Abstract: Systems and methods for inter-service authentication are disclosed. In one embodiment, a system may include a plurality of services and a cloud platform. The first service may generate a token comprising a first service identifier for communicating with a second service, and may request, from the cloud platform, a private key for the first service. The cloud platform may provide the private key to the first service. The first service may sign the token with the private key and may communicate a request to the second service with the signed token. The second service may retrieve the first service identifier and may request, from the cloud platform, a public key for the first service identifier. The cloud platform may provide the public key to the second service. The second service may validate the token using the public key, and may grant the request in response to the validation.

Abstract: Systems, methods, and apparatuses for generating a trusted chain code (“TCC”) message. The method includes receiving, by a computing system, an agreement message between a first entity and a second entity. The agreement message may be formatted as a smart contract whose execution causes a transfer of value in response to at least one of an occurrence of an event or a fulfillment of a condition. The smart contract includes chain code that corresponds to computer language to execute and corresponds to at least one of the occurrence of the event or the fulfillment of the condition. A chain code manifest is generated. The chain code manifest includes a hash of the chain code of the smart contract. A TCC message is generated including at least the smart contract and a digital signature on at least the chain code manifest. The TCC message is posted to a distributed ledger.

Abstract: An oral cleaning system (100, 200) configured to provide optimal oral cleaning using an oral cleaning device (10), the system capable of receiving, extracting, and assessing data from one or more sensors (28) of the oral cleaning device to determine whether optimal cleaning has been achieved during a primary oral cleaning session, and if not, generating a customized secondary cleaning routine configured to achieve optimized cleaning session. The customized secondary cleaning routine is offered to the user, and the system guides the user through the customized secondary cleaning routine to achieve optimal cleaning performance.

Abstract: Systems and methods for performing a process are provided. The methods include receiving, from a client, a request for an initiation of the process; transmitting, to a server, a request for executing the process; transmitting, to the client in response to the request, a first message that indicates that the process has been initiated; receiving, from the client, a request for a status of the process; transmitting, to the server, a query that relates to the status of an execution of the process; receiving a response to the query; and transmitting, to the client, a second message that indicates the status of the process.

Abstract: Method for targeted alteration of a duplex acceptor DNA sequence in a plant cell protoplast, comprising combining the duplex acceptor DNA sequence with a donor mutagenic nucleobase, wherein the duplex acceptor DNA sequence contains a first DNA sequence and a second DNA sequence which is the complement of the first DNA sequence and wherein the donor mutagenic nucleobase comprises at least one mismatch with respect to the duplex acceptor DNA sequence to be altered, preferably with respect to the first DNA sequence, wherein the method further comprises a step of introducing the donor mutagenic nucleobase into the cell protoplasts using polyethylene glycol (PEG) mediated transformation and the use of PEG protoplast transformation for enhancing the rate of targeted mutagenesis.

Abstract: A model management system receives data for an inventory of models including data regarding issues for each of the models. The model management system determines a model risk score for each of the models based on the issues for each of the models. As the issues are opened and closed, the model management system receives updates and in real-time, updates the model risk score. The model risk score can be determined using a severity assigned to each issue for each of the open issues for a given model as well as the number of issues at each severity. Risk scores can be calculated across a line of business and across an enterprise, for example. The model management system also provides one or more of: model development, model validation, model integration, model use, model maintenance, and model retirement.

Abstract: A method of providing high frequency ventilation to a patient, comprises delivering a flow of breathing gas to the patient, the flow of breathing gas having a first positive pressure level and a second positive pressure level, the first and second positive pressure levels alternating with one another in a plurality of cycles in the flow of breathing gas to have a frequency and an amplitude, the flow of breathing gas to the patient generating a mean airway pressure; determining whether the patient is breathing spontaneously or is trying to breath spontaneously; and, in response to the determination that the patient is breathing spontaneously or trying to breath spontaneously or according to the user settings for HFV and user intervention for non-spontaneous breathing patient, adjusting the mean airway pressure, modulating the frequency and duty cycle of the flow of breathing gas, or modulating the level of flow and pressure amplitude of the breathing gas, or two or more thereof.

Abstract: Methods are provided for the treatment of IL-6R related diseases. More specifically, specific dose regimens and pre-filled syringes are provided for subcutaneous administration, to subjects suffering an IL-6R related disease, of immunoglobulin single variable domains that bind IL-6R.

Abstract: An ultrasound probe includes an ultrasound probe housing and one or more ultrasound transducers disposed in the ultrasound probe housing. A dosimeter or ionizing radiation detector is disposed in or attached to the ultrasound probe housing. An alarm device receives radiation dose or radiation exposure data acquired by the dosimeter or ionizing radiation detector. The alarm device includes an electronic processor programmed to detect excessive radiation dose or radiation exposure received by the ultrasound probe based on the radiation dose or radiation exposure data acquired by the dosimeter or ionizing radiation detector, and output an alarm warning of the detection of excessive radiation dose or radiation exposure received by the ultrasound probe. In some embodiments, the dosimeter is a one-time use dosimeter that is not resettable.

Abstract: A system for air-conditioning and hot-water supply is configured to selectively perform a cooling operation and a heating operation. The system includes: an outdoor unit having a compressor and an outdoor heat exchanger; a plurality of indoor units each of which is connected to the outdoor unit and includes an indoor heat exchanger; a hot-water supply unit connected to the outdoor unit so as to be arranged in parallel to the indoor unit and including a refrigerant-water heat exchanger; and a controller configured to monitor a request for hot-water supply from the hot-water supply unit. The controller is further configured to continue a cooling operation after the request has occurred and until a predetermined condition is satisfied where the request for hot-water supply has occurred during the cooling operation at at least one of the plurality of indoor units, and then to start a heating operation.

