHEMOKINE-IMMUNOGLOBULIN FUSION POLYPEPTIDES, COMPOSITIONS, METHOD OF MAKING AND USE THEREOF
    Publication number: 20130330337
    Abstract: This application is directed to chemokine-immunoglobulin fusion polypeptides and chemokine-polymer conjugates. The fusion polypeptides and conjugates can be used for treating chemokine receptor-mediated disorders and modulating inflammation, inflammatory cell motility, cancer cell motility, or cancer cell survival.
    Type: Application
    Filed: August 8, 2013
    Publication date: December 12, 2013
    Applicant: Morehouse School Of Medicine
    Inventor: James W. Lillard, JR.
  • CHEMOKINE-IMMUNOGLOBULIN FUSION POLYPEPTIDES, COMPOSITIONS, METHOD OF MAKING AND USE THEREOF
    Publication number: 20130323245
    Abstract: This application is directed to chemokine-immunoglobulin fusion polypeptides and chemokine-polymer conjugates. The fusion polypeptides and conjugates can be used for treating chemokine receptor-mediated disorders and modulating inflammation, inflammatory cell motility, cancer cell motility, or cancer cell survival.
    Type: Application
    Filed: August 8, 2013
    Publication date: December 5, 2013
    Applicant: MOREHOUSE SCHOOL OF MEDICINE
    Inventor: James W. Lillard, JR.
  • CHEMOKINE-IMMUNOGLOBULIN FUSION POLYPEPTIDES, COMPOSITIONS, METHOD OF MAKING AND USE THEREOF
    Publication number: 20130315909
    Abstract: This application is directed to chemokine-immunoglobulin fusion polypeptides and chemokine-polymer conjugates. The fusion polypeptides and conjugates can be used for treating chemokine receptor-mediated disorders and modulating inflammation, inflammatory cell motility, cancer cell motility, or cancer cell survival.
    Type: Application
    Filed: August 8, 2013
    Publication date: November 28, 2013
    Applicant: Morehouse School Of Medicine
    Inventor: James W. Lillard, JR.
  • Methods for prevention and treatment of inflammation using anti-chemokine antibodies
    Patent number: 8580261
    Abstract: It is possible to inhibit inflammatory processes by administration of antibodies to chemokines. Identification of chemokines which are over-produced makes it possible to block specific chemokine activity using antibodies to the over-expressed chemokines.
    Type: Grant
    Filed: June 29, 2012
    Date of Patent: November 12, 2013
    Assignee: Morehouse School of Medicine
    Inventors: James W. Lillard, Jr., Udai P. Singh, Shailesh Singh, Jonathan Stiles
  • Nanoparticles for delivery of active agents
    Patent number: 8568784
    Abstract: Milled nanoparticles comprising a biologically active agent, at least one biopolymer and a coating containing at least one coating which is a polymer or ligand are produced using milling and coating techniques which have not previously been used for these applications.
    Type: Grant
    Filed: November 10, 2010
    Date of Patent: October 29, 2013
    Assignee: Morehouse School of Medicine
    Inventors: James W. Lillard, Rajesh Singh, Shailesh Singh
  • Compositions and methods for treating aids or cancer by inhibiting the secretion of microparticles
    Patent number: 8563506
    Abstract: Novel peptides that inhibit the release of microparticles from cells are disclosed. The peptide contains at least one VGFPV motif at the N-terminal and has a length of 10-100 amino acids. Also disclosed is polynucleotide encoding the peptide, expression vectors carrying the polynucleotide, and methods for treating AIDS and tumors using the novel peptides.
    Type: Grant
    Filed: December 4, 2012
    Date of Patent: October 22, 2013
    Assignee: Morehouse School of Medicine
    Inventors: Vincent Craig Bond, Michael Powell, Ming Bo Huang, Syed Ali, Andrea D. Raymond, Martin Neville Shelton, Francois Jean Villinger
  • Anti-CXCL9, anti-CXCL10, anti-CXCL11, anti-CXCL13, anti-CXCR3 and anti-CXCR5 agents for inflammatory disorders
    Patent number: 8563476
    Abstract: A method for detecting an inflammatory disease in a subject is disclosed. The method comprises the steps of (a) detecting a level of expression of one or more inflammatory disease markers in a biological sample obtained from the subject; and (b) comparing the level of expression of said one or more inflammatory disease markers in the biological sample to a normal level of expression of the one or more inflammatory disease markers, wherein the one or more inflammatory disease markers comprise one or more markers selected from the group consisting of CXCL9, CXCL10, CXCL11, CXCL13, CXCR3 and CXCR5. Also disclosed are a method for monitoring the course of treatment for an inflammatory disease in a subject and a kit for detecting an inflammatory disease in a subject.
