Patents Assigned to Morehouse School of Medicine
  • Nitrated lipids and methods of making and using thereof
    Patent number: 9295678
    Abstract: Described herein are nitrated lipids and methods of making and using the nitrated lipids.
    Type: Grant
    Filed: March 4, 2015
    Date of Patent: March 29, 2016
    Assignees: The UAB Research Foundation, The State of Oregon Acting By And Through The State Board Of Higher Education On Behalf of The University of Oregon, University College Cardiff Consultants Limited, Morehouse School of Medicine, Inc.
    Inventors: Bruce A. Freeman, Francisco Schopfer, Valerie O'Donnell, Paul Baker, Yuqing E. Chen, Bruce Branchaud
  • Method and compositions for the treatment and detection of endothelin-1 related kidney diseases
    Patent number: 9255931
    Abstract: The present application relates to methods of treating HIV-associated nephropathy (HIVAN) and/or focal segmental glomerulosclerosis (FSGS) using endothelin-1 (ET-1) antagonists. The application further relates to a composition for the treatment of HIVAN and/or FSGS. A kit for detecting the presence of ET-1 or ET-1-associated biomarker in a biological sample is also disclosed.
    Type: Grant
    Filed: June 16, 2011
    Date of Patent: February 9, 2016
    Assignee: MOREHOUSE SCHOOL OF MEDICINE
    Inventors: Gale Newman, Barbara A. Jacob-Mungin, Chamberlain Obialo
  • METHOD AND COMPOSITIONS FOR THE TREATMENT AND DETECTION OF ENDOTHELIN-1 RELATED KIDNEY DISEASES
    Publication number: 20150335703
    Abstract: The present application relates to methods of treating HIV-associated nephropathy (HIVAN) and/or focal segmental glomerulosclerosis (FSGS) using endothelin-1 (ET-1) antagonists. The application further relates to a composition for the treatment of HIVAN and/or FSGS. A kit for detecting the presence of ET-1 or ET-1-associated biomarker in a biological sample is also disclosed.
    Type: Application
    Filed: August 5, 2015
    Publication date: November 26, 2015
    Applicant: MOREHOUSE SCHOOL OF MEDICINE
    Inventors: Gale W. NEWMAN, Barbara A. Jacob-Mungin, Chamberlain Obialo
  • Nitrated lipids and methods of making and using thereof
    Patent number: 9006473
    Abstract: Described herein are nitrated lipids and methods of making and using the nitrated lipids.
    Type: Grant
    Filed: October 8, 2012
    Date of Patent: April 14, 2015
    Assignees: The UAB Research Foundation, The State of Oregon Acting By and Through the State Board of Higher Education on Behalf of The University of Oregon, University College Cardiff Consultants Limited, Morehouse School of Medicine, Inc.
    Inventors: Bruce A. Freeman, Francisco Schopfer, Valerie O'Donnell, Paul Baker, Yuqing E. Chen, Bruce Branchaud
  • Compositions and methods for diagnosis, prognosis and management of malaria
    Patent number: 8846048
    Abstract: Biomarkers for predicting the severity of malaria and methods for their detection are disclosed. In one aspect, the present application discloses CXCL4, CXCL10, VEGF, PGDF, IL-1Ra, IL-8, MIP-1?, sFas, Fas-L, sTNF-R2, and sTNF-R1 as biomarkers for the severity of malaria. In another aspect, the present application discloses a method for determining the severity of malaria and predicting mortality due to cerebral malaria. The method comprises the detection of the biomarkers CXCL4 and/or CXCL10 and at least one more biomarker and determining the severity of malaria and predicting mortality due to cerebral malaria based upon the ratio of expression of the biomarkers in the subject versus the expression of the biomarkers in a control.
    Type: Grant
    Filed: December 20, 2012
    Date of Patent: September 30, 2014
    Assignee: Morehouse School of Medicine
    Inventors: Jonathan K. Stiles, James W. Lillard, Henry Benjamin Armatei Armah, Nana Otoo Wilson
  • Chemokine-immunoglobulin fusion polypeptides, compositions, method of making and use thereof
    Patent number: 8796422
    Abstract: This application is directed to chemokine-immunoglobulin fusion polypeptides and chemokine-polymer conjugates. The fusion polypeptides and conjugates can be used for treating chemokine receptor-mediated disorders and modulating inflammation, inflammatory cell motility, cancer cell motility, or cancer cell survival.
    Type: Grant
    Filed: August 8, 2013
    Date of Patent: August 5, 2014
    Assignee: Morehouse School of Medicine
    Inventor: James W. Lillard, Jr.
  • Method for treating malaria
    Patent number: 8791067
    Abstract: Compositions and methods for preventing or ameliorating tissue damage caused by an inflammatory disorder or pathogenic infections are described. In one aspect, a method for preventing or ameliorating tissue damage caused by an inflammatory disorder or pathogenic infection comprises administering to a subject a therapeutically effective amount of a neuregulin. In another aspect, the composition comprises one or more active agents that: (a) increase expression or activity of a neuregulin; (b) inhibit the expression or activity of CXCL10, STAT3 or HEME; or (c) both (a) and (b).