Abstract: An embodiment of the present invention is directed to implementing a complex patching micro service architecture. An embodiment of the present invention is directed to controlling and managing patching of complex patterns using a micro service architecture. Using a defined library of micro services, an application owner may build a configuration to follow for patching routines. The configuration may be used as reference data and further used to establish a workflow for each patching iteration.

Abstract: A vehicle roll over protection system with at least one hoop member, longitudinal member, and connection device. The connection device couples the longitudinal member to the hoop member and includes first and second side plates that are fixedly attached on opposing sides of the hoop member in a substantially parallel arrangement to define a channel between the first and second side plates. Each side plate includes a cut-out that forms a cradle. The longitudinal member is received in the cradle. One or more wing plates are fixed to the longitudinal member. The wing plate(s) are received in the channel between the first and second side plates such that the first and second side plates act as displacement limiting features that limit the displacement of the longitudinal member relative to the hoop member in multiple directions.

Abstract: The invention relates to a build validation engine for a software build process. According to an embodiment of the present invention, a computer implemented system a build validation engine further configured to perform the steps comprising: receiving inputs from a software platform, the inputs comprising a build identifier and a mode indicator; initiating, via the build validation engine, validation of a plurality of configuration file categories for a software build; identifying and applying, via the build validation engine, a set of configuration rules, the set of configuration rules associated with each configuration file category and further comprising server class validation, inputs validation, indexes validation and props validation; and determining whether a successful build is achieved and if a successful build is not determined, failing the build and deleting corresponding deployment bundles.

Abstract: The appropriate positioning of a patient in an X-Ray imaging system can present difficulties for medical professional owing, on one hand to the small size of important anatomical aspects which need to be captured in X-Ray images, and on the other hand to the significant movements in a field of view presented by a typical patient. The present application proposes to obtain an image of the position of a patient in the field of view at approximately the same time that an initial X-Ray image is obtained. If it proves necessary to obtain a subsequent X-Ray image with updated field of view settings (for example, collimation parameters), the movement of the patient at the point of taking the second image is factored into the provision of updated field of view settings.

Abstract: A bronchoscopy scope guide (30) for a non-invasive ventilation (NIV) patient interface (10) comprises a semi-rigid scope guide tube (32), a bronchoscopy scope seal (48), and a semi-rigid grommet (34). The semi-rigid scope guide tube (32) includes a principal axis (36) and entrance and exit guide portions (38,40). The bronchoscopy scope seal (48) couples to the scope guide tube for sealing around a bronchoscopy scope when inserted through the scope guide tube. The semi-rigid grommet (34) is disposed about an outer circumference of and flexibly coupled to the scope guide tube (32) and is located in a principal plane (52) transverse to the principal axis of the scope guide tube.

Abstract: The present invention relates to methods for the preparation of an aerosol. More specifically the present invention provides methods for the preparation of an aerosol of immunoglobulin single variable domains wherein the amount of aggregate formation is significantly reduced. The invention further provides aerosols prepared by the methods of the invention, as well as compositions for use in the methods of the invention. The invention further relates to methods for the preparations of such compositions, to containers, kits and aerosol delivery systems comprising such compositions and to uses of the same.

Abstract: A system and related method are provided for dynamically modifying a rule-based matching system, A processor receives a source data entity, and then locates a matching data entity by a search based on the source data entity and a rule set. A rater assessment is provided by a rater that utilizes at least one factor that is independent of the rule set and comprises a degree of matching between the source and matching data entity. A revised rule set is dynamically created based on an output of the analyzer, which in turn is based on the source data entity, the matching data entity, the rater assessment, and the rule set. Once this is complete, a second matching data entity is located by searching for the second matching data entity based on the source data entity and the revised rule set.

Abstract: A device for light-based skin treatment is provided. The device comprises a light source for providing an incident light beam for treating a skin, optical elements for focusing the incident light beam in a focal point inside the skin, and a skin interface element for, during use of the device, providing optical coupling of the incident light beam from the device into the skin. The skin interface element comprises a transparent exit window for allowing the incident light beam to leave the device, on top of the exit window, a transparent mixture of a polar substance and an apolar substance, and on top of the transparent mixture, a transparent foil, the transparent foil being more hydrophobic than the exit window.

Abstract: A system, computer-readable storage medium and method provide a secure transaction by receiving, from a mobile wallet a request to assign a vendor specific payment account identifier (VSPAI) to a payment account identifier (PAI) associated with a user of the mobile wallet. Identifying information is verified of: (i) an issuer of the PAI, (ii) a specific vendor; and (iii) the user of the mobile wallet. In response to verifying, a unique VSPAI is created that is associated with the PAI of the user and the specific vendor. Then, when a payment request is received including the unique VSPAI for a transaction with a particular vendor, the particular vendor is verified as the specific vendor associated with the unique VSPAI. In response to verifying that the particular vendor, payment of the transaction by the issuer using the PAI associated with the unique VSPAI is facilitated.

Abstract: The present disclosure is directed to a lead frame design that includes a copper alloy base material coated with an electroplated copper layer, a precious metal, and an adhesion promotion compound. The layers compensate for scratches or surface irregularities in the base material while promoting adhesion from the lead frame to the conductive connectors, and to the encapsulant by coupling them to different layers of a multilayer coating on the lead frame. The first layer of the multilayer coating is a soft electroplated copper to smooth the surface of the base material. The second layer of the multilayer coating is a thin precious metal to facilitate a mechanical coupling between leads of the lead frame and conductive connectors. The third layer of the multilayer coating is the adhesion promotion compound for facilitating a mechanical coupling to an encapsulant around the lead frame.