    Type: Grant
    Filed: June 27, 2012
    Date of Patent: October 22, 2013
    Assignee: Morehouse School of Medicine
    Inventor: James W. Lillard, Jr.
  • Compositions and methods for treating aids or cancer by inhibiting the secretion of microparticles
    Patent number: 8551943
    Abstract: Novel peptides that inhibit the release of microparticles from cells are disclosed. The peptide contains at least one VGFPV motif at the N-terminal and has a length of 10-100 amino acids. Also disclosed is polynucleotide encoding the peptide, expression vectors carrying the polynucleotide, and methods for treating AIDS and tumors using the novel peptides.
    Type: Grant
    Filed: September 17, 2012
    Date of Patent: October 8, 2013
    Assignee: Morehouse School of Medicine
    Inventors: Vincent Craig Bond, Michael Powell, Ming Bo Huang, Syed Ali, Andrea D. Raymond, Martin Neville Shelton, Francois Jean Villinger
  • METHOD AND COMPOSITIONS FOR THE TREATMENT AND DETECTION OF ENDOTHELIN-1 RELATED KIDNEY DISEASES
    Publication number: 20130252898
    Abstract: The present application relates to methods of treating HIV-associated nephropathy (HIVAN) and/or focal segmental glomerulosclerosis (FSGS) using endothelin-1 (ET-1) antagonists. The application further relates to a composition for the treatment of HIVAN and/or FSGS. A kit for detecting the presence of ET-1 or ET-1-associated biomarker in a biological sample is also disclosed.
    Type: Application
    Filed: May 30, 2013
    Publication date: September 26, 2013
    Applicant: Morehouse School Of Medicine
    Inventors: Gale W. Newman, Barbara A. Jacob-Mungin, Chamberlain Obialo
  • Chemokine-immunoglobulin fusion polypeptides, compositions, method of making and use thereof
    Patent number: 8541564
    Abstract: This application is directed to chemokine-immunoglobulin fusion polypeptides and chemokine-polymer conjugates. The fusion polypeptides and conjugates can be used for treating chemokine receptor-mediated disorders and modulating inflammation, inflammatory cell motility, cancer cell motility, or cancer cell survival.
    Type: Grant
    Filed: May 25, 2012
    Date of Patent: September 24, 2013
    Assignee: Morehouse School of Medicine
    Inventor: James W. Lillard, Jr.
  • METHODS FOR PREVENTION AND TREATMENT OF INFLAMMATION USING ANTI-CHEMOKINE ANTIBODIES
    Publication number: 20130243761
    Abstract: The present invention provides a means of inhibiting the growth and metastasis of cancer cells by administering anti-chemokine antibodies. It is possible to identify the particular chemokines which are over-expressed in the tumor using methods of the invention and administer antibodies against that over-expressed chemokine.
    Type: Application
    Filed: May 3, 2013
    Publication date: September 19, 2013
    Applicant: MOREHOUSE SCHOOL OF MEDICINE
    Inventors: James W. Lillard, JR., Shailesh Singh, Jonathan K. Stiles
  • Methods and compositions for protecting and treating neuroinjury
    Patent number: 8530525
    Abstract: A method and composition for protecting and/or treating neuroinjury are disclosed. In one aspect, the present application discloses a method for protecting and/or treating a subject from organophosphate-induced neuronal injury. The method comprises administering to a subject an effective amount of 4R cembranoid, 4S cembranoid or a cembranoid analogue. In another aspect, the application discloses neuroprotective pharmaceutical compositions for protecting and/or treating a subject from organophosphate-induced neuronal injury. A kit for protecting and treating a subject from organophosphate-induced neurodamage is also disclosed.
    Type: Grant
    Filed: July 1, 2010
    Date of Patent: September 10, 2013
    Assignees: Morehouse School of Medicine, Universidad Central Del Caribe of Bayamon
    Inventors: Byron D. Ford, Peter A. Ferchmin, Vesna A. Eterovic
  • Anti-CXCL13 and anti-CXCR5 antibodies for the prevention and treatment of cancer and cancer cell migration
    Patent number: 8512701
    Abstract: Methods for prevention or inhibition of the growth or metastasis of cancer cells in a subject are disclosed. One method comprises the step of administering to the subject a therapeutically effective amount of an antibody to the chemokine CXCL13 and/or the chemokine receptor CXCR5. Another method comprises the step of administering to the subject a therapeutically effective amount of an expression vector that expresses an antibody to the chemokine CXCL13 and/or the chemokine receptor CXCR5.
    Type: Grant
    Filed: September 29, 2011
    Date of Patent: August 20, 2013
    Assignee: Morehouse School of Medicine
    Inventors: James W. Lillard, Rajesh Singh, Shailesh Singh
  • Nitrated Lipids and Methods of Making and Using Thereof
    Publication number: 20130210917
    Abstract: Described herein are nitrated lipids and methods of making and using the nitrated lipids.