    Type: Grant
    Filed: July 24, 2012
    Date of Patent: July 29, 2014
    Assignee: Morehouse School of Medicine
    Inventors: Byron D. Ford, Jonathan Stiles, Gregory Ford
  • Neuregulins for prevention and treatment of damage from acute assault on vascular and neuronal tissue and as regulators of neuronal stem cell migration
    Patent number: 8785369
    Abstract: Neuregulin, a known neuroprotein, has been found to ameliorate or prevent damage caused by mechanical or chemical assault to blood vessels and, when administered into the cerebral spinal fluid, can ameliorate damage to neuronal tissue caused by stroke or inflammation. Additionally, neuregulin has been found to be useful for enhancement of stem cell migration from the ventricle to the site of injury to the brain.
    Type: Grant
    Filed: January 26, 2009
    Date of Patent: July 22, 2014
    Assignee: Morehouse School of Medicine
    Inventor: Byron D. Ford
  • Methods for determination of haplotype dissection
    Patent number: 8759035
    Abstract: A method for molecular haplotyping of a subject is disclosed. The method comprises: randomly selecting a set of chromosomes in each of a plurality of lyzed diploid cells of the subject, collecting the selected chromosomes from said plurality of cells into a plurality of sample tubes, wherein each sample tube contains chromosomes selected from one or more cells, genotyping genomic DNA in each sample tube, and determining haplotype of the alleles based on allele nucleotide sequence information and corresponding nucleotide signal intensities from genotyping data. Other methods for molecular haplotyping using single cell lysate or single cell microdissection are also disclosed.
    Type: Grant
    Filed: June 18, 2009
    Date of Patent: June 24, 2014
    Assignee: Morehouse School of Medicine
    Inventors: Qing Song, Li Ma, Yan Xiao
  • Chimeric neuregulins and method of making and use thereof
    Patent number: 8748131
    Abstract: Composition containing a chimeric neuregulin polypeptides and method of making such polypeptides are disclosed. The chimeric neuregulin comprises a first moiety of at least 10 amino acids, wherein the first moiety is derived from a first polypeptide; and a second moiety of at least 5 amino acids, wherein the second moiety is derived from a second polypeptide; wherein the first polypeptide is a neuregulin and the chimeric neuregulin exhibits an enhanced binding affinity to integrin, Erb 3, or Erb 4 comparing to that of the first neuregulin.
    Type: Grant
    Filed: September 26, 2012
    Date of Patent: June 10, 2014
    Assignee: Morehouse School of Medicine
    Inventor: Byron D. Ford
  • ANTIMICROBIAL COMPOSITIONS AND METHODS OF USE THEREOF
    Publication number: 20140155319
    Abstract: The present application discloses a method for treating microbial infection using an antimicrobial composition comprises antimicrobial peptide which contains at least one VGFPV motif.
    Type: Application
    Filed: January 15, 2014
    Publication date: June 5, 2014
    Applicant: MOREHOUSE SCHOOL OF MEDICINE
    Inventors: VINCENT CRAIG BOND, MICHAEL POWELL, MING BO HUANG, SYED ALI, MARTIN NEVILLE SHELTON
  • Methods for determination of haplotype dissection
    Patent number: 8735059
    Abstract: A method for molecular haplotyping of a subject is disclosed. The method comprises: randomly selecting a set of chromosomes in each of a plurality of lyzed diploid cells of the subject, collecting the selected chromosomes from said plurality of cells into a plurality of sample tubes, wherein each sample tube contains chromosomes selected from one or more cells, genotyping genomic DNA in each sample tube, and determining haplotype of the alleles based on allele nucleotide sequence information and corresponding nucleotide signal intensities from genotyping data. Other methods for molecular haplotyping using single cell lysate or single cell microdissection are also disclosed.
    Type: Grant
    Filed: October 6, 2011
    Date of Patent: May 27, 2014
    Assignee: Morehouse School of Medicine
    Inventors: Qing Song, Li Ma, Yan Xiao
  • EXOSOME-MEDIATED DIAGNOSIS OF HEPATITIS VIRUS INFECTIONS AND DISEASES
    Publication number: 20140134606
    Abstract: A method for diagnosing hepatitis virus infection or a hepatitis disease condition in a subject based on hepatitis virus-associated biomarkers present on exosomes in a bodily fluid sample from the subject is disclosed. Also disclosed are a method for monitoring the course of a hepatitis virus infection or a hepatitis disease condition in a subject and a method for monitoring effectiveness of treatment to a subject with an anti-hepatitis virus agent based on hepatitis virus-associated biomarkers present on exosomes in bodily fluid samples from the subject, as well as a kit for diagnosing hepatitis virus infection and/or a hepatitis disease condition in a subject based on hepatitis virus-associated biomarkers on exosomes in bodily fluid samples from the subject.
    Type: Application
    Filed: January 21, 2014
    Publication date: May 15, 2014
    Applicant: MOREHOUSE SCHOOL OF MEDICINE
    Inventors: Gale W. NEWMAN, Sam Anyanwu
  • CHIMERIC NEUREGULINS AND METHOD OF MAKING AND USE THEREOF
    Publication number: 20140086897
    Abstract: Composition containing a chimeric neuregulin polypeptides and method of making such polypeptides are disclosed. The chimeric neuregulin comprises a first moiety of at least 10 amino acids, wherein the first moiety is derived from a first polypeptide; and a second moiety of at least 5 amino acids, wherein the second moiety is derived from a second polypeptide; wherein the first polypeptide is a neuregulin and the chimeric neuregulin exhibits an enhanced binding affinity to integrin, Erb 3, or Erb 4 comparing to that of the first neuregulin.
    Type: Application
    Filed: April 18, 2013
    Publication date: March 27, 2014
    Applicant: MOREHOUSE SCHOOL OF MEDICINE
    Inventor: Byron D. FORD
  • CHIMERIC NEUREGULINS AND METHOD OF MAKING AND USE THEREOF
    Publication number: 20140088009
    Abstract: Composition containing a chimeric neuregulin polypeptides and method of making such polypeptides are disclosed. The chimeric neuregulin comprises a first moiety of at least 10 amino acids, wherein the first moiety is derived from a first polypeptide; and a second moiety of at least 5 amino acids, wherein the second moiety is derived from a second polypeptide; wherein the first polypeptide is a neuregulin and the chimeric neuregulin exhibits an enhanced binding affinity to integrin, Erb 3, or Erb 4 comparing to that of the first neuregulin.
    Type: Application
    Filed: September 26, 2012
    Publication date: March 27, 2014
    Applicant: Morehouse School of Medicine
    Inventors: Byron D. Ford, James W. Lillard, JR.
  • Antimicrobial compositions and methods of use thereof
    Patent number: 8669226
    Abstract: The present application discloses a method for treating microbial infection using an antimicrobial composition comprises antimicrobial peptide which contains at least one VGFPV motif.
    Type: Grant
    Filed: October 7, 2011
    Date of Patent: March 11, 2014
    Assignee: Morehouse School of Medicine
    Inventors: Vincent Craig Bond, Michael Powell, Ming Bo Huang, Syed Ali, Martin Neville Shelton
  • Detecting cancer with anti-CCL25 and anti-CCR9 antibodies
    Patent number: 8658377
    Abstract: Methods for detecting cancer in a subject are disclosed. The method includes detecting the level of expression of one or more cancer markers in a biological sample obtained from the subject; and comparing the level of expression of the one or more cancer markers in the biological sample to a normal level of expression of the one or more cancer markers. The one or more cancer markers comprise CCL25 or CCR9 or both CCL25 and CCR9.
    Type: Grant
    Filed: December 13, 2011
    Date of Patent: February 25, 2014
    Assignee: Morehouse School of Medicine
    Inventors: James W. Lillard, Rajesh Singh, Shailesh Singh
  • COMPOSITION AND METHOD FOR REDUCING TISSUE DAMAGE FROM INFLAMMATORY DISORDER OR PATHOGENIC INFECTION
    Publication number: 20140030251
    Abstract: Compositions and methods for preventing or ameliorating tissue damage caused by an inflammatory disorder or pathogenic infections are described. In one aspect, a method for preventing or ameliorating tissue damage caused by an inflammatory disorder or pathogenic infection comprises administering to a subject a therapeutically effective amount of a neuregulin. In another aspect, the composition comprises one or more active agents that: (a) increase expression or activity of a neuregulin; (b) inhibit the expression or activity of CXCL10, STAT3 or HEME; or (c) both (a) and (b).
    Type: Application
    Filed: July 24, 2012
    Publication date: January 30, 2014
    Applicant: MOREHOUSE SCHOOL OF MEDICINE
    Inventors: Byron D. Ford, Jonathan Stiles, Gregory Ford
  • COMPOSITION FOR REDUCING NERVOUS SYSTEM INJURY AND METHOD OF MAKING AND USE THEREOF
    Publication number: 20140011817
    Abstract: This application discloses a composition comprising an amiloride and/or an amiloride analog which can be used for reducing nerve injury or nervous system injury in a subject. The formulation of such composition is also disclosed. The application further directs to methods for treating nerve injury or nervous system injury by administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising amiloride, an amiloride analog or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: August 21, 2013
    Publication date: January 9, 2014
    Applicant: Morehouse School of Medicine
    Inventors: Zhigang Xiong, Roger P. Simon
  • COMPOSITIONS AND METHODS FOR TREATING AIDS OR CANCER BY INHIBITING THE SECRETION OF MICROPARTICLES
    Publication number: 20140005117
    Abstract: Novel peptides that inhibit the release of microparticles from cells are disclosed. The peptide contains at least one VGFPV motif at the N-terminal and has a length of 10-100 amino acids. Also disclosed is polynucleotide encoding the peptide, expression vectors carrying the polynucleotide, and methods for treating AIDS and tumors using the novel peptides.
    Type: Application
    Filed: August 30, 2013
    Publication date: January 2, 2014
    Applicant: Morehouse School of Medicine
    Inventors: Vincent Craig BOND, Michael Powell, Ming Bo Huang, Syed Ali, Andrea D. Raymond, Martin Neville Shelton, Francois Jean Villinger