    Type: Application
    Filed: October 8, 2012
    Publication date: August 15, 2013
    Applicants: THE UAB RESEARCH FOUNDATION, Morehouse School of Medicine, Inc., University College Cardiff Consultants Limited, State of Oregon Acting By and Through the Board of Education on Behalf of the University of Oregon
    Inventors: Bruce A. Freeman, Francisco Schopfer, Valerie O'Donnell, Paul Baker, Yuqing E. Chen, Bruce Branchaud
  • Compositions and methods for treating cancer by inhibiting the secretion of microparticles
    Patent number: 8476237
    Abstract: Novel peptides that inhibit the release of microparticles from cells are disclosed. Also disclosed are polynucleotides encoding the peptides, expression vectors carrying the polynucleotides and methods for treating tumors using the novel peptides.
    Type: Grant
    Filed: September 17, 2012
    Date of Patent: July 2, 2013
    Assignee: Morehouse School of Medicine
    Inventors: Vincent Craig Bond, Michael Powell, Ming Bo Huang, Syed Ali, Andrea D. Raymond, Martin Neville Shelton, Francois Jean Villinger
  • COMPOSITIONS AND METHODS FOR EXOSOME TARGETED EXPRESSION
    Publication number: 20130156801
    Abstract: The present application relates to methods of producing exosomes. The application also provides a method for preparing a protein composition comprising culturing an exosome-producing cell expressing a Nef-fusion protein comprising a Nef-derived peptide fused to a protein of interest; isolating exosomes from the exosome-producing cell culture; and purifying the protein of interest from the isolated exosomes. The application further discloses compositions that comprise exosomes containing the Nef-fusion protein, as well as methods of using the Nef-fusion protein and exosomes containing the Nef-fusion protein.
    Type: Application
    Filed: December 15, 2011
    Publication date: June 20, 2013
    Applicant: MOREHOUSE SCHOOL OF MEDICINE
    Inventors: Vincent Craig BOND, Michael POWELL, Ming Bo HUANG, Syed ALI
  • COMPOSITIONS AND METHODS FOR TREATING AIDS OR CANCER BY INHIBITING THE SECRETION OF MICROPARTICLES
    Publication number: 20130123202
    Abstract: Novel peptides that inhibit the release of microparticles from cells are disclosed. The peptide contains at least one VGFPV motif at the N-terminal and has a length of 10-100 amino acids. Also disclosed is polynucleotide encoding the peptide, expression vectors carrying the polynucleotide, and methods for treating AIDS and tumors using the novel peptides.
    Type: Application
    Filed: December 4, 2012
    Publication date: May 16, 2013
    Applicant: MOREHOUSE SCHOOL OF MEDICINE
    Inventor: Morehouse School Of Medicine
  • COMPOSITIONS AND METHODS FOR DIAGNOSIS, PROGNOSIS AND MANAGEMENT OF MALARIA
    Publication number: 20130108647
    Abstract: Biomarkers for predicting the severity of malaria and methods for their detection are disclosed. In one aspect, the present application discloses CXCL4, CXCL10, VEGF, PGDF, IL-1Ra, IL-8, MIP-1?, sFas, Fas-L, sTNF-R2, and sTNF-R1 as biomarkers for the severity of malaria. In another aspect, the present application discloses a method for determining the severity of malaria and predicting mortality due to cerebral malaria. The method comprises the detection of the biomarkers CXCL4 and/or CXCL10 and at least one more biomarker and determining the severity of malaria and predicting mortality due to cerebral malaria based upon the ratio of expression of the biomarkers in the subject versus the expression of the biomarkers in a control.
    Type: Application
    Filed: December 20, 2012
    Publication date: May 2, 2013
    Applicant: MOREHOUSE SCHOOL OF MEDICINE
    Inventor: MOREHOUSE SCHOOL OF MEDICINE
  • Compositions and methods for treating aids or cancer by inhibiting the secretion of microparticles
    Patent number: 8431530
    Abstract: Novel peptides that inhibit the release of microparticles from cells are disclosed. The peptide contains at least one VGFPV motif at the N-terminal and has a length of 10-100 amino acids. Also disclosed is polynucleotide encoding the peptide, expression vectors carrying the polynucleotide, and methods for treating AIDS and tumors using the novel peptides.
    Type: Grant
    Filed: May 20, 2010
    Date of Patent: April 30, 2013
    Assignee: Morehouse School of Medicine
    Inventors: Vincent Craig Bond, Michael Powell, Ming Bo Huang, Syed Ali, Andrea D. Raymond, Martin Neville Shelton, Francois Jean Villinger